Cross sectional evaluation of the gut-microbiome metabolome axis in an Italian cohort of IBD patients.

abstract：:Accurately predicting the response of a cancer patient to a therapeutic agent is a core goal of precision medicine. Existing approaches were mainly relied primarily on genomic alterations in cancer cells that have been treated with different drugs. Here we focus on predicting drug response based on integration of the ...

journal_title：Scientific reports

authors： Wang Y,Fang J,Chen S

更新日期：2016-09-20 00:00:00

abstract：:Higher and lower levels of alertness typically lead to a leftward and rightward bias in attention, respectively. This relationship between alertness and spatial attention potentially has major implications for health and safety. The current study examined alertness and spatial attention under simulated shiftworking co...

journal_title：Scientific reports

authors： Chandrakumar D,Dorrian J,Banks S,Keage HAD,Coussens S,Gupta C,Centofanti SA,Stepien JM,Loetscher T

更新日期：2020-09-11 00:00:00

abstract：:Spinal muscular atrophy (SMA) is caused by homozygous mutation of the survival motor neuron 1 (SMN1) gene. Disease severity inversely correlates to the amount of SMN protein produced from the homologous SMN2 gene. We show that SMN protein is naturally released in exosomes from all cell types examined. Fibroblasts from...

journal_title：Scientific reports

authors： Nash LA,McFall ER,Perozzo AM,Turner M,Poulin KL,De Repentigny Y,Burns JK,McMillan HJ,Warman Chardon J,Burger D,Kothary R,Parks RJ

更新日期：2017-10-24 00:00:00

abstract：:The performances of two identical biofilters, filled with a new composite packing material (named CM-5) embedded with functional microorganisms or sterilized CM-5 without microorganisms, were investigated for H2S treatment. Running parameters in terms of microbial counts, pressure drops, and inlet and outlet H2S conce...

journal_title：Scientific reports

authors： Zhu R,Li S,Bao X,Dumont É

更新日期：2017-02-13 00:00:00

abstract：:In spite of much work on topological insulators (TIs), systematic experiments for TI/TI heterostructures remain absent. We grow a high quality heterostructure containing single quintuple layer (QL) of Bi2Se3 on 19 QLs of Bi2Te3 and compare its transport properties with 20 QLs Bi2Se3 and 20 QLs Bi2Te3. All three films ...

journal_title：Scientific reports

authors： Zhao Y,Chang CZ,Jiang Y,DaSilva A,Sun Y,Wang H,Xing Y,Wang Y,He K,Ma X,Xue QK,Wang J

更新日期：2013-10-28 00:00:00

abstract：:The Mont-Blanc massif, being iconic with its large glaciers and peaks of over 4,000 m, will experience a sharp increase in summer temperatures during the twenty-first century. By 2100, the impact of climate change on the cryosphere and hydrosphere in the Alps is expected to lead to a decrease in annual river discharge...

journal_title：Scientific reports

authors： Laurent L,Buoncristiani JF,Pohl B,Zekollari H,Farinotti D,Huss M,Mugnier JL,Pergaud J

更新日期：2020-06-26 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Sykora-Bodie ST,Bezy V,Johnston DW,Newton E,Lohmann KJ

更新日期：2018-04-19 00:00:00

abstract：:As a two-dimensional material, graphene has attracted increasing attention as heat dissipation material owing to its excellent thermal transport property. In this work, we fabricated sisal nanocrystalline cellulose/functionalized graphene papers (NPGs) with high thermal conductivity by vacuum-assisted self-assembly me...

journal_title：Scientific reports

authors： Ren L,Wang M,Lu S,Pan L,Xiong Z,Zhang Z,Peng Q,Li Y,Yu J

更新日期：2019-03-14 00:00:00

abstract：:Preclinical studies show that the dopamine D3 receptor (D3R) is involved in the reinstatement of drug seeking and motivation for drugs of abuse. A D3R gene variant, Ser9Gly (rs6280) has been linked to nicotine dependence, yet the mechanisms underlying its involvement in nicotine dependence is unclear. This study inves...

journal_title：Scientific reports

authors： Chukwueke CC,Kowalczyk WJ,Di Ciano P,Gendy M,Taylor R,Heishman SJ,Le Foll B

更新日期：2020-03-05 00:00:00

abstract：:Small oligomers formed early along human islet amyloid polypeptide (hIAPP) aggregation is responsible for the cell death in Type II diabetes. The epigallocatechin gallate (EGCG), a green tea extract, was found to inhibit hIAPP fibrillation. However, the inhibition mechanism and the conformational distribution of the s...

journal_title：Scientific reports

authors： Mo Y,Lei J,Sun Y,Zhang Q,Wei G

更新日期：2016-09-13 00:00:00

abstract：:The growing attention to the luminescent nanocarriers is strongly stimulated by their potential application as drug delivery systems and by the necessity to monitor their distribution in cells and tissues. In this communication we report on the synthesis of amphiphilic polypeptides bearing C-terminal phosphorescent la...

journal_title：Scientific reports

authors： Vlakh EG,Grachova EV,Zhukovsky DD,Hubina AV,Mikhailova AS,Shakirova JR,Sharoyko VV,Tunik SP,Tennikova TB

更新日期：2017-02-03 00:00:00

abstract：:A biofilm has a unique structure composed of microorganisms, extracellular polymeric substances (EPSs), etc., and it is layered on a substrate in water. In material science, it is important to detect the biofilm formed on a surface to prevent biofouling. EPSs, the major component of the biofilm, mainly consist of poly...

journal_title：Scientific reports

authors： Tanaka N,Kogo T,Hirai N,Ogawa A,Kanematsu H,Takahara J,Awazu A,Fujita N,Haruzono Y,Ichida S,Tanaka Y

更新日期：2019-05-30 00:00:00

abstract：:Bast fibres are long extraxylary cells which mechanically support the phloem and they are divided into xylan- and gelatinous-type, depending on the composition of their secondary cell walls. The former, typical of jute/kenaf bast fibres, are characterized by the presence of xylan and a high degree of lignification, wh...

journal_title：Scientific reports

authors： Guerriero G,Behr M,Legay S,Mangeot-Peter L,Zorzan S,Ghoniem M,Hausman JF

更新日期：2017-07-10 00:00:00

abstract：:The interplay between the quasi 1-dimensional CuO-chains and the 2-dimensional CuO2 planes of YBa(2)Cu(3)O(6+x) (YBCO) has been in focus for a long time. Although the CuO-chains are known to be important as charge reservoirs that enable superconductivity for a range of oxygen doping levels in YBCO, the understanding o...

journal_title：Scientific reports

authors： Magnuson M,Schmitt T,Strocov VN,Schlappa J,Kalabukhov AS,Duda LC

更新日期：2014-11-12 00:00:00

abstract：:River ecosystem health assessments provide the foundation for river ecological protection and integrated management. To evaluate the aquatic ecosystem health of the Fan River basin, benthic macroinvertebrate indices (the Multimeric Macroinvertebrates Index Flanders (MMIF) and Family Biotic Index (FBI)), a habitat inde...

journal_title：Scientific reports

authors： Chen J,Wang Y,Li F,Liu Z

更新日期：2019-10-01 00:00:00

abstract：:After HSP70 binds to the J domain of the substrate and co-chaperone protein, ATP is hydrolyzed to ADP, and the nucleotide exchange factors (NEFs) promote the release of ADP. Under physiological conditions, the nucleotide exchange step is the rate-limiting step, which is accelerated by NEFs. In this study, the promoter...

journal_title：Scientific reports

authors： Chen S,Qiu G

更新日期：2020-10-14 00:00:00

abstract：:Alcohol consumption has been shown to cause dysbiosis, but the mechanism involved in it is unknown. Recurrent colitis is known to induce expression of α-defensins in the colon, but the effect of alcohol consumption on it is not known. We investigated the effect of ethanol on α-defensin expression in the small intestin...

journal_title：Scientific reports

authors： Shukla PK,Meena AS,Rao V,Rao RG,Balazs L,Rao R

更新日期：2018-11-02 00:00:00

abstract：:Graft contracture is a common problem associated with the regeneration processes of tissue-engineered bladders. Currently, most strategies used for incorporating bioactive molecules into biomaterial designs do not work during all phases of tissue regeneration. In this study, we used a growth factor-PLGA nanoparticle t...

journal_title：Scientific reports

authors： Jiang X,Lin H,Jiang D,Xu G,Fang X,He L,Xu M,Tang B,Wang Z,Cui D,Chen F,Geng H

更新日期：2016-02-08 00:00:00

abstract：:Sea scorpions (Eurypterida, Chelicerata) of the Lower Devonian (~400 Mya) lived as large, aquatic predators. The structure of modern chelicerate eyes is very different from that of mandibulate compound eyes [Mandibulata: Crustacea and Tracheata (Hexapoda, such as insects, and Myriapoda)]. Here we show that the visual ...

journal_title：Scientific reports

authors： Schoenemann B,Poschmann M,Clarkson ENK

更新日期：2019-11-28 00:00:00

abstract：:The human β-defensin-1 (HBD1) is an antimicrobial peptide constitutively expressed by epithelial cells at mucosal surfaces. In addition to its microbicidal properties, the loss of HBD1 expression in several cancers suggests that it may also have an anti-tumor activity. Here, we investigated the link between HBD1 expre...

journal_title：Scientific reports

authors： Bonamy C,Sechet E,Amiot A,Alam A,Mourez M,Fraisse L,Sansonetti PJ,Sperandio B

更新日期：2018-12-21 00:00:00

abstract：:Propofol sedation has been applied during esophagogastroduodenoscopy procedures, but whether topical pharyngeal anesthesia should be administered at the same time has rarely been reported. Our study examined the role of topical pharyngeal anesthesia in sedated endoscopies in a randomized controlled double-blinded clin...

journal_title：Scientific reports

authors： Sun X,Xu Y,Zhang X,Li A,Zhang H,Yang T,Liu Y

更新日期：2018-04-27 00:00:00

abstract：:Parasite death via ion channel activations is the hallmark of anthelmintic and antiparasitic drugs. Glutamate gated chloride channel (GluCl) is a prominent targets for drug selection and design in parasitology. We report several iodine-fluorine based lead activators of GluCl by computational studies and structure-acti...

journal_title：Scientific reports

authors： Rajasekharan SK,Lee JH,Ravichandran V,Kim JC,Park JG,Lee J

更新日期：2019-02-14 00:00:00

abstract：:The therapeutic potential of nonthermal plasma for cancer treatment has been reported recently. The heterogeneity of cancer cells need to be addressed to design effective anticancer treatments. Here, we show that treatment with nonthermal atmospheric-pressure plasma dissolved in a liquid (liquid plasma) induces oxidat...

journal_title：Scientific reports

authors： Nguyen NH,Park HJ,Yang SS,Choi KS,Lee JS

更新日期：2016-07-01 00:00:00

abstract：:Antimicrobial resistance (AMR) is a major public health threat. Plasmids are able to transfer AMR genes among bacterial isolates. Whole genome sequencing (WGS) is a powerful tool to monitor AMR determinants. However, plasmids are difficult to reconstruct from WGS data. This study aimed to improve the characterization,...

journal_title：Scientific reports

authors： Berbers B,Saltykova A,Garcia-Graells C,Philipp P,Arella F,Marchal K,Winand R,Vanneste K,Roosens NHC,De Keersmaecker SCJ

更新日期：2020-03-09 00:00:00

abstract：:Teleost fish exhibit a remarkable diversity in the control of sex determination, offering the opportunity to identify novel differentiation mechanisms and their ecological consequences. Here, we perform GWAS using 4715 fish and 46,501 SNP to map sex determination to three separate genomic locations in Atlantic salmon ...

journal_title：Scientific reports

authors： Kijas J,McWilliam S,Naval Sanchez M,Kube P,King H,Evans B,Nome T,Lien S,Verbyla K

更新日期：2018-04-04 00:00:00

abstract：:In this work we have studied the effects of pharmacological concentrations of melatonin (1 µM-1 mM) on pancreatic stellate cells (PSC). Cell viability was analyzed by AlamarBlue test. Production of reactive oxygen species (ROS) was monitored following CM-H2DCFDA and MitoSOX Red-derived fluorescence. Total protein carb...

journal_title：Scientific reports

authors： Gonzalez A,Estaras M,Martinez-Morcillo S,Martinez R,García A,Estévez M,Santofimia-Castaño P,Tapia JA,Moreno N,Pérez-López M,Míguez MP,Blanco-Fernández G,Lopez-Guerra D,Fernandez-Bermejo M,Mateos JM,Vara D,Roncero V,Sali

更新日期：2020-04-14 00:00:00

abstract：:The self-cleaning property is usually connected to superhydrophobic surfaces (SHSs) where the dust particles can be easily removed by the rolling motion of droplets. It seems that superhydrophobicity (its durability is questionable nowadays) is a necessity. However here, it is disclosed that self-cleaning can also be ...

journal_title：Scientific reports

authors： Quan YY,Zhang LZ,Qi RH,Cai RR

更新日期：2016-12-05 00:00:00

abstract：:LiYF4:Eu nanophosphors with a single tetragonal phase are synthesized, and various strategies to enhance the Eu(3+) emission from the nanophosphors are investigated. The optimized Eu(3+) concentration is 35 mol%, and the red emission peaks due to the (5)D0 →(7)FJ (J = 1 and 2) transitions of Eu(3+) ions are further en...

journal_title：Scientific reports

authors： Kim SY,Won YH,Jang HS

更新日期：2015-01-19 00:00:00

abstract：:How chromosomes fold into 3D structures and how genome functions are affected or even controlled by their spatial organization remain challenging questions. Hi-C experiment has provided important structural insights for chromosome, and Hi-C data are used here to construct the 3D chromatin structure which are character...

journal_title：Scientific reports

authors： Xie WJ,Meng L,Liu S,Zhang L,Cai X,Gao YQ

更新日期：2017-06-06 00:00:00

abstract：:Bacteriophage capsids constitute icosahedral shells of exceptional stability that protect the viral genome. Many capsids display on their surface decoration proteins whose structure and function remain largely unknown. The decoration protein pb10 of phage T5 binds at the centre of the 120 hexamers formed by the major ...

journal_title：Scientific reports

authors： Vernhes E,Renouard M,Gilquin B,Cuniasse P,Durand D,England P,Hoos S,Huet A,Conway JF,Glukhov A,Ksenzenko V,Jacquet E,Nhiri N,Zinn-Justin S,Boulanger P

更新日期：2017-02-06 00:00:00