Abstract:
:The current study aimed to evaluate the efficacy of linked color imaging (LCI) in improving the visibility of superficial non-ampullary duodenal epithelial tumors (SNADETs). We prospectively evaluated 44 consecutive patients diagnosed with SNADETs. Three trainees and three experts assessed the visibility scores of white light imaging (WLI), LCI, and blue laser imaging-bright (BLI-b) for SNADETs, which ranged from 1 (not detectable without repeated cautious examination) to 4 (excellent visibility). In addition, the L* a* b* color values and color differences (ΔE*) were evaluated using the CIELAB color space system. For SNADETs, the visibility scores of LCI (3.53 ± 0.59) were significantly higher than those of WLI and BLI-b (2.66 ± 0.79 and 3.41 ± 0.64, respectively). The color differences (ΔE*) between SNADETs and the adjacent normal duodenal mucosa in LCI mode (19.09 ± 8.33) were significantly higher than those in WLI and BLI-b modes (8.67 ± 4.81 and 12.92 ± 7.95, respectively). In addition, the visibility score of SNADETs and the color differences in LCI mode were significantly higher than those in WLI and BLI-b modes regardless of the presence of milk white mucosa (MWM). LCI has potential benefits, and it is considered a promising clinical modality that can increase the visibility of SNADETs regardless of the presence of MWM.This study was registered at the University Hospital Medical Information Network (UMIN000028840).
journal_name
Sci Repjournal_title
Scientific reportsauthors
Okimoto K,Maruoka D,Matsumura T,Tokunaga M,Kaneko T,Oura H,Akizue N,Ohta Y,Saito K,Arai M,Kato J,Kato Ndoi
10.1038/s41598-020-77726-3subject
Has Abstractpub_date
2020-11-26 00:00:00pages
20667issue
1issn
2045-2322pii
10.1038/s41598-020-77726-3journal_volume
10pub_type
杂志文章abstract::Discovered in 1813, the conoscopic interference pattern observed due to light propagating through a crystal, kept between crossed polarizers, shows isochromates and isogyres, respectively containing information about the dynamic and geometric phase acquired by the beam. We propose and demonstrate a closed-fringe Fouri...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33141
更新日期:2016-09-14 00:00:00
abstract::Estradiol derived from neural aromatization of testosterone plays a key role in the organization and activation of neural structures underlying male behaviors. This study evaluated the contribution of the estrogen receptor (ER) β in estradiol-induced modulation of social and mood-related behaviors by using mice lackin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63427-4
更新日期:2020-04-10 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-69680-x
更新日期:2020-08-27 00:00:00
abstract::Secondary thrombocytosis (ST) is frequently observed in children with a variety of clinical conditions. The leading cause of ST is respiratory tract infection (RTI) in children. Nasopharyngeal aspirate samples were collected and assessed for common respiratory viruses. The relationships between virus infections and se...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22964
更新日期:2016-03-11 00:00:00
abstract::Caspases are proteases traditionally associated with inflammation and cell death. Recently, they have also been shown to modulate cell proliferation and differentiation. The aim of the current research was to search for osteogenic molecules affected by caspase inhibition and to specify the individual caspases critical...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64294-9
更新日期:2020-05-04 00:00:00
abstract::P-type doping in high Al-content AlGaN alloys is a main challenge for realizing AlGaN-based deep ultraviolet optoelectronics devices. According to the first-principles calculations, Mg activation energy may be reduced so that a high hole concentration can be obtained by introducing nanoscale (AlN)5/(GaN)1 superlattice...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44223
更新日期:2017-03-14 00:00:00
abstract::Enamel proteins form a scaffold for growing hydroxyapatite crystals during enamel formation. They are then almost completely degraded during enamel maturation, resulting in a protein content of only 1% (w/v) in mature enamel. Nevertheless, this small amount of remaining proteins has important effects on the mechanical...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15194
更新日期:2015-10-15 00:00:00
abstract::Insect glutathione S-transferases (GSTs) play important roles in insecticide/drug resistance and stress response. Medically, GSTs of house dust mites (Dermatophagoides pteronyssinus and Blomia tropicalis) and German cockroach (Blattella germanica) are human allergens. In this study, classes, isoforms and B-cell and al...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18759-z
更新日期:2018-01-11 00:00:00
abstract::Sampling various compartments within the lower airways to examine human bronchial epithelial cells (HBEC) is essential for understanding numerous lung diseases. Conventional methods to identify HBEC in bronchoalveolar lavage (BAL) and wash (BW) have throughput limitations in terms of efficiency and ensuring adequate c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42214
更新日期:2017-02-06 00:00:00
abstract::We measured the interleukin-34 (IL-34) level in sera from patients with systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) using an enzyme-linked immunosorbent assay (ELISA). Blood tests, including assays to determine C-reactive protein (CRP), complement (C) 3, C4, immunoglobulin (Ig) A, IgG, IgM...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21859-z
更新日期:2018-02-22 00:00:00
abstract::We advance the concept that the charge factors of the simple overlap model and the polarizabilities of Judd-Ofelt theory for the luminescence of europium complexes can be effectively and uniquely modeled by perturbation theory on the semiempirical electronic wave function of the complex. With only three adjustable con...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13695
更新日期:2015-09-02 00:00:00
abstract::Repeated social defeat stress (R-SDS) induces multiple behavioral changes in mice. However, the relationships between these behavioral changes were not fully understood. In the first experiment, to examine how the social avoidance is related to R-SDS-impaired behavioral flexibility, 10-week-old male C57BL/6N mice rece...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28803-1
更新日期:2018-07-11 00:00:00
abstract::Glypican-3 (GPC3) is a cell-surface heparan sulfate proteoglycan highly expressed in hepatocellular carcinoma (HCC). We have generated a group of high-affinity mouse monoclonal antibodies targeting GPC3. Here, we report the humanization and testing of these antibodies for clinical development. We compared the affinity...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33878
更新日期:2016-09-26 00:00:00
abstract::Enhanced and immediate expression of cyclooxygenase-2 (COX-2) mRNA is observed in IL-1β-stimulated OA chondrocytes but the synthesis of protein found significantly delayed. Here we investigated the role of stress granules (SGs), ribonucleoprotein complexes that regulate mRNA translation, in the delayed translation of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27611
更新日期:2016-06-08 00:00:00
abstract::Monocytes/macrophages have been found to be an important component of colitis. However, the key chemokine that initiates the CCR2+ monocytes migration from circulation to colitis tissue remains to be undiscovered. PC3-secreted microprotein (PSMP) is a novel chemokine whose receptor is CCR2. The physiological and patho...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05255-7
更新日期:2017-07-11 00:00:00
abstract::Protein ubiquitination and degradation represent druggable vulnerabilities of cancer cells. We used gene expression and functional annotation analyses to identify genes in the ubiquitin pathway which are differentially expressed between normal breast and basal-like tumors. With this approach we identified 16 ubiquitin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17836-7
更新日期:2017-12-13 00:00:00
abstract::Bioactive gibberellins (GAs) are essential phytohormones involved in the regulation of many aspects of plant development. GA receptors are crucial in GA signal transduction in plants. The GA receptor GoGID1 promotes plant elongation and improves biomass production when ectopically expressed in tobacco. Here, we discov...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41296
更新日期:2017-01-27 00:00:00
abstract::Mitochondrial dysfunction and significant changes in metabolic pathways accompany cancer development and are responsible for maintaining the tumor microenvironment. Normal mitochondria can trigger intrinsic apoptosis by releasing cytochrome c into the cytosol. The survival of malignant cells highly depends on the supp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71118-3
更新日期:2020-08-25 00:00:00
abstract::In this study, 44 compounds in the petroleum ether extract of Maqian (Zanthoxylum myriacanthum var. pubescens) bark, a traditional Dai herbal medicine, were identified by GC-MS. Major components included 3(2H)-benzofuranone, asarinin and (dimethoxymethyl)-3-methoxy-benzene. A total of 18 compounds were isolated from t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45805
更新日期:2017-04-06 00:00:00
abstract::Tunicates are marine invertebrates that compose the closest phylogenetic group to the vertebrates. These chordates present a particularly diverse range of regenerative abilities and life-history strategies. Consequently, tunicates provide an extraordinary perspective into the emergence and diversity of these traits. H...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23749-w
更新日期:2018-04-03 00:00:00
abstract::The concept of remission for patients with inflammatory bowel diseases has recently evolved, and should also include histological healing of the mucosa, difficult to evaluate since there is no agreement on pathological scores and those available are quite complex to use in the daily routine. We evaluated the possible ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07338-x
更新日期:2017-07-28 00:00:00
abstract::It has been reported that in patients with operable stage I non-small cell lung cancer (NSCLC), overall survival (OS) is better in those who undergo hypofractionated stereotactic radiation therapy (HSRT) than in those who undergo surgery. However, the reason that HSRT has a better OS has not been fully explored. Here,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04978-x
更新日期:2017-07-07 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-22377-8
更新日期:2018-03-06 00:00:00
abstract::Crystallization is the bottleneck in macromolecular crystallography; even when a protein crystallises, crystal packing often influences ligand-binding and protein-protein interaction interfaces, which are the key points of interest for functional and drug discovery studies. The human hypoxia-inducible factor prolyl hy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76307-8
更新日期:2020-12-15 00:00:00
abstract::Enterovirus 71 (EV71) is the predominant causative pathogen of hand-foot-and-mouth disease (HFMD). Contrary to other HFMD-causing enterovirus, EV71 can lead to severe neurological complications, even death. MicroRNAs (miRNAs) are small non-coding RNAs that constitute the largest family of gene regulators participating...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16616-7
更新日期:2017-11-27 00:00:00
abstract::Cytochrome P450 monooxygenases (P450s) are heme-thiolate proteins whose role as drug targets against pathogens, as well as in valuable chemical production and bioremediation, has been explored. In this study we performed comprehensive comparative analysis of P450s in 13 newly explored oomycete pathogens. Three hundred...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11572
更新日期:2015-07-01 00:00:00
abstract::Hypertension is a public health issue in Iran. The study aimed to estimate the prevalence, awareness, treatment, and control of hypertension, and to explore their determinants among 10,040 Kurdish adults from Ravansar Non-Communicable Disease (RaNCD) cohort study in Iran. Univariate, and multivariate analyses were use...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48232-y
更新日期:2019-08-27 00:00:00
abstract::Glaucoma optic neuropathy (GON) is a condition where pathogenic intraocular pressure (IOP) results in axonal damage following retinal ganglion cell (RGC) death, and further results in secondary damage of the lateral geniculate nucleus (LGN). Therapeutic targets for glaucoma thus focus on both the LGN and RGC. However,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06501
更新日期:2014-10-13 00:00:00
abstract::Optical coherence tomography angiography (OCTA) seems not to image the choroidal blood flow pattern in the normal individual because of the OCT light attenuation. Our purpose in the current study was to visualize the large choroidal blood flow pattern after subtraction of the choriocapillaris projection artifact in no...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34102-6
更新日期:2018-10-24 00:00:00
abstract::Measurement techniques that allow the global analysis of cellular responses while retaining single-cell sensitivity are increasingly needed in order to understand complex and dynamic biological processes. In this context, compromises between sensitivity, degree of multiplexing, throughput, and invasiveness are often u...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53428-3
更新日期:2019-11-19 00:00:00