当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Perfluorooctanoic acid in indoor particulate matter triggers oxidative stress and inflammation in corneal and retinal cells.

Perfluorooctanoic acid in indoor particulate matter triggers oxidative stress and inflammation in corneal and retinal cells.

Abstract：

:To investigate the particle size distribution of particulate matter and the concentration of specific perfluorinated compounds in indoor dust samples from several locations. Then, we used cell-based assays to investigate the effect of perfluorinated compounds on human corneal epithelial (HCEpiC), endothelial cells (HCEC) and retinal pigment epithelial cells (RPE). Indoor dust samples were collected at five different locations and PM50-10, PM10-2.5, and PM2.5-1 were fractionized. The presence and levels of 8:2 fluorotelomer alcohol, 10:2 fluorotelomer alcohol, and perfluorooctanoic acid were detected by gas chromatography-mass spectrometry. The effect of perfluorooctanoic acid on the activation of reactive oxygen species, transepithelial resistance as well as the expression of interleukin (IL)-6 and IL-8 were determined. The basolateral media of human corneal epithelial or human corneal endothelial cells were used to treat human corneal endothelial or retinal pigment epithelial cells, respectively to indicate the potential of ocular surface inflammation may result in retinal inflammation. Among perfluorinated compounds, only perfluorooctanoic acid was detected in all indoor dust samples. Perfluorooctanoic acid had the highest concentration among all perfluorinated compounds in the samples. Exposure to perfluorooctanoic acid impaired tight junction sealing and increased the levels of reactive oxygen species in human corneal epithelial cells. In human corneal epithelial cells, secretion of IL-6 and IL-8 in both apical and basolateral media was promoted significantly by perfluorooctanoic acid treatment. Stimulation with the basolateral media from perfluorooctanoic acid-treated human corneal epithelial cells induced inflammation in human corneal endothelial cells. The treatment of retinal pigment epithelial cells with the basolateral media from stimulated human corneal endothelial cells also elicited the secretion of proinflammatory cytokines. The results indicate that perfluorooctanoic acid exposure impaired the tight junction of corneal cells and caused inflammatory reactions in the retina. Exposure of the cornea to perfluorooctanoic acid contained in particulate matter might induce oxidative stress and inflammation in the retina and represent a risk factor for age-related macular degeneration.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Tien PT,Lin HJ,Tsai YY,Lim YP,Chen CS,Chang CY,Lin CJ,Chen JJ,Wu SM,Huang YJ,Wan L

doi

10.1038/s41598-020-72600-8

subject

Has Abstract

pub_date

2020-09-24 00:00:00

pages

15702

issue

1

issn

2045-2322

pii

10.1038/s41598-020-72600-8

journal_volume

10

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Gallium phosphide optical metasurfaces for visible light applications.

    abstract：:There are few materials that are broadly used for fabricating optical metasurfaces for visible light applications. Gallium phosphide (GaP) is a material that, due to its optical properties, has the potential to become a primary choice but due to the difficulties in fabrication, GaP thin films deposited on transparent ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-77753-0

    authors： Melli M,West M,Hickman S,Dhuey S,Lin D,Khorasaninejad M,Chang C,Jolly S,Tae H,Poliakov E,St Hilaire P,Cabrini S,Peroz C,Klug M

    更新日期：2020-11-26 00:00:00

  • Identification of significantly mutated subnetworks in the breast cancer genome.

    abstract：:Recent studies showed that somatic cancer mutations target genes that are in specific signaling and cellular pathways. However, in each patient only a few of the pathway genes are mutated. Current approaches consider only existing pathways and ignore the topology of the pathways. For this reason, new efforts have been...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80204-5

    authors： Ajwad R,Domaratzki M,Liu Q,Feizi N,Hu P

    更新日期：2021-01-12 00:00:00

  • Surface enhanced Raman spectroscopy of Chlamydia trachomatis and Neisseria gonorrhoeae for diagnostics, and extra-cellular metabolomics and biochemical monitoring.

    abstract：:SERS spectra excited at 785 nm of the bacteria Chlamydia trahomatis (elementary bodies, EB) and Neisseria gonorrheoae, the causative pathogens for the two most common sexually transmitted diseases (STD), chlamydia and gonorrhea, respectively, are reported. Although both are Gram-negative bacteria, the SERS signatures ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-23562-5

    authors： Chen Y,Premasiri WR,Ziegler LD

    更新日期：2018-03-26 00:00:00

  • Neural predictors of cognitive improvement by multi-strategic memory training based on metamemory in older adults with subjective memory complaints.

    abstract：:Previous studies have indicated that memory training may help older people improve cognition. However, evidence regarding who will benefit from such memory trainings has not been fully discovered yet. Understanding the clinical and neural inter-individual differences for predicting cognitive improvement is important f...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-19390-2

    authors： Park S,Ryu SH,Yoo Y,Yang JJ,Kwon H,Youn JH,Lee JM,Cho SJ,Lee JY

    更新日期：2018-01-18 00:00:00

  • Calcium oxalate crystals increased enolase-1 secretion from renal tubular cells that subsequently enhanced crystal and monocyte invasion through renal interstitium.

    abstract：:Calcium oxalate monohydrate (COM) crystals cause kidney stone disease by still unclear mechanisms. The present study aimed to characterize changes in secretion of proteins from basolateral compartment of renal tubular epithelial cells after exposure to COM crystals and then correlated them with the stone pathogenesis....

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep24064

    authors： Chiangjong W,Thongboonkerd V

    更新日期：2016-04-05 00:00:00

  • Bioconversion of chitin and concomitant production of chitinase and N-acetylglucosamine by novel Achromobacter xylosoxidans isolated from shrimp waste disposal area.

    abstract：:Marine pollution is a significant issue in recent decades, with the increase in industries and their waste harming the environment and ecosystems. Notably, the rise in shellfish industries contributes to tons of shellfish waste composed of up to 58% chitin. Chitin, the second most ample polymer next to cellulose, is i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-68772-y

    authors： Subramanian K,Sadaiappan B,Aruni W,Kumarappan A,Thirunavukarasu R,Srinivasan GP,Bharathi S,Nainangu P,Renuga PS,Elamaran A,Balaraman D,Subramanian M

    更新日期：2020-07-17 00:00:00

  • Alterations of cerebral perfusion in asymptomatic internal carotid artery steno-occlusive disease.

    abstract：:Patients with asymptomatic occlusion in the internal carotid arteries (ICA) have been shown to have a better preserved hemodynamic status of the brain as compared to patients with symptoms. This study was aimed to explore the cerebral perfusion alterations in asymptomatic patients using multi-parametric arterial spin-...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-02094-4

    authors： Chen YF,Tang SC,Wu WC,Kao HL,Kuo YS,Yang SC

    更新日期：2017-05-12 00:00:00

  • Magnetic thin-film insulator with ultra-low spin wave damping for coherent nanomagnonics.

    abstract：:Wave control in the solid state has opened new avenues in modern information technology. Surface-acoustic-wave-based devices are found as mass market products in 100 millions of cellular phones. Spin waves (magnons) would offer a boost in today's data handling and security implementations, i.e., image processing and s...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep06848

    authors： Yu H,Kelly Od,Cros V,Bernard R,Bortolotti P,Anane A,Brandl F,Huber R,Stasinopoulos I,Grundler D

    更新日期：2014-10-30 00:00:00

  • Entanglement convertibility by sweeping through the quantum phases of the alternating bonds XXZ chain.

    abstract：:We study the entanglement structure and the topological edge states of the ground state of the spin-1/2 XXZ model with bond alternation. We employ parity-density matrix renormalization group with periodic boundary conditions. The finite-size scaling of Rényi entropies S2 and S∞ are used to construct the phase diagram ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep26453

    authors： Tzeng YC,Dai L,Chung MC,Amico L,Kwek LC

    更新日期：2016-05-24 00:00:00

  • Reduced FcRn-mediated transcytosis of IgG2 due to a missing Glycine in its lower hinge.

    abstract：:Neonatal Fc-receptor (FcRn), the major histocompatibility complex (MHC) class I-like Fc-receptor, transports immunoglobuline G (IgG) across cell layers, extending IgG half-life in circulation and providing newborns with humoral immunity. IgG1 and IgG2 have similar half-lives, yet IgG2 displays lower foetal than matern...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-40731-2

    authors： Stapleton NM,Brinkhaus M,Armour KL,Bentlage AEH,de Taeye SW,Temming AR,Mok JY,Brasser G,Maas M,van Esch WJE,Clark MR,Williamson LM,van der Schoot CE,Vidarsson G

    更新日期：2019-05-14 00:00:00

  • Tuning mitochondrial structure and function to criticality by fluctuation-driven mechanotransduction.

    abstract：:Cells in vascular walls are exposed to blood pressure variability (BPV)-induced cycle-by-cycle fluctuations in mechanical forces which vary considerably with pathology. For example, BPV is elevated in hypertension but reduced under anesthesia. We hypothesized that the extent of mechanical fluctuations applied to vascu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-57301-1

    authors： Bartolák-Suki E,Suki B

    更新日期：2020-01-15 00:00:00

  • Homogeneity of lithium distribution in cylinder-type Li-ion batteries.

    abstract：:Spatially-resolved neutron powder diffraction with a gauge volume of 2 × 2 × 20 mm(3) has been applied as an in situ method to probe the lithium concentration in the graphite anode of different Li-ion cells of 18650-type in charged state. Structural studies performed in combination with electrochemical measurements an...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep18380

    authors： Senyshyn A,Mühlbauer MJ,Dolotko O,Hofmann M,Ehrenberg H

    更新日期：2015-12-18 00:00:00

  • Anti-apoptotic activity of ETB receptor agonist, IRL-1620, protects neural cells in rats with cerebral ischemia.

    abstract：:Endothelin-B receptor agonist, IRL-1620, provides significant neuroprotection following cerebral ischemia in rats. Whether this neuroprotection is due to inhibition of apoptosis is unknown. IRL-1620-treated rats following permanent middle cerebral artery occlusion (MCAO) showed significant improvement in neurological ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-46203-x

    authors： Briyal S,Ranjan AK,Hornick MG,Puppala AK,Luu T,Gulati A

    更新日期：2019-07-18 00:00:00

  • Molecular characterization of colorectal adenomas with and without malignancy reveals distinguishing genome, transcriptome and methylome alterations.

    abstract：:The majority of colorectal cancer (CRC) arises from precursor lesions known as polyps. The molecular determinants that distinguish benign from malignant polyps remain unclear. To molecularly characterize polyps, we utilized Cancer Adjacent Polyp (CAP) and Cancer Free Polyp (CFP) patients. CAPs had tissues from the res...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-21525-4

    authors： Druliner BR,Wang P,Bae T,Baheti S,Slettedahl S,Mahoney D,Vasmatzis N,Xu H,Kim M,Bockol M,O'Brien D,Grill D,Warner N,Munoz-Gomez M,Kossick K,Johnson R,Mouchli M,Felmlee-Devine D,Washechek-Aletto J,Smyrk T,Oberg A,

    更新日期：2018-02-16 00:00:00

  • Analysis of long non-coding RNA expression profiles in pancreatic ductal adenocarcinoma.

    abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and lethal malignancies. Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcripts that have been implicated in cancer biogenesis and prognosis. By repurposing microarray probes, we herein analysed the lncRNA expression...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep33535

    authors： Fu XL,Liu DJ,Yan TT,Yang JY,Yang MW,Li J,Huo YM,Liu W,Zhang JF,Hong J,Hua R,Chen HY,Sun YW

    更新日期：2016-09-15 00:00:00

  • Energy metabolism in intestinal epithelial cells during maturation along the crypt-villus axis.

    abstract：:Intestinal epithelial cells continuously migrate and mature along crypt-villus axis (CVA), while the changes in energy metabolism during maturation are unclear in neonates. The present study was conducted to test the hypothesis that the energy metabolism in intestinal epithelial cells would be changed during maturatio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep31917

    authors： Yang H,Wang X,Xiong X,Yin Y

    更新日期：2016-08-25 00:00:00

  • Mycobacterium tuberculosis Rv3160c is a TetR-like transcriptional repressor that regulates expression of the putative oxygenase Rv3161c.

    abstract：:Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is a major health threat listed among the top 10 causes of death worldwide. Treatment of multidrug-resistant Mtb requires use of additional second-line drugs that prolong the treatment process and result in higher death rates. Our team previously identified a 2...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-81104-y

    authors： Tükenmez H,Sarkar S,Anoosheh S,Kruchanova A,Edström I,Harrison GA,Stallings CL,Almqvist F,Larsson C

    更新日期：2021-01-15 00:00:00

  • BMP6 Regulates Proliferation and Apoptosis of Human Sertoli Cells Via Smad2/3 and Cyclin D1 Pathway and DACH1 and TFAP2A Activation.

    abstract：:Sertoli cells are essential for regulating normal spermatogenesis. However, the mechanisms underlying human Sertoli cell development remain largely elusive. Here we examined the function and signaling pathways of BMP6 in regulating human Sertoli cells. RT-PCR, immunocytochemistry and Western blots revealed that BMP6 a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep45298

    authors： Wang H,Yuan Q,Sun M,Niu M,Wen L,Fu H,Zhou F,Chen Z,Yao C,Hou J,Shen R,Lin Q,Liu W,Jia R,Li Z,He Z

    更新日期：2017-04-07 00:00:00

  • Alexithymia and personality traits of patients with inflammatory bowel disease.

    abstract：:Psychological factors, specific lifestyles and environmental stressors may influence etiopathogenesis and evolution of chronic diseases. We investigate the association between Chronic Inflammatory Bowel Diseases (IBD) and psychological dimensions such as personality traits, defence mechanisms, and Alexithymia, i.e. de...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep41786

    authors： La Barbera D,Bonanno B,Rumeo MV,Alabastro V,Frenda M,Massihnia E,Morgante MC,Sideli L,Craxì A,Cappello M,Tumminello M,Miccichè S,Nastri L

    更新日期：2017-02-02 00:00:00

  • Clinical features of irreversible rejection after allogeneic uterus transplantation in cynomolgus macaques.

    abstract：:Uterus transplantation (UTx) is a potential option for women with uterine factor infertility to have a child. The clinical features indicating irreversible rejection of the uterus are unknown. In our experimental series of allogeneic UTx in cynomolgus macaques, six female macaques were retrospectively examined, which ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-70914-1

    authors： Kisu I,Emoto K,Masugi Y,Yamada Y,Matsubara K,Obara H,Matoba Y,Banno K,Kato Y,Saiki Y,Itagaki I,Kawamoto I,Iwatani C,Murase M,Nakagawa T,Tsuchiya H,Ishigaki H,Urano H,Ema M,Ogasawara K,Aoki D,Nakagawa K,Shiina

    更新日期：2020-08-17 00:00:00

  • Correlative nonlinear optical microscopy and infrared nanoscopy reveals collagen degradation in altered parchments.

    abstract：:This paper presents the correlative imaging of collagen denaturation by nonlinear optical microscopy (NLO) and nanoscale infrared (IR) spectroscopy to obtain morphological and chemical information at different length scales. Such multiscale correlated measurements are applied to the investigation of ancient parchments...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep26344

    authors： Latour G,Robinet L,Dazzi A,Portier F,Deniset-Besseau A,Schanne-Klein MC

    更新日期：2016-05-19 00:00:00

  • Structural basis for a class of nanomolar influenza A neuraminidase inhibitors.

    abstract：:The influenza virus neuraminidase (NA) is essential for the virus life cycle. The rise of resistance mutations against current antiviral therapies has increased the need for the development of novel inhibitors. Recent efforts have targeted a cavity adjacent to the catalytic site (the 150-cavity) in addition to the pri...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep02871

    authors： Kerry PS,Mohan S,Russell RJ,Bance N,Niikura M,Pinto BM

    更新日期：2013-10-16 00:00:00

  • Author Correction: Efficient Characterization and Classification of Contrast Sensitivity Functions in Aging.

    abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-019-42527-w

    authors： Yan FF,Hou F,Lu ZL,Hu X,Huang CB

    更新日期：2019-04-12 00:00:00

  • Structure and membership of gut microbial communities in multiple fish cryptic species under potential migratory effects.

    abstract：:The animal gut microbiota evolves quickly towards a complex community and plays crucial roles in its host's health and development. Factors such as host genetics and environmental changes are regarded as important for controlling the dynamics of animal gut microbiota. Migratory animals are an important group for study...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-64570-8

    authors： Le MH,Wang D

    更新日期：2020-05-05 00:00:00

  • Genetic spectrum of retinal dystrophies in Tunisia.

    abstract：:We report the molecular basis of the largest Tunisian cohort with inherited retinal dystrophies (IRD) reported to date, identify disease-causing pathogenic variants and describe genotype-phenotype correlations. A subset of 26 families from a cohort of 73 families with clinical diagnosis of autosomal recessive IRD (AR-...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67792-y

    authors： Habibi I,Falfoul Y,Turki A,Hassairi A,El Matri K,Chebil A,Schorderet DF,El Matri L

    更新日期：2020-07-08 00:00:00

  • His-tag protein monitoring by a fast mix-and-measure immunoassay.

    abstract：:Here, we present a fast mix-and-measure immunoassay for the specific semiquantitative detection of His-tagged proteins, for example in E. coli cell lysate. The assay is based on Förster resonance energy transfer (FRET) between a lanthanide dye-labeled low-affinity His-peptide and an acceptor-labeled anti-His-tag antib...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05613

    authors： Kreisig T,Prasse AA,Zscharnack K,Volke D,Zuchner T

    更新日期：2014-07-08 00:00:00

  • Molecular diagnostic assays based on cpn60 UT sequences reveal the geographic distribution of subgroup 16SrXIII-(A/I)I phytoplasma in Mexico.

    abstract：:Geographically diverse samples from strawberry exhibiting symptoms of Strawberry Green Petal (SbGP), periwinkle plants with virescence, and blackberry, blueberry, and raspberry plants displaying yellowing and inedible fruits, were assayed for the presence of phytoplasma DNA. PCR targeting the 16S rRNA-encoding gene an...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00895-1

    authors： Pérez-López E,Rodríguez-Martínez D,Olivier CY,Luna-Rodríguez M,Dumonceaux TJ

    更新日期：2017-04-19 00:00:00

  • Multiple oligomeric structures of a bacterial small heat shock protein.

    abstract：:Small heat shock proteins are ubiquitous molecular chaperones that form the first line of defence against the detrimental effects of cellular stress. Under conditions of stress they undergo drastic conformational rearrangements in order to bind to misfolded substrate proteins and prevent cellular protein aggregation. ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep24019

    authors： Mani N,Bhandari S,Moreno R,Hu L,Prasad BVV,Suguna K

    更新日期：2016-04-07 00:00:00

  • Adaptation of retinal ganglion cell function during flickering light in the mouse.

    abstract：:Rapid dilation of retinal vessels in response to flickering light (functional hyperemia) is a well-known autoregulatory response driven by increased neural activity in the inner retina. Little is known about flicker-induced changes of activity of retinal neurons themselves. We non-invasively investigated flicker-induc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54930-4

    authors： Chou TH,Toft-Nielsen J,Porciatti V

    更新日期：2019-12-05 00:00:00

  • Iterative consensus spectral clustering improves detection of subject and group level brain functional modules.

    abstract：:Specialized processing in the brain is performed by multiple groups of brain regions organized as functional modules. Although, in vivo studies of brain functional modules involve multiple functional Magnetic Resonance Imaging (fMRI) scans, the methods used to derive functional modules from functional networks of the ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-63552-0

    authors： Gupta S,Rajapakse JC

    更新日期：2020-05-05 00:00:00