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Vinculin Force Sensor Detects Tumor-Osteocyte Interactions.

Abstract：

:This study utilized a Förster resonance energy transfer (FRET)-based molecular tension sensor and live cell imaging to evaluate the effect of osteocytes, a mechanosensitive bone cell, on the migratory behavior of tumor cells. Two cell lines derived from MDA-MB-231 breast cancer cells were transfected with the vinculin tension sensor to quantitatively evaluate the force in focal adhesions of the tumor cell. Tumor cells treated with MLO-A5 osteocyte-conditioned media (CM) decreased the tensile forces in their focal adhesions and decreased their migratory potential. Tumor cells treated with media derived from MLO-A5 cells exposed to fluid flow-driven shear stress (FFCM) increased the tensile forces and increased migratory potential. Focal adhesion tension in tumor cells was also affected by distance from MLO-A5 cells when the two cells were co-cultured, where tumor cells close to MLO-A5 cells exhibited lower tension and decreased cell motility. Overall, this study demonstrates that focal adhesion tension is involved in altered migratory potential of tumor cells, and tumor-osteocyte interactions decrease the tension and motility of tumor cells.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Li F,Chen A,Reeser A,Wang Y,Fan Y,Liu S,Zhao X,Prakash R,Kota D,Li BY,Yokota H,Liu J

doi

10.1038/s41598-019-42132-x

subject

Has Abstract

pub_date

2019-04-04 00:00:00

pages

5615

issue

1

issn

2045-2322

pii

10.1038/s41598-019-42132-x

journal_volume

9

pub_type

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