Abstract:
:Transistor biosensors are mass-fabrication-compatible devices of interest for point of care diagnosis as well as molecular interaction studies. While the actual transistor gates in processors reach the sub-10 nm range for optimum integration and power consumption, studies on design rules for the signal-to-noise ratio (S/N) optimization in transistor-based biosensors have been so far restricted to 1 µm2 device gate area, a range where the discrete nature of the defects can be neglected. In this study, which combines experiments and theoretical analysis at both numerical and analytical levels, we extend such investigation to the nanometer range and highlight the effect of doping type as well as the noise suppression opportunities offered at this scale. In particular, we show that, when a single trap is active near the conductive channel, the noise can be suppressed even beyond the thermal limit by monitoring the trap occupancy probability in an approach analog to the stochastic resonance effect used in biological systems.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kutovyi Y,Madrid I,Zadorozhnyi I,Boichuk N,Kim SH,Fujii T,Jalabert L,Offenhaeusser A,Vitusevich S,Clément Ndoi
10.1038/s41598-020-69493-ysubject
Has Abstractpub_date
2020-07-29 00:00:00pages
12678issue
1issn
2045-2322pii
10.1038/s41598-020-69493-yjournal_volume
10pub_type
杂志文章abstract::Partial thrombosis of the false lumen in uncomplicated type B aortic dissection (uTBAD) is associated with an increased late mortality risk. Whether the serum cortisol level can affect false lumen thrombosis in patients with uTBAD has not been well characterized. This study was performed on 87 patients with uTBAD. A c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19691-6
更新日期:2018-01-19 00:00:00
abstract::The corneal endothelium is essential for maintaining corneal transparency; therefore, corneal endothelial dysfunction causes serious vision loss. Tissue engineering-based therapy is potentially a less invasive and more effective therapeutic modality. We recently started a first-in-man clinical trial of cell-based ther...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15005
更新日期:2015-10-07 00:00:00
abstract::While the worldwide standardization of agricultural production has been advocated and recommended, relatively little research has focused on the ecological significance of such a shift. The ecological concerns stemming from the standardization of agricultural production may require new methodology. In this study, we c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21675
更新日期:2016-02-22 00:00:00
abstract::Glucagon-like peptide-1 (GLP-1) promotes insulin secretion from pancreatic β-cells in a glucose dependent manner. Several pathways mediate this action by rapid, kinase phosphorylation-dependent, but gene expression-independent mechanisms. Since GLP-1-induced insulin secretion requires glucose metabolism, we aimed to a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02838-2
更新日期:2017-06-01 00:00:00
abstract::Tetrastatin, a 230 amino acid sequence from collagen IV, was previously demonstrated to inhibit melanoma progression. In the present paper, we identified the minimal active sequence (QKISRCQVCVKYS: QS-13) that reproduced the anti-tumor effects of whole Tetrastatin in vivo and in vitro on melanoma cell proliferation, m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28003-x
更新日期:2018-06-29 00:00:00
abstract::Protein phosphorylation enables a rapid adjustment of cellular activities to diverse intracellular and environmental stimuli. Many phosphoproteins are targeted on more than one site, which allows the integration of multiple signals and the implementation of complex responses. However, the hierarchy and interplay betwe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80357-3
更新日期:2021-01-13 00:00:00
abstract::While saline soils account for 6.5% of the total land area globally, it comprises about 70% of the area in northwestern China. Microbiota in these saline soils are particularly important because they are critical to maintaining ecosystem services. However, little is known about the microbial diversity and community co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22788-7
更新日期:2018-03-14 00:00:00
abstract::Neuronal activity-dependent synaptic plasticity, a basis for learning and memory, is tightly correlated with the pattern of increase in intracellular Ca(2+) concentration ([Ca(2+)](i)). Here, using combined application of electrophysiological experiments and systems biological simulation, we show that such a correlati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00143
更新日期:2011-01-01 00:00:00
abstract::Levels of neutral poly-/perfluoroalkyl substances (nPFASs) in air and snow collected from Ny-Ålesund were measured and their air-snow exchange was determined to investigate whether they could re-volatilize into the atmosphere driven by means of air-snow exchange. The total concentration of 12 neutral PFASs ranged from...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08912
更新日期:2015-03-09 00:00:00
abstract::Ethnic admixtures may interfere with the definition of type 1 diabetes (T1D) risk determinants. The role of HLA, PTPN22, INS-VNTR, and CTLA4 in T1D predisposition was analyzed in Brazilian T1D patients (n = 915), with 81.7% self-reporting as white and 789 controls (65.6% white). The results were corrected for populati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43513
更新日期:2017-03-06 00:00:00
abstract::We present a detailed study to resolve the discrepancy between the existing theoretically estimated oscillator strengths and the recently observed result from the X-ray free electron laser (XFEL) experiment performed at the Linac Coherent Light Source (LCLS) for the intensity ratio between two of the strongest emissio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43916-x
更新日期:2019-05-16 00:00:00
abstract::Mapping the location of bound cellulase enzymes provides information on the micro-scale distribution of amenable and recalcitrant sites in pretreated woody biomass for biofuel applications. The interaction of a fluorescently labelled cellulase enzyme cocktail with steam-exploded pine (SEW) was quantified using confoca...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44386
更新日期:2017-03-10 00:00:00
abstract::Broadly neutralizing antibodies developed from the IGHV1-69 germline gene are known to bind to the stem region of hemagglutinin in diverse influenza viruses but the sequence determinants for the antigen recognition, including neutralization potency and binding affinity, are not clearly understood. Such understanding c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15053
更新日期:2015-10-12 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-37133-1
更新日期:2018-12-14 00:00:00
abstract::The room-temperature magnetic properties of ball-milled strontium hexaferrite particles consolidated by spark-plasma sintering are strongly influenced by the milling time. Scanning electron microscopy revealed the ball-milled SrFe12O19 particles to have sizes varying over several hundred nanometers. X-Ray powder-diffr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14112
更新日期:2015-09-15 00:00:00
abstract::Pesticides are the main tactics for pest control because they reduce the pest population very fast and their efficiency does not depend on abiotic factors. However, the indiscriminate use of these substances can speed up the development of resistant populations and causing environmental contamination. Therefore, alter...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26043-x
更新日期:2018-05-16 00:00:00
abstract::The current flowing through a Mott spin junction depends on the relative spin orientation of the two ferromagnetic layers comprising the "source" and "drain" sides of the junction. The resulting current asymmetry is detected as giant or tunnelling magnetoresistance depending on whether the two ferromagnets are separat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13453-6
更新日期:2017-10-16 00:00:00
abstract::Next generation sequencing is becoming the method of choice for functional genomic studies that use pooled shRNA or CRISPR libraries. A key challenge in sequencing these mixed-oligo libraries is that they are highly susceptible to hairpin and/or heteroduplex formation. This results in polyclonal, low quality, and inco...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01170-z
更新日期:2017-04-21 00:00:00
abstract::Human populations worldwide are increasingly confronted with infectious diseases and antimicrobial resistance spreading faster and appearing more frequently. Knowledge regarding their occurrence and worldwide transmission is important to control outbreaks and prevent epidemics. Here, we performed shotgun sequencing of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11444
更新日期:2015-07-10 00:00:00
abstract::We extend an agent-based multiscale model of vascular tumour growth and angiogenesis to describe transarterial chemoembolisation (TACE) therapies. The model accounts for tumour and normal cells that are both nested in a vascular system that changes its structure according to tumour-related growth factors. Oxygen promo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65012-1
更新日期:2020-06-29 00:00:00
abstract::Antimicrobial peptides (AMPs) exhibit broad-spectrum antimicrobial activity, and have promise as new therapeutic agents. While the adult North American bullfrog (Rana [Lithobates] catesbeiana) is a prolific source of high-potency AMPs, the aquatic tadpole represents a relatively untapped source for new AMP discovery. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38442-1
更新日期:2019-02-06 00:00:00
abstract::The freshwater crustacean Daphnia is known for its ability to develop inducible morphological defences that thwart predators. These defences are developed only in the presence of predators and are realized as morphological shape alterations e.g. 'neckteeth' in D. pulex and 'crests' in D. longicephala. Both are discuss...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09649-5
更新日期:2017-08-29 00:00:00
abstract::The long-standing challenge for forming Al-based BMGs and their matrix composites with a critical size larger than 1 mm have not been answered over the past three decades. In this paper, we reported formation of a series of BMG matrix composites which contain a high Al content up to 55 at.%. These composites can be ca...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03353
更新日期:2013-11-27 00:00:00
abstract::The serotonin transporter (SERT) is an integral membrane protein that exploits preexisting sodium-, chloride-, and potassium ion gradients to catalyze the thermodynamically unfavorable movement of synaptic serotonin into the presynaptic neuron. SERT has garnered significant clinical attention partly because it is the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23789
更新日期:2016-04-01 00:00:00
abstract::Interferometry-based online partial discharge (PD) monitor presented in this paper can detect the occurrence of PD sensitively, evaluate the peak value of the discharge inception voltage with random waveform and the damage extent relatively cost effectively. The interferograms affected by the PD are collected online. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76134-x
更新日期:2020-11-04 00:00:00
abstract::Frequency shifts in signals of bats flying near conspecifics have been interpreted as a spectral jamming avoidance response (JAR). However, several prerequisites supporting a JAR hypothesis have not been controlled for in previous studies. We recorded flight and echolocation behavior of foraging Pipistrellus pipistrel...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30978
更新日期:2016-08-09 00:00:00
abstract::We report the observation of a large linear magnetoresistance in the ohmic regime in commonplace commercial n-type silicon wafer with a P dopant density of (1.4±0.1) ×10(15) cm(-3), and report measurements of it in the temperature range 30-200 K. It arises from the deformation of current paths, which causes a part of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00565
更新日期:2012-01-01 00:00:00
abstract::Patients with stress-induced exhaustion disorder (SED) demonstrate cognitive dysfunction similar to patients with minor traumatic brain injury (TBI). We have previously detected elevated concentrations of astrocyte-derived extracellular vesicles (EVs) in patients with TBI. As such, we hypothesized that astrocyte-deriv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81453-8
更新日期:2021-01-21 00:00:00
abstract::The molecular mechanisms underlying viral pathogenesis are yet poorly understood owed to the large number of factors involved and the complexity of their interactions. Could we identify a minimal set of host transcription factors (TF) whose misregulation would result in the transcriptional profile characteristic of in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01006
更新日期:2012-01-01 00:00:00
abstract::Lithium (Li) is the cornerstone maintenance treatment for bipolar disorders (BD), but response rates are highly variable. To date, no clinical or biological marker is available to reliably define eligibility criteria for a maintenance treatment with Li. We examined whether the prophylactic response to Li (assessed ret...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69073-0
更新日期:2020-07-22 00:00:00