Control strategies of 3-cell Central Pattern Generator via global stimuli.

Abstract:

:The study of the synchronization patterns of small neuron networks that control several biological processes has become an interesting growing discipline. Some of these synchronization patterns of individual neurons are related to some undesirable neurological diseases, and they are believed to play a crucial role in the emergence of pathological rhythmic brain activity in different diseases, like Parkinson's disease. We show how, with a suitable combination of short and weak global inhibitory and excitatory stimuli over the whole network, we can switch between different stable bursting patterns in small neuron networks (in our case a 3-neuron network). We develop a systematic study showing and explaining the effects of applying the pulses at different moments. Moreover, we compare the technique on a completely symmetric network and on a slightly perturbed one (a much more realistic situation). The present approach of using global stimuli may allow to avoid undesirable synchronization patterns with nonaggressive stimuli.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Lozano Á,Rodríguez M,Barrio R

doi

10.1038/srep23622

subject

Has Abstract

pub_date

2016-03-29 00:00:00

pages

23622

issn

2045-2322

pii

srep23622

journal_volume

6

pub_type

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