A 'clicked' tetrameric hydroxamic acid glycopeptidomimetic antagonizes sugar-lectin interactions on the cellular level.

abstract：:Tomato spotted wilt virus is a wide-spread plant disease in the world. It can threaten thousands of plants with a persistent and propagative manner. Early disease detection is expected to be able to control the disease spread, to facilitate management practice, and further to guarantee accompanying economic benefits. ...

journal_title：Scientific reports

authors： Wang D,Vinson R,Holmes M,Seibel G,Bechar A,Nof S,Tao Y

更新日期：2019-03-13 00:00:00

abstract：:Coral reefs around the world are undergoing severe decline in the past few decades. Mass coral mortalities have predominantly been reported to be caused by coral bleaching or disease outbreaks. Temporary hypoxic conditions caused by algal blooms can trigger mass coral mortalities though are reported rarely. In this st...

journal_title：Scientific reports

authors： Raj KD,Mathews G,Obura DO,Laju RL,Bharath MS,Kumar PD,Arasamuthu A,Kumar TKA,Edward JKP

更新日期：2020-12-17 00:00:00

abstract：:The dorsal anterior cingulate cortex (dACC) has been identified as a core region affected by many disorders, representing a promising target for neuromodulation. High Definition-transcranial Direct Current Stimulation (HD-tDCS) is a non-invasive neuromodulation technique that has already shown promising outcomes and h...

journal_title：Scientific reports

authors： To WT,Eroh J,Hart J Jr,Vanneste S

更新日期：2018-03-13 00:00:00

abstract：:We have recently demonstrated that the rate-limiting enzymes in human glucose metabolism organize into cytoplasmic clusters to form a multienzyme complex, the glucosome, in at least three different sizes. Quantitative high-content imaging data support a hypothesis that the glucosome clusters regulate the direction of ...

journal_title：Scientific reports

authors： Jeon M,Kang HW,An S

更新日期：2018-02-09 00:00:00

abstract：:The evaporation of seawater in arid climates is currently the main accepted driving mechanism for the formation of ancient and recent salt deposits in shallow basins. However, the deposition of huge amounts of marine salts, including the formation of tens of metres of highly soluble types (tachyhydrite and bischofite)...

journal_title：Scientific reports

authors： Debure M,Lassin A,Marty NC,Claret F,Virgone A,Calassou S,Gaucher EC

更新日期：2019-08-12 00:00:00

abstract：:MCR-1 is a phosphoethanolamine (pEtN) transferase that modifies the pEtN moiety of lipid A, conferring resistance to colistin, which is an antibiotic belonging to the class of polypeptide antibiotics known as polymyxins and is the last-line antibiotic used to treat multidrug resistant bacterial infections. Here we det...

journal_title：Scientific reports

authors： Hu M,Guo J,Cheng Q,Yang Z,Chan EWC,Chen S,Hao Q

更新日期：2016-12-13 00:00:00

abstract：:Metformin is used to treat type 2 diabetes. Metformin activates AMP-activated kinase (AMPK), which may contribute to the action of metformin. Metformin also shows anti-proliferation activity. However, the mechanism is remained unknown. We found that treatment of MCF-7 cells with metformin induced the demethylase activ...

journal_title：Scientific reports

authors： Tanaka Y,Konishi A,Obinata H,Tsuneoka M

更新日期：2019-12-10 00:00:00

abstract：:Dogs' attachment towards humans might be the core of their social skillset, yet the origins of their ability to build such a bond are still unclear. Here we show that adult, hand-reared wolves, similarly to dogs, form individualized relationship with their handler. During separation from their handler, wolves, much li...

journal_title：Scientific reports

authors： Lenkei R,Újváry D,Bakos V,Faragó T

更新日期：2020-10-14 00:00:00

abstract：:Melanosomes (melanin-bearing organelles) are common in the fossil record occurring as dense packs of globular microbodies. The organic component comprising the melanosome, melanin, is often preserved in fossils, allowing identification of the chemical nature of the constituent pigment. In present-day vertebrates, mela...

journal_title：Scientific reports

authors： Pinheiro FL,Prado G,Ito S,Simon JD,Wakamatsu K,Anelli LE,Andrade JAF,Glass K

更新日期：2019-11-04 00:00:00

abstract：:The glycocalyx regulates the interaction of mammalian cells with extracellular molecules, such as cytokines. However, it is unknown to which extend the glycocalyx of distinct cancer cells control the binding and uptake of nanoparticles. In the present study, exome sequencing data of cancer patients and analysis of dis...

journal_title：Scientific reports

authors： von Palubitzki L,Wang Y,Hoffmann S,Vidal-Y-Sy S,Zobiak B,Failla AV,Schmage P,John A,Osorio-Madrazo A,Bauer AT,Schneider SW,Goycoolea FM,Gorzelanny C

更新日期：2020-12-31 00:00:00

abstract：:The recent emergence of highly virulent human adenoviruses (HAdVs) with new tissue tropisms underscores the need to determine their ontogeny. Here we report complete high quality genome sequences and analyses for all the previously unsequenced HAdV serotypes (n = 20) within HAdV species D. Analysis of nucleotide seque...

journal_title：Scientific reports

authors： Robinson CM,Singh G,Lee JY,Dehghan S,Rajaiya J,Liu EB,Yousuf MA,Betensky RA,Jones MS,Dyer DW,Seto D,Chodosh J

更新日期：2013-01-01 00:00:00

abstract：:Zeolites/molecular sieves with uniform, molecular-sized pores are important for many adsorption-based separation processes. Pore size gaps, however, exist in the current zeolite family. This leads to a great challenge of separating molecules with size differences at ~0.01 nm level. Here, we report a novel concept, por...

journal_title：Scientific reports

authors： Song Z,Huang Y,Xu WL,Wang L,Bao Y,Li S,Yu M

更新日期：2015-09-11 00:00:00

abstract：:In this work, we demonstrate an innovative approach, combing a novel active screen plasma (ASP) technique with green chemical synthesis, for a direct fabrication of uniform Pt nanowire arrays on large-area supports. The ASP treatment enables in-situ N-doping and surface modification to the support surface, significant...

journal_title：Scientific reports

authors： Du S,Lin K,Malladi SK,Lu Y,Sun S,Xu Q,Steinberger-Wilckens R,Dong H

更新日期：2014-09-22 00:00:00

abstract：:A single bout of electroacupuncture results in muscle contractions and increased whole body glucose uptake in women with polycystic ovary syndrome (PCOS). Women with PCOS have transcriptional and epigenetic alterations in the adipose tissue and we hypothesized that electroacupuncture induces epigenetic and transcripti...

journal_title：Scientific reports

authors： Kokosar M,Benrick A,Perfilyev A,Nilsson E,Källman T,Ohlsson C,Ling C,Stener-Victorin E

更新日期：2018-01-30 00:00:00

abstract：:Mitigating climate change effects involves strategic decisions by individuals that may choose to limit their emissions at a cost. Everyone shares the ensuing benefits and thereby individuals can free ride on the effort of others, which may lead to the tragedy of the commons. For this reason, climate action can be conv...

journal_title：Scientific reports

authors： Góis AR,Santos FP,Pacheco JM,Santos FC

更新日期：2019-11-07 00:00:00

abstract：:Misfolding and aggregation of prion protein (PrP) causes neurodegenerative diseases like Creutzfeldt-Jakob disease (CJD) and scrapie. Besides the consensus that spontaneous conversion of normal cellular PrPC into misfolded and aggregating PrPSc is the central event in prion disease, an alternative hypothesis suggests ...

journal_title：Scientific reports

authors： Czech A,Konarev PV,Goebel I,Svergun DI,Wills PR,Ignatova Z

更新日期：2019-02-21 00:00:00

abstract：:Small molecule based targeted therapies for the treatment of metastatic melanoma hold promise but responses are often not durable, and tumors frequently relapse. Response to adoptive cell transfer (ACT)-based immunotherapy in melanoma patients are durable but patients develop resistance primarily due to loss of antige...

journal_title：Scientific reports

authors： Dextras C,Dashnyam M,Griner LAM,Sundaresan J,Chim B,Yu Z,Vodnala S,Lee CR,Hu X,Southall N,Marugan JJ,Jadhav A,Restifo NP,Acquavella N,Ferrer M,Singh A

更新日期：2020-03-30 00:00:00

abstract：:Nettles are commonly consumed in South Africa, Europe and Asia and are used in traditional medicine to treat a variety of ailments. In this study, the nutritional value of the leaves of nettles (Laportea alatipes and Obetia tenax) was evaluated and compared, when cooked and uncooked. The results showed a decrease in t...

journal_title：Scientific reports

authors： Mahlangeni NT,Moodley R,Jonnalagadda SB

更新日期：2020-06-17 00:00:00

abstract：:The importance of self-feedback autaptic transmission in modulating spike-time irregularity is still poorly understood. By using a biophysical model that incorporates autaptic coupling, we here show that self-innervation of neurons participates in the modulation of irregular neuronal firing, primarily by regulating th...

journal_title：Scientific reports

authors： Guo D,Wu S,Chen M,Perc M,Zhang Y,Ma J,Cui Y,Xu P,Xia Y,Yao D

更新日期：2016-05-17 00:00:00

abstract：:Numerous studies have reported cold atmospheric plasma cytotoxic activities in various cancer cell lines, either by direct exposure to non-thermal plasma or indirectly by activating a medium (plasma-activated medium, PAM) prior to cell treatment. We suggested the use of in vitro 3D tumor model spheroids to determine t...

journal_title：Scientific reports

authors： Chauvin J,Gibot L,Griseti E,Golzio M,Rols MP,Merbahi N,Vicendo P

更新日期：2019-03-19 00:00:00

abstract：:Chemotherapy often induces oral ulcerative mucositis (OUM) in patients with cancer, characterized by severe painful inflammation. Mouth-washing with the Japanese herbal medicine hangeshashinto (HST) ameliorates chemotherapy-induced OUM in patients with colorectal cancer. Previously, we demonstrated that HST decreased ...

journal_title：Scientific reports

authors： Miyano K,Eto M,Hitomi S,Matsumoto T,Hasegawa S,Hirano A,Nagabuchi K,Asai N,Uzu M,Nonaka M,Omiya Y,Kaneko A,Ono K,Fujii H,Higami Y,Kono T,Uezono Y

更新日期：2020-01-17 00:00:00

abstract：:Broadband acoustic absorbers with thin thickness are highly desired in practical situations such as architectural acoustics, yet it is still challenging to achieve high absorption by using structure with limited thickness. Here we report the theoretical optimal design, numerical simulation and experimental demonstrati...

journal_title：Scientific reports

authors： Gao YX,Lin YP,Zhu YF,Liang B,Yang J,Yang J,Cheng JC

更新日期：2020-07-01 00:00:00

abstract：:Gastroenterologists are still unable to differentiate between some of the most ordinary disorders of the gut and consequently patients are misdiagnosed. We have developed a swallowable gas sensor capsule for addressing this. The gases of the gut are the by-product of the fermentation processes during digestion, affect...

journal_title：Scientific reports

authors： Ou JZ,Cottrell JJ,Ha N,Pillai N,Yao CK,Berean KJ,Ward SA,Grando D,Muir JG,Harrison CJ,Wijesiriwardana U,Dunshea FR,Gibson PR,Kalantar-Zadeh K

更新日期：2016-09-16 00:00:00

abstract：:Recent advances in next-generation sequencing technologies have paved the path for a considerable amount of sequencing data at a relatively low cost. This has revolutionized the genomics and transcriptomics studies. However, different challenges are now created in handling such data with available bioinformatics platf...

journal_title：Scientific reports

authors： Naranpanawa DNU,Chandrasekara CHWMRB,Bandaranayake PCG,Bandaranayake AU

更新日期：2020-10-26 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) and cytokeratin 18 (CK18) were previously reported to be elevated in nonalcoholic fatty liver disease (NAFLD). We aim to analyze the differential roles of FGF21, cell apoptosis marker CK18 fragment M30 and total cell death marker CK18 M65ED in monitoring the different stages of NAFL...

journal_title：Scientific reports

authors： Wu G,Li H,Fang Q,Zhang J,Zhang M,Zhang L,Wu L,Hou X,Lu J,Bao Y,Jia W

更新日期：2017-07-11 00:00:00

abstract：:In this work, we experimentally investigate near-field capacitive coupling between a pair of single-gap split ring resonators (SRRs) in a terahertz metamaterial. The unit cell of our design comprises of two coupled SRRs with the split gaps facing each other. The coupling between two SRRs is examined by changing the ga...

journal_title：Scientific reports

authors： Rao SJM,Srivastava YK,Kumar G,Roy Chowdhury D

更新日期：2018-11-13 00:00:00

abstract：:In the current research, to find if the combination of chitosan nerve conduits seeded with autologous bone marrow mononuclear cells (BM-MNCs) can be used to bridge 30 mm long peroneal nerve defects in goats, 15 animals were separated into BM-MNC group (n = 5), vehicle group (n = 5), and autologous nerve graft group (n...

journal_title：Scientific reports

authors： Muheremu A,Chen L,Wang X,Wei Y,Gong K,Ao Q

更新日期：2017-03-13 00:00:00

abstract：:We study the time-development processes of spin and charge transport phenomena in a topological Dirac semimetal attached to a ferromagnetic insulator with a precessing magnetization. Compared to conventional normal metals, topological Dirac semimetals manifest a large inverse spin Hall effect when a spin current is pu...

journal_title：Scientific reports

authors： Misawa T,Nomura K

更新日期：2019-12-23 00:00:00

abstract：:Intestinal alkaline phosphatase (IAP) regulates bicarbonate secretion, detoxifies lipopolysaccharide (LPS), regulates gut microbes, and dephosphorylates proinflammatory nucleotides. IAP also exhibits anti-inflammatory effects in a Toll-like Receptor-4 (TLR-4) dependent manner. However, it is not known whether IAP indu...

journal_title：Scientific reports

authors： Singh SB,Carroll-Portillo A,Coffman C,Ritz NL,Lin HC

更新日期：2020-02-20 00:00:00

abstract：:In neuroblastoma (NB), one of the most common paediatric solid tumours, activation of anaplastic lymphoma kinase (ALK) is often associated with poor outcomes. Although genetic studies have identified copy number alteration and nonsynonymous mutations of ALK, the regulatory mechanism of ALK signalling at protein levels...

journal_title：Scientific reports

authors： Satoh S,Takatori A,Ogura A,Kohashi K,Souzaki R,Kinoshita Y,Taguchi T,Hossain MS,Ohira M,Nakamura Y,Nakagawara A

更新日期：2016-09-08 00:00:00