Co-delivery of paclitaxel and cetuximab by nanodiamond enhances mitotic catastrophe and tumor inhibition.

abstract：:Many efforts have been made in the last 30 years to develop more relevant in vitro models to study genotoxic responses of drugs and environmental contaminants. While 2D HepaRG cells are one of the most promising models for liver toxicology, a switch to 3D cultures that integrate both in vivo architecture and cell-cell...

journal_title：Scientific reports

authors： Mandon M,Huet S,Dubreil E,Fessard V,Le Hégarat L

更新日期：2019-07-22 00:00:00

abstract：:The purpose of this study was to analyze spatiotemporal parameters of gait in children using varyingly loaded Backpacks(BP). This cross-sectional study examined 231 schoolchildren (118 boys, 113 girls) aged six to 12 years, carrying a traditional BP to manipulate loading (Crossing Backpack Children Arpenaz 7 Litres, J...

journal_title：Scientific reports

authors： Paez-Moguer J,Montes-Alguacil J,Garcia-Paya I,Medina-Alcantara M,Evans AM,Gijon-Nogueron G

更新日期：2019-08-21 00:00:00

abstract：:Common reference values of arterial stiffness indices could be effective screening tool in detecting vascular phenotypes at risk. However, populations of the same ethnicity may differ in vascular phenotype due to different environmental pressure. We examined applicability of normative equations for central augmentatio...

journal_title：Scientific reports

authors： Jeroncic A,Gunjaca G,Mrsic DB,Mudnic I,Brizic I,Polasek O,Boban M

更新日期：2016-05-27 00:00:00

abstract：:All species face the important adaptive problem of efficiently locating high-quality nutritional resources. We explored whether human spatial cognition is enhanced for high-calorie foods, in a large multisensory experiment that covertly tested the location memory of people who navigated a maze-like food setting. We fo...

journal_title：Scientific reports

authors： de Vries R,Morquecho-Campos P,de Vet E,de Rijk M,Postma E,de Graaf K,Engel B,Boesveldt S

更新日期：2020-10-08 00:00:00

abstract：:In the present study, we tested whether the volatile metabolome was altered by mutations of the Alzheimer's disease (AD)-implicated amyloid precursor protein gene (APP) and comprehensively examined urinary volatiles that may potentially serve as candidate biomarkers of AD. Establishing additional biomarkers in screeni...

journal_title：Scientific reports

authors： Kimball BA,Wilson DA,Wesson DW

更新日期：2016-01-14 00:00:00

abstract：:We provide a unified and exact framework for the variance-based uncertainty relations. This unified framework not only recovers some well-known previous uncertainty relations, but also fixes the deficiencies of them. Utilizing the unified framework, we can construct the new uncertainty relations in both product and su...

journal_title：Scientific reports

authors： Zheng X,Ma SQ,Zhang GF,Fan H,Liu WM

更新日期：2020-01-10 00:00:00

abstract：:Prenatal ethanol exposure (PEE) is an established risk factor for intrauterine growth retardation. The present study was designed to determine whether PEE can increase the susceptibility of high-fat diet (HFD)-induced metabolic syndrome (MS) in adult offspring in a sex-specific manner, based on a generalized linear mo...

journal_title：Scientific reports

authors： He Z,Li J,Luo H,Zhang L,Ma L,Chen L,Wang H

更新日期：2015-12-03 00:00:00

abstract：:Small amphipods (Halice sp. MT-2017) with body length <1 cm were collected from the Challenger Deep (~10,920 m below sea level). The divergence time of their lineage was approximately 109 Mya, making this group ancient compared to others under study. The mitochondrial genome of Halice sp. shared the usual gene compone...

journal_title：Scientific reports

authors： Li JY,Zeng C,Yan GY,He LS

更新日期：2019-02-22 00:00:00

abstract：:A main controversy in cancer research is whether metastatic abilities are present in the most advanced clone of the primary tumor or result from independently acquired aberrations in early disseminated cancer cells as suggested by the linear and the parallel progression models, respectively. The genetic concordance be...

journal_title：Scientific reports

authors： Krøigård AB,Larsen MJ,Brasch-Andersen C,Lænkholm AV,Knoop AS,Jensen JD,Bak M,Mollenhauer J,Thomassen M,Kruse TA

更新日期：2017-03-09 00:00:00

abstract：:Understanding cancer-prone environments is important to efficiently detect and prevent cancers. The associations between miRNA and cancer-prone environments are still largely unknown in gastric cancer (GC). Six miRNAs that are differentially expressed during gastric carcinogenesis were selected, and quantitative real-...

journal_title：Scientific reports

authors： Kim B,Jang J,Heo YJ,Kang SY,Yoo H,Sohn I,Min BH,Kim KM

更新日期：2020-04-20 00:00:00

abstract：:Real-time quantitative polymerase chain reaction (qPCR) data are found to display periodic patterns in the fluorescence intensity as a function of sample number for fixed cycle number. This behavior is seen for technical replicate datasets recorded on several different commercial instruments; it occurs in the baseline...

journal_title：Scientific reports

authors： Spiess AN,Rödiger S,Burdukiewicz M,Volksdorf T,Tellinghuisen J

更新日期：2016-12-13 00:00:00

abstract：:This study examined the performance and photo-bias stability of double-channel ZnSnO/InZnO (ZTO/IZO) thin-film transistors. The field-effect mobility (μFE) and photo-bias stability of the double-channel device were improved by increasing the thickness of the front IZO film (t(int)) compared to the single-ZTO-channel d...

journal_title：Scientific reports

authors： Jung HY,Kang Y,Hwang AY,Lee CK,Han S,Kim DH,Bae JU,Shin WS,Jeong JK

更新日期：2014-01-20 00:00:00

abstract：:N-acetyltransferase 2 (NAT2) acetylator status can be classified into three groups depending on the number of rapid alleles (e.g., NAT2*4): rapid, intermediate, and slow acetylators. Such acetylator status may influence the occurrence of adverse drug reactions (ADRs) during sulfasalazine treatment. This systematic rev...

journal_title：Scientific reports

authors： Yee J,Kim SM,Han JM,Lee N,Yoon HY,Gwak HS

更新日期：2020-02-27 00:00:00

abstract：:The family Trichomycteridae is one of the most diverse groups of freshwater catfishes in South and Central America with eight subfamilies, 41 genera and more than 300 valid species. Its members are widely distributed throughout South America, reaching Costa Rica in Central America and are recognized by extraordinary a...

journal_title：Scientific reports

authors： Ochoa LE,Datovo A,DoNascimiento C,Roxo FF,Sabaj MH,Chang J,Melo BF,Silva GSC,Foresti F,Alfaro M,Oliveira C

更新日期：2020-02-14 00:00:00

abstract：:Mechanistic disease progression studies using animal models require objective and quantifiable assessment of tissue pathology. Currently quantification relies heavily on staining methods which can be expensive, labor/time-intensive, inconsistent across laboratories and batch, and produce uneven staining that is prone ...

journal_title：Scientific reports

authors： Ternes L,Huang G,Lanciault C,Thibault G,Riggers R,Gray JW,Muschler J,Chang YH

更新日期：2020-12-01 00:00:00

abstract：:A detailed molecular understanding of botulinum neurotoxin (BoNT)/host-cell-receptor interactions is fundamental both for developing strategies against botulism and for generating improved BoNT variants for medical applications. The X-ray crystal structure of the receptor-binding domain (HC) of BoNT/A1 in complex with...

journal_title：Scientific reports

authors： Benoit RM,Schärer MA,Wieser MM,Li X,Frey D,Kammerer RA

更新日期：2017-03-02 00:00:00

abstract：:We present the design and performance characterization of a Faraday laser directly lasing on the Rb 1529 nm transition (Rb, 5P 3/2 - 4D 5/2) with high stability, narrow spectral linewidth and low cost. This system does not need an additional frequency-stabilized pump laser as a prerequisite to preparing Rb atom from 5...

journal_title：Scientific reports

authors： Chang P,Peng H,Zhang S,Chen Z,Luo B,Chen J,Guo H

更新日期：2017-08-21 00:00:00

abstract：:We aimed to investigate the diagnostic accuracy of contrast-enhanced ultrasound (CEUS) in evaluating blunt abdominal trauma for patients presenting to the emergency department. Electronic search of Scopus and Pubmed was performed from inception to September 2016. Human studies investigating the diagnostic accuracy of ...

journal_title：Scientific reports

authors： Zhang Z,Hong Y,Liu N,Chen Y

更新日期：2017-06-30 00:00:00

abstract：:There are a number of psychological phenomena in which dramatic emotional responses are evoked by seemingly innocuous perceptual stimuli. A well known example is the 'uncanny valley' effect whereby a near human-looking artifact can trigger feelings of eeriness and repulsion. Although such phenomena are reasonably well...

journal_title：Scientific reports

authors： Moore RK

更新日期：2012-01-01 00:00:00

abstract：:Shape memory alloys are typical temperature-sensitive metallic functional materials due to superelasticity and shape recovery characteristics. The conventional shape memory effect involves the formation and deformation of thermally induced martensite and its reverse transformation. The shape recovery process usually t...

journal_title：Scientific reports

authors： Yang S,Omori T,Wang C,Liu Y,Nagasako M,Ruan J,Kainuma R,Ishida K,Liu X

更新日期：2016-02-16 00:00:00

abstract：:Information concerning the pathogenic role of honey bee viruses in invasive species are still scarce. The aim of this investigation was to assess the presence of several honey bee viruses, such as Black Queen Cell Virus (BQCV), Kashmir Bee Virus (KBV), Slow Paralysis Virus (SPV), Sac Brood Virus (SBV), Israeli Acute P...

journal_title：Scientific reports

authors： Mazzei M,Cilia G,Forzan M,Lavazza A,Mutinelli F,Felicioli A

更新日期：2019-07-12 00:00:00

abstract：:Influenza's propensity for antigenic drift and shift, and to elicit predominantly strain specific antibodies (Abs) leaves humanity susceptible to waves of new strains with pandemic potential for which limited or no immunity may exist. Subsequently new clinical interventions are needed. To identify hemagglutinin (HA) e...

journal_title：Scientific reports

authors： Nogales A,Piepenbrink MS,Wang J,Ortega S,Basu M,Fucile CF,Treanor JJ,Rosenberg AF,Zand MS,Keefer MC,Martinez-Sobrido L,Kobie JJ

更新日期：2018-03-12 00:00:00

abstract：:Adenosine receptors (ARs) are potential therapeutic targets for Parkinson's disease, diabetes, pain, stroke and cancers. Prediction of subtype selectivity is therefore important from both therapeutic and mechanistic perspectives. In this paper, we introduced a shape similarity profile as molecular descriptor, namely t...

journal_title：Scientific reports

authors： He SB,Ben Hu,Kuang ZK,Wang D,Kong DX

更新日期：2016-11-04 00:00:00

abstract：:Pilonidal sinus disease (PSD) is increasing globally. A recent meta-analysis and merged-data analysis showed that recurrence rates in PSD depend essentially on follow-up time and specific surgical procedures. However, the global distribution of surgical approaches and respective recurrence rates have never been studie...

journal_title：Scientific reports

authors： Doll D,Orlik A,Maier K,Kauf P,Schmid M,Diekmann M,Vogt AP,Stauffer VK,Luedi MM

更新日期：2019-10-22 00:00:00

abstract：:The present study reports the use of one-dimensional carbon wrapped VO2(M) nanofiber (VO2(M)/C) as a cost-effective counter electrode for dye-sensitized solar cells (DSSCs); where M denotes monoclinic crystal system. Uniform short length nanofiber was synthesised by a sol-gel based simple and versatile electrospinning...

journal_title：Scientific reports

authors： Gnanasekar S,Kollu P,Jeong SK,Grace AN

更新日期：2019-03-26 00:00:00

abstract：:Leukotriene E4 (LTE4) the most stable of the cysteinyl leukotrienes (cysLTs) binds poorly to classical type 1 (CysLT1) and 2 (CysLT2) receptors although it induces potent responses in human airways in vivo, such as bronchoconstriction, airway hyperresponsiveness and inflammatory cell influx suggesting the presence of ...

journal_title：Scientific reports

authors： Foster HR,Fuerst E,Branchett W,Lee TH,Cousins DJ,Woszczek G

更新日期：2016-02-02 00:00:00

abstract：:The high manufacturing cost for metallic glasses hampers actual commercial applications of this class of fascinating materials. In this letter, the effect of oxygen impurity on the glass forming ability and tensile properties of Zr-BMG composites were studied. Our results have demonstrated that oxygen was absorbed and...

journal_title：Scientific reports

authors： Cheng JL,Chen G,Liu CT,Li Y

更新日期：2013-01-01 00:00:00

abstract：:Circuit QED on a chip has become a powerful platform for simulating complex many-body physics. In this report, we realize a Dicke-Ising model with an antiferromagnetic nearest-neighbor spin-spin interaction in circuit QED with a superconducting qubit array. We show that this system exhibits a competition between the c...

journal_title：Scientific reports

authors： Zhang Y,Yu L,Liang JQ,Chen G,Jia S,Nori F

更新日期：2014-02-13 00:00:00

abstract：:A fast Endospore Germinability Assay (EGA) was validated with traditional plate counts to enumerate single endospore germination events for monitoring surface sterilization. The assay is based on a time-gated luminescence microscopy technique enabling visualization and enumeration of individual germinating endospores....

journal_title：Scientific reports

authors： Yung PT,Lester E,Ponce A

更新日期：2020-01-16 00:00:00

abstract：:Despite the detailed characterization of the inflammatory and endothelial changes observed in Sickle Cell Disease (SCD), the hierarchical relationship between elements involved in the pathogenesis of this complex disease is yet to be described. Meta-analyses of gene expression studies from public repositories represen...

journal_title：Scientific reports

authors： Hounkpe BW,Fiusa MM,Colella MP,da Costa LN,Benatti Rde O,Saad ST,Costa FF,dos Santos MN,De Paula EV

更新日期：2015-12-09 00:00:00