Atlantic Deep-water Response to the Early Pliocene Shoaling of the Central American Seaway.

abstract：:Lipidised analgesic peptide prodrugs self-assemble into peptide nanofibers; with the nanofiber morphology protecting the peptide from plasma degradation and improving therapeutic efficacy. Extending this learning, we hypothesised that a self-assembling lipidized peptide arginine vasopressin (AVP) receptor agonist, tha...

journal_title：Scientific reports

authors： Patel S,Volpe AB,Awwad S,Schätzlein AG,Haider S,Liu B,Uchegbu IF

更新日期：2020-04-29 00:00:00

abstract：:Artificially structured coatings are widely employed to minimize materials deterioration and corrosion, the annual direct cost of which is over 3% of the gross domestic product (GDP) for industrial countries. Manufacturing higher performance anticorrosive coatings is one of the most efficient approaches to reduce this...

journal_title：Scientific reports

authors： Chen B,Guizar-Sicairos M,Xiong G,Shemilt L,Diaz A,Nutter J,Burdet N,Huo S,Mancuso J,Monteith A,Vergeer F,Burgess A,Robinson I

更新日期：2013-01-01 00:00:00

abstract：:Cutaneous allodynia (CA) is a pain in response to non-nociceptive stimulation and a marker of central sensitisation. Probable migraine (PM) is a migraine subtype that fulfils all but one criterion of migraine. Headache intensity and the disability of individuals with PM are similar or lower than individuals with migra...

journal_title：Scientific reports

authors： Han SM,Kim KM,Cho SJ,Yang KI,Kim D,Yun CH,Chu MK

更新日期：2021-01-28 00:00:00

abstract：:Mendelian randomisation studies from Asia suggest detrimental influences of alcohol on cardiovascular risk factors, but such associations are observed mainly in men. The absence of associations of genetic variants (e.g. rs671 in ALDH2) with such risk factors in women - who drank little in these populations - provides ...

journal_title：Scientific reports

authors： Cho Y,Shin SY,Won S,Relton CL,Davey Smith G,Shin MJ

更新日期：2015-12-21 00:00:00

abstract：:Stroke incidence is a multifactorial disease and especially hyperhomocysteinemia is associated with a higher risk of stroke. Previous studies have reported a folate metabolism disorder associated with the MTHFR gene. We investigated four single nucleotide polymorphisms in the MTHFR 3'-UTR [2572 C > A (rs4846049), 4869...

journal_title：Scientific reports

authors： Kim JO,Park HS,Ryu CS,Shin JW,Kim J,Oh SH,Kim OJ,Kim NK

更新日期：2017-09-29 00:00:00

abstract：:Neutrophils play an important role in the occurrence and development of acute lung injury (ALI). Leukotriene B4 (LTB4), a hydrolysis product of epoxide leukotriene A4 (LTA4) catalyzed by LTA4 hydrolase (LTA4H), is one of the most potent chemoattractants for neutrophil. Bufexamac is a drug widely used as an anti-inflam...

journal_title：Scientific reports

authors： Xiao Q,Dong N,Yao X,Wu D,Lu Y,Mao F,Zhu J,Li J,Huang J,Chen A,Huang L,Wang X,Yang G,He G,Xu Y,Lu W

更新日期：2016-04-29 00:00:00

abstract：:Deferiprone (DFP) is a hydroxypyridinone-derived iron chelator currently in clinical use for iron chelation therapy. DFP has also been known to elicit antiproliferative activities, yet the mechanism of this effect has remained elusive. We herein report that DFP chelates the Fe2+ ion at the active sites of selected iro...

journal_title：Scientific reports

authors： Khodaverdian V,Tapadar S,MacDonald IA,Xu Y,Ho PY,Bridges A,Rajpurohit P,Sanghani BA,Fan Y,Thangaraju M,Hathaway NA,Oyelere AK

更新日期：2019-03-18 00:00:00

abstract：:Transjugular intrahepatic portosystemic shunt (TIPS) can treat portal hypertensive complications and modifies hepatic hemodynamics. Modification of liver perfusion can alter contrast enhancement dynamics of liver nodules. This study investigated the diagnostic performance of contrast-enhanced ultrasound (CEUS) to diag...

journal_title：Scientific reports

authors： Chang J,Dumitrache A,Böhling N,Abu-Omar J,Meyer C,Strobel D,Luetkens J,Luu AM,Rockstroh J,Strassburg CP,Trebicka J,Gonzalez-Carmona MA,Marinova M,Praktiknjo M

更新日期：2020-11-26 00:00:00

abstract：:Adequate responses to environmental stresses are essential for cell survival. The regulation of cellular energetics that involves mitochondrial energy production and oxidative stress is central in the process of stress adaptation and response. The p38α signalling pathway plays a key role in the response to stress stim...

journal_title：Scientific reports

authors： Trempolec N,Muñoz JP,Slobodnyuk K,Marin S,Cascante M,Zorzano A,Nebreda AR

更新日期：2017-09-12 00:00:00

abstract：:Helicobacter pylori is presumed to infect gastric tissue via the oral cavity in childhood, whereas risk factors for H. pylori infection in the oral cavity are unknown. In this study, we analysed the effects of Streptococcus mutans, a major cariogenic bacterial species, on H. pylori colonisation in the oral cavity, as ...

journal_title：Scientific reports

authors： Nomura R,Kadota T,Ogaya Y,Matayoshi S,Iwashita N,Okawa R,Nakano K

更新日期：2020-07-27 00:00:00

abstract：:Aquaporin 9 (AQP9), as an aquaglyceroporin, is expressed in many immune cells and plays important role in tumor initiation and progression. However, the relationship between AQP9 and tumor-infiltrating cells, and its prognostic value in cancers still require comprehensive understanding. Herein, we aimed to elucidate t...

journal_title：Scientific reports

authors： Liu X,Xu Q,Li Z,Xiong B

更新日期：2020-11-27 00:00:00

abstract：:Olfactory receptors are believed to play a central role in insects host-seeking, mating, and ovipositing. On the basis of male and female antennal transcriptome of adult Apolygus lucorum, a total of 110 candidate A. lucorum odorant receptors (AlucOR) were identified in this study including five previously annotated Al...

journal_title：Scientific reports

authors： An XK,Sun L,Liu HW,Liu DF,Ding YX,Li LM,Zhang YJ,Guo YY

更新日期：2016-11-28 00:00:00

abstract：:Chaotic resonance is a phenomenon that can replace the fluctuation source in stochastic resonance from additive noise to chaos. We previously developed a method to control the chaotic state for suitably generating chaotic resonance by external feedback even when the external adjustment of chaos is difficult, establish...

journal_title：Scientific reports

authors： Nobukawa S,Shibata N,Nishimura H,Doho H,Wagatsuma N,Yamanishi T

更新日期：2019-09-02 00:00:00

abstract：:Reliable quantification of miRNA expression by qRT-PCR crucially depends on validated housekeepers for data normalization. Here we present thoroughly tested miRNAs eligible as references in immunological studies utilizing endothelial cells and macrophages, respectively. Endothelial cells (cell line: TIME) and macropha...

journal_title：Scientific reports

authors： Link F,Krohn K,Schumann J

更新日期：2019-09-04 00:00:00

abstract：:Intractable diseases such as cancer are associated with breakdown in multiple individual functions, which conspire to create unhealthy phenotype-combinations. An important challenge is to decipher how these functions are coordinated in health and disease. We approach this by drawing on dynamical systems theory. We pos...

journal_title：Scientific reports

authors： Deritei D,Aird WC,Ercsey-Ravasz M,Regan ER

更新日期：2016-03-16 00:00:00

abstract：:In this work we revisit the important and controversial concept of quantum weak values, aiming to provide a simplified understanding to its associated physics and the origin of anomaly. Taking the Stern-Gerlach setup as a working system, we base our analysis on an exact treatment in terms of quantum Bayesian approach....

journal_title：Scientific reports

authors： Qin L,Feng W,Li XQ

更新日期：2016-02-03 00:00:00

abstract：:While molecular-targeted drugs have demonstrated strong therapeutic efficacy against diverse diseases such as cancer and infection, the appearance of drug resistance associated with genetic variations in individual patients or pathogens has severely limited their clinical efficacy. Therefore, precision medicine approa...

journal_title：Scientific reports

authors： Ono F,Chiba S,Isaka Y,Matsumoto S,Ma B,Katayama R,Araki M,Okuno Y

更新日期：2020-02-07 00:00:00

abstract：:A reduction in the particle size is expected to improve the properties and increase the application potential of high-entropy alloys. Therefore, in this study, a novel sol-gel autocombustion technique was first used to synthesize high-entropy alloys. The average grain size of the prepared nanocrystalline CoCrCuNiAl hi...

journal_title：Scientific reports

authors： Niu B,Zhang F,Ping H,Li N,Zhou J,Lei L,Xie J,Zhang J,Wang W,Fu Z

更新日期：2017-06-13 00:00:00

abstract：:Fertilisation datasets collected from field experiments (n = 21) in tea-producing areas from 2016 to 2018 were used to build a quantitative evaluation of the fertility of tropical soils (QUEFTS) model to estimate nutrient uptake of tea plants, and to investigate relationships between tea yield and nutrient accumulatio...

journal_title：Scientific reports

authors： Tang S,Liu Y,Zheng N,Li Y,Ma Q,Xiao H,Zhou X,Xu X,Jiang T,He P,Wu L

更新日期：2020-02-04 00:00:00

abstract：:To ensure the reliability of the planned multi-center clinical trial, we assessed the consistence and comparability of the quantitative parameters of the eight PET/CT units that will be used in this trial. PET/CT images were scanned using a PET NEMA image quality phantom (Biodex) on the eight units of Discovery PET/CT...

journal_title：Scientific reports

authors： Zhu Y,Geng C,Huang J,Liu J,Wu N,Xin J,Xu H,Yu L,Geng J

更新日期：2018-06-13 00:00:00

abstract：:The intrauterine environment is particularly vulnerable to environmental exposures. We previously established a mouse model that provided evidence for pregnancy complications and placental anti-angiogenesis in response to Aroclor 1254 (A-1254), a mixture of polychlorinated biphenyls (PCBs). Importantly, these effects ...

journal_title：Scientific reports

authors： Kalkunte S,Huang Z,Lippe E,Kumar S,Robertson LW,Sharma S

更新日期：2017-01-10 00:00:00

abstract：:In many human cancers, including hepatocellular carcinoma (HCC), high density of infiltrating tumor-associated macrophages (TAM) is associated with poor prognosis. Most TAMs express a M2 phenotype subsequently supporting tumor growth. How tumor cells polarize these TAMs to a pro-tumor M2 phenotype is still poorly unde...

journal_title：Scientific reports

authors： Shiau DJ,Kuo WT,Davuluri GVN,Shieh CC,Tsai PJ,Chen CC,Lin YS,Wu YZ,Hsiao YP,Chang CP

更新日期：2020-08-12 00:00:00

abstract：:Although the growth of graphene by chemical vapor deposition is a production technique that guarantees high crystallinity and superior electronic properties on large areas, it is still a challenge for manufacturers to efficiently scale up the production to the industrial scale. In this context, issues related to the p...

journal_title：Scientific reports

authors： Lisi N,Dikonimos T,Buonocore F,Pittori M,Mazzaro R,Rizzoli R,Marras S,Capasso A

更新日期：2017-08-30 00:00:00

abstract：:Looking for single molecule electronic devices, we have investigated the charge transport properties of individual tetra-phenylporphyrin molecules on different substrates by ultrahigh-vacuum scanning tunneling microscopy and spectroscopy and by first-principles calculations. The tetra-phenylporphyrins with a Co atom (...

journal_title：Scientific reports

authors： Zoldan VC,Faccio R,Pasa AA

更新日期：2015-02-10 00:00:00

abstract：:Compromised activity of the DNA repair enzymes may raise the risk of a number of cancers. We analyzed polymorphisms in the Xeroderma Pigmentosum, Complementation Group C (XPC) gene for their correlation with urinary bladder cancer. Ala499Val and Lys939Gln polymorphisms were genotyped in 234 urinary bladder cancer case...

journal_title：Scientific reports

authors： Sankhwar M,Sankhwar SN,Bansal SK,Gupta G,Rajender S

更新日期：2016-06-01 00:00:00

abstract：:Most large herbivores in arid landscapes need to drink which constrains their movements and makes them vulnerable to disturbance. Asiatic wild ass or khulan (Equus hemionus) were widespread and abundant throughout the arid landscapes of Central Asia and Mongolia, but have undergone dramatic population declines and ran...

journal_title：Scientific reports

authors： Payne JC,Buuveibaatar B,Bowler DE,Olson KA,Walzer C,Kaczensky P

更新日期：2020-02-19 00:00:00

abstract：:Contact investigation is an important and effective active case-finding strategy, but there is a lack of research on congregate settings in countries with an intermediate incidence. This study determined the incidence of and risk factors for tuberculosis (TB) development after exposure in congregate settings. This ret...

journal_title：Scientific reports

authors： Park SY,Han S,Kim YM,Kim J,Lee S,Yang J,Kim UN,Park MS

更新日期：2020-01-28 00:00:00

abstract：:In specific cases, chromatin clearly forms long-range loops that place distant regulatory elements in close proximity to transcription start sites, but we have limited understanding of many loops identified by Chromosome Conformation Capture (such as Hi-C) analyses. In efforts to elucidate their characteristics and fu...

journal_title：Scientific reports

authors： Sobhy H,Kumar R,Lewerentz J,Lizana L,Stenberg P

更新日期：2019-03-14 00:00:00

abstract：:Auricle defects are important and common occurrences in forensic medicine. The accurate measurement and assessment of auricle defects is key to identifying and evaluating injury, and the currently available methods are known to be labor intensive and inaccurate. In this paper, we introduce an identification and docume...

journal_title：Scientific reports

authors： Zhan G,Han L,Li Z,Liu Z,Fu J,Zhong K

更新日期：2018-02-12 00:00:00

abstract：:Guanine-rich quadruplex (G-QD) are formed by conversion of nucleotides with specific sequences by stabilization of positively charged K+ or Na+. These G-QD structures differentially absorb two-directional (right- and left-handed) circularly polarized light, which can discriminate the parallel or anti-parallel structur...

journal_title：Scientific reports

authors： Kim R,Youn YS,Kang M,Kim E

更新日期：2020-11-24 00:00:00