Population pharmacokinetics of peginterferon α2a in patients with chronic hepatitis B.

abstract：:The success of mesenchymal stem cell transplantation is highly dependent on their survival and controlled fate regulation. This study demonstrates that dual-delivery of connective tissue growth factor (CTGF) and fibroblast growth factor 2 (FGF-2) from a core-shell fiber of Silk Fibroin/poly(L-lactic acid-co-ε-caprolac...

journal_title：Scientific reports

authors： Xu R,Zhao H,Muhammad H,Dong M,Besenbacher F,Chen M

更新日期：2017-08-17 00:00:00

abstract：:The overlap between pain and reward processing pathways leds researchers to hypothesize that there are interactions between them in the human brain. Two hypotheses have been proposed. The "competition hypothesis" posits that reward can reduce pain-related neural activity and vice versa. The "salience hypothesis" sugge...

journal_title：Scientific reports

authors： Cui F,Zhu X,Gu R,Luo YJ

更新日期：2016-05-19 00:00:00

abstract：:Optical coherence tomography angiography (OCTA) seems not to image the choroidal blood flow pattern in the normal individual because of the OCT light attenuation. Our purpose in the current study was to visualize the large choroidal blood flow pattern after subtraction of the choriocapillaris projection artifact in no...

journal_title：Scientific reports

authors： Maruko I,Kawano T,Arakawa H,Hasegawa T,Iida T

更新日期：2018-10-24 00:00:00

abstract：:O antigen (O-Ag) in many bacteria is synthesized via the Wzx/Wzy-dependent pathway in which Wzy polymerizes lipid-linked O-Ag subunits to modal lengths regulated by Wzz. Characterization of 83 site-directed mutants of Wzy from Pseudomonas aeruginosa PAO1 (WzyPa) in topologically-mapped periplasmic (PL) and cytoplasmic...

journal_title：Scientific reports

authors： Islam ST,Huszczynski SM,Nugent T,Gold AC,Lam JS

更新日期：2013-12-06 00:00:00

abstract：:Photonic crystal materials are based on a periodic modulation of the dielectric constant on length scales comparable to the wavelength of light. These materials can exhibit photonic band gaps; frequency regions for which the propagation of electromagnetic radiation is forbidden due to the depletion of the density of s...

journal_title：Scientific reports

authors： Marichy C,Muller N,Froufe-Pérez LS,Scheffold F

更新日期：2016-02-25 00:00:00

abstract：:We present active manipulation of the structural vibrations of an elastic body to generate an acoustic illusion. The resultant illusion misrepresents the nature, size and number of objects in the exterior acoustic domain. We demonstrate our technique, herein termed active structural acoustic illusion, using an elastic...

journal_title：Scientific reports

authors： Eggler D,Kessissoglou N

更新日期：2020-06-17 00:00:00

abstract：:In East Greenland, a dramatic increase of tuberculosis (TB) incidence has been observed in recent years. Classical genotyping suggests a genetically similar Mycobacterium tuberculosis (Mtb) strain population as cause, however, precise transmission patterns are unclear. We performed whole genome sequencing (WGS) of Mtb...

journal_title：Scientific reports

authors： Bjorn-Mortensen K,Soborg B,Koch A,Ladefoged K,Merker M,Lillebaek T,Andersen AB,Niemann S,Kohl TA

更新日期：2016-09-12 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Ayaz G,Razizadeh N,Yaşar P,Kars G,Kahraman DC,Saatci Ö,Şahin Ö,Çetin-Atalay R,Muyan M

更新日期：2020-06-16 00:00:00

abstract：:Acinetobacter baumannii is a common cause of health care associated infections worldwide. A. pittii is an opportunistic pathogen also frequently isolated from Acinetobacter infections other than those from A. baumannii. Knowledge of Acinetobacter virulence factors and their role in pathogenesis is scarce. Also, there ...

journal_title：Scientific reports

authors： Lázaro-Díez M,Chapartegui-González I,Redondo-Salvo S,Leigh C,Merino D,Segundo DS,Fernández A,Navas J,Icardo JM,Acosta F,Ocampo-Sosa A,Martínez-Martínez L,Ramos-Vivas J

更新日期：2017-07-04 00:00:00

abstract：:Nowadays efficient down conversion for white light emission is mainly based on rare-earth doped phosphors or cadmium-containing quantum dots. Although they exhibit high luminescence efficiency, the rare-earth mining and cadmium pollution have so far led to extremely high environmental cost, which conflicts the origina...

journal_title：Scientific reports

authors： Shen PC,Lin MS,Lin CF

更新日期：2014-06-16 00:00:00

abstract：:Multigene expression signatures provide a molecular subdivision of early breast cancer associated with patient outcome. A gap remains in the validation of such signatures in clinical treatment groups of patients within population-based cohorts of unselected primary breast cancer representing contemporary disease stage...

journal_title：Scientific reports

authors： Vallon-Christersson J,Häkkinen J,Hegardt C,Saal LH,Larsson C,Ehinger A,Lindman H,Olofsson H,Sjöblom T,Wärnberg F,Ryden L,Loman N,Malmberg M,Borg Å,Staaf J

更新日期：2019-08-21 00:00:00

abstract：:Transgenic rice producing insecticidal proteins from Bacillus thuringiensis (Bt) could help protect the plants from damage by lepidopteran pests. However, one concern is the potential of Bt rice to harm non-target natural enemies, which play a vital role in pest control. In the present study, the potential effects of ...

journal_title：Scientific reports

authors： Tian JC,Romeis J,Liu K,Zhang FC,Zheng XS,Xu HX,Chen GH,He XC,Lu ZX

更新日期：2017-08-10 00:00:00

abstract：:Pseudomonas aeruginosa is an opportunistic pathogen and a leading cause of nosocomial infections. Unfortunately, P. aeruginosa has low antibiotic susceptibility due to several chromosomally encoded antibiotic resistance genes. Hence, we carried out mechanistic studies to determine how azithromycin affects quorum sensi...

journal_title：Scientific reports

authors： Zeng J,Zhang N,Huang B,Cai R,Wu B,E S,Fang C,Chen C

更新日期：2016-04-14 00:00:00

abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) activates NF-κB during infection. We examined the ability of all 22 PRRSV genes for NF-κB regulation and determined the nucleocapsid (N) protein as the NF-κB activator. Protein inhibitor of activated STAT1 (signal transducer and activator of transcription 1) ...

journal_title：Scientific reports

authors： Ke H,Lee S,Kim J,Liu HC,Yoo D

更新日期：2019-07-30 00:00:00

abstract：:The identification of the most influential individuals in structured populations is an important research question, with many applications across the social and natural sciences. Here, we study this problem in evolutionary populations on static networks, where invading cheaters can lead to the collapse of cooperation....

journal_title：Scientific reports

authors： Yang G,Cavaliere M,Zhu C,Perc M

更新日期：2020-02-10 00:00:00

abstract：:Previous studies in model eukaryotes have demonstrated that phosphorylation of heterochromatin protein 1 (HP1) is important for dynamically regulating its various functions. However, in the malaria parasite Plasmodium falciparum both the function of HP1 phosphorylation and the identity of the protein kinases targeting...

journal_title：Scientific reports

authors： Bui HTN,Niederwieser I,Bird MJ,Dai W,Brancucci NMB,Moes S,Jenoe P,Lucet IS,Doerig C,Voss TS

更新日期：2019-11-13 00:00:00

abstract：:Antibiogram profile of 1590 clinical bacterial isolates based on thirteen different antimicrobial compounds showed that 1.6% of the bacterial isolates are multidrug resistant. Distribution pattern based on 16S rRNA sequence analysis showed that Pseudomonas aeruginosa constituted the largest group (83.6%) followed by B...

journal_title：Scientific reports

authors： Kumar M,Gupta A,Sahoo RK,Jena J,Debata NK,Subudhi E

更新日期：2016-03-18 00:00:00

abstract：:Retinal diseases generally are vision-threatening conditions that warrant appropriate clinical decision-making which currently solely dependents upon extensive clinical screening by specialized ophthalmologists. In the era where molecular assessment has improved dramatically, we aimed at the identification of biomarke...

journal_title：Scientific reports

authors： Kuiper JJ,Beretta L,Nierkens S,van Leeuwen R,Ten Dam-van Loon NH,Ossewaarde-van Norel J,Bartels MC,de Groot-Mijnes JD,Schellekens P,de Boer JH,Radstake TR

更新日期：2017-01-27 00:00:00

abstract：:Laser-driven ion acceleration is often analyzed assuming that ionization reaches a steady state early in the interaction of the laser pulse with the target. This assumption breaks down for materials of high atomic number for which the ionization occurs concurrently with the acceleration process. Using particle-in-cell...

journal_title：Scientific reports

authors： Li J,Arefiev AV,Bulanov SS,Kawahito D,Bailly-Grandvaux M,Petrov GM,McGuffey C,Beg FN

更新日期：2019-01-24 00:00:00

abstract：:Mitochondria-generated reactive oxygen species (mROS) are frequently associated with DNA damage and cell cycle arrest, but physiological increases in mROS serve to regulate specific cell functions. T3 is a major regulator of mROS, including hydrogen peroxide (H2O2). Here we show that exogenous thyroid hormone (T3) adm...

journal_title：Scientific reports

authors： Tan L,Bogush N,Naib H,Perry J,Calvert JW,Martin DIK,Graham RM,Naqvi N,Husain A

更新日期：2019-11-27 00:00:00

abstract：:A fundamental strategy to enhance optical transmission through a continuous metallic film based on strong interference dominated by interface phase shift is developed. In a metallic film coated with a thin semiconductor film, both transmission and absorption are simultaneously enhanced as a result of dramatically redu...

journal_title：Scientific reports

authors： Li Q,Du K,Mao K,Fang X,Zhao D,Ye H,Qiu M

更新日期：2016-07-12 00:00:00

abstract：:Birds have a remarkable ability to obtain navigational information from the Earth's magnetic field. The primary detection mechanism of this compass sense is uncertain but appears to involve the quantum spin dynamics of radical pairs formed transiently in cryptochrome proteins. We propose here a new version of the curr...

journal_title：Scientific reports

authors： Kattnig DR,Hore PJ

更新日期：2017-09-14 00:00:00

abstract：:Scanning micro-mirror actuators are silicon-based oscillatory micro-electro-mechanical systems (MEMS). They enable laser distance measurements for automotive LIDAR applications as well as projection modules for the consumer market. For MEMS applications, the geometric structure is typically designed to serve a number ...

journal_title：Scientific reports

authors： Nabholz U,Schatz F,Mehner JE,Degenfeld-Schonburg P

更新日期：2019-03-08 00:00:00

abstract：:Both between- and within-individual variation in behaviour can be important in determining mating opportunities and reproductive outcomes. Such behavioural variability can be induced by environmental conditions, especially if individuals vary in their tolerance levels or resource allocation patterns. We tested the eff...

journal_title：Scientific reports

authors： Lehtonen TK,Svensson PA,Wong BBM

更新日期：2018-06-19 00:00:00

abstract：:Fire blight, caused by the enterobacterium Erwinia amylovora, is a destructive disease, which can affect most members of the Rosaceae family. Since no significant genomic differences have been found by others to explain differences in virulence, we used here a gel-based proteomic approach to elucidate mechanisms and k...

journal_title：Scientific reports

authors： Holtappels M,Noben JP,Van Dijck P,Valcke R

更新日期：2018-08-03 00:00:00

abstract：:Dietary exposure of insects to a feeding deterrent substance for hours to days can induce habituation and concomitant desensitization of the response of peripheral gustatory neurons to such a substance. In the present study, larvae of the herbivore Helicoverpa armigera were fed on diets containing either a high, mediu...

journal_title：Scientific reports

authors： Ma Y,Li J,Tang Q,Zhang X,Zhao X,Yan F,van Loon JJ

更新日期：2016-12-14 00:00:00

abstract：:III-nitride materials have been linked with a vast number of exciting applications from power electronics to solar cells. Herein, polycrystalline InN, GaN and systematically controlled InxGa1-xN composite thin films are fabricated on FTO glass by a facile, low-cost and scalable aerosol assisted chemical vapor depositi...

journal_title：Scientific reports

authors： McInnes A,Sagu JS,Mehta D,Wijayantha KGU

更新日期：2019-02-19 00:00:00

abstract：:Global lake systems have undergone rapid degradation over the past century. Scientists and managers are struggling to manage the highly degraded lake systems to cope with escalating anthropogenic pressures. Improved knowledge of how lakes and social systems co-evolved up to the present is vital for understanding, mode...

journal_title：Scientific reports

authors： Zhang K,Yang X,Kattel G,Lin Q,Shen J

更新日期：2018-11-21 00:00:00

abstract：:Whereas epidemiologic studies consistently identify different rates and types of problematic behavior in boys and girls, there has been little research examining the ecocultural context in which these gender differences in child behavior problems develop, especially in non-Western settings. This qualitative study in r...

journal_title：Scientific reports

authors： Langer JA,Ramos JV,Ghimire L,Rai S,Kohrt BA,Burkey MD

更新日期：2019-05-21 00:00:00

abstract：:Since fatigue is prevalent in modern societies, it is necessary to clarify the neural mechanisms of fatigue. The regulation of performance through fatigue sensation is one of the mechanisms that decreases performance in fatigue. However, it is unknown whether subjective feeling of fatigue is necessary for the regulati...

journal_title：Scientific reports

authors： Ishii A,Tanaka M,Yoshikawa T,Watanabe Y

更新日期：2017-11-23 00:00:00