当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Chinese olive extract ameliorates hepatic lipid accumulation in vitro and in vivo by regulating lipid metabolism.

Chinese olive extract ameliorates hepatic lipid accumulation in vitro and in vivo by regulating lipid metabolism.

Abstract：

:Chinese olive contains plenty of polyphenols, which possess a wide range of biological actions. In this study, we aimed to investigate the role of the ethyl acetate fraction of Chinese olive fruit extract (CO-EtOAc) in the modulation of lipid accumulation in vitro and in vivo. In cellular studies, CO-EtOAc attenuated oleic acid-induced lipid accumulation; we then elucidated the molecular mechanisms of CO-EtOAc in FL83B mouse hepatocytes. CO-EtOAc suppressed the mRNA levels of fatty acid transporter genes (CD36 and FABP) and lipogenesis genes (SREBP-1c, FAS, and ACC1), but upregulated genes that govern lipolysis (HSL) and lipid oxidation (PPARα, CPT-1, and ACOX). Moreover, CO-EtOAc increased the protein expression of phosphorylated AMPK, ACC1, CPT-1, and PPARα, but downregulated the expression of mature SREBP-1c and FAS. AMPK plays an essential role in CO-EtOAc-mediated amelioration of lipid accumulation. Furthermore, we confirmed that CO-EtOAc significantly inhibited body weight gain, epididymal adipose tissue weight, and hepatic lipid accumulation via regulation of the expression of fatty acid transporter, lipogenesis, and fatty acid oxidation genes and proteins in C57BL/6 mice fed a 60% high-fat diet. Therefore, Chinese olive fruits may have the potential to improve the metabolic abnormalities associated with fatty liver under high fat challenge.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Yeh YT,Cho YY,Hsieh SC,Chiang AN

doi

10.1038/s41598-018-19553-1

subject

Has Abstract

pub_date

2018-01-18 00:00:00

pages

1057

issue

1

issn

2045-2322

pii

10.1038/s41598-018-19553-1

journal_volume

8

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Distribution and characteristics of rodent picornaviruses in China.

    abstract：:Rodents are important reservoir hosts of many important zoonotic viruses. The family Picornaviridae contains clinically important pathogens that infect humans and animals, and increasing numbers of rodent picornaviruses have recently been associated with zoonoses. We collected 574 pharyngeal and anal swab specimens fr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep34381

    authors： Du J,Lu L,Liu F,Su H,Dong J,Sun L,Zhu Y,Ren X,Yang F,Guo F,Liu Q,Wu Z,Jin Q

    更新日期：2016-09-29 00:00:00

  • Acid-base adjustments and first evidence of denticle corrosion caused by ocean acidification conditions in a demersal shark species.

    abstract：:Global ocean acidification is expected to chronically lower the pH to 7.3 (>2200 µatm seawater pCO2) by the year 2300. Acute hypercapnia already occurs along the South African west and south coasts due to upwelling- and low-oxygen events, with increasing frequency. In the present project we investigated the impact of ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54795-7

    authors： Dziergwa J,Singh S,Bridges CR,Kerwath SE,Enax J,Auerswald L

    更新日期：2019-12-19 00:00:00

  • The BR domain of PsrP interacts with extracellular DNA to promote bacterial aggregation; structural insights into pneumococcal biofilm formation.

    abstract：:The major human pathogen Streptococcus pneumoniae is a leading cause of disease and death worldwide. Pneumococcal biofilm formation within the nasopharynx leads to long-term colonization and persistence within the host. We have previously demonstrated that the capsular surface-associated pneumococcal serine rich repea...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep32371

    authors： Schulte T,Mikaelsson C,Beaussart A,Kikhney A,Deshmukh M,Wolniak S,Pathak A,Ebel C,Löfling J,Fogolari F,Henriques-Normark B,Dufrêne YF,Svergun D,Nygren PÅ,Achour A

    更新日期：2016-09-01 00:00:00

  • Modification of Susceptible and Toxic Herbs on Grassland Disease.

    abstract：:Recent research shows that continuous overgrazing not only causes grassland biodiversity to decline, but also causes light fungal disease. Achnatherum inebrians is susceptible to fungal diseases and increases in prevalence during over grazing due its toxicity to livestock. This study aimed to examine the effects of A....

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep30635

    authors： Yao X,Fan Y,Chai Q,Johnson RD,Nan Z,Li C

    更新日期：2016-09-16 00:00:00

  • Anticancer effects of epigallocatechin-3-gallate nanoemulsion on lung cancer cells through the activation of AMP-activated protein kinase signaling pathway.

    abstract：:Epigallocatechin-3-gallate (EGCG), a green tea-derived polyphenol, exhibits antitumor activities. An EGCG nanoemulsion (nano-EGCG) was prepared to improve the stability and reduce the side effects of EGCG for treatment of human lung cancer cells, and the antitumor effects were studied. The possible molecular mechanism...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-62136-2

    authors： Chen BH,Hsieh CH,Tsai SY,Wang CY,Wang CC

    更新日期：2020-03-20 00:00:00

  • Identification of the novel 3' UTR sequences of human IL-21 mRNA as potential targets of miRNAs.

    abstract：:Hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma worldwide. However, the strategy of HBV to escape from the host immune system remains largely unknown. In this study, we examined extracellular vesicles (EVs) secreted from human hepatocytes infected with HBV. EVs includeing exosomes are ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07853-x

    authors： Enomoto Y,Takagi R,Naito Y,Kiniwa T,Tanaka Y,Hamada-Tsutsumi S,Kawano M,Matsushita S,Ochiya T,Miyajima A

    更新日期：2017-08-10 00:00:00

  • Left and right ventricular functions may be impaired in children diagnosed with subclinical hypothyroidism.

    abstract：:Subclinical hypothyroidism (SH) may influence both ventricular functions. The aim of this study was to evaluation the findings of Tissue Doppler Imaging (TDI) and other echocardiography modalities in children with SH. We compared left ventricular mass index (LVMI) and TDI parameters of patients with SH and children wi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76327-4

    authors： Akın A,Unal E,Yildirim R,Ture M,Balik H,Haspolat YK

    更新日期：2020-11-12 00:00:00

  • Origin of Symmetric Dimer Images of Si(001) Observed by Low-Temperature Scanning Tunneling Microscopy.

    abstract：:It has been a long-standing puzzle why buckled dimers of the Si(001) surface appeared symmetric below ~20 K in scanning tunneling microscopy (STM) experiments. Although such symmetric dimer images were concluded to be due to an artifact induced by STM measurements, its underlying mechanism is still veiled. Here, we de...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27868

    authors： Ren XY,Kim HJ,Niu CY,Jia Y,Cho JH

    更新日期：2016-06-13 00:00:00

  • Epidemiological profile of mucosal melanoma in Brazil.

    abstract：:Mucosal melanomas are primary malignant neoplasias originated from melanocytes within mucous membranes in any part of mucosal surface lining, more commonly, in the nasal cavity and accessory sinuses, oral cavity, lips, pharynx, vulvar, vaginal, cervix and anorectal mucosa. Epidemiology data regarding mucosal melanomas...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-57253-6

    authors： Cohen Goldemberg D,de Melo AC,de Melo Pino LC,Thuler LCS

    更新日期：2020-01-16 00:00:00

  • Biological profile of monocyte-derived macrophages in coronary heart disease patients: implications for plaque morphology.

    abstract：:The prevalence of a macrophage phenotype in atherosclerotic plaque may drive its progression and/or instability. Macrophages from coronary plaques are not available, and monocyte-derived macrophages (MDMs) are usually considered as a surrogate. We compared the MDM profile obtained from coronary artery disease (CAD) pa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44847-3

    authors： Eligini S,Cosentino N,Fiorelli S,Fabbiocchi F,Niccoli G,Refaat H,Camera M,Calligaris G,De Martini S,Bonomi A,Veglia F,Fracassi F,Crea F,Marenzi G,Tremoli E

    更新日期：2019-06-18 00:00:00

  • A common protocol for the simultaneous processing of multiple clinically relevant bacterial species for whole genome sequencing.

    abstract：:Whole-genome sequencing is likely to become increasingly used by local clinical microbiology laboratories, where sequencing volume is low compared with national reference laboratories. Here, we describe a universal protocol for simultaneous DNA extraction and sequencing of numerous different bacterial species, allowin...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80031-8

    authors： Raven KE,Girgis ST,Akram A,Blane B,Leek D,Brown N,Peacock SJ

    更新日期：2021-01-08 00:00:00

  • Contribution of birth weight and adult waist circumference to cardiovascular disease risk in a longitudinal study.

    abstract：:To determine the association of birth weight (BW) and waist circumference (WC) on cardiovascular disease (CVD). The longitudinal cohort study consisted of 745 participants who were able to provide their birth weight information and were followed from 2002 to 2014. During the follow-up, 83 events of CVD were confirmed....

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10176-6

    authors： Tian J,Qiu M,Li Y,Zhang X,Wang H,Sun S,Sharp NS,Tong W,Zeng H,Zheng S,Song X,Wang W,Ning G

    更新日期：2017-08-29 00:00:00

  • The atlas of StW 573 and the late emergence of human-like head mobility and brain metabolism.

    abstract：:Functional morphology of the atlas reflects multiple aspects of an organism's biology. More specifically, its shape indicates patterns of head mobility, while the size of its vascular foramina reflects blood flow to the brain. Anatomy and function of the early hominin atlas, and thus, its evolutionary history, are poo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-60837-2

    authors： Beaudet A,Clarke RJ,Heaton JL,Pickering TR,Carlson KJ,Crompton RH,Jashashvili T,Bruxelles L,Jakata K,Bam L,Van Hoorebeke L,Kuman K,Stratford D

    更新日期：2020-03-16 00:00:00

  • Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion.

    abstract：:The hippocampus has a significant association with memory, cognition and emotions. The dopaminergic projections from both the ventral tegmental area and substantia nigra are thought to be involved in hippocampal activity. To date, however, few studies have investigated dopaminergic innervation in the hippocampus or th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep44426

    authors： Castro-Hernández J,Adlard PA,Finkelstein DI

    更新日期：2017-03-14 00:00:00

  • Histone acetylation as a new mechanism for bilirubin-induced encephalopathy in the Gunn rat.

    abstract：:Bilirubin neurotoxicity has been studied for decades and has been shown to affect various mechanisms via significant modulation of gene expression. This suggests that vital regulatory mechanisms of gene expression, such as epigenetic mechanisms, could play a role in bilirubin neurotoxicity. Histone acetylation has rec...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-32106-w

    authors： Vianello E,Zampieri S,Marcuzzo T,Tordini F,Bottin C,Dardis A,Zanconati F,Tiribelli C,Gazzin S

    更新日期：2018-09-12 00:00:00

  • Serum alpha-mannosidase as an additional barrier to eliciting oligomannose-specific HIV-1-neutralizing antibodies.

    abstract：:Oligomannose-type glycans on HIV-1 gp120 form a patch that is targeted by several broadly neutralizing antibodies (bnAbs) and that therefore is of interest to vaccine design. However, attempts to elicit similar oligomannose-specific bnAbs by immunizing with oligomannosidic glycoconjugates have only been modestly succe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-64500-8

    authors： Bruxelle JF,Kirilenko T,Qureshi Q,Lu N,Trattnig N,Kosma P,Pantophlet R

    更新日期：2020-05-05 00:00:00

  • Altered Gut Microbiota Profiles in Sows and Neonatal Piglets Associated with Porcine Epidemic Diarrhea Virus Infection.

    abstract：:Porcine epidemic diarrhea virus (PEDV) is a devastating cause of diarrhea in pigs worldwide. Most of studies have focused on molecular and pathogenic characterization of PEDV, whereas there were limited studies in understanding the role of gut microbiota (GM) in viral-associated diarrhea. Here, using the Illumina MiSe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-17830-z

    authors： Song D,Peng Q,Chen Y,Zhou X,Zhang F,Li A,Huang D,Wu Q,Ye Y,He H,Wang L,Tang Y

    更新日期：2017-12-12 00:00:00

  • Comparison of Two Protocols of Carbon Tetrachloride-Induced Cirrhosis in Rats - Improving Yield and Reproducibility.

    abstract：:Despite being a cardinal experimental model, the induction of cirrhosis in rats by repeated exposure to carbon tetrachloride (CCl4) has low reproducibility. Here, we compared two models of cirrhosis induced by orogastric administration of CCl4 once (CCl4-1xWk) or twice a week (CCl4-2xWk) for 12 weeks in male Sprague-D...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-27427-9

    authors： Fortea JI,Fernández-Mena C,Puerto M,Ripoll C,Almagro J,Bañares J,Bellón JM,Bañares R,Vaquero J

    更新日期：2018-06-15 00:00:00

  • Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages.

    abstract：:Tumor necrosis factor (TNF) is best known for inducing a rapid but transient NF-κB-mediated inflammatory response. We investigated later phases of TNF signaling, after the initial transient induction of inflammatory genes has subsided, in primary human macrophages. TNF signaling induced expression of late response gen...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep31959

    authors： Huynh L,Kusnadi A,Park SH,Murata K,Park-Min KH,Ivashkiv LB

    更新日期：2016-08-25 00:00:00

  • Optical coherence tomographic features of macular telangiectasia type 2: Korean Macular Telangiectasia Type 2 Study-Report No. 1.

    abstract：:We analysed the imaging findings of macular telangiectasia (MacTel) type 2 in Korea using spectral domain optical coherence tomography (SD-OCT) and investigated their relationship with visual acuity and clinical stages. A retrospective multicentre cross-sectional study was conducted in six tertiary hospitals in Korea ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73803-9

    authors： Kim YH,Chung YR,Oh J,Kim SW,Lee CS,Yun C,Lee B,Ahn SM,Choi EY,Jang S,Lee K

    更新日期：2020-10-06 00:00:00

  • Fabrication of self-assembled spherical Gold Particles by pulsed UV Laser Treatment.

    abstract：:We report on the fabrication of spherical Au spheres by pulsed laser treatment using a KrF excimer laser (248 nm, 25 ns) under ambient conditions as a fast and high throughput fabrication technique. The presented experiments were realized using initial Au layers of 100 nm thickness deposited on optically transparent a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29661-7

    authors： Schmidl G,Jia G,Gawlik A,Kreusch J,Schmidl F,Dellith J,Dathe A,Lin ZH,Huang JS,Plentz J

    更新日期：2018-07-26 00:00:00

  • Phosphatidylethanolamine-phosphatidylserine binding synergy of seven coagulation factors revealed using Nanodisc arrays on silicon photonic sensors.

    abstract：:Blood coagulation is regulated through protein-protein and protein-lipid interactions that occur at the sub-endothelium following vascular damage. Soluble clotting proteins bind to membrane components in a phosphatidylserine (PS) dependent manner to assemble multi-protein complexes that regulate clot formation; howeve...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73647-3

    authors： Medfisch SM,Muehl EM,Morrissey JH,Bailey RC

    更新日期：2020-10-15 00:00:00

  • DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma.

    abstract：:Decrease in blood concentration of branched-chain amino acids, especially leucine, is known to promote liver carcinogenesis in patients with chronic liver disease, but the mechanism is unclear. We herein established hepatocellular carcinoma (HCC) cells knocked out for DEPDC5 by using the CRISPR/Cas9 system, and elucid...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-18323-9

    authors： Mizuno Y,Shimada S,Akiyama Y,Watanabe S,Aida T,Ogawa K,Ono H,Mitsunori Y,Ban D,Kudo A,Arii S,Yamaoka S,Tanabe M,Tanaka S

    更新日期：2018-01-08 00:00:00

  • Enhanced delignification of steam-pretreated poplar by a bacterial laccase.

    abstract：:The recalcitrance of woody biomass, particularly its lignin component, hinders its sustainable transformation to fuels and biomaterials. Although the recent discovery of several bacterial ligninases promises the development of novel biocatalysts, these enzymes have largely been characterized using model substrates: di...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42121

    authors： Singh R,Hu J,Regner MR,Round JW,Ralph J,Saddler JN,Eltis LD

    更新日期：2017-02-07 00:00:00

  • hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells.

    abstract：:c-FLIP (cellular FLICE-inhibitory protein) is the pivotal regulator of TRAIL resistance in cancer cells, It is a short-lived protein degraded through the ubiquitin/proteasome pathway. The discovery of factors and mechanisms regulating its protein stability is important for the comprehension of TRAIL resistance by tumo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep22999

    authors： Gao X,Feng J,He Y,Xu F,Fan X,Huang W,Xiong H,Liu Q,Liu W,Liu X,Sun X,He QY,Zhang Q,Liu L

    更新日期：2016-03-14 00:00:00

  • Untargeted LC-HRMS-based metabolomics to identify novel biomarkers of metastatic colorectal cancer.

    abstract：:Colorectal cancer is one of the main causes of cancer death worldwide, and novel biomarkers are urgently needed for its early diagnosis and treatment. The utilization of metabolomics to identify and quantify metabolites in body fluids may allow the detection of changes in their concentrations that could serve as diagn...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-55952-8

    authors： Martín-Blázquez A,Díaz C,González-Flores E,Franco-Rivas D,Jiménez-Luna C,Melguizo C,Prados J,Genilloud O,Vicente F,Caba O,Pérez Del Palacio J

    更新日期：2019-12-27 00:00:00

  • Tailoring femtosecond 1.5-μm Bessel beams for manufacturing high-aspect-ratio through-silicon vias.

    abstract：:Three-dimensional integrated circuits (3D ICs) are an attractive replacement for conventional 2D ICs as high-performance, low-power-consumption, and small-footprint microelectronic devices. However, one of the major remaining challenges is the manufacture of high-aspect-ratio through-silicon vias (TSVs), which is a cr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40785

    authors： He F,Yu J,Tan Y,Chu W,Zhou C,Cheng Y,Sugioka K

    更新日期：2017-01-18 00:00:00

  • Non-thermal plasma treatment improves chicken sperm motility via the regulation of demethylation levels.

    abstract：:The quality of avian semen is an important economic trait in poultry production. The present study examines the in vitro effects of non-thermal dielectric barrier discharge plasma on chicken sperm to determine the plasma conditions that can produce the optimum sperm quality. Exposure to 11.7 kV of plasma for 20 s is f...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-26049-5

    authors： Zhang JJ,Do HL,Chandimali N,Lee SB,Mok YS,Kim N,Kim SB,Kwon T,Jeong DK

    更新日期：2018-05-15 00:00:00

  • Change of the relative line strengths due to the resonance induced population transfer between Fe XVII and FeXVI ions.

    abstract：:We present a detailed study to resolve the discrepancy between the existing theoretically estimated oscillator strengths and the recently observed result from the X-ray free electron laser (XFEL) experiment performed at the Linac Coherent Light Source (LCLS) for the intensity ratio between two of the strongest emissio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43916-x

    authors： Wu C,Gao X

    更新日期：2019-05-16 00:00:00

  • Preserved immune functionality and high CMV-specific T-cell responses in HIV-infected individuals with poor CD4+ T-cell immune recovery.

    abstract：:Poor CD4+ T-cell recovery after cART has been associated with skewed T-cell maturation, inflammation and immunosenescence; however, T-cell functionality in those individuals has not been fully characterized. In the present study, we assessed T-cell function by assessing cytokine production after polyclonal, CMV and HI...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-12013-2

    authors： Gómez-Mora E,García E,Urrea V,Massanella M,Puig J,Negredo E,Clotet B,Blanco J,Cabrera C

    更新日期：2017-09-15 00:00:00