Abstract:
:The anisotropic shape of DNA molecules allows them to form lyotropic liquid crystals (LCs) at high concentrations. This liquid crystalline arrangement is also found in vivo (e.g., in bacteriophage capsids, bacteria or human sperm nuclei). However, the role of DNA liquid crystalline organization in living organisms still remains an open question. Here we show that in vitro, the DNA spatial structure is significantly changed in mesophases compared to non-organized DNA molecules. DNA LCs were prepared from pBluescript SK (pBSK) plasmid DNA and investigated by photochemical analysis of structural transitions (PhAST). We reveal significant differences in the probability of UV-induced pyrimidine dimer photoproduct formation at multiple loci on the DNA indicative of changes in major groove architecture.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Brach K,Hatakeyama A,Nogues C,Olesiak-Banska J,Buckle M,Matczyszyn Kdoi
10.1038/s41598-018-22863-zsubject
Has Abstractpub_date
2018-03-14 00:00:00pages
4528issue
1issn
2045-2322pii
10.1038/s41598-018-22863-zjournal_volume
8pub_type
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