Noise suppression beyond the thermal limit with nanotransistor biosensors.

Abstract:

:Transistor biosensors are mass-fabrication-compatible devices of interest for point of care diagnosis as well as molecular interaction studies. While the actual transistor gates in processors reach the sub-10 nm range for optimum integration and power consumption, studies on design rules for the signal-to-noise ratio (S/N) optimization in transistor-based biosensors have been so far restricted to 1 µm2 device gate area, a range where the discrete nature of the defects can be neglected. In this study, which combines experiments and theoretical analysis at both numerical and analytical levels, we extend such investigation to the nanometer range and highlight the effect of doping type as well as the noise suppression opportunities offered at this scale. In particular, we show that, when a single trap is active near the conductive channel, the noise can be suppressed even beyond the thermal limit by monitoring the trap occupancy probability in an approach analog to the stochastic resonance effect used in biological systems.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Kutovyi Y,Madrid I,Zadorozhnyi I,Boichuk N,Kim SH,Fujii T,Jalabert L,Offenhaeusser A,Vitusevich S,Clément N

doi

10.1038/s41598-020-69493-y

subject

Has Abstract

pub_date

2020-07-29 00:00:00

pages

12678

issue

1

issn

2045-2322

pii

10.1038/s41598-020-69493-y

journal_volume

10

pub_type

杂志文章
  • Relationship between serum cortisol level and degree of false lumen thrombosis in patients with uncomplicated type B aortic dissection.

    abstract::Partial thrombosis of the false lumen in uncomplicated type B aortic dissection (uTBAD) is associated with an increased late mortality risk. Whether the serum cortisol level can affect false lumen thrombosis in patients with uTBAD has not been well characterized. This study was performed on 87 patients with uTBAD. A c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-19691-6

    authors: Wu Y,Sun Y,Wei X,Zhang L,Han T,Zhao Z,Zhou J,Jing Z

    更新日期:2018-01-19 00:00:00

  • Density-gradient centrifugation enables the purification of cultured corneal endothelial cells for cell therapy by eliminating senescent cells.

    abstract::The corneal endothelium is essential for maintaining corneal transparency; therefore, corneal endothelial dysfunction causes serious vision loss. Tissue engineering-based therapy is potentially a less invasive and more effective therapeutic modality. We recently started a first-in-man clinical trial of cell-based ther...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15005

    authors: Okumura N,Kusakabe A,Hirano H,Inoue R,Okazaki Y,Nakano S,Kinoshita S,Koizumi N

    更新日期:2015-10-07 00:00:00

  • An ecological method to understand agricultural standardization in peach orchard ecosystems.

    abstract::While the worldwide standardization of agricultural production has been advocated and recommended, relatively little research has focused on the ecological significance of such a shift. The ecological concerns stemming from the standardization of agricultural production may require new methodology. In this study, we c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep21675

    authors: Wan NF,Zhang MY,Jiang JX,Ji XY,Hao-Zhang

    更新日期:2016-02-22 00:00:00

  • GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation.

    abstract::Glucagon-like peptide-1 (GLP-1) promotes insulin secretion from pancreatic β-cells in a glucose dependent manner. Several pathways mediate this action by rapid, kinase phosphorylation-dependent, but gene expression-independent mechanisms. Since GLP-1-induced insulin secretion requires glucose metabolism, we aimed to a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-02838-2

    authors: Carlessi R,Chen Y,Rowlands J,Cruzat VF,Keane KN,Egan L,Mamotte C,Stokes R,Gunton JE,Bittencourt PIH,Newsholme P

    更新日期:2017-06-01 00:00:00

  • Conformation-dependent binding of a Tetrastatin peptide to αvβ3 integrin decreases melanoma progression through FAK/PI3K/Akt pathway inhibition.

    abstract::Tetrastatin, a 230 amino acid sequence from collagen IV, was previously demonstrated to inhibit melanoma progression. In the present paper, we identified the minimal active sequence (QKISRCQVCVKYS: QS-13) that reproduced the anti-tumor effects of whole Tetrastatin in vivo and in vitro on melanoma cell proliferation, m...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-28003-x

    authors: Lambert E,Fuselier E,Ramont L,Brassart B,Dukic S,Oudart JB,Dupont-Deshorgue A,Sellier C,Machado C,Dauchez M,Monboisse JC,Maquart FX,Baud S,Brassart-Pasco S

    更新日期:2018-06-29 00:00:00

  • Regulation of trehalase activity by multi-site phosphorylation and 14-3-3 interaction.

    abstract::Protein phosphorylation enables a rapid adjustment of cellular activities to diverse intracellular and environmental stimuli. Many phosphoproteins are targeted on more than one site, which allows the integration of multiple signals and the implementation of complex responses. However, the hierarchy and interplay betwe...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-80357-3

    authors: Dengler L,Örd M,Schwab LM,Loog M,Ewald JC

    更新日期:2021-01-13 00:00:00

  • Soil pH is equally important as salinity in shaping bacterial communities in saline soils under halophytic vegetation.

    abstract::While saline soils account for 6.5% of the total land area globally, it comprises about 70% of the area in northwestern China. Microbiota in these saline soils are particularly important because they are critical to maintaining ecosystem services. However, little is known about the microbial diversity and community co...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-22788-7

    authors: Zhao S,Liu JJ,Banerjee S,Zhou N,Zhao ZY,Zhang K,Tian CY

    更新日期:2018-03-14 00:00:00

  • Dynamic impact of temporal context of Ca²⁺ signals on inhibitory synaptic plasticity.

    abstract::Neuronal activity-dependent synaptic plasticity, a basis for learning and memory, is tightly correlated with the pattern of increase in intracellular Ca(2+) concentration ([Ca(2+)](i)). Here, using combined application of electrophysiological experiments and systems biological simulation, we show that such a correlati...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep00143

    authors: Kawaguchi SY,Nagasaki N,Hirano T

    更新日期:2011-01-01 00:00:00

  • Neutral poly-/perfluoroalkyl substances in air and snow from the Arctic.

    abstract::Levels of neutral poly-/perfluoroalkyl substances (nPFASs) in air and snow collected from Ny-Ålesund were measured and their air-snow exchange was determined to investigate whether they could re-volatilize into the atmosphere driven by means of air-snow exchange. The total concentration of 12 neutral PFASs ranged from...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep08912

    authors: Xie Z,Wang Z,Mi W,Möller A,Wolschke H,Ebinghaus R

    更新日期:2015-03-09 00:00:00

  • The influence of population stratification on genetic markers associated with type 1 diabetes.

    abstract::Ethnic admixtures may interfere with the definition of type 1 diabetes (T1D) risk determinants. The role of HLA, PTPN22, INS-VNTR, and CTLA4 in T1D predisposition was analyzed in Brazilian T1D patients (n = 915), with 81.7% self-reporting as white and 789 controls (65.6% white). The results were corrected for populati...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep43513

    authors: Gomes KF,Santos AS,Semzezem C,Correia MR,Brito LA,Ruiz MO,Fukui RT,Matioli SR,Passos-Bueno MR,Silva ME

    更新日期:2017-03-06 00:00:00

  • Change of the relative line strengths due to the resonance induced population transfer between Fe XVII and FeXVI ions.

    abstract::We present a detailed study to resolve the discrepancy between the existing theoretically estimated oscillator strengths and the recently observed result from the X-ray free electron laser (XFEL) experiment performed at the Linac Coherent Light Source (LCLS) for the intensity ratio between two of the strongest emissio...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43916-x

    authors: Wu C,Gao X

    更新日期:2019-05-16 00:00:00

  • Visualising recalcitrance by colocalisation of cellulase, lignin and cellulose in pretreated pine biomass using fluorescence microscopy.

    abstract::Mapping the location of bound cellulase enzymes provides information on the micro-scale distribution of amenable and recalcitrant sites in pretreated woody biomass for biofuel applications. The interaction of a fluorescently labelled cellulase enzyme cocktail with steam-exploded pine (SEW) was quantified using confoca...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep44386

    authors: Donaldson L,Vaidya A

    更新日期:2017-03-10 00:00:00

  • Discovering neutralizing antibodies targeting the stem epitope of H1N1 influenza hemagglutinin with synthetic phage-displayed antibody libraries.

    abstract::Broadly neutralizing antibodies developed from the IGHV1-69 germline gene are known to bind to the stem region of hemagglutinin in diverse influenza viruses but the sequence determinants for the antigen recognition, including neutralization potency and binding affinity, are not clearly understood. Such understanding c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15053

    authors: Tung CP,Chen IC,Yu CM,Peng HP,Jian JW,Ma SH,Lee YC,Jan JT,Yang AS

    更新日期:2015-10-12 00:00:00

  • Publisher Correction: Antimicrobial spray nanocoating of supramolecular Fe(III)-tannic acid metal-organic coordination complex: applications to shoe insoles and fruits.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-018-37133-1

    authors: Park JH,Choi S,Moon HC,Seo H,Kim JY,Hong SP,Lee BS,Kang E,Lee J,Ryu DH,Choi IS

    更新日期:2018-12-14 00:00:00

  • Magnetic properties of ball-milled SrFe12O19 particles consolidated by Spark-Plasma Sintering.

    abstract::The room-temperature magnetic properties of ball-milled strontium hexaferrite particles consolidated by spark-plasma sintering are strongly influenced by the milling time. Scanning electron microscopy revealed the ball-milled SrFe12O19 particles to have sizes varying over several hundred nanometers. X-Ray powder-diffr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep14112

    authors: Stingaciu M,Topole M,McGuiness P,Christensen M

    更新日期:2015-09-15 00:00:00

  • Carvacrol and linalool co-loaded in β-cyclodextrin-grafted chitosan nanoparticles as sustainable biopesticide aiming pest control.

    abstract::Pesticides are the main tactics for pest control because they reduce the pest population very fast and their efficiency does not depend on abiotic factors. However, the indiscriminate use of these substances can speed up the development of resistant populations and causing environmental contamination. Therefore, alter...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-26043-x

    authors: Campos EVR,Proença PLF,Oliveira JL,Pereira AES,de Morais Ribeiro LN,Fernandes FO,Gonçalves KC,Polanczyk RA,Pasquoto-Stigliani T,Lima R,Melville CC,Della Vechia JF,Andrade DJ,Fraceto LF

    更新日期:2018-05-16 00:00:00

  • Spin-polarised electrons in a one-magnet-only Mott spin junction.

    abstract::The current flowing through a Mott spin junction depends on the relative spin orientation of the two ferromagnetic layers comprising the "source" and "drain" sides of the junction. The resulting current asymmetry is detected as giant or tunnelling magnetoresistance depending on whether the two ferromagnets are separat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13453-6

    authors: De Pietro L,Bertolini G,Peter Q,Cabrera H,Vindigni A,Gürlü O,Pescia D,Ramsperger U

    更新日期:2017-10-16 00:00:00

  • Enhancing the throughput and multiplexing capabilities of next generation sequencing for efficient implementation of pooled shRNA and CRISPR screens.

    abstract::Next generation sequencing is becoming the method of choice for functional genomic studies that use pooled shRNA or CRISPR libraries. A key challenge in sequencing these mixed-oligo libraries is that they are highly susceptible to hairpin and/or heteroduplex formation. This results in polyclonal, low quality, and inco...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01170-z

    authors: Islam MF,Watanabe A,Wong L,Lazarou C,Vizeacoumar FS,Abuhussein O,Hill W,Uppalapati M,Geyer CR,Vizeacoumar FJ

    更新日期:2017-04-21 00:00:00

  • Meta-genomic analysis of toilet waste from long distance flights; a step towards global surveillance of infectious diseases and antimicrobial resistance.

    abstract::Human populations worldwide are increasingly confronted with infectious diseases and antimicrobial resistance spreading faster and appearing more frequently. Knowledge regarding their occurrence and worldwide transmission is important to control outbreaks and prevent epidemics. Here, we performed shotgun sequencing of...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep11444

    authors: Nordahl Petersen T,Rasmussen S,Hasman H,Carøe C,Bælum J,Schultz AC,Bergmark L,Svendsen CA,Lund O,Sicheritz-Pontén T,Aarestrup FM

    更新日期:2015-07-10 00:00:00

  • Hybrid Modelling of Transarterial Chemoembolisation Therapies (TACE) for Hepatocellular Carcinoma (HCC).

    abstract::We extend an agent-based multiscale model of vascular tumour growth and angiogenesis to describe transarterial chemoembolisation (TACE) therapies. The model accounts for tumour and normal cells that are both nested in a vascular system that changes its structure according to tumour-related growth factors. Oxygen promo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65012-1

    authors: Perfahl H,Jain HV,Joshi T,Horger M,Malek N,Bitzer M,Reuss M

    更新日期:2020-06-29 00:00:00

  • Antimicrobial peptides from Rana [Lithobates] catesbeiana: Gene structure and bioinformatic identification of novel forms from tadpoles.

    abstract::Antimicrobial peptides (AMPs) exhibit broad-spectrum antimicrobial activity, and have promise as new therapeutic agents. While the adult North American bullfrog (Rana [Lithobates] catesbeiana) is a prolific source of high-potency AMPs, the aquatic tadpole represents a relatively untapped source for new AMP discovery. ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-38442-1

    authors: Helbing CC,Hammond SA,Jackman SH,Houston S,Warren RL,Cameron CE,Birol I

    更新日期:2019-02-06 00:00:00

  • Biomechanical properties of predator-induced body armour in the freshwater crustacean Daphnia.

    abstract::The freshwater crustacean Daphnia is known for its ability to develop inducible morphological defences that thwart predators. These defences are developed only in the presence of predators and are realized as morphological shape alterations e.g. 'neckteeth' in D. pulex and 'crests' in D. longicephala. Both are discuss...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-09649-5

    authors: Kruppert S,Horstmann M,Weiss LC,Witzel U,Schaber CF,Gorb SN,Tollrian R

    更新日期:2017-08-29 00:00:00

  • Designing novel bulk metallic glass composites with a high aluminum content.

    abstract::The long-standing challenge for forming Al-based BMGs and their matrix composites with a critical size larger than 1 mm have not been answered over the past three decades. In this paper, we reported formation of a series of BMG matrix composites which contain a high Al content up to 55 at.%. These composites can be ca...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep03353

    authors: Chen ZP,Gao JE,Wu Y,Wang H,Liu XJ,Lu ZP

    更新日期:2013-11-27 00:00:00

  • Mechanism of Paroxetine (Paxil) Inhibition of the Serotonin Transporter.

    abstract::The serotonin transporter (SERT) is an integral membrane protein that exploits preexisting sodium-, chloride-, and potassium ion gradients to catalyze the thermodynamically unfavorable movement of synaptic serotonin into the presynaptic neuron. SERT has garnered significant clinical attention partly because it is the ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep23789

    authors: Davis BA,Nagarajan A,Forrest LR,Singh SK

    更新日期:2016-04-01 00:00:00

  • Online quantitative partial discharge monitor based on interferometry.

    abstract::Interferometry-based online partial discharge (PD) monitor presented in this paper can detect the occurrence of PD sensitively, evaluate the peak value of the discharge inception voltage with random waveform and the damage extent relatively cost effectively. The interferograms affected by the PD are collected online. ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76134-x

    authors: Xue L,Zhu Y,Yang C,Kumarawadu S

    更新日期:2020-11-04 00:00:00

  • No evidence for spectral jamming avoidance in echolocation behavior of foraging pipistrelle bats.

    abstract::Frequency shifts in signals of bats flying near conspecifics have been interpreted as a spectral jamming avoidance response (JAR). However, several prerequisites supporting a JAR hypothesis have not been controlled for in previous studies. We recorded flight and echolocation behavior of foraging Pipistrellus pipistrel...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30978

    authors: Götze S,Koblitz JC,Denzinger A,Schnitzler HU

    更新日期:2016-08-09 00:00:00

  • Linear magnetoresistance in n-type silicon due to doping density fluctuations.

    abstract::We report the observation of a large linear magnetoresistance in the ohmic regime in commonplace commercial n-type silicon wafer with a P dopant density of (1.4±0.1) ×10(15) cm(-3), and report measurements of it in the temperature range 30-200 K. It arises from the deformation of current paths, which causes a part of ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep00565

    authors: Porter NA,Marrows CH

    更新日期:2012-01-01 00:00:00

  • Leakage of astrocyte-derived extracellular vesicles in stress-induced exhaustion disorder: a cross-sectional study.

    abstract::Patients with stress-induced exhaustion disorder (SED) demonstrate cognitive dysfunction similar to patients with minor traumatic brain injury (TBI). We have previously detected elevated concentrations of astrocyte-derived extracellular vesicles (EVs) in patients with TBI. As such, we hypothesized that astrocyte-deriv...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-81453-8

    authors: Wallensten J,Nager A,Åsberg M,Borg K,Beser A,Wilczek A,Mobarrez F

    更新日期:2021-01-21 00:00:00

  • Computational design of host transcription-factors sets whose misregulation mimics the transcriptomic effect of viral infections.

    abstract::The molecular mechanisms underlying viral pathogenesis are yet poorly understood owed to the large number of factors involved and the complexity of their interactions. Could we identify a minimal set of host transcription factors (TF) whose misregulation would result in the transcriptional profile characteristic of in...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep01006

    authors: Carrera J,Elena SF

    更新日期:2012-01-01 00:00:00

  • A DNA methylation signature discriminates between excellent and non-response to lithium in patients with bipolar disorder type 1.

    abstract::Lithium (Li) is the cornerstone maintenance treatment for bipolar disorders (BD), but response rates are highly variable. To date, no clinical or biological marker is available to reliably define eligibility criteria for a maintenance treatment with Li. We examined whether the prophylactic response to Li (assessed ret...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69073-0

    authors: Marie-Claire C,Lejeune FX,Mundwiller E,Ulveling D,Moszer I,Bellivier F,Etain B

    更新日期:2020-07-22 00:00:00