Abstract：
:The purpose of this study was to permit bone marrow mesenchymal stem cells (BMSCs) to reach their full potential in the treatment of chronic wounds. A biocompatible multifunctional crosslinker based temperature sensitive hydrogel was developed to deliver BMSCs, which improve the chronic inflammation microenvironments of wounds. A detailed in vitro investigation found that the hydrogel is suitable for BMSC encapsulation and can promote BMSC secretion of TGF-β1 and bFGF. In vivo, full-thickness skin defects were made on the backs of db/db mice to mimic diabetic ulcers. It was revealed that the hydrogel can inhibit pro-inflammatory M1 macrophage expression. After hydrogel association with BMSCs treated the wound, significantly greater wound contraction was observed in the hydrogel + BMSCs group. Histology and immunohistochemistry results confirmed that this treatment contributed to the rapid healing of diabetic skin wounds by promoting granulation tissue formation, angiogenesis, extracellular matrix secretion, wound contraction, and re-epithelialization. These results show that a hydrogel laden with BMSCs may be a promising therapeutic strategy for the management of diabetic ulcers.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Chen S,Shi J,Zhang M,Chen Y,Wang X,Zhang L,Tian Z,Yan Y,Li Q,Zhong W,Xing M,Zhang L,Zhang Ldoi
10.1038/srep18104subject
Has Abstractpub_date
2015-12-08 00:00:00pages
18104issn
2045-2322pii
srep18104journal_volume
5pub_type
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pub_type： 杂志文章
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