当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Anaphylaxis induced by Thalassophryne nattereri venom in mice is an IgE/IgG1-mediated, IL-4-dependent phenomenon.

Anaphylaxis induced by Thalassophryne nattereri venom in mice is an IgE/IgG1-mediated, IL-4-dependent phenomenon.

Abstract：

:We hypothesized that beyond the Thalassophryne nattereri venoms ability to induce in mice a strong specific-Th2 response with high levels of specific IgE/IgG1, it would be able to trigger anaphylaxis in sensitized individuals. To investigate whether the venom is capable of inducing an allergic reaction in mice and characterize soluble and cellular mediators involved in this process, BALB/c female mice were sensitized intraperitoneally with decreasing-dose of venom at weekly intervals for 4 weeks and challenged by intraperitoneal, oral or epicutaneous routes with venom 2 weeks later. Our data show that sensitized-mice challenged by all routes showed intense symptoms of anaphylaxis, dependent on the anaphylactic IgG1 and IgE antibodies and mast cells. The late-phase reaction developed after initial symptoms was characterized by the influx of eosinophils, dependent on IL-5, IL-17A and eotaxin produced by Th2 cells in inflamed lungs and skin draining lymph-nodes. Using C57BL/6 deficient mice we demonstrated that IL-4 KO mice failed to develop anaphylactic symptoms or local Th2 inflammation, producing low levels of IgG1 and increased levels of IgG2a. Together our results demonstrated that the venom of T. nattereri has allergenic proteins that can trigger an allergic process, a phenomenon IgE-IgG1 dependent, IL-4-mediated and negatively regulated by IFN-γ.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Bruni FM,Coutinho EMM,Andrade-Barros AI,Grund LZ,Lopes-Ferreira M,Lima C

doi

10.1038/s41598-019-57231-y

subject

Has Abstract

pub_date

2020-01-17 00:00:00

pages

584

issue

1

issn

2045-2322

pii

10.1038/s41598-019-57231-y

journal_volume

10

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Morphological, physiological and anatomical traits of plant functional types in temperate grasslands along a large-scale aridity gradient in northeastern China.

    abstract：:At the species level, plants can respond to climate changes by changing their leaf traits; however, there is scant information regarding the responses of morphological, physiological and anatomical traits of plant functional types (PFTs) to aridity. Herein, the leaf traits of five PFTs representing 17 plant species in...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40900

    authors： Guo C,Ma L,Yuan S,Wang R

    更新日期：2017-01-20 00:00:00

  • The genetic and environmental aetiology of spatial, mathematics and general anxiety.

    abstract：:Individuals differ in their level of general anxiety as well as in their level of anxiety towards specific activities, such as mathematics and spatial tasks. Both specific anxieties correlate moderately with general anxiety, but the aetiology of their association remains unexplored. Moreover, the factor structure of s...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42218

    authors： Malanchini M,Rimfeld K,Shakeshaft NG,Rodic M,Schofield K,Selzam S,Dale PS,Petrill SA,Kovas Y

    更新日期：2017-02-21 00:00:00

  • Genome-wide mapping of DNase I hypersensitive sites reveals chromatin accessibility changes in Arabidopsis euchromatin and heterochromatin regions under extended darkness.

    abstract：:Light, as the energy source in photosynthesis, is essential for plant growth and development. Extended darkness causes dramatic gene expression changes. In this study, we applied DNase-seq (DNase I hypersensitive site sequencing) to study changes of chromatin accessibility in euchromatic and heterochromatic regions un...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04524-9

    authors： Liu Y,Zhang W,Zhang K,You Q,Yan H,Jiao Y,Jiang J,Xu W,Su Z

    更新日期：2017-06-22 00:00:00

  • In situ Scanning Electron Microscopy of Silicon Anode Reactions in Lithium-Ion Batteries during Charge/Discharge Processes.

    abstract：:A comprehensive understanding of the charge/discharge behaviour of high-capacity anode active materials, e.g., Si and Li, is essential for the design and development of next-generation high-performance Li-based batteries. Here, we demonstrate the in situ scanning electron microscopy (in situ SEM) of Si anodes in a con...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep36153

    authors： Chen CY,Sano T,Tsuda T,Ui K,Oshima Y,Yamagata M,Ishikawa M,Haruta M,Doi T,Inaba M,Kuwabata S

    更新日期：2016-10-26 00:00:00

  • High-precision 14C and 40Ar/39Ar dating of the Campanian Ignimbrite (Y-5) reconciles the time-scales of climatic-cultural processes at 40 ka.

    abstract：:The Late Pleistocene Campanian Ignimbrite (CI) super-eruption (Southern Italy) is the largest known volcanic event in the Mediterranean area. The CI tephra is widely dispersed through western Eurasia and occurs in close stratigraphic association with significant palaeoclimatic and Palaeolithic cultural events. Here we...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep45940

    authors： Giaccio B,Hajdas I,Isaia R,Deino A,Nomade S

    更新日期：2017-04-06 00:00:00

  • Junction formation and current transport mechanisms in hybrid n-Si/PEDOT:PSS solar cells.

    abstract：UNLABELLED:We investigated hybrid inorganic-organic solar cells combining monocrystalline n-type silicon (n-Si) and a highly conductive polymer poly(3,4-ethylenedioxythiophene)-poly(styrene sulfonate) ( PEDOT:PSS). The build-in potential, photo- and dark saturation current at this hybrid interface are monitored for va...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep13008

    authors： Jäckle S,Mattiza M,Liebhaber M,Brönstrup G,Rommel M,Lips K,Christiansen S

    更新日期：2015-08-17 00:00:00

  • In silico investigation of a KCNQ1 mutation associated with short QT syndrome.

    abstract：:Short QT syndrome (SQTS) is a rare condition characterized by abnormally 'short' QT intervals on the ECG and increased susceptibility to cardiac arrhythmias and sudden death. This simulation study investigated arrhythmia dynamics in multi-scale human ventricle models associated with the SQT2-related V307L KCNQ1 'gain-...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-08367-2

    authors： Adeniran I,Whittaker DG,El Harchi A,Hancox JC,Zhang H

    更新日期：2017-08-16 00:00:00

  • Real world data analysis of next generation sequencing and protein expression in metastatic breast cancer patients.

    abstract：:Next generation sequencing (NGS) together with protein expression analysis is back bone of molecularly targeted therapy in precision medicine. Our retrospective study shows our experience with NGS of 324 genes in combination with protein expression in patients with advanced breast cancer (aBC). The primary purpose was...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67393-9

    authors： Hempel D,Ebner F,Garg A,Trepotec Z,Both A,Stein W,Gaumann A,Güttler L,Janni W,DeGregorio A,Hempel L,Milani V

    更新日期：2020-06-26 00:00:00

  • Selective tracking of FFAR3-expressing neurons supports receptor coupling to N-type calcium channels in mouse sympathetic neurons.

    abstract：:Activation of short-chain free fatty acid receptors 3 (FFAR3) has been suggested to promote sympathetic outflow in postganglionic sympathetic neurons or hamper it by a negative coupling to N-type calcium (CaV2.2) channels. Heterogeneity of FFAR3 expression in sympathetic neurons, however, renders single neurons studie...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35690-z

    authors： Colina C,Puhl HL 3rd,Ikeda SR

    更新日期：2018-11-26 00:00:00

  • Genome-wide characterisation and expression profile of the grapevine ATL ubiquitin ligase family reveal biotic and abiotic stress-responsive and development-related members.

    abstract：:The Arabidopsis Tóxicos en Levadura (ATL) protein family is a class of E3 ubiquitin ligases with a characteristic RING-H2 Zn-finger structure that mediates diverse physiological processes and stress responses in plants. We carried out a genome-wide survey of grapevine (Vitis vinifera L.) ATL genes and retrieved 96 seq...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep38260

    authors： Ariani P,Regaiolo A,Lovato A,Giorgetti A,Porceddu A,Camiolo S,Wong D,Castellarin S,Vandelle E,Polverari A

    更新日期：2016-12-02 00:00:00

  • Scanning tunnelling microscope light emission: Finite temperature current noise and over cut-off emission.

    abstract：:The spectral distribution of light emitted from a scanning tunnelling microscope junction not only bears its intrinsic plasmonic signature but is also imprinted with the characteristics of optical frequency fluc- tuations of the tunnel current. Experimental spectra from gold-gold tunnel junctions are presented that sh...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03766-x

    authors： Kalathingal V,Dawson P,Mitra J

    更新日期：2017-06-14 00:00:00

  • Mutation of regulatory phosphorylation sites in PFKFB2 worsens renal fibrosis.

    abstract：:Fatty acid oxidation is the major energy pathway used by the kidney, although glycolysis becomes more important in the low oxygen environment of the medulla. Fatty acid oxidation appears to be reduced in renal fibrosis, and drugs that reverse this improve fibrosis. Expression of glycolytic genes is more variable, but ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71475-z

    authors： Lee M,Harley G,Katerelos M,Gleich K,Sullivan MA,Laskowski A,Coughlan M,Fraser SA,Mount PF,Power DA

    更新日期：2020-09-03 00:00:00

  • Addressing the impact of urban exposure on the incidence of type 2 diabetes mellitus: The PERU MIGRANT Study.

    abstract：:The aim of this study was to estimate the incidence of T2DM in three population groups: rural, rural-to-urban migrants and urban dwellers. Data from the PERU MIGRANT Study was analysed. The baseline assessment was conducted in 2007-2008 using a single-stage random sample and further follow-up was undertaken in 2015-16...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-23812-6

    authors： Ruiz-Alejos A,Carrillo-Larco RM,Miranda JJ,Anderson CAM,Gilman RH,Smeeth L,Bernabé-Ortiz A

    更新日期：2018-04-03 00:00:00

  • Identification of HLA-A*02:06:01 as the primary disease susceptibility HLA allele in cold medicine-related Stevens-Johnson syndrome with severe ocular complications by high-resolution NGS-based HLA typing.

    abstract：:Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening acute inflammatory vesiculobullous reactions of the skin and mucous membranes. These severe cutaneous drug reactions are known to be caused by inciting drugs and infectious agents. Previously, we have reported the association of H...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-52619-2

    authors： Nakatani K,Ueta M,Khor SS,Hitomi Y,Okudaira Y,Masuya A,Wada Y,Sotozono C,Kinoshita S,Inoko H,Tokunaga K

    更新日期：2019-11-07 00:00:00

  • A ParDE-family toxin antitoxin system in major resistance plasmids of Enterobacteriaceae confers antibiotic and heat tolerance.

    abstract：:Toxin-antitoxin (TA) systems were initially discovered as plasmid addiction systems on low-copy-number plasmids. Thousands of TA loci have since been identified on chromosomes, plasmids and mobile elements in bacteria and archaea with diverse roles in bacterial physiology and in maintenance of genetic elements. Here, ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-46318-1

    authors： Kamruzzaman M,Iredell J

    更新日期：2019-07-08 00:00:00

  • Egg oil from Portunus trituberculatus alleviated obesity and regulated gut microbiota in mice.

    abstract：:Egg oil from Portunus trituberculatus (Pt-egg oil) can overcome insulin resistance resulting from abundant bioactive lipids. However, its effects on obesity and gut microbiota were unclear. Here, we evaluated whether Pt-egg oil could improve obesity and gut microbiota or not in high-fat diet feeding mice. Results exhi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-65199-3

    authors： Hu S,Yang H,Gao X,Li S,Jiang W,Liu Y

    更新日期：2020-05-21 00:00:00

  • Modulation Doping of Silicon using Aluminium-induced Acceptor States in Silicon Dioxide.

    abstract：:All electronic, optoelectronic or photovoltaic applications of silicon depend on controlling majority charge carriers via doping with impurity atoms. Nanoscale silicon is omnipresent in fundamental research (quantum dots, nanowires) but also approached in future technology nodes of the microelectronics industry. In ge...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep46703

    authors： König D,Hiller D,Gutsch S,Zacharias M,Smith S

    更新日期：2017-04-20 00:00:00

  • Disorder and defects are not intrinsic to boron carbide.

    abstract：:A unique combination of useful properties in boron-carbide, such as extreme hardness, excellent fracture toughness, a low density, a high melting point, thermoelectricity, semi-conducting behavior, catalytic activity and a remarkably good chemical stability, makes it an ideal material for a wide range of technological...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep19330

    authors： Mondal S,Bykova E,Dey S,Ali SI,Dubrovinskaia N,Dubrovinsky L,Parakhonskiy G,van Smaalen S

    更新日期：2016-01-18 00:00:00

  • Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death.

    abstract：:Therapies that target the signal transduction and metabolic pathways of cancer stem cells (CSCs) are innovative strategies to effectively reduce the recurrence and significantly improve the outcome of glioblastoma multiforme (GBM). CSCs exhibit an increased rate of glycolysis, thus rendering them intrinsically more se...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep15556

    authors： Daniele S,Giacomelli C,Zappelli E,Granchi C,Trincavelli ML,Minutolo F,Martini C

    更新日期：2015-10-23 00:00:00

  • A new primitive Neornithischian dinosaur from the Jurassic of Patagonia with gut contents.

    abstract：:We describe a new species of an ornithischian dinosaur, Isaberrysaura mollensis gen. et sp. nov. The specimen, consisting in an almost complete skull and incomplete postcranium was collected from the marine-deltaic deposits of the Los Molles Formation (Toarcian-Bajocian), being the first reported dinosaur for this uni...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42778

    authors： Salgado L,Canudo JI,Garrido AC,Moreno-Azanza M,Martínez LC,Coria RA,Gasca JM

    更新日期：2017-02-16 00:00:00

  • liputils: a Python module to manage individual fatty acid moieties from complex lipids.

    abstract：:Lipidomic analyses address the problem of characterizing the lipid components of given cells, tissues and organisms by means of chromatographic separations coupled to high-resolution, tandem mass spectrometry analyses. A number of software tools have been developed to help in the daunting task of mass spectrometry sig...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-70259-9

    authors： Manzini S,Busnelli M,Colombo A,Kiamehr M,Chiesa G

    更新日期：2020-08-07 00:00:00

  • A validated computational framework to predict outcomes in TAVI.

    abstract：:Transcatheter aortic valve implantation (TAVI) still presents complications: paravalvular leakage (PVL) and onset of conduction abnormalities leading to permanent pacemaker implantation. Our aim was testing a validated patient-specific computational framework for prediction of TAVI outcomes and possible complications....

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-66899-6

    authors： Bosi GM,Capelli C,Cheang MH,Delahunty N,Mullen M,Taylor AM,Schievano S

    更新日期：2020-06-18 00:00:00

  • Gradient Relationship between Increased Mean Corpuscular Volume and Mortality Associated with Cerebral Ischemic Stroke and Ischemic Heart Disease: A Longitudinal Study on 66,294 Taiwanese.

    abstract：:The gradient relationship between mean corpuscular volume (MCV) and mortality due to ischemic vascular disease has not been researched using a large-scale population-based study. This study evaluated the association between MCV and death attributable to cerebrovascular disease (CVD) and cardiovascular disease (CAD) in...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-34403-w

    authors： Wu TH,Fann JC,Chen SL,Yen AM,Wen CJ,Lu YR,Chen HH,Chiu SY,Liou HH

    更新日期：2018-11-08 00:00:00

  • A combined method to quantify the retinal metabolic rate of oxygen using photoacoustic ophthalmoscopy and optical coherence tomography.

    abstract：:Quantitatively determining physiological parameters at a microscopic level in the retina furthers the understanding of the molecular pathways of blinding diseases, such as diabetic retinopathy and glaucoma. An essential parameter, which has yet to be quantified noninvasively, is the retinal oxygen metabolic rate (rMRO...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep06525

    authors： Song W,Wei Q,Liu W,Liu T,Yi J,Sheibani N,Fawzi AA,Linsenmeier RA,Jiao S,Zhang HF

    更新日期：2014-10-06 00:00:00

  • Ecophysiological consequences of alcoholism on human gut microbiota: implications for ethanol-related pathogenesis of colon cancer.

    abstract：:Chronic consumption of excess ethanol increases the risk of colorectal cancer. The pathogenesis of ethanol-related colorectal cancer (ER-CRC) is thought to be partly mediated by gut microbes. Specifically, bacteria in the colon and rectum convert ethanol to acetaldehyde (AcH), which is carcinogenic. However, the effec...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27923

    authors： Tsuruya A,Kuwahara A,Saito Y,Yamaguchi H,Tsubo T,Suga S,Inai M,Aoki Y,Takahashi S,Tsutsumi E,Suwa Y,Morita H,Kinoshita K,Totsuka Y,Suda W,Oshima K,Hattori M,Mizukami T,Yokoyama A,Shimoyama T,Nakayama T

    更新日期：2016-06-13 00:00:00

  • Convergence behaviour and Control in Non-Linear Biological Networks.

    abstract：:Control of genetic regulatory networks is challenging to define and quantify. Previous control centrality metrics, which aim to capture the ability of individual nodes to control the system, have been found to suffer from plausibility and applicability problems. Here we present a new approach to control centrality bas...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09746

    authors： Karl S,Dandekar T

    更新日期：2015-06-11 00:00:00

  • Dynamical Analysis of Standing Balance Control on Sloped Surfaces in Individuals with Lumbar Disc Herniation.

    abstract：:The changes of balance control mechanism caused by lumbar disc herniation (LDH) has not been well understood. This study aimed to investigate the effects of LDH on the balance control during standing on sloped surfaces. Ten patients with LDH and 10 gender- and age-matched healthy subjects were instructed to stand quie...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-58455-z

    authors： Li J,Zhang Y,Song S,Hou Y,Hong Y,Yue S,Li K

    更新日期：2020-02-03 00:00:00

  • Loss of A20 in BM-MSCs regulates the Th17/Treg balance in Rheumatoid Arthritis.

    abstract：:Mesenchymal stem cells (MSCs) are multi-potent cells that are self-renewable and possess the potential to differentiate into multiple lineages. Several studies demonstrated that MSCs could regulate a Th17/Treg balance and could be a potential therapeutic target for Rheumatoid Arthritis (RA). A20 is highly expressed in...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-18693-0

    authors： Feng Z,Zhai Y,Zheng Z,Yang L,Luo X,Dong X,Han Q,Jin J,Chen ZN,Zhu P

    更新日期：2018-01-11 00:00:00

  • Fermionic order by disorder in a van der Waals antiferromagnet.

    abstract：:CeTe3 is a unique platform to investigate the itinerant magnetism in a van der Waals (vdW) coupled metal. Despite chemical pressure being a promising route to boost quantum fluctuation in this system, a systematic study on the chemical pressure effect on Ce3+(4f1) states is absent. Here, we report on the successful gr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-72300-3

    authors： Okuma R,Ueta D,Kuniyoshi S,Fujisawa Y,Smith B,Hsu CH,Inagaki Y,Si W,Kawae T,Lin H,Chuang FC,Masuda T,Kobayashi R,Okada Y

    更新日期：2020-09-17 00:00:00

  • Effect of green tea consumption on blood pressure: a meta-analysis of 13 randomized controlled trials.

    abstract：:The studies investigating the effects of green tea on blood pressure (BP) have generated inconsistent results. The aim of this study is to quantitatively evaluate the effects of green tea on BP control. PubMed, Embase, and the Cochrane Library (updated to March 2014) were searched for randomized controlled trials eval...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/srep06251

    authors： Peng X,Zhou R,Wang B,Yu X,Yang X,Liu K,Mi M

    更新日期：2014-09-01 00:00:00