Abstract:
:This study demonstrated the usefulness of radiomic features based on the Hessian index of differential topology for the prediction of prognosis prior to treatment in head-and-neck (HN) cancer patients. The Hessian index, which can indicate tumor heterogeneity with convex, concave, and other points (saddle points), was calculated as the number of negative eigenvalues of the Hessian matrix at each voxel on computed tomography (CT) images. Three types of signatures were constructed in a training cohort (n = 126), one type each from CT conventional features, Hessian index features, and combined features from the conventional and index feature sets. The prognostic value of the signatures were evaluated using statistically significant difference (p value, log-rank test) to compare the survival curves of low- and high-risk groups. In a test cohort (n = 68), the p values of the models built with conventional, index, combined features, and clinical variables were 2.95 [Formula: see text] 10-2, 1.85 [Formula: see text] 10-2, 3.17 [Formula: see text] 10-2, and 1.87 [Formula: see text] 10-3, respectively. When the features were integrated with clinical variables, the p values of conventional, index, and combined features were 3.53 [Formula: see text] 10-3, 1.28 [Formula: see text] 10-3, and 1.45 [Formula: see text] 10-3, respectively. This result indicates that index features could provide more prognostic information than conventional features and further increase the prognostic value of clinical variables in HN cancer patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Le QC,Arimura H,Ninomiya K,Kabata Ydoi
10.1038/s41598-020-78338-7subject
Has Abstractpub_date
2020-12-04 00:00:00pages
21301issue
1issn
2045-2322pii
10.1038/s41598-020-78338-7journal_volume
10pub_type
杂志文章abstract::Balance is a very important function that allows maintaining a stable stance needed for many daily life activities and for preventing falls. We investigated whether balance control could be improved by a placebo procedure consisting of verbal suggestion. Thirty healthy volunteers were randomized in two groups (placebo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42888-2
更新日期:2019-04-23 00:00:00
abstract::Clinical success of effective gene therapy is mainly hampered by the insufficiency of safe and efficient internalization of a transgene to the targeted cellular site. Therefore, the development of a safe and efficient nanocarrier system is one of the fundamental challenges to transfer the therapeutic genes to the dise...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78123-6
更新日期:2020-12-08 00:00:00
abstract::The aim of this study was to identify the synergistic effect of microRNA expression with classical risk factors of coronary heart disease (CHD) and to explore their diagnostic value for coronary stenotic lesions in subjects with CHD. Plasma samples were obtained from 66 subjects with CHD and from 58 control individual...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14925
更新日期:2015-10-08 00:00:00
abstract::One of the key motivations in producing 3D structures has always been the realization of metamaterials with effective constituent properties that can be tuned in all propagation directions at various frequencies. Here, we report the investigation of spatially oriented "Nanograter" structures with orientation-dependent...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28764
更新日期:2016-06-30 00:00:00
abstract::A wide-band and tunable Q-switched erbium-doped fiber (EDF) laser operating at 1560.5 nm with a tungsten ditelluride (WTe2) saturable absorber (SA) is demonstrated. The semi-metallic nature of WTe2 as well as its small band gap and excellent nonlinear optical properties make it an excellent SA material. The laser cavi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66664-9
更新日期:2020-06-17 00:00:00
abstract::Numerous studies have investigated the association between eosinophilia and clinical outcome of patients with chronic obstructive pulmonary disease (COPD) but the evidence is conflicting. We conducted a pooled analysis of outcome measures comparing eosinophilic and non-eosinophilic COPD patients. We searched articles ...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-017-13745-x
更新日期:2017-10-18 00:00:00
abstract::Traditionally, the practice of the tibial component placement in total knee arthroplasty has focused on achieving maximum coverage without malrotation. However, the concept of maximizing coverage has not been well defined or researched and yet biased results are often produced. This study aimed to evaluate the effect ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67613-2
更新日期:2020-06-29 00:00:00
abstract::The cycling between GDP- and GTP- bound forms of the Ras protein is partly regulated by the binding of Sos. The structural/dynamic behavior of the complex formed between activated Sos and Ras at the point of the functional cycle where the nucleotide exchange is completed has not been described to date. Here we show th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29706
更新日期:2016-07-14 00:00:00
abstract::The rise of antibiotic resistance (AMR) is one of the most important public health threats worldwide.Today, increasing attention is being paid to multidrug resistant staphylococci isolated from healthcare and non-healthcare environments as the treatment of these bacteria has become increasingly difficult. In this stud...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45886-6
更新日期:2019-08-01 00:00:00
abstract::A major challenge in nanofabrication is to pattern unconventional substrates that cannot be processed for a variety of reasons, such as incompatibility with spin coating, electron beam lithography, optical lithography, or wet chemical steps. Here, we present a versatile nanofabrication method based on re-usable silico...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07802
更新日期:2015-01-15 00:00:00
abstract::Light-inducible gene regulation has great potential for remote and noninvasive control of the fate and function of target cells. One method to achieve such control is delivery of heat shock protein (HSP) promoter-driven protein expression vectors and photothermal heaters into the cells, followed by activation by illum...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04912-1
更新日期:2017-07-05 00:00:00
abstract::Laryngeal squamous cell carcinoma is a major medical problem worldwide. Although our understanding of genetic changes and their consequences in laryngeal cancer has opened new therapeutic pathways over the years, the diagnostic as well as treatment options still need to be improved. In our previous study, we identifie...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56870-5
更新日期:2020-01-08 00:00:00
abstract::Influenza virus remains an emerging virus and causes pandemics with high levels of fatality. After screening different plant extracts with potential anti-influenza activity, a water extract of Taxodium distichum stems (TDSWex) showed excellent activity against influenza viruses. The EC50 of TDSWex was 0.051 ± 0.024 mg...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36015
更新日期:2016-10-31 00:00:00
abstract::To date, only bar/pat gene derived from Streptomyces has been used to generate the commercial PPT-resistant crops currently available in the market. The limited source of bar/pat gene is probably what has caused the decrease in PPT-tolerance, which has become the main concern of those involved in field management prog...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15495
更新日期:2015-10-23 00:00:00
abstract::Glucagon is a pancreatic hormone and increases the blood glucose levels. It may be incorporated in a dual hormone artificial pancreas, a device to automatically and continuously control blood glucose levels of individuals with diabetes. Artificial pancreas systems have been developed for use in the subcutaneous tissue...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70813-5
更新日期:2020-08-13 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-37133-1
更新日期:2018-12-14 00:00:00
abstract::The hepatic asialoglycoprotein receptor (ASGP-R) is posttranslationally modified in the Golgi en route to the plasma membrane, where it mediates clearance of desialylated serum glycoproteins. It is known that content of plasma membrane-associated ASGP-R is decreased after ethanol exposure, although the mechanisms rema...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17127
更新日期:2015-11-26 00:00:00
abstract::Living organisms in drying environments build anisotropic structures and exhibit directionality through self-organization of biopolymers. However, the process of macro-scale assembly is still unknown. Here, we introduce a dissipative structure through a non-equilibrium process between hydration and deposition in the d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05883-z
更新日期:2017-07-21 00:00:00
abstract::Insertion sequence (IS) 6110 is found at multiple sites in the Mycobacterium tuberculosis genome and displays a high degree of polymorphism with respect to copy number and insertion sites. Therefore, IS6110 is considered to be a useful molecular marker for diagnosis and strain typing of M. tuberculosis. Generally IS61...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12567
更新日期:2015-07-28 00:00:00
abstract::We report a non-iterative localization algorithm that utilizes the scaling of a three-dimensional (3D) image in the axial direction and focuses on evaluating the radial symmetry center of the scaled image to achieve the desired single-particle localization. Using this approach, we analyzed simulated 3D particle images...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02462
更新日期:2013-01-01 00:00:00
abstract::Prolonged intake of excessive amounts of ethanol is known to have adverse effects on the central nervous system (CNS). Here we investigated the effects of acute and chronic ethanol exposure and withdrawal from chronic ethanol exposure on glymphatic function, which is a brain-wide metabolite clearance system connected ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20424-y
更新日期:2018-02-02 00:00:00
abstract::Sarcopenia is an aging condition involving low muscle mass and function. Fetuin-A (FetA) appears to be a factor for body composition remodeling. We hypothesized that age increases FetA levels and deteriorates the myocardial function by affecting diastolic function, especially in people with sarcopenia. We enrolled 541...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12078
更新日期:2015-07-10 00:00:00
abstract::Nontuberculous mycobacteria (NTM) are environmental bacteria increasingly associated to public health problems. In water systems, free-living amoebae (FLA) feed on bacteria by phagocytosis, but several bacteria, including many NTM, are resistant to this predation. Thus, FLA can be seen as a training ground for pathoge...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46270
更新日期:2017-04-10 00:00:00
abstract::NETs constitute a network of DNA and proteins released by neutrophils in response to infectious and immunologic triggers. NET proteins are recognized as autoantigens in ANCA vasculitis; limited knowledge is available in other autoimmune pathologies. The composition of NETs produced ex vivo by resting and Phorbol-myris...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-019-44379-w
更新日期:2019-05-28 00:00:00
abstract::Glucagon is the main counterregulatory hormone in the body. Still, the mechanism involved in the regulation of glucagon secretion from pancreatic alpha cells remains elusive. Dysregulated glucagon secretion is common in patients with Cystic Fibrosis (CF) that develop CF related diabetes (CFRD). CF is caused by a mutat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00098-8
更新日期:2017-03-07 00:00:00
abstract::The use of lithium (Li) metal anodes has been reconsidered because of the necessity for a higher energy density in secondary batteries. However, Li metal anodes suffer from 'dead' Li formation and surface deactivation which consequently form a porous layer of redundant Li aggregates. In this work, a fibrous metal felt...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30830
更新日期:2016-08-03 00:00:00
abstract::The purpose of this study was to permit bone marrow mesenchymal stem cells (BMSCs) to reach their full potential in the treatment of chronic wounds. A biocompatible multifunctional crosslinker based temperature sensitive hydrogel was developed to deliver BMSCs, which improve the chronic inflammation microenvironments ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18104
更新日期:2015-12-08 00:00:00
abstract::The excessive release and accumulation of glutamate in the brain is known to be associated with excitotoxicity. CE, an extract derived from the plant Coeloglossum viride var. Bracteatum, exerted neuroprotective effects against amyloid toxicity and oxidative stress in cortical neurons. The aims of this study are to exa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08957-0
更新日期:2017-08-23 00:00:00
abstract::Evolutions of Asian and Australian monsoons have important significance for understanding the past global change but are still a controversial subject. Here, we explore systematically the effects of plate movement and plateau uplift on the formation and evolution of the Asian and Australian monsoons by numerical simul...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40344
更新日期:2017-01-13 00:00:00
abstract::To evaluate the efficacy and safety of CyberKnife Stereotactic Body Radiation Therapy (SBRT) in the treatment of adrenal gland metastases (AGM), we designed a large-scale multicenter retrospective study to report the safety and efficacy of SBRT for inoperable AGM. In this study, 75 (61 males, 14 females) patients with...
journal_title:Scientific reports
pub_type: 杂志文章,多中心研究
doi:10.1038/s41598-020-64770-2
更新日期:2020-05-12 00:00:00