Abstract:
:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and lethal malignancies. Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcripts that have been implicated in cancer biogenesis and prognosis. By repurposing microarray probes, we herein analysed the lncRNA expression profiles in two public PDAC microarray datasets and identified 34 dysregulated lncRNAs in PDAC. In addition, the expression of 6 selected lncRNAs was confirmed in Ren Ji cohort and pancreatic cell lines, and their association with 80 PDAC patients' clinicopathological features and prognosis was investigated. Results indicated that AFAP1-AS1, UCA1 and ENSG00000218510 might be involved in PDAC progression and significantly associated with overall survival of PDAC. UCA1 and ENSG00000218510 expression status may serve as independent prognostic biomarkers for overall survival of PDAC. Gene set enrichment analysis (GSEA) analysis suggested that high AFAP1-AS1, UCA1 and low ENSG00000218510 expression were correlated with several tumorigenesis related pathways. Functional experiments demonstrated that AFAP1-AS1 and UCA1 were required for efficient invasion and/or proliferation promotion in PDAC cell lines, while ENSG00000218510 acted the opposite. Our findings provide novel information on lncRNAs expression profiles which might be beneficial to the precise diagnosis, subcategorization and ultimately, the individualized therapy of PDAC.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Fu XL,Liu DJ,Yan TT,Yang JY,Yang MW,Li J,Huo YM,Liu W,Zhang JF,Hong J,Hua R,Chen HY,Sun YWdoi
10.1038/srep33535subject
Has Abstractpub_date
2016-09-15 00:00:00pages
33535issn
2045-2322pii
srep33535journal_volume
6pub_type
杂志文章abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-25896-6
更新日期:2018-05-15 00:00:00
abstract::The mitochondrial genome (mt genome) provides important information for understanding molecular evolution and phylogenetics. As such, the two complete mt genomes of Ampelophaga rubiginosa and Rondotia menciana were sequenced and annotated. The two circular genomes of A. rubiginosa and R. menciana are 15,282 and 15,636...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06930-5
更新日期:2017-07-26 00:00:00
abstract::ABX464 is a first-in-class, clinical-stage, small molecule for oral administration that has shown strong anti-inflammatory effects in the DSS-model for inflammatory bowel disease (IBD) and also prevents replication of the HIV virus. ABX464 which binds to cap binding complex (CBC) has demonstrated safety and efficacy i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37813-y
更新日期:2019-01-28 00:00:00
abstract::The association between active musical engagement (as leisure activity or professionally) and mental health is still unclear, with earlier studies reporting contrasting findings. Here we tested whether musical engagement predicts (1) a diagnosis of depression, anxiety, schizophrenia, bipolar or stress-related disorder...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49099-9
更新日期:2019-08-30 00:00:00
abstract::The poor intracellular uptake and non-specific binding of anticancer drugs into cancer cells are the bottlenecks in cancer therapy. Nanocarrier platforms provide the opportunities to improve the drug efficacy. Here we show a carbon-based nanomaterial nanodiamond (ND) that carried paclitaxel (PTX), a microtubule inhibi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09983-8
更新日期:2017-08-29 00:00:00
abstract::Using species distribution models and information on genetic structure and within-population variance observed in a series of common garden trials, we reconstructed a historical biogeography of trembling aspen in North America. We used an ensemble classifier modelling approach (RandomForest) to reconstruct palaeoclima...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04871-7
更新日期:2017-07-05 00:00:00
abstract::Human children show unique cognitive skills for dealing with the social world but their cognitive performance is paralleled by great apes in many tasks dealing with the physical world. Recent studies suggested that members of a songbird family-corvids-also evolved complex cognitive skills but a detailed understanding ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77060-8
更新日期:2020-12-10 00:00:00
abstract::Nanothermometry methods with intracellular sensitivities have the potential to make important contributions to fundamental cell biology and medical fields, as temperature is a relevant physical parameter for molecular reactions to occur inside the cells and changes of local temperature are well identified therapeutic ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44023-7
更新日期:2019-05-17 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-48219-9
更新日期:2019-08-15 00:00:00
abstract::Chronic consumption of excess ethanol increases the risk of colorectal cancer. The pathogenesis of ethanol-related colorectal cancer (ER-CRC) is thought to be partly mediated by gut microbes. Specifically, bacteria in the colon and rectum convert ethanol to acetaldehyde (AcH), which is carcinogenic. However, the effec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27923
更新日期:2016-06-13 00:00:00
abstract::Electrical power systems are one of the most important infrastructures that support our society. However, their vulnerabilities have raised great concern recently due to several large-scale blackouts around the world. In this paper, we investigate the robustness of power systems against cascading failures initiated by...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27625
更新日期:2016-06-21 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-58755-4
更新日期:2020-01-30 00:00:00
abstract::Epigenetic mechanisms are known to exert control over gene expression and determine cell fate. Genetic mutations in epigenetic regulators are responsible for several neurologic disorders. Mutations of the chromatin remodeling protein Lsh/HELLS can cause the human Immunodeficiency, Centromere instability and Facial ano...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00804-6
更新日期:2017-04-25 00:00:00
abstract::In this work, we analysed processive sliding and breakage of actin filaments at various heavy meromyosin (HMM) densities and ATP concentrations in IVMA. We observed that with addition of ATP solution, the actin filaments fragmented stochastically; we then determined mean length and velocity of surviving actin filament...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32043
更新日期:2016-08-24 00:00:00
abstract::The neurology of male sexuality has been poorly studied owing to difficulties in studying brain circuitry in humans. Dopamine (DA) is essential for both physiological and behavioural responses, including the regulation of sexuality. Previous studies have revealed that alterations in DA synthesis in dopaminergic neuron...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44595
更新日期:2017-03-15 00:00:00
abstract::We consider synchronization properties of arrays of spin-torque nano-oscillators coupled via an RC load. We show that while the fully synchronized state of identical oscillators may be locally stable in some parameter range, this synchrony is not globally attracting. Instead, regimes of different levels of composition...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04918-9
更新日期:2017-07-05 00:00:00
abstract::Transistor biosensors are mass-fabrication-compatible devices of interest for point of care diagnosis as well as molecular interaction studies. While the actual transistor gates in processors reach the sub-10 nm range for optimum integration and power consumption, studies on design rules for the signal-to-noise ratio ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69493-y
更新日期:2020-07-29 00:00:00
abstract::High throughput sequencing techniques are poorly adapted for in vivo studies of parasites, which require prior in vitro culturing and purification. Trypanosomatids, a group of kinetoplastid protozoans, possess a distinctive feature in their transcriptional mechanism whereby a specific Spliced Leader (SL) sequence is a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03987-0
更新日期:2017-06-16 00:00:00
abstract::The band structures of dilute-As AlNAs alloys with As composition ranging from 0% up to 12.5% are studied by using First-Principle Density Functional Theory (DFT) calculation. The energy band gap shows remarkable reduction from 6.19 eV to 3.87 eV with small amount of As content in the AlNAs alloy, which covers the dee...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22215
更新日期:2016-02-24 00:00:00
abstract::Hippocampal volumes are smaller in psychiatric disorder patients and lower levels of hippocampal neurogenesis are the hypothesized cause. Understanding which molecular processes regulate hippocampal progenitor differentiation might aid in the identification of novel drug targets that can promote larger hippocampal vol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15042-z
更新日期:2017-11-08 00:00:00
abstract::Antibody humanization is a key step in the preclinical phase of the development of therapeutic antibodies, originally developed and tested in non-human models (most typically, in mouse). The standard technique of Complementarity-Determining Regions (CDR) grafting into human Framework Regions of germline sequences has ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32986-y
更新日期:2018-10-04 00:00:00
abstract::Human risk-taking attitudes can be influenced by two logically equivalent but descriptively different frames, termed the framing effect. The classic hypothetical vignette-based task (Asian disease problem) and a recently developed reward-based gambling task have been widely used to assess individual differences in the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30071
更新日期:2016-07-20 00:00:00
abstract::Ecosystem functions are regulated by compositional and functional traits of bacterial communities, shaped by stochastic and deterministic processes. Biogeographical studies have revealed microbial community taxonomy in a given ecosystem to change alongside varying environmental characteristics. Considering that stable...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40315-0
更新日期:2019-03-06 00:00:00
abstract::Methane concentration in caves is commonly much lower than the external atmosphere, yet the cave CH4 depletion causal mechanism is contested and dynamic links to external diurnal and seasonal temperature cycles unknown. Here, we report a continuous 3-year record of cave methane and other trace gases in Jenolan Caves, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07769-6
更新日期:2017-08-16 00:00:00
abstract::Many freshwater and coastal marine ecosystems across the world may have undergone an ecosystem regime change due to a combination of rising anthropogenic disturbances and regional climate change. Such a change in aquatic ecosystems is commonly seen as shifts in algal species. But considerably less detail is known abou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07265
更新日期:2014-12-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-71638-y
更新日期:2020-09-09 00:00:00
abstract::Cancer patients often use dietary supplements while on therapy, but little is known about interactions of supplements with cancer chemotherapy. Black raspberries (BRB) have anti-cancer effects, but have not been evaluated for interference with chemotherapy for castrate-resistant prostate cancer (CRPC). Here we studied...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39589-1
更新日期:2019-03-13 00:00:00
abstract::Natural killer (NK) cells are essential for immunosurveillance against transformed cells. Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channel gated by ADP-ribose (ADPR). However, the role of TRPM2-mediated Ca(2+) signaling in the antitumor response of NK cells has not been explored. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09482
更新日期:2015-03-25 00:00:00
abstract::Although previous findings identified an association between C-reactive protein (CRP) levels, and impaired cognitive functions in patients with schizophrenia (SZ), little is currently known about the relationship between inflammation, cognition, and sex in SZ. The current study aimed to explore the association between...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73043-x
更新日期:2020-09-29 00:00:00
abstract::Mortality of glioblastoma multiforme (GBM) has not improved over the last two decades despite medical breakthroughs in the treatment of other types of cancers. Nanoparticles hold tremendous promise to overcome the pharmacokinetic challenges and off-target adverse effects. However, an inhibitory effect of nanoparticles...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59146-5
更新日期:2020-02-11 00:00:00