Epidemiological profile of mucosal melanoma in Brazil.

Abstract:

:Mucosal melanomas are primary malignant neoplasias originated from melanocytes within mucous membranes in any part of mucosal surface lining, more commonly, in the nasal cavity and accessory sinuses, oral cavity, lips, pharynx, vulvar, vaginal, cervix and anorectal mucosa. Epidemiology data regarding mucosal melanomas in Brazil is scarce, hence the motivation to conduct this research paper. The χ2 test was used to compare categorical variables. Forward stepwise logistic regression method was used in the multivariate analysis to identify independent predictors of early death. A total of 801 patients were included in the analysis. Surgical resection is frequently the first approach to primary tumours (65.3%), even though the utility of lymph node surgery and radiation therapy is not well established. Advanced stage was observed in more than two thirds of patients. Early death was observed in 28.3%. MM cases with regional or distant metastases as well as those located in unusual locations had almost 4 times more risk for early death. Besides that, MM located in lips, oral cavity and pharynx and those receiving chemotherapy had 2 times more risk of early death.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Cohen Goldemberg D,de Melo AC,de Melo Pino LC,Thuler LCS

doi

10.1038/s41598-019-57253-6

subject

Has Abstract

pub_date

2020-01-16 00:00:00

pages

505

issue

1

issn

2045-2322

pii

10.1038/s41598-019-57253-6

journal_volume

10

pub_type

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