Quantification of the Metabolic State in Cell-Model of Parkinson's Disease by Fluorescence Lifetime Imaging Microscopy.

abstract：:Age-related hearing loss (ARHI) is the most common sensory disorder in the elderly. Although telomere attrition has been shown as a determinant in the pathobiology of various age-related diseases, it remains unknown whether telomere length is associated with ARHI. We hypothesized that decreased leukocyte telomere leng...

journal_title：Scientific reports

authors： Liu H,Luo H,Yang T,Wu H,Chen D

更新日期：2017-08-31 00:00:00

abstract：:Detecting neuroplastic changes during locomotor neurorehabilitation is crucial for independent primal motor behaviours. However, long-term locomotor training-related neuroplasticity remains unexplored. We compared the effects of end-effector robot-assisted gait training (E-RAGT) and bodyweight-supported treadmill trai...

journal_title：Scientific reports

authors： Kim H,Park G,Shin JH,You JH

更新日期：2020-07-27 00:00:00

abstract：:In external radiotherapy (RT), the use of flattening filter-free (FFF) radiation beams obtained by removing the flattening filter (FF) in standard linear accelerators is rapidly increasing, and the benefits of clinical use are the issue of research. Advanced treatment techniques have increased the interest in the oper...

journal_title：Scientific reports

authors： Arslan A,Sengul B

更新日期：2020-06-02 00:00:00

abstract：:Foods and beverage aroma results from multicomponent mixtures of volatile compounds present in the food that interact with olfactory receptors and produce a perceptual response in the brain. However, the perceptual interactions that occur when complex odor mixtures are combined are not well understood. Here we used Ga...

journal_title：Scientific reports

authors： Johnson AJ,Hjelmeland AK,Heymann H,Ebeler SE

更新日期：2019-05-21 00:00:00

abstract：:Urinary biomarkers augment the diagnosis of acute kidney injury (AKI), with AKI after cardiovascular surgeries being a prototype of prognosis scenario. Glutathione S-transferases (GST) were evaluated as biomarkers of AKI. Urine samples were collected in 141 cardiovascular surgical patients and analyzed for urinary alp...

journal_title：Scientific reports

authors： Shu KH,Wang CH,Wu CH,Huang TM,Wu PC,Lai CH,Tseng LJ,Tsai PR,Connolly R,Wu VC

更新日期：2016-08-16 00:00:00

abstract：:The P2X receptor family of ATP-gated cation channels are attractive drug targets for pain and inflammatory disease, but no subtype-selective agonists, and few partially selective agonists have been described to date. As proof-of-concept for the discovery of novel P2X receptor agonists, here we demonstrate the use of D...

journal_title：Scientific reports

authors： Grimes L,Griffiths J,Pasqualetto G,Brancale A,Kemp PJ,Young MT,van der Goes van Naters W

更新日期：2020-05-19 00:00:00

abstract：:Defects of vitamin B6 metabolism are responsible for severe neurological disorders, such as pyridoxamine 5'-phosphate oxidase deficiency (PNPOD; OMIM: 610090), an autosomal recessive inborn error of metabolism that usually manifests with neonatal-onset severe seizures and subsequent encephalopathy. At present, 27 path...

journal_title：Scientific reports

authors： Barile A,Nogués I,di Salvo ML,Bunik V,Contestabile R,Tramonti A

更新日期：2020-08-12 00:00:00

abstract：:Target-guided synthesis is an approach to drug discovery that allows the target to self-assemble its own binding agents. So far, target-guided synthesis and especially in situ click chemistry have attracted extensive attention and have led to the identification of highly potent inhibitors for proteins. In this study, ...

journal_title：Scientific reports

authors： Hu MH,Chen X,Chen SB,Ou TM,Yao M,Gu LQ,Huang ZS,Tan JH

更新日期：2015-11-25 00:00:00

abstract：:To investigate the particle size distribution of particulate matter and the concentration of specific perfluorinated compounds in indoor dust samples from several locations. Then, we used cell-based assays to investigate the effect of perfluorinated compounds on human corneal epithelial (HCEpiC), endothelial cells (HC...

journal_title：Scientific reports

authors： Tien PT,Lin HJ,Tsai YY,Lim YP,Chen CS,Chang CY,Lin CJ,Chen JJ,Wu SM,Huang YJ,Wan L

更新日期：2020-09-24 00:00:00

abstract：:Bending light in a controllable way is desired in various applications such as beam steering, navigating and cloaking. Different from the conventional way to bend light by refractive index gradient, transformation optics or special beams through wavefront design such as Airy beams and surface plasmons, we proposed a m...

journal_title：Scientific reports

authors： Han B,Xu L,Dou Y,Xu J,Zhang G

更新日期：2015-10-29 00:00:00

abstract：:Dietary gluten causes severe disorders like celiac disease in gluten-intolerant humans. However, currently understanding of its impact in tolerant individuals is limited. Our objective was to test whether gliadin, one of the detrimental parts of gluten, would impact the metabolic effects of an obesogenic diet. Mice we...

journal_title：Scientific reports

authors： Zhang L,Andersen D,Roager HM,Bahl MI,Hansen CH,Danneskiold-Samsøe NB,Kristiansen K,Radulescu ID,Sina C,Frandsen HL,Hansen AK,Brix S,Hellgren LI,Licht TR

更新日期：2017-03-16 00:00:00

abstract：:Angiogenesis, the formation of new blood vessels, is a vital process for tissue growth and development. The Notch cell-cell signalling pathway plays an important role in endothelial cell specification during angiogenesis. Dll4 - Notch1 signalling directs endothelial cells into migrating tip or proliferating stalk cell...

journal_title：Scientific reports

authors： Tiemeijer LA,Frimat JP,Stassen OMJA,Bouten CVC,Sahlgren CM

更新日期：2018-04-23 00:00:00

abstract：:Exploration of genetic variant-to-gene relationships by quantitative trait loci such as expression QTLs is a frequently used tool in genome-wide association studies. However, the wide range of public QTL databases and the lack of batch annotation features complicate a comprehensive annotation of GWAS results. In this ...

journal_title：Scientific reports

authors： Munz M,Wohlers I,Simon E,Reinberger T,Busch H,Schaefer AS,Erdmann J

更新日期：2020-11-24 00:00:00

abstract：:Cholangiocarcinoma (CCA) represents a rare form of primary liver cancer with increasing incidence but dismal prognosis. Surgical treatment has remained the only potentially curative treatment option, but it remains unclear which patients benefit most from liver surgery, highlighting the need for new preoperative strat...

journal_title：Scientific reports

authors： Loosen SH,Roderburg C,Kauertz KL,Koch A,Vucur M,Schneider AT,Binnebösel M,Ulmer TF,Lurje G,Schoening W,Tacke F,Trautwein C,Longerich T,Dejong CH,Neumann UP,Luedde T

更新日期：2017-12-05 00:00:00

abstract：:In this study, ITS, ITS2, matK, rbcL and psbA-trnH in Rehmannia were successfully amplified and sequenced, but some ITS sequences need to be proofread according to ITS2 sequences. Compared with rbcL, matK and psbA-trnH, ITS and ITS2 had higher mutation rate and more information sites, and ITS2 had higher interspecific...

journal_title：Scientific reports

authors： Duan H,Wang W,Zeng Y,Guo M,Zhou Y

更新日期：2019-11-21 00:00:00

abstract：:This study demonstrated the usefulness of radiomic features based on the Hessian index of differential topology for the prediction of prognosis prior to treatment in head-and-neck (HN) cancer patients. The Hessian index, which can indicate tumor heterogeneity with convex, concave, and other points (saddle points), was...

journal_title：Scientific reports

authors： Le QC,Arimura H,Ninomiya K,Kabata Y

更新日期：2020-12-04 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Choi S,Rogers DJ,Sandana EV,Bove P,Teherani FH,Nenstiel C,Hoffmann A,McClintock R,Razeghi M,Look D,Gentle A,Phillips MR,Ton-That C

更新日期：2017-11-16 00:00:00

abstract：:The recalcitrance of woody biomass, particularly its lignin component, hinders its sustainable transformation to fuels and biomaterials. Although the recent discovery of several bacterial ligninases promises the development of novel biocatalysts, these enzymes have largely been characterized using model substrates: di...

journal_title：Scientific reports

authors： Singh R,Hu J,Regner MR,Round JW,Ralph J,Saddler JN,Eltis LD

更新日期：2017-02-07 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Choi HS,Yoo HS,An Y,Yoon SY,Park SP,Kim YK

更新日期：2020-10-29 00:00:00

abstract：:Focal adhesion kinase (FAK) is a 125 kDa protein recruited as a participant in focal adhesion dynamics and serves as a signaling scaffold for the assembly and subsequent maturation of focal contact. Identification of new FAK binding proteins could reveal potential signaling targets and contribute to further developmen...

journal_title：Scientific reports

authors： Nguyen BT,Pyun JC,Lee SG,Kang MJ

更新日期：2019-09-09 00:00:00

abstract：:The neuronal accumulation of phosphorylated tau plays a critical role in the pathogenesis of Alzheimer's disease (AD). Here, we examined the effect of fisetin, a flavonol, on tau levels. Treatment of cortical cells or primary neurons with fisetin resulted in significant decreases in the levels of phosphorylated tau. I...

journal_title：Scientific reports

authors： Kim S,Choi KJ,Cho SJ,Yun SM,Jeon JP,Koh YH,Song J,Johnson GV,Jo C

更新日期：2016-04-26 00:00:00

abstract：:Exploiting pattern formation - such as that observed in nature - in the context of micro/nanotechnology could have great benefits if coupled with the traditional top-down lithographic approach. Here, we demonstrate an original and simple method to produce unique, localized and controllable self-organised patterns on e...

journal_title：Scientific reports

authors： Seghir R,Arscott S

更新日期：2015-10-06 00:00:00

abstract：:This work reports the first study of current-driven magnetization noise in a single, nanometerscale, ferromagnetic (Co) particle, attached to normal metal leads by high-resistance tunneling junctions. As the tunnel current increases at low temperature, the magnetic switching field decreases, its probability distributi...

journal_title：Scientific reports

authors： Jiang W,Birk FT,Davidović D

更新日期：2013-01-01 00:00:00

abstract：:Land-use intensification on arable land is expanding and posing a threat to biodiversity and ecosystem services worldwide. We develop methods to link funding for avian breeding habitat conservation and management at landscape scales to equilibrium abundance of a migratory species at the continental scale. We apply thi...

journal_title：Scientific reports

authors： Mattsson BJ,Devries JH,Dubovsky JA,Semmens D,Thogmartin WE,Derbridge JJ,Lopez-Hoffman L

更新日期：2020-03-18 00:00:00

abstract：:Periventricular nodular heterotopia (PNH) is a neural migration disorder which often presents clinically with seizures. However, the underlying functional neural basis of PNH is still unclear. We aimed to explore the underlying pathological mechanism of PNH by combining both whole brain functional connectivity (FC) an...

journal_title：Scientific reports

authors： Liu W,Hu X,An D,Zhou D,Gong Q

更新日期：2019-12-05 00:00:00

abstract：:We performed a metabolomics study using liquid chromatography-mass spectrometry (LC-MS) combined with multivariate data analysis (MVDA) to discriminate global urine profiles in urine samples from esophageal squamous cell carcinoma (ESCC) patients and healthy controls (NC). Our work evaluated the feasibility of employi...

journal_title：Scientific reports

authors： Xu J,Chen Y,Zhang R,He J,Song Y,Wang J,Wang H,Wang L,Zhan Q,Abliz Z

更新日期：2016-10-11 00:00:00

abstract：:Live birth is the most important concern for assisted reproductive technology (ART) patients. Therefore, in the medical reproductive centre, obstetricians often need to answer the following question: "What are the chances that I will have a healthy baby after ART treatment?" To date, our obstetricians have no referenc...

journal_title：Scientific reports

authors： Gao H,Liu DE,Li Y,Wu X,Tan H

更新日期：2021-01-11 00:00:00

abstract：:Plants would experience more complex environments, such as sudden heat shock (SHS) stress combined with elevated CO2 in the future, and might adapt to this stressful condition by optimizing photosynthetic carbon metabolism (PCM). It is interesting to understand whether this acclimation process would be altered in diff...

journal_title：Scientific reports

authors： Qu M,Chen G,Bunce JA,Zhu X,Sicher RC

更新日期：2018-05-18 00:00:00

abstract：:Air pollution has aroused significant public concern in China, therefore, long-term air-quality data with high temporal and spatial resolution are needed to understand the variations of air pollution in China. However, the yearly variations with high spatial resolution of air quality and six air pollutants are still u...

journal_title：Scientific reports

authors： Guo H,Gu X,Ma G,Shi S,Wang W,Zuo X,Zhang X

更新日期：2019-10-23 00:00:00

abstract：:At the post-synaptic density (PSD), large protein complexes dynamically form and dissociate in response to synaptic activity, comprising the biophysical basis for learning and memory. The use of detergents to isolate the PSD and release its membrane-associated proteins complicates studies of these activity-dependent p...

journal_title：Scientific reports

authors： Lautz JD,Gniffke EP,Brown EA,Immendorf KB,Mendel RD,Smith SEP

更新日期：2019-07-26 00:00:00