Global metabolomics reveals potential urinary biomarkers of esophageal squamous cell carcinoma for diagnosis and staging.

abstract：:Kuding tea is implicated in alleviating metabolic disorders in traditional Chinese medicine. However, the role of Ilex latifolia Thunb (kuding tea), one of the large leaf kuding tea species, in the prevention of the development of obesity remains to be determined. We show here that 7-week-old male mice treated with an...

journal_title：Scientific reports

authors： Wu H,Chen YL,Yu Y,Zang J,Wu Y,He Z

更新日期：2017-11-07 00:00:00

abstract：:Polypyrrole complex nitrogen-doped porous carbon matrix (PPy/N-PCM) was synthesized by a simple two-step method. Firstly, graphene oxide was prepared by the modified Hummers method. Secondly, Polypyrrole was compounded on the graphene oxide substrate, and the carbon matrix with a high specific surface area was obtaine...

journal_title：Scientific reports

authors： Feng M,Lu W,Zhou Y,Zhen R,He H,Wang Y,Li C

更新日期：2020-09-21 00:00:00

abstract：:Dysregulation in acetylation homeostasis has been implicated in the pathogenesis of the amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder. It is known that the acetylation of transcriptional factors regulates their activity. The acetylation state of NF-kB RelA has been found to dictate the neurop...

journal_title：Scientific reports

authors： Schiaffino L,Bonafede R,Scambi I,Parrella E,Pizzi M,Mariotti R

更新日期：2018-08-27 00:00:00

abstract：:The feedback between dyke and sill intrusions and the evolution of stresses within volcanic systems is poorly understood, despite its importance for magma transport and volcano instability. Long-lived ocean island volcanoes are crosscut by thousands of dykes, which must be accommodated through a combination of flank s...

journal_title：Scientific reports

authors： Thiele ST,Cruden AR,Micklethwaite S,Bunger AP,Köpping J

更新日期：2020-10-15 00:00:00

abstract：:The present work is aimed at studying the dynamic behaviour of the tryptopnanase (tna) operon, which encodes the proteins necessary to uptake and metabolise tryptophan to use it as a carbon source in the absence of glucose. To this end, we designed a micro-bioreactor capable of driving a bacterial culture to a station...

journal_title：Scientific reports

authors： Orozco-Gómez DI,Sosa-Hernández JE,Gallardo-Navarro ÓA,Santana-Solano J,Santillán M

更新日期：2019-04-01 00:00:00

abstract：:High-density linkage maps can improve the precision of QTL localization. A high-density SNP-based linkage map containing 3207 markers covering 3072.7 cM of the Brassica napus genome was constructed in the KenC-8 × N53-2 (KNDH) population. A total of 67 and 38 QTLs for seed oil and protein content were identified with ...

journal_title：Scientific reports

authors： Chao H,Wang H,Wang X,Guo L,Gu J,Zhao W,Li B,Chen D,Raboanatahiry N,Li M

更新日期：2017-04-10 00:00:00

abstract：:The side effects of cisplatin (CDDP), notably nephrotoxicity, greatly limited its use in clinical chemotherapy. HuangQi Injections (HI), a commonly used preparation of the well-known Chinese herbal medicine Astragali radix, appeared to be promising treatment for nephrotoxicity without compromising the anti-tumor activ...

journal_title：Scientific reports

authors： Li CY,Song HT,Wang XX,Wan YY,Ding XS,Liu SJ,Dai GL,Liu YH,Ju WZ

更新日期：2017-06-15 00:00:00

abstract：:This study aimed to determine whether formyl peptide receptors (FPRs) regulated the differentiation of neural stem cells (NSCs). FPRs promote the migration of NSCs both in vitro and in vivo. However, the role of FPRs during differentiation of NSCs is unknown. Analysis by Western blot showed significantly increased exp...

journal_title：Scientific reports

authors： Zhang L,Wang G,Chen X,Xue X,Guo Q,Liu M,Zhao J

更新日期：2017-03-16 00:00:00

abstract：:The largest tsunamis are generated by seafloor uplift resulting from rupture of offshore subduction-zone megathrusts. The rupture of the shallowest part of a megathrust often produces unexpected outsize tsunami relative to their seismic magnitude. These are so called 'tsunami earthquakes', which are difficult to ident...

journal_title：Scientific reports

authors： Manta F,Occhipinti G,Feng L,Hill EM

更新日期：2020-07-06 00:00:00

abstract：:The ability of human embryonic stem cells (hESCs) to differentiate into skeletal muscle cells is an important criterion in using them as a cell source to ameliorate skeletal muscle impairments. However, differentiation of hESCs into skeletal muscle cells still remains a challenge, often requiring introduction of trans...

journal_title：Scientific reports

authors： Hwang Y,Suk S,Shih YR,Seo T,Du B,Xie Y,Li Z,Varghese S

更新日期：2014-08-01 00:00:00

abstract：:We aimed to establish a high-performing and robust classification strategy, using magnetic resonance imaging (MRI), along with combinations of feature extraction and selection in human and machine learning using radiomics or deep features by employing a small dataset. Using diffusion and contrast-enhanced T1-weighted ...

journal_title：Scientific reports

authors： Yun J,Park JE,Lee H,Ham S,Kim N,Kim HS

更新日期：2019-04-05 00:00:00

abstract：:Amyloid precursor protein (APP) intracellular domain (AICD) is a product of APP processing with transcriptional modulation activity, whose overexpression causes various Alzheimer's disease (AD)-related dysfunctions. Here we report that 1-(3',4'-dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid) (CHF50...

journal_title：Scientific reports

authors： Branca C,Sarnico I,Ruotolo R,Lanzillotta A,Viscomi AR,Benarese M,Porrini V,Lorenzini L,Calzà L,Imbimbo BP,Ottonello S,Pizzi M

更新日期：2014-04-09 00:00:00

abstract：:Aluminium nitride (AlN) is a promising semiconductor material for use as a substrate in high-power, high-frequency electronic and deep-ultraviolet optoelectronic devices. We study the feasibility of a novel AlN fabrication technique by using the Al/GaN substitution reaction method. The substitution method we propose h...

journal_title：Scientific reports

authors： Noorprajuda M,Ohtsuka M,Adachi M,Fukuyama H

更新日期：2020-08-03 00:00:00

abstract：:The aim of this systematic review was to assess the performance of anthropometric tools to determine obesity in the general population (CRD42018086888). Our review included 32 studies. To detect obesity with body mass index (BMI), the meta-analyses rendered a sensitivity of 51.4% (95% CI 38.5-64.2%) and a specificity ...

journal_title：Scientific reports

authors： Sommer I,Teufer B,Szelag M,Nussbaumer-Streit B,Titscher V,Klerings I,Gartlehner G

更新日期：2020-07-29 00:00:00

abstract：:Archaeologically defined Upper Palaeolithic (UP, 45,000-10,000 years ago) "cultures" are often used as proxies to designate fossil populations. While recent genomic studies have partly clarified the complex relationship between European UP "cultures" and past population dynamics, they leave open numerous questions reg...

journal_title：Scientific reports

authors： Mounier A,Heuzé Y,Samsel M,Vasilyev S,Klaric L,Villotte S

更新日期：2020-12-14 00:00:00

abstract：:Metasurfaces are ideal candidates for conformal wave manipulation on curved objects due to their low profiles and rich functionalities. Here we design and analyze conformal metasurfaces for practical optical applications at 532 nm visible band for the first time. The inclusions are silicon disk nanoantennas embedded i...

journal_title：Scientific reports

authors： Cheng J,Jafar-Zanjani S,Mosallaei H

更新日期：2016-12-08 00:00:00

abstract：:Here we investigated whether endothelial colony forming cells (ECFC) and mesenchymal progenitor cells (MPC) form vascular networks and restore blood flow in ischemic skeletal muscle, and whether host myeloid cells play a role. ECFC + MPC, ECFC alone, MPC alone, or vehicle alone were injected into the hind limb ischemi...

journal_title：Scientific reports

authors： Kang KT,Lin RZ,Kuppermann D,Melero-Martin JM,Bischoff J

更新日期：2017-04-10 00:00:00

abstract：:Ribonucleotide reductases (RNR) catalyze the last step of deoxyribonucleotide synthesis, and are therefore essential to DNA-based life. Three forms of RNR exist: classes I, II, and III. While eukaryotic cells use only class Ia RNR, bacteria can harbor any combination of classes, granting them adaptability. The opportu...

journal_title：Scientific reports

authors： Crespo A,Pedraz L,Van Der Hofstadt M,Gomila G,Torrents E

更新日期：2017-12-20 00:00:00

abstract：:Mammalian motor cortex consists of several interconnected subregions thought to play distinct roles in voluntary movements, yet their specific role in decision making and execution is not completely elucidated. Here we used transient optogenetic inactivation of the caudal forelimb area (CFA) and rostral forelimb area ...

journal_title：Scientific reports

authors： Morandell K,Huber D

更新日期：2017-11-17 00:00:00

abstract：:Identifying the occurrence mechanism of drug-induced side effects (SEs) is critical for design of drug target and new drug development. The expression of genes in biological processes is regulated by transcription factors(TFs) and/or microRNAs. Most of previous studies were focused on a single level of gene or gene se...

journal_title：Scientific reports

authors： Jia X,Jin Q,Liu X,Bian X,Wang Y,Liu L,Ma H,Tan F,Gu M,Chen X

更新日期：2017-07-20 00:00:00

abstract：:Roots have important roles for plants to withstand adverse environmental conditions, including salt stress. Biostimulant application was shown to enhance plant resilience towards abiotic stresses. Here, we studied the effect of a tannin-based biostimulant on tomato (Solanum lycopersicum L.) grown under salt stress con...

journal_title：Scientific reports

authors： Campobenedetto C,Mannino G,Beekwilder J,Contartese V,Karlova R,Bertea CM

更新日期：2021-01-11 00:00:00

abstract：:Pesticides are the main tactics for pest control because they reduce the pest population very fast and their efficiency does not depend on abiotic factors. However, the indiscriminate use of these substances can speed up the development of resistant populations and causing environmental contamination. Therefore, alter...

journal_title：Scientific reports

authors： Campos EVR,Proença PLF,Oliveira JL,Pereira AES,de Morais Ribeiro LN,Fernandes FO,Gonçalves KC,Polanczyk RA,Pasquoto-Stigliani T,Lima R,Melville CC,Della Vechia JF,Andrade DJ,Fraceto LF

更新日期：2018-05-16 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Ahmad MN,Karim NU,Normaya E,Piah BM,Iqbal A,Bulat KHK

更新日期：2020-11-05 00:00:00

abstract：:Heterostructures based on two-dimensional (2D) materials have sparked wide interests in both fundamental physics and applied devices. Recently, Dirac/Weyl semimetals are emerging as capable functional materials for optoelectronic devices. However, thus far the interfacial coupling of an all-semimetal 2D heterostructur...

journal_title：Scientific reports

authors： Liu Y,Liu C,Wang X,He L,Wan X,Xu Y,Shi Y,Zhang R,Wang F

更新日期：2018-08-27 00:00:00

abstract：:Goldlined spinefoot, Siganus guttatus, inhabits tropical and subtropical waters and synchronizes its spawning around the first quarter moon likely using an hourglass-like lunar timer. In previous studies, we have found that clock genes (Cryptochrome3 and Period1) could play the role of state variable in the diencephal...

journal_title：Scientific reports

authors： Takeuchi Y,Kabutomori R,Yamauchi C,Miyagi H,Takemura A,Okano K,Okano T

更新日期：2018-04-18 00:00:00

abstract：:As an important online information retaining and processing function, working memory plays critical roles in many other cognitive functions. Several long-term factors, such as age, addiction and diseases, have been affirmed to impair working memory, but whether or how the short-term factors, like painful stimuli or em...

journal_title：Scientific reports

authors： Chen M,Wang YZ,Ma CC,Li QZ,Zhou H,Fu J,Yang QQ,Zhang YM,Liu Y,Cao JL

更新日期：2017-07-03 00:00:00

abstract：:Aim of this retrospective analysis was to evaluate the survival times after percutaneous irreversible electroporation (IRE) in inoperable liver tumors not amenable to thermal ablation. 71 patients (14 females, 57 males, median age 63.5 ± 10.8 years) with 103 liver tumors were treated in 83 interventions using IRE (Nan...

journal_title：Scientific reports

authors： Niessen C,Thumann S,Beyer L,Pregler B,Kramer J,Lang S,Teufel A,Jung EM,Stroszczynski C,Wiggermann P

更新日期：2017-03-07 00:00:00

abstract：:Recruitment is one of the dominant processes regulating fish population productivity. It is, however, notoriously difficult to predict, as it is the result of a complex multi-step process. Various fine-scale drivers might act on the pathway from adult population characteristics to spawning behaviour and egg production...

journal_title：Scientific reports

authors： Brosset P,Smith AD,Plourde S,Castonguay M,Lehoux C,Van Beveren E

更新日期：2020-09-30 00:00:00

abstract：:In this study, novel ZnS@In2S3 core@shell hollow nanospheres were fabricated by a facile refluxing method for the first time, and the formation mechanism of hollow structure with interior architecture was discussed based on ion-exchange Ostwald ripening. As the photocatalytic material for degradation of gaseous o-Dich...

journal_title：Scientific reports

authors： Liu B,Hu X,Li X,Li Y,Chen C,Lam KH

更新日期：2017-11-27 00:00:00

abstract：:CRISPR/Cas9-mediated genome editing is a next-generation strategy for genetic modifications. Typically, sgRNA is constitutively expressed relying on RNA polymerase III promoters. Polymerase II promoters initiate transcription in a flexible manner, but sgRNAs generated by RNA polymerase II promoter lost their nuclease ...

journal_title：Scientific reports

authors： Xie C,Chen YL,Wang DF,Wang YL,Zhang TP,Li H,Liang F,Zhao Y,Zhang GY

更新日期：2017-07-19 00:00:00