MiR-146a-5p suppresses activation and proliferation of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis through directly targeting Wnt1 and Wnt5a.

abstract：:In this study we report the enhancement of UV photodetection and wavelength tunable light induced NO gas sensing at room temperature using Au-ZnO nanocomposites synthesized by a simple photochemical process. Plasmonic Au-ZnO nanostructures with a size less than the incident wavelength have been found to exhibit a loca...

journal_title：Scientific reports

authors： Gogurla N,Sinha AK,Santra S,Manna S,Ray SK

更新日期：2014-09-26 00:00:00

abstract：:The non-enzymatic browning, namely Maillard reaction is commonly invoked to account for abiotic chemical transformations of organic matter. Here we report a new reaction pathway via the Maillard reaction to systematically synthesize a series of nitrogen-doped carbon dots (C-dots) with superhigh quantum yield (QY) and ...

journal_title：Scientific reports

authors： Wei W,Xu C,Wu L,Wang J,Ren J,Qu X

更新日期：2014-01-06 00:00:00

abstract：:Invariant Natural killer T (iNKT) cells rapidly produce copious amounts of multiple cytokines after in vivo activation, allowing for the direct detection of a number of cytokines directly ex vivo. However, for some cytokines this approach is suboptimal. Here, we report technical variations that allow the improved dete...

journal_title：Scientific reports

authors： Sag D,Özkan M,Kronenberg M,Wingender G

更新日期：2017-11-30 00:00:00

abstract：:The microbiota colonized on human body is renowned as "a forgotten organ" due to its big impacts on human health and disease. Recently, microbiome studies have identified a large number of microbes differentially regulated in a variety of conditions, such as disease and diet. However, methods for discovering biologica...

journal_title：Scientific reports

authors： Ma W,Huang C,Zhou Y,Li J,Cui Q

更新日期：2017-01-10 00:00:00

abstract：:We study the tight-binding model for a graphene tube with perimeter N threaded by a magnetic field. We show exactly that this model has different nontrivial topological phases as the flux changes. The winding number, as an indicator of topological quantum phase transition (QPT) fixes at N/3 if N/3 equals to its intege...

journal_title：Scientific reports

authors： Lin S,Zhang G,Li C,Song Z

更新日期：2016-08-24 00:00:00

abstract：:Cell fusion can occur between mesenchymal stem cells (MSCs) transplanted to improve cardiac function and cells of the recipient. The therapeutic benefit or detriment of resultant cell hybrids is unknown. Here we augment fusion of transplanted MSCs with recipient cardiac cell types via viral fusogens to determine how c...

journal_title：Scientific reports

authors： Freeman BT,Ogle BM

更新日期：2016-02-05 00:00:00

abstract：:Immunopathology corresponds to self-damage of the inflammatory response, resulting from oxidizing molecules produced when the immune system is activated. Immunopathology often contributes to age-related diseases and is believed to accelerate ageing. Prevention of immunopathology relies on endogenous antioxidant enzyme...

journal_title：Scientific reports

authors： Dhinaut J,Balourdet A,Teixeira M,Chogne M,Moret Y

更新日期：2017-09-29 00:00:00

abstract：:Organic thin-film transistors for high frequency applications require large transconductances in combination with minimal parasitic capacitances. Techniques aiming at eliminating parasitic capacitances are prone to produce a mismatch between electrodes, in particular gaps between the gate and the interlayer electrodes...

journal_title：Scientific reports

authors： Zojer K,Rothländer T,Kraxner J,Schmied R,Palfinger U,Plank H,Grogger W,Haase A,Gold H,Stadlober B

更新日期：2016-09-27 00:00:00

abstract：:Here we investigated the feasibility of using microwave spectroscopy for characterization of normal and breast cancer cell lines cultured in vitro. Healthy non-tumorigenic, MCF-10A and breast cancer, MDA-MB-231, Hs578T, T47D and MCF-7 cell lines were electrically characterized using the open-ended coaxial probe techni...

journal_title：Scientific reports

authors： Hussein M,Awwad F,Jithin D,El Hasasna H,Athamneh K,Iratni R

更新日期：2019-03-18 00:00:00

abstract：:Concussions carry devastating potential for cognitive, neurologic, and socio-emotional disease, but no objective test reliably identifies a concussion and its severity. A variety of neurological insults compromise sound processing, particularly in complex listening environments that place high demands on brain process...

journal_title：Scientific reports

authors： Kraus N,Thompson EC,Krizman J,Cook K,White-Schwoch T,LaBella CR

更新日期：2016-12-22 00:00:00

abstract：:Studies have demonstrated that inflammatory bowel disease (IBD) patients are at an increased risk of developing anxiety and/or depression. IBD patients with depression/anxiety have higher rates of hospitalization and increased disease severity than those without. So far, there is a paucity of data concerning the impac...

journal_title：Scientific reports

authors： Gao X,Tang Y,Lei N,Luo Y,Chen P,Liang C,Duan S,Zhang Y

更新日期：2021-01-14 00:00:00

abstract：:Barley (Hordeum vulgare L.) produces five leucine-derived hydroxynitrile glucosides, potentially involved in alleviating pathogen and environmental stresses. These compounds include the cyanogenic glucoside epiheterodendrin. The biosynthetic genes are clustered. Total hydroxynitrile glucoside contents were previously ...

journal_title：Scientific reports

authors： Ehlert M,Jagd LM,Braumann I,Dockter C,Crocoll C,Motawia MS,Møller BL,Lyngkjær MF

更新日期：2019-04-05 00:00:00

abstract：:Although semantic processing has traditionally been associated with brain responses maximal at 350-400 ms, recent studies reported that words of different semantic types elicit topographically distinct brain responses substantially earlier, at 100-200 ms. These earlier responses have, however, been achieved using insu...

journal_title：Scientific reports

authors： Moseley RL,Pulvermüller F,Shtyrov Y

更新日期：2013-01-01 00:00:00

abstract：:The objective was to establish and evaluate a method for manufacture of custom trays for edentulous jaws using computer aided design and fused deposition modeling (FDM) technologies. A digital method for design the custom trays for edentulous jaws was established. The tissue surface data of ten standard mandibular ede...

journal_title：Scientific reports

authors： Chen H,Yang X,Chen L,Wang Y,Sun Y

更新日期：2016-01-14 00:00:00

abstract：:Conventional transistor electronics are reaching their limits in terms of scalability, power dissipation, and the underlying Boolean system architecture. To overcome this obstacle neuromorphic analogue systems are recently highly investigated. Particularly, the use of memristive devices in VLSI analogue concepts provi...

journal_title：Scientific reports

authors： Hansen M,Zahari F,Kohlstedt H,Ziegler M

更新日期：2018-06-11 00:00:00

abstract：:During pregnancy a variety of immunological changes occur to accommodate the fetus. It is unknown whether these changes continue to affect humoral immunity postpartum or how quickly they resolve. IgG levels were measured to P. falciparum and P. vivax antigens in 201 postpartum and 201 controls over 12 weeks. Linear mi...

journal_title：Scientific reports

authors： McLean AR,Boel ME,McGready R,Ataide R,Drew D,Tsuboi T,Beeson JG,Nosten F,Simpson JA,Fowkes FJ

更新日期：2016-08-25 00:00:00

abstract：:Activities involving observation of wild organisms (e.g. wildlife watching, tidepooling) can provide recreational and learning opportunities, with biologically diverse animal assemblages expected to be more stimulating to humans. In turn, more diverse communities may enhance human interest and facilitate provisioning ...

journal_title：Scientific reports

authors： Fairchild TP,Fowler MS,Pahl S,Griffin JN

更新日期：2018-10-15 00:00:00

abstract：:While the feasibility of transpapillary drug delivery has previously been established, localized transport via the mammary ducts may be improved with tailored drug delivery formulations. The objective of this study was to investigate the impact of nanoemulsion encapsulation on transpapillary delivery in vitro. Nanoemu...

journal_title：Scientific reports

authors： Kurtz SL,Lawson LB

更新日期：2019-08-14 00:00:00

abstract：:The commensal microbiome is known to influence a variety of host phenotypes. Microbiome profiling followed by differential abundance analysis has been established as an effective approach to study the mechanisms of host-microbiome interactions. However, it is challenging to interpret the collective functions of the re...

journal_title：Scientific reports

authors： Kou Y,Xu X,Zhu Z,Dai L,Tan Y

更新日期：2020-12-08 00:00:00

abstract：:In ART programs in sub-Saharan Africa, a growing proportion of HIV-infected persons initiating first-line antiretroviral therapy (ART) have a history of prior antiretroviral drug use (PAU). We assessed the effect of PAU on the risk of pre-treatment drug resistance (PDR) and virological failure (VF) in a multicountry c...

journal_title：Scientific reports

authors： Inzaule SC,Kityo CM,Siwale M,Akanmu AS,Wellington M,de Jager M,Ive P,Mandaliya K,Stevens W,Boender TS,Ondoa P,Sigaloff KCE,Naniche D,Rinke de Wit TF,Hamers RL

更新日期：2018-10-25 00:00:00

abstract：:Successful tick feeding is facilitated by an assortment of pharmacologically-active factors in tick saliva that create an immunologically privileged micro-environment in the host's skin. Through a process known as saliva-assisted transmission, bioactive tick salivary factors modulate the host environment, promoting tr...

journal_title：Scientific reports

authors： Hermance ME,Widen SG,Wood TG,Thangamani S

更新日期：2019-09-11 00:00:00

abstract：:Septic shock is associated with multiple injuries to organs and tissues. These events may induce the regenerative response of adult stem cells. However, little is known about how endogenous stem cells are modulated by sepsis. This study analyzed the circulation of hematopoietic stem cells (HSCs), endothelial progenito...

journal_title：Scientific reports

authors： Skirecki T,Mikaszewska-Sokolewicz M,Godlewska M,Dołęgowska B,Czubak J,Hoser G,Kawiak J,Zielińska-Borkowska U

更新日期：2019-03-01 00:00:00

abstract：:Brain metastasis is a significant unmet clinical problem in breast cancer treatment. It is always associated with poor prognosis and high morbidity. Recently, Slit2/Robo1 pathway has been demonstrated to be involved in the progression of breast carcinoma. However, until present, there are no convincing reports that su...

journal_title：Scientific reports

authors： Qin F,Zhang H,Ma L,Liu X,Dai K,Li W,Gu F,Fu L,Ma Y

更新日期：2015-09-24 00:00:00

abstract：:A GalNAc/Gal-specific lectin (CGL) from the edible mussel Crenomytilus grayanus has been demonstrated to exhibit antibacterial properties. However, the mechanism of immune modulation by CGL in mammalian cells remains unclear. Here, we demonstrated that CGL can activate immune responses in macrophages and in mice. In t...

journal_title：Scientific reports

authors： Chernikov OV,Wong WT,Li LH,Chikalovets IV,Molchanova VI,Wu SH,Liao JH,Hua KF

更新日期：2017-07-24 00:00:00

abstract：:Nowadays efficient down conversion for white light emission is mainly based on rare-earth doped phosphors or cadmium-containing quantum dots. Although they exhibit high luminescence efficiency, the rare-earth mining and cadmium pollution have so far led to extremely high environmental cost, which conflicts the origina...

journal_title：Scientific reports

authors： Shen PC,Lin MS,Lin CF

更新日期：2014-06-16 00:00:00

abstract：:Lactic acidosis is common in critical care; by contrast, a subtype called alcohol-associated lactic acidosis (AALA) is rarely encountered. The primary purpose of this study was to determine the prognosis of AALA in critically ill patients and the second aim was to determine whether the survival was associated to the p...

journal_title：Scientific reports

authors： Yang CC,Chan KS,Tseng KL,Weng SF

更新日期：2016-10-17 00:00:00

abstract：:The Mongol invasion of Eastern Europe, and especially its sudden withdrawal from Hungary in 1242 CE, has generated much speculation and an array of controversial theories. None of them, however, considered multifaceted environmental drivers and the coupled analysis of historical reports and natural archives. Here we i...

journal_title：Scientific reports

authors： Büntgen U,Di Cosmo N

更新日期：2016-05-26 00:00:00

abstract：:Up to 40% of congenital diseases present disturbances of brain and craniofacial development resulting in simultaneous alterations of both systems. Currently, the best available method to preclinically visualize the brain and the bones simultaneously is to co-register micro-magnetic resonance (µMR) and micro-computed t...

journal_title：Scientific reports

authors： Llambrich S,Wouters J,Himmelreich U,Dierssen M,Sharpe J,Gsell W,Martínez-Abadías N,Vande Velde G

更新日期：2020-10-30 00:00:00

abstract：:There are few materials that are broadly used for fabricating optical metasurfaces for visible light applications. Gallium phosphide (GaP) is a material that, due to its optical properties, has the potential to become a primary choice but due to the difficulties in fabrication, GaP thin films deposited on transparent ...

journal_title：Scientific reports

authors： Melli M,West M,Hickman S,Dhuey S,Lin D,Khorasaninejad M,Chang C,Jolly S,Tae H,Poliakov E,St Hilaire P,Cabrini S,Peroz C,Klug M

更新日期：2020-11-26 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory condition with variable clinical presentation and disease progression. Importantly, animal models of RA are widely used to examine disease pathophysiology/treatments. Here, we exploited known vendor colony-based differences in endocrine/immune responses to gain insig...

journal_title：Scientific reports

authors： Bodnar TS,Taves MD,Lavigne KM,Woodward TS,Soma KK,Weinberg J

更新日期：2017-04-06 00:00:00