Design and development of potential tissue engineering scaffolds from structurally different longitudinal parts of a bovine-femur.

abstract：:Native collagen is arranged in bundles of aligned fibrils to withstand in vivo mechanical loads. Reproducing such a process under in vitro conditions has not met with major success. Our approach has been to induce nanolinks, during the self-assembly process, leading to delayed rather than inhibited fibrillogenesis. Fo...

journal_title：Scientific reports

authors： Nidhin M,Vedhanayagam M,Sangeetha S,Kiran MS,Nazeer SS,Jayasree RS,Sreeram KJ,Nair BU

更新日期：2014-08-06 00:00:00

abstract：:Multiplexed error-robust fluorescence in situ hybridization (MERFISH) allows simultaneous imaging of numerous RNA species in their native cellular environment and hence spatially resolved single-cell transcriptomic measurements. However, the relatively modest brightness of signals from single RNA molecules can become ...

journal_title：Scientific reports

authors： Xia C,Babcock HP,Moffitt JR,Zhuang X

更新日期：2019-05-22 00:00:00

abstract：:To identify novel phenotypic associations related to Cytochrome P450 Family 2 Subfamily A Member 6 (CYP2A6), we investigated the human phenome in a total of 11,271 individuals. Initially, we conducted a phenome-wide association study in 3,401 nicotine-exposed elderly subjects considering 358 phenotypic traits. We iden...

journal_title：Scientific reports

authors： Polimanti R,Jensen KP,Gelernter J

更新日期：2017-04-21 00:00:00

abstract：:Confident characterization of the microheterogeneity of protein glycosylation through identification of intact glycopeptides remains one of the toughest analytical challenges for glycoproteomics. Recently proposed mass spectrometry (MS)-based methods still have some defects such as lack of the false discovery rate (FD...

journal_title：Scientific reports

authors： Zeng WF,Liu MQ,Zhang Y,Wu JQ,Fang P,Peng C,Nie A,Yan G,Cao W,Liu C,Chi H,Sun RX,Wong CC,He SM,Yang P

更新日期：2016-05-03 00:00:00

abstract：:Surfactant solutions typically feature tunable nanoscale, internal structures. Although rarely utilized, they can be a powerful platform for probing thermal transport in nanoscale domains and across interfaces with nanometer-size radius. Here, we examine the structure and thermal transport in solution of AOT (Dioctyl ...

journal_title：Scientific reports

authors： Cao F,Liu Y,Xu J,He Y,Hammouda B,Qiao R,Yang B

更新日期：2015-11-04 00:00:00

abstract：:Hedgehog interacting protein (Hhip) is essential for islet formation and beta-cell proliferation during pancreatic development; abnormally elevated Hhip expression has been linked to human pancreatitis. Here, we investigate the role of Hhip in modulating insulin secretion in adult Hhip mice (Hhip +/- vs. Hhip+/+) fed ...

journal_title：Scientific reports

authors： Nchienzia H,Liao MC,Zhao XP,Chang SY,Lo CS,Chenier I,Ingelfinger JR,Chan JSD,Zhang SL

更新日期：2019-08-01 00:00:00

abstract：:Recent skin metagenomic studies have investigated the harbored viral diversity and its possible influence on healthy skin microbial populations, and tried to establish global patterns of skin-phage evolution. However, the detail associated with the phages that potentially play a role in skin health has not been invest...

journal_title：Scientific reports

authors： van Zyl LJ,Abrahams Y,Stander EA,Kirby-McCollough B,Jourdain R,Clavaud C,Breton L,Trindade M

更新日期：2018-08-16 00:00:00

abstract：:The familial forms of early onset pre-eclampsia and related syndromes (HELLP) present with hypertension and proteinuria in the mother and growth restriction of the fetus. Genetically, these clinically similar entities are caused by different founder-dependent, placentally-expressed paralogous genes. All susceptibility...

journal_title：Scientific reports

authors： Oudejans CB,Poutsma A,Michel OJ,Thulluru HK,Mulders J,van de Vrugt HJ,Sistermans EA,van Dijk M

更新日期：2016-08-24 00:00:00

abstract：:Kalata B1 has been demonstrated to have bioactivity relating to membrane disruption. In this study, we conducted coarse-grained molecular dynamics simulations to gain further insight into kB1 bioactivity. The simulations were performed at various concentrations of kB1 to capture the overall progression of its activity...

journal_title：Scientific reports

authors： Nawae W,Hannongbua S,Ruengjitchatchawalya M

更新日期：2014-02-03 00:00:00

abstract：:Three-dimensional (3D) cell cultures produce more in vivo-like multicellular structures such as spheroids that cannot be obtained in two-dimensional (2D) cell cultures. Thus, they are increasingly employed as models for cancer and drug research, as well as tissue engineering. It has proven challenging to stabilize sph...

journal_title：Scientific reports

authors： Lou YR,Kanninen L,Kaehr B,Townson JL,Niklander J,Harjumäki R,Jeffrey Brinker C,Yliperttula M

更新日期：2015-09-01 00:00:00

abstract：:Obstructive heart defects (OHDs) are a major health concern worldwide. The platelet-derived growth factor (PDGF) genes are known to have regulatory functions that are essential for proper heart development. In a zebrafish model, Pdgfra was further demonstrated to interact with ethanol during craniofacial development. ...

journal_title：Scientific reports

authors： Tang X,Eberhart JK,Cleves MA,Li J,Li M,MacLeod S,Nembhard WN,Hobbs CA

更新日期：2018-07-23 00:00:00

abstract：:We experimentally perform the simulation of open quantum dynamics in single-qudit systems. Using a spatial light modulator as a dissipative optical device, we implement dissipative-dynamical maps onto qudits encoded in the transverse momentum of spontaneous parametric down-converted photon pairs. We show a well-contro...

journal_title：Scientific reports

authors： Marques B,Matoso AA,Pimenta WM,Gutiérrez-Esparza AJ,Santos MF,Pádua S

更新日期：2015-11-03 00:00:00

abstract：:The weak correlation between pain and structural changes in knee osteoarthritis is widely reported. In a previous within-person, knee-matched case-control study among Caucasians, the severity of radiographic osteoarthritis (ROA) was strongly associated with both the presence of frequent knee pain and pain severity. We...

journal_title：Scientific reports

authors： Wang K,Kim HA,Felson DT,Xu L,Kim DH,Nevitt MC,Yoshimura N,Kawaguchi H,Lin J,Kang X,Zhang Y

更新日期：2018-01-22 00:00:00

abstract：:Development of tissue engineering scaffolds with native-like biology and microarchitectures is a prerequisite for stem cell mediated generation of off-the-shelf-tissues. So far, the field of tissue engineering has not full-filled its grand potential of engineering such combinatorial scaffolds for engineering functiona...

journal_title：Scientific reports

authors： Guermani E,Shaki H,Mohanty S,Mehrali M,Arpanaei A,Gaharwar AK,Dolatshahi-Pirouz A

更新日期：2016-07-28 00:00:00

abstract：:Ethidium bromide (EB) and acridine orange (AO) bind to nucleic acids and are thus considered as potential mutagens. In this study, the effects of EB and AO on the germination behaviours of white, yellow, red, and purple maize seeds were investigated. The results indicate that low concentrations of EB (50 μg mL-1) and ...

journal_title：Scientific reports

authors： Zhang Y,Shi H,Deng B

更新日期：2018-09-19 00:00:00

abstract：:Upconversion nanoparticles (UCNPs) are utilized extensively for biomedical imaging, sensing, and therapeutic applications, yet the molecular weight of UCNPs has not previously been reported. Herein, we present a theory based upon the crystal structure of UCNPs to estimate the molecular weight of UCNPs: enabling insigh...

journal_title：Scientific reports

authors： Mackenzie LE,Goode JA,Vakurov A,Nampi PP,Saha S,Jose G,Millner PA

更新日期：2018-01-18 00:00:00

abstract：:The anuran amphibian Xenopus laevis can regenerate its limbs for a limited time during the larval stage, while limbs are still developing. Using this regeneration model, we evaluated the proximo-distal blastema cell identity when endogenous retinoids were increased by CYP26 inhibition or when RAR-specific agonists alt...

journal_title：Scientific reports

authors： Cuervo R,Chimal-Monroy J

更新日期：2013-01-01 00:00:00

abstract：:Determining mechanisms that naturally protect species from developing cancer is critical in order to prevent and treat cancer. Here, we describe a novel cancer-suppressing mechanism, via the secretion of bioactive factors by mammary cells, that is present in domesticated mammals with a low mammary cancer incidence. Sp...

journal_title：Scientific reports

authors： Ledet MM,Harman RM,Fan JC,Schmitt-Matzen E,Diaz-Rubio ME,Zhang S,Van de Walle GR

更新日期：2020-11-25 00:00:00

abstract：:Studies on dsDNA bacteriophages have revealed that a DNA packaging complex assembles at a special vertex called the 'portal vertex' and consists of a portal, a DNA packaging ATPase and other components. AdV protein IVa2 is presumed to function as a DNA packaging ATPase. However, a protein that functions as a portal is...

journal_title：Scientific reports

authors： Ahi YS,Hassan AO,Vemula SV,Li K,Jiang W,Zhang GJ,Mittal SK

更新日期：2017-08-08 00:00:00

abstract：:Non-response to intravitreal ranibizumab represents a frequent problem in pachychoroid neovasculopathy (PNV). To investigate the effectivity of switching to aflibercept, the database of the Ludwig Maximilians University, Munich, was screened for patients fulfilling the following inclusion criteria: (i) diagnosis of PN...

journal_title：Scientific reports

authors： Schworm B,Luft N,Keidel LF,Herold TR,Wolf A,Priglinger SG,Siedlecki J

更新日期：2020-05-21 00:00:00

abstract：:Complex interactions occur between tumor and host immune system at each site in the metastatic setting, the outcome of which can determine behavior ranging from dormancy to rapid growth. An additional layer of complexity arises from the understanding that cytotoxic T cells can traffic through the host circulatory syst...

journal_title：Scientific reports

authors： Walker R,Poleszczuk J,Pilon-Thomas S,Kim S,Anderson AARA,Czerniecki BJ,Harrison LB,Moros EG,Enderling H

更新日期：2018-06-21 00:00:00

abstract：:A new concept for treatment of infections is induction of our own antimicrobial peptides and the presented novel class of inducer, aroylated phenylenediamines (APDs), gives up to 20 to 30-fold induction of the human antimicrobial peptide LL-37, in vitro. In addition, oral administration of an APD in a rabbit model of ...

journal_title：Scientific reports

authors： Ottosson H,Nylén F,Sarker P,Miraglia E,Bergman P,Gudmundsson GH,Raqib R,Agerberth B,Strömberg R

更新日期：2016-11-09 00:00:00

abstract：:Plasmonic photothermal therapy (PPTT) using plasmonic nanoparticles as efficient photoabsorbing agents has been proposed previously. One critical step in PPTT is to effectively deliver gold nanoparticles into the cells. This study demonstrates that the delivery of gold nanorods (AuNRs) can be greatly enhanced by combi...

journal_title：Scientific reports

authors： Wang YH,Chen SP,Liao AH,Yang YC,Lee CR,Wu CH,Wu PC,Liu TM,Wang CR,Li PC

更新日期：2014-07-14 00:00:00

abstract：:Thirty-nine UK adapted wheat cultivars dating from between 1790 and 2012 were grown in replicated randomised field trials for three years, milled, and white flour analysed for the contents of dietary fibre components (arabinoxylan and β-glucan) and polar metabolites (sugars, amino acids, organic acids, choline and bet...

journal_title：Scientific reports

authors： Lovegrove A,Pellny TK,Hassall KL,Plummer A,Wood A,Bellisai A,Przewieslik-Allen A,Burridge AJ,Ward JL,Shewry PR

更新日期：2020-04-03 00:00:00

abstract：:Sucralose is a widely-used artificial high-intensity sweetener. Although doubts have been raised about the safety of sucralose by several researchers, it can still be found in a broad range of foods and beverages worldwide, including in baked goods. Sucralose may decompose at high temperatures, and participate in chlo...

journal_title：Scientific reports

authors： Dong S,Liu G,Hu J,Zheng M

更新日期：2013-10-15 00:00:00

abstract：:The human brain is lateralised to the right for visuospatial attention, particularly when reorienting attention to unexpected stimuli. However, the developmental characteristics of lateralisation remain unclear. To address this question, we devised a saccade task applicable for both adults and children. To assess the ...

journal_title：Scientific reports

authors： Sanefuji M,Yamashita H,Torio M,Katsuki D,Akamine S,Ishizaki Y,Kishimoto J,Sakai Y,Takada H,Yoshida K,Ohga S

更新日期：2018-05-15 00:00:00

abstract：:The production of male and female offspring is often determined by the presence of specific sex chromosomes which control sex-specific expression, and sex chromosomes evolve through reduced recombination and specialized gene content. Here we present the genomes of Chrysomya rufifacies, a monogenic blow fly (females pr...

journal_title：Scientific reports

authors： Andere AA,Pimsler ML,Tarone AM,Picard CJ

更新日期：2020-09-25 00:00:00

abstract：:China's reported cases of Human Immunodeficiency Virus (HIV) and AIDS increased from over 50000 in 2011 to more than 130000 in 2017, while AIDS related search indices on Baidu from 2.1 million to 3.7 million in the same time periods. In China, people seek AIDS related knowledge from Baidu which one of the world's larg...

journal_title：Scientific reports

authors： Li K,Liu M,Feng Y,Ning C,Ou W,Sun J,Wei W,Liang H,Shao Y

更新日期：2019-01-23 00:00:00

abstract：:Multiple sequence alignment (MSA) is an integral part of molecular biology. But handling massive number of large sequences is still a bottleneck for most of the state-of-the-art software tools. Knowledge driven algorithms utilizing features of input sequences, such as high similarity in case of DNA sequences, can help...

journal_title：Scientific reports

authors： Vineetha V,Biji CL,Nair AS

更新日期：2019-04-29 00:00:00

abstract：:The time evolution of the distribution and shareability of quantum coherence of a tripartite system in a non-Markovian environment is examined. The total coherence can be decomposed into various contributions, ranging from local, global bipartite and global tripartite, which characterize the type of state. We identify...

journal_title：Scientific reports

authors： Radhakrishnan C,Chen PW,Jambulingam S,Byrnes T,Ali MM

更新日期：2019-02-20 00:00:00