Anticancer effects of epigallocatechin-3-gallate nanoemulsion on lung cancer cells through the activation of AMP-activated protein kinase signaling pathway.

abstract：:The association between perioperative blood transfusion (PBT) with adverse oncological outcomes have been previously reported in multiple malignancies including RCC. Nevertheless, the importance of transfusion timing is still unclear. The primary purpose of this study is to appraise whether the receipt of intraoperati...

journal_title：Scientific reports

authors： Abu-Ghanem Y,Dotan Z,Zilberman DE,Kaver I,Ramon J

更新日期：2019-02-04 00:00:00

abstract：:In populations of Drosophila larvae, both, an aggregation and a dispersal behavior can be observed. However, the mechanisms coordinating larval locomotion in respect to other animals, especially in close proximity and during/after physical contacts are currently only little understood. Here we test whether relevant in...

journal_title：Scientific reports

authors： Otto N,Risse B,Berh D,Bittern J,Jiang X,Klämbt C

更新日期：2016-08-11 00:00:00

abstract：:To assess the correlation between penile hypersensitivity and premature ejaculation (PE), a total of 420 consecutive subjects attending our andrologic clinic for suspected PE were enrolled. The entire cohort was asked to complete the self-report intravaginal ejaculation latency time (IELT) by stopwatch. According to t...

journal_title：Scientific reports

authors： Guo L,Liu Y,Wang X,Yuan M,Yu Y,Zhang X,Zhao S

更新日期：2017-09-05 00:00:00

abstract：:Water, methane, and ammonia are commonly considered to be the key components of the interiors of Uranus and Neptune. Modelling the planets' internal structure, evolution, and dynamo heavily relies on the properties of the complex mixtures with uncertain exact composition in their deep interiors. Therefore, characteris...

journal_title：Scientific reports

authors： Guarguaglini M,Hernandez JA,Okuchi T,Barroso P,Benuzzi-Mounaix A,Bethkenhagen M,Bolis R,Brambrink E,French M,Fujimoto Y,Kodama R,Koenig M,Lefevre F,Miyanishi K,Ozaki N,Redmer R,Sano T,Umeda Y,Vinci T,Ravasio A

更新日期：2019-07-12 00:00:00

abstract：:Aberrant regulation of BCL-2 family members enables evasion of apoptosis and tumor resistance to chemotherapy. BCL-2 and functionally redundant counterpart, MCL-1, are frequently over-expressed in high-risk diffuse large B-cell lymphoma (DLBCL). While clinical inhibition of BCL-2 has been achieved with the BH3 mimetic...

journal_title：Scientific reports

authors： Dey J,Deckwerth TL,Kerwin WS,Casalini JR,Merrell AJ,Grenley MO,Burns C,Ditzler SH,Dixon CP,Beirne E,Gillespie KC,Kleinman EF,Klinghoffer RA

更新日期：2017-12-21 00:00:00

abstract：:Nine new bicyclic cembranoids, sarcophytrols M-U(1-9), were isolated from the South China Sea soft coral Sarcophyton trocheliophorum as minor components, along with one known related cembranoid 10. Their structures were elucidated by detailed spectroscopic analysis and chemical conversion. The chemical structures of t...

journal_title：Scientific reports

authors： Liang LF,Chen WT,Li XW,Wang HY,Guo YW

更新日期：2017-04-21 00:00:00

abstract：:Previous reports on epigenetic mechanisms involved in alcohol abuse have focus on hepatic and neuronal regions, leaving the immune system and specifically monocyte-derived dendritic cells (MDDCs) understudied. Our lab has previously shown histone deacetylases are modulated in cells derived from alcohol users and after...

journal_title：Scientific reports

authors： Parira T,Figueroa G,Laverde A,Casteleiro G,Gomez Hernandez ME,Fernandez-Lima F,Agudelo M

更新日期：2017-09-11 00:00:00

abstract：:It has been shown that bamboo leaf flavone (BLF) displays biological and pharmacological activities in mammals. However, the effects of BLF on broiler gut microbiota and related immune function have not been investigated. The aim of this study was to test our hypothesis that BLF can improve the health status of broile...

journal_title：Scientific reports

authors： Shu G,Kong F,Xu D,Yin L,He C,Lin J,Fu H,Wang K,Tian Y,Zhao X

更新日期：2020-07-23 00:00:00

abstract：:Receptor tyrosine kinases (RTKs) are key regulators of normal cellular processes and have a critical role in the development and progression of many diseases. RTK ligand-induced stimulation leads to activation of the cytoplasmic kinase domain that controls the intracellular signalling. Although the kinase domain of RT...

journal_title：Scientific reports

authors： Inizan F,Hanna M,Stolyarchuk M,Chauvot de Beauchêne I,Tchertanov L

更新日期：2020-03-25 00:00:00

abstract：:Lung cancer is one of the leading causes of cancer-related deaths. It is diagnosed mostly at the locally advanced or metastatic stage. Recently, micro RNAs (miRs) and their distribution in circulation have been implicated in physiological and pathological processes. In this study, miR-126 was evaluated in serum, exoso...

journal_title：Scientific reports

authors： Grimolizzi F,Monaco F,Leoni F,Bracci M,Staffolani S,Bersaglieri C,Gaetani S,Valentino M,Amati M,Rubini C,Saccucci F,Neuzil J,Tomasetti M,Santarelli L

更新日期：2017-11-10 00:00:00

abstract：:To explore the pathologies of Kashin-Beck disease (KBD) and KBD accompanied with dental fluorosis (DF), we conducted a comparative analysis of gene expression profiles. 12 subjects were recruited, including 4 KBD patients, 4 patients with KBD and DF and 4 healthy subjects. Genome-wide expression profiles from their pe...

journal_title：Scientific reports

authors： Zhang Q,Ma J,Liu H,He D,Chen L,Wu H,Jiang H,Lu Q,Bai S

更新日期：2018-01-09 00:00:00

abstract：:We propose a scheme for generating an entangled state for two atoms trapped in two separate cavities coupled to each other. The scheme is based on the competition between the unitary dynamics induced by the classical fields and the collective decays induced by the dissipation of two non-local bosonic modes. In this sc...

journal_title：Scientific reports

authors： Jin Z,Su SL,Zhu AD,Wang HF,Shen LT,Zhang S

更新日期：2017-12-15 00:00:00

abstract：:Ammonia can be utilised as an alternative nitrogen source to glutamine to support cell proliferation. However, the underlying molecular mechanisms and whether all cells have this ability is not fully understood. We find that eleven cancer and non-cancerous cell lines have opposite abilities to tolerate and utilise amm...

journal_title：Scientific reports

authors： Lie S,Wang T,Forbes B,Proud CG,Petersen J

更新日期：2019-02-06 00:00:00

abstract：:The nuclear pore complex (NPC) is one of the largest supramolecular structures in eukaryotic cells. Its octagonal ring-scaffold perforates the nuclear envelope and features a unique molecular machinery that regulates nucleocytoplasmic transport. NPCs are composed of ~30 different nucleoporins (Nups), averaged at 8, 16...

journal_title：Scientific reports

authors： Mi L,Goryaynov A,Lindquist A,Rexach M,Yang W

更新日期：2015-03-23 00:00:00

abstract：:A number of human and animal in vitro or in vivo studies have investigated the relationship between dietary choline and betaine and cancer risk, suggesting that choline and betaine consumption may be protective for cancer. There are also a few epidemiologic studies exploring this relationship, however, with inconsiste...

journal_title：Scientific reports

authors： Sun S,Li X,Ren A,Du M,Du H,Shu Y,Zhu L,Wang W

更新日期：2016-10-19 00:00:00

abstract：:The food supply is being increasingly challenged by climate change and water scarcity. However, incremental changes in traditional cropping systems have achieved only limited success in meeting these multiple challenges. In this study, we applied a systematic approach, using model simulation and data from two groups o...

journal_title：Scientific reports

authors： Meng Q,Wang H,Yan P,Pan J,Lu D,Cui Z,Zhang F,Chen X

更新日期：2017-02-03 00:00:00

abstract：:Some 1,3-diarylureas and 1-((1,4-trans)-4-aryloxycyclohexyl)-3-arylureas (cHAUs) activate heme-regulated kinase causing protein synthesis inhibition via phosphorylation of the eukaryotic translation initiation factor 2 (eIF2) in mammalian cancer cells. To evaluate if these agents have potential to inhibit trypanosome ...

journal_title：Scientific reports

authors： Machado FC,Franco CH,Dos Santos Neto JV,Dias-Teixeira KL,Moraes CB,Lopes UG,Aktas BH,Schenkman S

更新日期：2018-03-20 00:00:00

abstract：:Myocyte Enhancer Factor 2 (MEF2) mediates cardiac remodelling in heart failure (HF) and is also a target of β-adrenergic signalling, a front-line treatment for HF. We identified global gene transcription networks involved in HF with and without β-blocker treatment. Experimental HF by transverse aortic constriction (TA...

journal_title：Scientific reports

authors： Tobin SW,Hashemi S,Dadson K,Turdi S,Ebrahimian K,Zhao J,Sweeney G,Grigull J,McDermott JC

更新日期：2017-06-30 00:00:00

abstract：:The Roma population is a European ethnic minority characterized by recent and multiple dispersals and founder effects. After their origin in South Asia around 1,500 years ago, they migrated West. In Europe, they diverged into ethnolinguistically distinct migrant groups that spread across the continent. Previous geneti...

journal_title：Scientific reports

authors： García-Fernández C,Font-Porterias N,Kučinskas V,Sukarova-Stefanovska E,Pamjav H,Makukh H,Dobon B,Bertranpetit J,Netea MG,Calafell F,Comas D

更新日期：2020-09-02 00:00:00

abstract：:The poor control of the adhesion of TiO2 nanotubes (TNTs) layers to a non-anodized titanium (Ti) substrate has limited their widespread application, because the stripping mechanism has not yet been revealed. Here, we report a novel method to control the detachment of TNTs by post-treatment of the as-fabricated samples...

journal_title：Scientific reports

authors： Zhao M,Li J,Li Y,Wang J,Zuo Y,Jiang J,Wang H

更新日期：2014-11-24 00:00:00

abstract：:Engineered protein scaffolds are an alternative to monoclonal antibodies in research and drug design due to their small size, ease of production, versatility, and specificity for chosen targets. One key consideration when engineering such proteins is retaining the original scaffold structure and stability upon inserti...

journal_title：Scientific reports

authors： Zalar M,Indrakumar S,Levy CW,Tunnicliffe RB,Peters GHJ,Golovanov AP

更新日期：2019-06-21 00:00:00

abstract：:Combined treatment with 5-aminolevulinic acid (5-ALA) and X-rays improves tumor suppression in vivo. This is because the accumulated protoporphyrin IX from 5-ALA enhances the generation of ROS by the X-ray irradiation. In the present study, a high-energy medical linear accelerator was used instead of a non-medical low...

journal_title：Scientific reports

authors： Takahashi J,Murakami M,Mori T,Iwahashi H

更新日期：2018-02-09 00:00:00

abstract：:Achieving 180° magnetization reversal with an electric field rather than a current or magnetic field is a fundamental challenge and represents a technological breakthrough towards new memory cell designs. Here we propose a mesoscale morphological engineering approach to accomplishing full 180° magnetization reversals ...

journal_title：Scientific reports

authors： Wang JJ,Hu JM,Ma J,Zhang JX,Chen LQ,Nan CW

更新日期：2014-12-16 00:00:00

abstract：:Nonulosonic acids are found in the surface polysaccharides of many bacterial species and are often implicated in pathogenesis. Here, the structure of a novel 5,7-diacetamido-3,5,7,9-tetradeoxynon-2-ulosonic acid recovered from the capsular polysaccharide of a multiply antibiotic resistant Acinetobacter baumannii isola...

journal_title：Scientific reports

authors： Kenyon JJ,Notaro A,Hsu LY,De Castro C,Hall RM

更新日期：2017-09-12 00:00:00

abstract：:Pyrochar (PC) is always with high pH value, and improper application might increase rice paddy ammonia volatilization (PAV), which is the main nitrogen loss through air during rice production. Differently, hydrochar (HC) takes the advantages of high productive rate and always with lower pH value compared with PC. Howe...

journal_title：Scientific reports

authors： Liu X,Cheng Y,Liu Y,Chen D,Chen Y,Wang Y

更新日期：2020-11-05 00:00:00

abstract：:It is highly important to understand the heterogeneous wettability properties of porous media for enhanced oil recovery (EOR). However, wettability measurements are still challenging in directly investigating the wettability of porous media. In this paper, we propose a multidimensional nuclear magnetic resonance (NMR)...

journal_title：Scientific reports

authors： Wang J,Xiao L,Liao G,Zhang Y,Guo L,Arns CH,Sun Z

更新日期：2018-09-07 00:00:00

abstract：:Endogenous stress represents a major source of genome instability, but is in essence difficult to apprehend. Incorporation of labeled radionuclides into DNA constitutes a tractable model to analyze cellular responses to endogenous attacks. Here we show that incorporation of [(3)H]thymidine into CHO cells generates oxi...

journal_title：Scientific reports

authors： Saintigny Y,Chevalier F,Bravard A,Dardillac E,Laurent D,Hem S,Dépagne J,Radicella JP,Lopez BS

更新日期：2016-07-11 00:00:00

abstract：:The objective of this meta-analysis is to compare hybrid surgery (HS) and cervical discectomy and fusion (ACDF) for multilevel cervical degenerative disc diseases (DDD). Systematic searches of all published studies through March 2015 were identified from Cochrane Library, Medline, PubMed, Embase, ScienceDirect, CNKI, ...

journal_title：Scientific reports

authors： Tian P,Fu X,Li ZJ,Sun XL,Ma XL

更新日期：2015-08-26 00:00:00

abstract：:This research presents an analysis of the frequencies and vibration modes of the structure of the superficial seiches of Lake Chapala using mathematical modelling and measurements. The HAMSOM model was run with wind fields from coastal meteorological stations and for different lake storage levels. The lake water level...

journal_title：Scientific reports

authors： Avalos Cueva D,Monzón CO,Filonov A,Tereshchenko I,Limón Covarrubias P,Galaviz González JR

更新日期：2019-08-14 00:00:00

abstract：:Early diagnosis of Parkinson's disease (PD) remains a challenge to date. New evidence highlights the potential clinical value of circulating trace amines (TAs) in early-stage PD and their involvement in disease progression. A new ultra performance chromatography mass spectrometry (UPLC-MS/MS) method was developed to q...

journal_title：Scientific reports

authors： D'Andrea G,Pizzolato G,Gucciardi A,Stocchero M,Giordano G,Baraldi E,Leon A

更新日期：2019-04-16 00:00:00