A direct comparison of interphase FISH versus low-coverage single cell sequencing to detect aneuploidy reveals respective strengths and weaknesses.

abstract：:Triazophos (TAP) is a widely used phosphorus pesticide in China that possesses a potential risk for water pollution. We have studied the removal efficiency of TAP using pilot-scale horizontal subsurface flow constructed wetlands (HSCWs) as well as the contribution of plants, substrates and other pathways to its remova...

journal_title：Scientific reports

authors： Wu J,Li Z,Wu L,Zhong F,Cui N,Dai Y,Cheng S

更新日期：2017-07-14 00:00:00

abstract：:The endo-levanase BT1760 of a human gut commensal Bacteroides thetaiotaomicron randomly cuts a β-2,6-linked fructan, levan, into fructo-oligosaccharides providing a prebiotic substrate for gut microbiota. Here we introduce the crystal structure of BT1760 at resolution of 1.65 Å. The fold of the enzyme is typical for G...

journal_title：Scientific reports

authors： Ernits K,Eek P,Lukk T,Visnapuu T,Alamäe T

更新日期：2019-06-11 00:00:00

abstract：:Faithful DNA replication is a prerequisite for cell proliferation. Several cytological studies have shown that chromosome structures alter in the S-phase of the cell cycle. However, the molecular mechanisms behind the alteration of chromosome structures associated with DNA replication have not been elucidated. Here, w...

journal_title：Scientific reports

authors： Ruan K,Yamamoto TG,Asakawa H,Chikashige Y,Kimura H,Masukata H,Haraguchi T,Hiraoka Y

更新日期：2015-07-30 00:00:00

abstract：:Humans interact with the oceans in diverse and profound ways. The scope, magnitude, footprint and ultimate cumulative impacts of human activities can threaten ocean ecosystems and have changed over time, resulting in new challenges and threats to marine ecosystems. A fundamental gap in understanding how humanity is af...

journal_title：Scientific reports

authors： Halpern BS,Frazier M,Afflerbach J,Lowndes JS,Micheli F,O'Hara C,Scarborough C,Selkoe KA

更新日期：2019-08-12 00:00:00

abstract：:Cardiac magnetic resonance (CMR) has emerged as a powerful tool for in vivo assessments of cardiac parameters in experimental animal models of cardiovascular diseases, but its reproducibility in this setting remains poorly explored. To address this issue, we investigated the test-retest reproducibility of preclinical ...

journal_title：Scientific reports

authors： Joubert M,Tager P,Legallois D,Defourneaux E,Le Guellec B,Gerber B,Morello R,Manrique A

更新日期：2017-07-27 00:00:00

abstract：:This study aims to identify patterns of surface heat fluxes, and corresponding surface ocean responses, associated with synoptic-scale atmospheric events and their modulation on seasonal time scales. In particular, northerly and southerly wind events associated with atmospheric disturbances were analyzed using high-te...

journal_title：Scientific reports

authors： Tomita H,Cronin MF,Ohishi S

更新日期：2021-01-11 00:00:00

abstract：:EEG is known to contain considerable inter-trial and inter-subject variability, which poses a challenge in any group-level EEG analyses. A true experimental effect must be reproducible even with variabilities in trials, sessions, and subjects. Extracting components that are reproducible across trials and subjects bene...

journal_title：Scientific reports

authors： Tanaka H

更新日期：2020-01-09 00:00:00

abstract：:We demonstrate a method for the preparation of negative-index fibre Bragg gratings (FBGs) using 800 nm femtosecond laser overexposure and thermal regeneration. A positive-index type I-IR FBG was first inscribed in H2-free single-mode fibre using a femtosecond laser directed through a phase mask, and then a highly pola...

journal_title：Scientific reports

authors： He J,Wang Y,Liao C,Wang C,Liu S,Yang K,Wang Y,Yuan X,Wang GP,Zhang W

更新日期：2016-03-16 00:00:00

abstract：:The DEAD-box RNA helicase DDX3 plays divergent roles in tumorigenesis, however, its function in mitosis is unclear. Immunofluorescence indicated that DDX3 localized to centrosome throughout the cell cycle and colocalized with centrosome-associated p53 during mitosis in HCT116 and U2OS cells. DDX3 depletion promoted ch...

journal_title：Scientific reports

authors： Chen WJ,Wang WT,Tsai TY,Li HK,Lee YW

更新日期：2017-08-25 00:00:00

abstract：:Mixed species biofilms are shaped and influenced by interactions between species. In the oral cavity, dysbiosis of the microbiome leads to diseases such as periodontitis. Porphyromonas gingivalis is a keystone pathogen of periodontitis. In this study, we showed that polymicrobial biofilm formation promoted the toleran...

journal_title：Scientific reports

authors： Zhu B,Macleod LC,Newsome E,Liu J,Xu P

更新日期：2019-03-20 00:00:00

abstract：:Plant extracts contain many active compounds, which are tremendously fruitful for plant defence against several insect pests. The prime objectives of the present study were to calculate the extraction yield and to evaluate the leaf extracts of Citrullus colocynthis (L.), Cannabis indica (L.) and Artemisia argyi (L.) a...

journal_title：Scientific reports

authors： Ahmed M,Peiwen Q,Gu Z,Liu Y,Sikandar A,Hussain D,Javeed A,Shafi J,Iqbal MF,An R,Guo H,Du Y,Wang W,Zhang Y,Ji M

更新日期：2020-01-16 00:00:00

abstract：:Tinnitus (phantom auditory perception associated with hearing loss) can seriously affect wellbeing. Its neural substrate is unknown however it has been linked with abnormal activity in auditory pathways. Though no cure currently exists, repetitive transcranial magnetic stimulation (rTMS) has been shown to reduce tinni...

journal_title：Scientific reports

authors： Mulders WH,Vooys V,Makowiecki K,Tang AD,Rodger J

更新日期：2016-12-01 00:00:00

abstract：:The tumour suppressor p53 is mutated in cancer, including over 96% of high-grade serous ovarian cancer (HGSOC). Mutations cause loss of wild-type p53 function due to either gain of abnormal function of mutant p53 (mutp53), or absent to low mutp53. Massively parallel sequencing (MPS) enables increased accuracy of detec...

journal_title：Scientific reports

authors： Cole AJ,Dwight T,Gill AJ,Dickson KA,Zhu Y,Clarkson A,Gard GB,Maidens J,Valmadre S,Clifton-Bligh R,Marsh DJ

更新日期：2016-05-18 00:00:00

abstract：:Neurogenesis of hippocampal granule cells (GCs) persists throughout mammalian life and is important for learning and memory. How newborn GCs differentiate and mature into an existing circuit during this time period is not yet fully understood. We established a method to visualize postnatally generated GCs in organotyp...

journal_title：Scientific reports

authors： Radic T,Jungenitz T,Singer M,Beining M,Cuntz H,Vlachos A,Deller T,Schwarzacher SW

更新日期：2017-03-03 00:00:00

abstract：:Specific HPV genotypes have been recognized as risk factors inducing head and neck cancers (HNC). The aim of this study was to validate a real-time PCR assay to detect accurately High Risk HPV DNA in Formalin Fixed Paraffin Embedded (FFPE) and oral cytobrush samples and compare the results with conventional PCR. Repea...

journal_title：Scientific reports

authors： Harlé A,Guillet J,Thomas J,Sastre-Garau X,Rouyer M,Ramacci C,Gilson P,Dubois C,Dolivet G,Leroux A,Salleron J,Merlin JL

更新日期：2018-07-27 00:00:00

abstract：:Hemodialysis patients are a special group of patients with higher mortality rates. Hemodialysis patients with vitamin D deficiency {plasma levels of 25-hydroxyvitamin D [25(OH)D] below 20 ng/mL} are associated with even higher mortality rates. The prognostic importance of vitamin D deficiency in hemodialysis patients ...

journal_title：Scientific reports

authors： Hsu HJ,Wu IW,Hsu KH,Sun CY,Chen CY,Lee CC

更新日期：2020-05-05 00:00:00

abstract：:Graphene plasmonics has become a highlighted research area due to the outstanding properties of deep-subwavelength plasmon excitation, long relaxation time, and electro-optical tunability. Although the giant conductivity of a graphene layer enables the low-dimensional confinement of light, the atomic scale of the laye...

journal_title：Scientific reports

authors： Kim Y,Yu S,Park N

更新日期：2017-02-27 00:00:00

abstract：:Kmmig1 as a disrupted mutant of MIG1 encoding a regulator for glucose repression in Kluyveromyces marxianus exhibits a histidine-auxotrophic phenotype. Genome-wide expression analysis revealed that only HIS4 in seven HIS genes for histidine biosynthesis was down-regulated in Kmmig1. Consistently, introduction of HIS4 ...

journal_title：Scientific reports

authors： Nurcholis M,Murata M,Limtong S,Kosaka T,Yamada M

更新日期：2019-07-09 00:00:00

abstract：:In this paper, we propose a real time, ultrahigh accuracy and full-field-of-view (RUF) algorithm for full field of view (FOV) imaging system. The proposed algorithm combines rough matching and precise matching method to stitch multiple images with the whole FOV in short time and high imaging quality. In order to verif...

journal_title：Scientific reports

authors： Liu SB,Wang JH,Yuan RY,Zhao WX,Li L,Wang QH

更新日期：2020-07-24 00:00:00

abstract：:The early Pliocene shoaling of the Central American Seaway (CAS), ~4.7-4.2 million years ago (mega annum-Ma), is thought to have strengthened Atlantic Meridional Overturning Circulation (AMOC). The associated increase in northward flux of heat and moisture may have significantly influenced the evolution of Pliocene cl...

journal_title：Scientific reports

authors： Bell DB,Jung SJ,Kroon D,Hodell DA,Lourens LJ,Raymo ME

更新日期：2015-07-20 00:00:00

abstract：:The dynamic structure of proteins is essential for their functions and may include large conformational transitions which can be studied by molecular dynamics (MD) simulations. However, details of these transitions are difficult to automatically track. To facilitate their analysis, we developed two scores of correlati...

journal_title：Scientific reports

authors： Taddese B,Garnier A,Abdi H,Henrion D,Chabbert M

更新日期：2020-09-28 00:00:00

abstract：:Genotyping-by-sequencing (GBS) or restriction-site associated DNA marker sequencing (RAD-seq) is a practical and cost-effective method for analysing large genomes from high diversity species. This method of sequencing, coupled with methylation-sensitive enzymes (often referred to as methylation-sensitive restriction e...

journal_title：Scientific reports

authors： Mayne BT,Leemaqz SY,Buckberry S,Rodriguez Lopez CM,Roberts CT,Bianco-Miotto T,Breen J

更新日期：2018-02-01 00:00:00

abstract：:Arbuscular mycorrhizal (AM) symbioses are an attractive means of improving the efficiency of soil phosphorus (P) that difficult to be used by plants and may provide a sustainable way of maintaining high yields while reducing P applications. However, quantifying the contribution of indigenous AM fungi on phosphorus upt...

journal_title：Scientific reports

authors： Hou L,Zhang X,Feng G,Li Z,Zhang Y,Cao N

更新日期：2021-01-13 00:00:00

abstract：:Both genetic and environmental factors are suggested to influence overweight and obesity risks. Although individual loci and genes have been frequently shown to be associated with body mass index (BMI), the overall interaction of these genes and their role in BMI remains underexplored. Data were collected in 90 health...

journal_title：Scientific reports

authors： Joseph PV,Jaime-Lara RB,Wang Y,Xiang L,Henderson WA

更新日期：2019-05-15 00:00:00

abstract：:The relationship between alcohol consumption and mortality generally exhibits a U-shaped curve. The longevity observed with moderate alcohol consumption may be explained by other confounding factors, and, if such a relationship is present, the mechanism is not well understood. Indeed, the optimal amount of alcohol con...

journal_title：Scientific reports

authors： Dixit S,Whooley MA,Vittinghoff E,Roberts JD,Heckbert SR,Fitzpatrick AL,Lin J,Leung C,Mukamal KJ,Marcus GM

更新日期：2019-02-05 00:00:00

abstract：:A fundamental task in cancer research aims at the identification of new pharmacological therapies that can affect tumor growth. Differentiation therapy might exploit this function not only for hematological diseases, such as acute promyelocytic leukemia (APML) but also for epithelial tumors, including lung cancer. Her...

journal_title：Scientific reports

authors： Zito G,Naselli F,Saieva L,Raimondo S,Calabrese G,Guzzardo C,Forte S,Rolfo C,Parenti R,Alessandro R

更新日期：2017-07-06 00:00:00

abstract：:Antigen-presenting cells including dendritic cells (DCs) express mannan receptors (MR) on their surface, which can be exploited in cancer therapy by designing immune-stimulatory viruses coated with mannan-modified capsids that then bind to DCs and initiate a potent immune response. Although the combination of anti-ang...

journal_title：Scientific reports

authors： Wang Y,Zhang J,Wu Y,Ding ZY,Luo XM,Liu J,Zhong WN,Deng GH,Xia XY,Deng YT,Wei YQ,Jiang Y

更新日期：2015-06-18 00:00:00

abstract：:Recent discoveries have highlighted the novel metabolic functions of adipose tissue in enhancing hypermetabolism after trauma. As the exact function and expression profiles of serum lipids and free fatty acids (FFA) are essentially unknown, we determined the lipidomic expression profile after burn in correlation to cl...

journal_title：Scientific reports

authors： Qi P,Abdullahi A,Stanojcic M,Patsouris D,Jeschke MG

更新日期：2016-12-16 00:00:00

abstract：:Behavioural studies revealed that the dog-human relationship resembles the human mother-child bond, but the underlying mechanisms remain unclear. Here, we report the results of a multi-method approach combining fMRI (N = 17), eye-tracking (N = 15), and behavioural preference tests (N = 24) to explore the engagement of...

journal_title：Scientific reports

authors： Karl S,Boch M,Zamansky A,van der Linden D,Wagner IC,Völter CJ,Lamm C,Huber L

更新日期：2020-12-17 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract of uncertain origin, which includes ulcerative colitis (UC) and Crohn's disease (CD). The composition of gut microbiota may change in IBD affected individuals, but whether dysbiosis is the cause or the consequence of infla...

journal_title：Scientific reports

authors： Santoru ML,Piras C,Murgia A,Palmas V,Camboni T,Liggi S,Ibba I,Lai MA,Orrù S,Blois S,Loizedda AL,Griffin JL,Usai P,Caboni P,Atzori L,Manzin A

更新日期：2017-08-25 00:00:00