MiR-146a-5p suppresses activation and proliferation of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis through directly targeting Wnt1 and Wnt5a.

abstract：:The lateral motion of a magnetic skyrmion, arising because of the skyrmion Hall effect, imposes a number of restrictions on the use of this spin state in the racetrack memory. A skyrmionium is a more promising spin texture for memory applications, since it has zero total topological charge and propagates strictly alon...

journal_title：Scientific reports

authors： Kolesnikov AG,Stebliy ME,Samardak AS,Ognev AV

更新日期：2018-11-16 00:00:00

abstract：:Transgenic rice producing insecticidal proteins from Bacillus thuringiensis (Bt) could help protect the plants from damage by lepidopteran pests. However, one concern is the potential of Bt rice to harm non-target natural enemies, which play a vital role in pest control. In the present study, the potential effects of ...

journal_title：Scientific reports

authors： Tian JC,Romeis J,Liu K,Zhang FC,Zheng XS,Xu HX,Chen GH,He XC,Lu ZX

更新日期：2017-08-10 00:00:00

abstract：:Lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are associated with the development of atherosclerosis. We aimed to assess the genetic determinants of Lp-PLA2 activity and mass by genotyping multiple polymorphisms in PLA2G7, the gene encoding Lp-PLA2, among 1258 participants from the Chinese Multi-provincial ...

journal_title：Scientific reports

authors： Qi Y,Zhao D,Jia Z,Wang W,Wang M,Sun J,Liu J,Li Y,Xie W,Liu J

更新日期：2016-12-01 00:00:00

abstract：:Clostridium difficile is a gastrointestinal pathogen but how the bacterium colonises this niche is still little understood. Sortase enzymes covalently attach specific bacterial proteins to the peptidoglycan cell wall and are often involved in colonisation by pathogens. Here we show C. difficile proteins CD2537 and CD3...

journal_title：Scientific reports

authors： Peltier J,Shaw HA,Wren BW,Fairweather NF

更新日期：2017-08-23 00:00:00

abstract：:Understanding the response of the plant community to increasing nitrogen (N) deposition is helpful for improving pasture management in semi-arid areas. We implemented a 5-year N addition experiment in a Stipa krylovii steppe of Inner Mongolia, northern China. The aboveground biomass (AGB) and species richness were mea...

journal_title：Scientific reports

authors： He K,Qi Y,Huang Y,Chen H,Sheng Z,Xu X,Duan L

更新日期：2016-08-30 00:00:00

abstract：:The coal fires, a global catastrophe for hundreds of years, have been proved extremely difficult to control, and hit almost every coal-bearing area globally. Meanwhile, underground coal fires contain tremendous reservoir of geothermal energy. Approximately one billion tons of coal burns underground annually in the wor...

journal_title：Scientific reports

authors： Shi B,Su H,Li J,Qi H,Zhou F,Torero JL,Chen Z

更新日期：2017-07-13 00:00:00

abstract：:We show that through the wave energy conserved and reversible process of coherent interactions of scalar waves in a multi-channel system joint by a common junction, it is possible to generate outgoing waves only in certain channels by controlling the incoming waves. We refer to such processes as coherent perfect chann...

journal_title：Scientific reports

authors： Zhang X,Meng C,Yang Z

更新日期：2017-10-24 00:00:00

abstract：:The classical view of nerve growth factor (NGF) action in the nervous system is linked to its retrograde axonal transport. However, almost nothing is known on the trafficking properties of its unprocessed precursor proNGF, characterized by different and generally opposite biological functions with respect to its matur...

journal_title：Scientific reports

authors： De Nadai T,Marchetti L,Di Rienzo C,Calvello M,Signore G,Di Matteo P,Gobbo F,Turturro S,Meucci S,Viegi A,Beltram F,Luin S,Cattaneo A

更新日期：2016-02-01 00:00:00

abstract：:Foot-and-mouth disease (FMD) is a highly contagious disease of livestock affecting animal production and trade throughout Asia and Africa. Understanding FMD virus (FMDV) global movements and evolution can help to reconstruct the disease spread between endemic regions and predict the risks of incursion into FMD-free co...

journal_title：Scientific reports

authors： Bachanek-Bankowska K,Di Nardo A,Wadsworth J,Mioulet V,Pezzoni G,Grazioli S,Brocchi E,Kafle SC,Hettiarachchi R,Kumarawadu PL,Eldaghayes IM,Dayhum AS,Meenowa D,Sghaier S,Madani H,Abouchoaib N,Hoang BH,Vu PP,Dukpa K,Gu

更新日期：2018-10-02 00:00:00

abstract：:The environmental fate of the herbicide fenoxaprop-ethyl (FE) in water, sediment and water-sediment microcosm was studied and degradation products fenoxaprop (FA), ethyl-2-(4-hydroxyphenoxy)propanoate (EHPP), 2-(4-hydroxyphenoxy)propanoic acid (HPPA) and 6-chloro-2,3-dihydrobenzoxazol-2-one (CDHB) were monitored. FE, ...

journal_title：Scientific reports

authors： Jing X,Yao G,Liu D,Liu M,Wang P,Zhou Z

更新日期：2016-05-26 00:00:00

abstract：:Social immunity forms an essential part of the defence repertoire of social insects. In response to infestation by the parasitic mite Varroa destructor and its associated viruses, honey bees (Apis mellifera L.) have developed a specific behaviour (varroa-sensitive hygiene, or VSH) that helps protect the colony from th...

journal_title：Scientific reports

authors： Mondet F,Kim SH,de Miranda JR,Beslay D,Le Conte Y,Mercer AR

更新日期：2016-05-03 00:00:00

abstract：:Some studies have reported that upper limb tightness is a risk factor for shoulder/elbow pain in high school baseball pitchers; but there has been insufficient research on the relationship between lower limb tightness and shoulder and elbow pain in pitchers. This study aimed to clarify the correlation among pre-season...

journal_title：Scientific reports

authors： Hamano N,Shitara H,Tajika T,Ichinose T,Sasaki T,Kamiyama M,Miyamoto R,Kuboi T,Endo F,Yamamoto A,Takagishi K,Chikuda H

更新日期：2020-11-17 00:00:00

abstract：:Great interest has been shown in mesenchymal stem cell (MSC) therapy in a wide variety of clinical domains. However, the therapeutic efficiency depends on the proliferation and migration of MSCs. Chemokine receptors are involved in regulating the proliferation and migration to the specific organs of MSCs in different ...

journal_title：Scientific reports

authors： Liu L,Chen JX,Zhang XW,Sun Q,Yang L,Liu A,Hu S,Guo F,Liu S,Huang Y,Yang Y,Qiu HB

更新日期：2018-01-09 00:00:00

abstract：:Multi-modal three dimensional (3D) optical imaging combining both structural sensitivity and molecular specificity is highly desirable in biomedical research. In this paper, we present a method termed oblique scanning laser microscopy (OSLM) to combine optical coherence tomography (OCT), for simultaneously volumetric ...

journal_title：Scientific reports

authors： Zhang L,Capilla A,Song W,Mostoslavsky G,Yi J

更新日期：2017-08-17 00:00:00

abstract：:Pandanus odorifer (Forssk) Kuntze grows naturally along the coastal regions and withstands salt-sprays as well as strong winds. A combination of omics approaches and enzyme activity studies was employed to comprehend the mechanistic basis of high salinity tolerance in P. odorifer. The young seedlings of P. odorifer we...

journal_title：Scientific reports

authors： Rashmi D,Barvkar VT,Nadaf A,Mundhe S,Kadoo NY

更新日期：2019-01-30 00:00:00

abstract：:In patients with type 1 diabetes mellitus (T1DM), glucose dynamics are influenced by insulin reactions, diet, lifestyle, etc., and characterized by instability and nonlinearity. With the objective of a dependable decision support system for T1DM self-management, we aim to model glucose dynamics using their nonlinear c...

journal_title：Scientific reports

authors： Frandes M,Timar B,Timar R,Lungeanu D

更新日期：2017-07-24 00:00:00

abstract：:Circulating tumor cells (CTCs) are important clinical indicators for prognosis and treatment efficacy. However, CTC investigation is hampered by their low number, making the establishment of permanent CTC lines very challenging. We derived and characterized nine CTC lines using blood samples from a patient with metast...

journal_title：Scientific reports

authors： Soler A,Cayrefourcq L,Mazard T,Babayan A,Lamy PJ,Assou S,Assenat E,Pantel K,Alix-Panabières C

更新日期：2018-10-29 00:00:00

abstract：:The demand for high efficiency intermediate band (IB) solar cells is driving efforts in producing high quality IB photovoltaic materials. Here, we demonstrate ZnTe:O highly mismatched alloys synthesized by high dose ion implantation and pulsed laser melting exhibiting optically active IB states and efficient sub-gap p...

journal_title：Scientific reports

authors： Li J,Ye J,Ren F,Tang D,Yang Y,Tang K,Gu S,Zhang R,Zheng Y

更新日期：2017-03-10 00:00:00

abstract：:Phomopsis sp. XP-8, an endophytic fungus from the bark of Tu-Chung (Eucommia ulmoides Oliv) showed capability to biosynthesize pinoresinol (Pin) and pinoresinol diglucoside (PDG) from glucose (glu) and phenylalanine (Phe). To verify the mass flow in the biosynthesis pathway, [13C6]-labeled glu and [13C6]-labeled Phe w...

journal_title：Scientific reports

authors： Zhang Y,Shi J,Ni Y,Liu Y,Zhao Z,Zhao X,Gao Z

更新日期：2019-12-06 00:00:00

abstract：:Glacial refugia are centers of high biodiversity. Therefore, knowledge on their locations and reactions of associated populations and landscapes to climatic changes is crucial for conservation management. We here investigated the biogeography of a butterfly species linked to open forest habitats. Using mitochondrial a...

journal_title：Scientific reports

authors： Wendt M,Husemann M,Kramp K,Schmitt T

更新日期：2021-01-08 00:00:00

abstract：:Finding overlapping communities of complex networks remains a challenge in network science. To address this challenge, one of the widely used approaches is finding the communities of links by optimizing the objective function, partition density. In this study, we show that partition density suffers from inverse resolu...

journal_title：Scientific reports

authors： Lee J,Zhang ZY,Lee J,Brooks BR,Ahn YY

更新日期：2017-09-29 00:00:00

abstract：:Calotropis gigantea (C. gigantea) extract with an ecofriendly nanotechnology approach could provide promising antimicrobial activity against skin pathogens. This study investigates the antimicrobial capability of green synthesized binary ZnO-CuO nanocomposites from C. gigantea against non-MDR (Staphylococcus aureus an...

journal_title：Scientific reports

authors： Govindasamy GA,Mydin RBSMN,Sreekantan S,Harun NH

更新日期：2021-01-08 00:00:00

abstract：:It remains unclear how infantile febrile seizures (FS) enhance adult seizure susceptibility. Here we showed that the transient increase of interleukin-1β (IL-1β) after prolonged FS promoted adult seizure susceptibility, which was blocked by interleukin-1 receptor antagonist (IL-1Ra) within a critical time window. Post...

journal_title：Scientific reports

authors： Feng B,Tang Y,Chen B,Xu C,Wang Y,Dai Y,Wu D,Zhu J,Wang S,Zhou Y,Shi L,Hu W,Zhang X,Chen Z

更新日期：2016-02-23 00:00:00

abstract：:In this work, we use exact matrix diagonalization to explore the many-body localization (MBL) transitions in quantum Ising chains with disordered nearest-neighbour couplings, disordered next-nearest-neighbour couplings and disordered external fields. It is demonstrated that the fidelity can be used to characterize the...

journal_title：Scientific reports

authors： Hu T,Xue K,Li X,Zhang Y,Ren H

更新日期：2017-04-03 00:00:00

abstract：:This study aimed to investigate the possible association between diabetes susceptibility gene transcription factor 7-like 2 (TCF7L2) and gestational diabetes mellitus (GDM) in a Chinese Han population. A total of 556 GDM patients and 500 Non-GDM were included. Eighteen single nucleotide polymorphisms (SNPs) were evalu...

journal_title：Scientific reports

authors： Ye D,Fei Y,Ling Q,Xu W,Zhang Z,Shu J,Li C,Dong F

更新日期：2016-07-28 00:00:00

abstract：:Liver failure, whether arising directly from acute liver failure or from decompensated chronic liver disease is an increasing problem worldwide and results in many deaths. In the UK only 10% of individuals requiring a liver transplant receive one. Thus the need for alternative treatments is paramount. A BioArtificial ...

journal_title：Scientific reports

authors： Selden C,Bundy J,Erro E,Puschmann E,Miller M,Kahn D,Hodgson H,Fuller B,Gonzalez-Molina J,Le Lay A,Gibbons S,Chalmers S,Modi S,Thomas A,Kilbride P,Isaacs A,Ginsburg R,Ilsley H,Thomson D,Chinnery G,Mankahla N,Loo

更新日期：2017-11-06 00:00:00

abstract：:Steep-slope transistors allow to scale down the supply voltage and the energy per computed bit of information as compared to conventional field-effect transistors (FETs), due to their sub-60 mV/decade subthreshold swing at room temperature. Currently pursued approaches to achieve such a subthermionic subthreshold swin...

journal_title：Scientific reports

authors： Vitale WA,Casu EA,Biswas A,Rosca T,Alper C,Krammer A,Luong GV,Zhao QT,Mantl S,Schüler A,Ionescu AM

更新日期：2017-03-23 00:00:00

abstract：:Overlapping idiopathic membranous nephropathy (IMN) and immunoglobulin A nephropathy (IgAN) is rare. This study aims to investigate the unique prognostic, clinical, and renal histopathological characteristics of IMN+IgAN. This retrospective observational study included 73 consecutive cases of IMN+IgAN and 425 cases of...

journal_title：Scientific reports

authors： Chen X,Chen Y,Shi K,Lv Y,Tong H,Zhao G,Chen C,Chen B,Li D,Lu Z

更新日期：2017-09-13 00:00:00

abstract：:Most traits of agricultural importance are quantitative traits controlled by numerous genes. However, it remains unclear about the molecular mechanisms underpinning quantitative traits. Here, we report the molecular characteristics of the genes controlling three quantitative traits randomly selected from three diverse...

journal_title：Scientific reports

authors： Zhang M,Liu YH,Xu W,Smith CW,Murray SC,Zhang HB

更新日期：2020-06-22 00:00:00

abstract：:Mucosal melanomas are primary malignant neoplasias originated from melanocytes within mucous membranes in any part of mucosal surface lining, more commonly, in the nasal cavity and accessory sinuses, oral cavity, lips, pharynx, vulvar, vaginal, cervix and anorectal mucosa. Epidemiology data regarding mucosal melanomas...

journal_title：Scientific reports

authors： Cohen Goldemberg D,de Melo AC,de Melo Pino LC,Thuler LCS

更新日期：2020-01-16 00:00:00