Abstract:
:Cancer patients often use dietary supplements while on therapy, but little is known about interactions of supplements with cancer chemotherapy. Black raspberries (BRB) have anti-cancer effects, but have not been evaluated for interference with chemotherapy for castrate-resistant prostate cancer (CRPC). Here we studied whether BRB and some of their constituents interact with docetaxel and cabazitaxel on CRPC cells in culture and implanted into nude mice. Ellagic acid increased, but BRB extract inhibited, microtubule assembly. Ellagic acid decreased tubulin polymerization by cabazitaxel and bound to tubulin. Ellagic acid, its metabolite urolithin A, BRB extract, and the anthocyanin metabolite protocatechuic acid (PCA) did not alter cytotoxicity of taxanes. Ellagic acid inhibited drug efflux in CRPC cells, but BRB extract and PCA did not. None of these compounds altered CYP3A4 activity. Although dietary ellagic acid did not alter the tumor growth inhibition by docetaxel of xenografted 22Rv1 cells, ellagic acid has the potential to interfere with taxane chemotherapy by reducing tubulin polymerization while inhibiting P-glycoprotein drug efflux. These data are cause for concern of consuming ellagic acid during treatment for CRPC and indicate need for further research, but BRB consumption appears safe.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Eskra JN,Schlicht MJ,Bosland MCdoi
10.1038/s41598-019-39589-1subject
Has Abstractpub_date
2019-03-13 00:00:00pages
4367issue
1issn
2045-2322pii
10.1038/s41598-019-39589-1journal_volume
9pub_type
杂志文章abstract::Controlled quantum teleportation involves a third party as a controller for the teleportation of state. Here, we present the novel protocols for controlling teleportation of the arbitrary two-qubit and three-qubit states through five-qubit and seven-qubit cluster states respectively. In these schemes, Alice sends the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70446-8
更新日期:2020-08-12 00:00:00
abstract::Deep eutectic solvents have been recently reported as an interesting alternative to improve the therapeutic efficacy of conventional drugs, hence called therapeutic deep eutectic solvents (THEDES). The main objective of this work was to evaluate the potential of limonene (LIM) based THEDES as new possible systems for ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51472-7
更新日期:2019-10-17 00:00:00
abstract::Macrophages are immune cells responsible for tissue debridement and fighting infection. Clofazimine, an FDA-approved antibiotic, accumulates and precipitates as rod-shaped, crystal-like drug inclusions within macrophage lysosomes. Drug treatment as well as pathophysiological states could induce changes in macrophage m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42180-3
更新日期:2019-04-05 00:00:00
abstract::Lytic transglycosylases (LTs) catalyze the non-hydrolytic cleavage of the bacterial cell wall by an intramolecular transacetalization reaction. This reaction is critically and broadly important in modifications of the bacterial cell wall in the course of its biosynthesis, recycling, manifestation of virulence, inserti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22527-y
更新日期:2018-03-07 00:00:00
abstract::Exposure to silica can cause lung fibrosis and cancer. Identification of molecular targets is important for the intervention and/or prevention of silica-induced lung diseases. Telomeres consist of tandem repeats of DNA sequences at the end of chromosomes, preventing chromosomal fusion and degradation. Regulator of tel...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17645-y
更新日期:2017-12-11 00:00:00
abstract::Solvent-free, nonvolatile, room-temperature alkylated-π functional molecular liquids (FMLs) are rapidly emerging as a new generation of fluid matter. However, precision design to tune their physicochemical properties remains a serious challenge because the properties are governed by subtle π-π interactions among funct...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03584-1
更新日期:2017-06-13 00:00:00
abstract::Potassium channel tetramerization domain containing 12 (KCTD12), the auxiliary GABAB receptor subunit, is identified as a susceptibility gene for bipolar I (BPI) disorder in the Han Chinese population. Moreover, the single-nucleotide polymorphism (SNP) rs17026688 in glutamate decarboxylase-like protein 1 (GADL1) is sh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46655-1
更新日期:2019-07-16 00:00:00
abstract::Immunoglobulin A is the dominant antibody isotype found in mucosal secretions and enforces host-microbiota symbiosis in mice, yet selective IgA-deficiency (sIgAd) in humans is often described as asymptomatic. Here, we determined the effects of IgA deficiency on human gut microbiota composition and evaluated the possib...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49923-2
更新日期:2019-09-19 00:00:00
abstract::The therapeutic effects of C16, which is an inhibitor of RNA-dependent protein kinase (PKR), on growth of hepatocellular carcinoma (HCC) cells and tumor progression in vitro and in vivo were evaluated. Huh7 cells, a human HCC cell line, were used. The effects of C16 on cell viability were evaluated with the MTT assay,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61579-x
更新日期:2020-03-20 00:00:00
abstract::Substance P (SP) has been implicated in major depressive disorder (MDD), with SP antagonists being studied as potential antidepressants. Although impaired neural plasticity is considered a key mechanism in MDD pathophysiology, the association between SP and brain structural changes in depression has not been investiga...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10100-y
更新日期:2017-08-29 00:00:00
abstract::Metabolic syndrome (MS) and Framingham risk score (FRS) can be used for predicting the risk of developing cardiovascular diseases (CVD). Previous studies that compared FRS and MS have focused on high-income urban areas. This study focused on the comparison between FRS and MS when used in nomadic minorities in mountain...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34587-1
更新日期:2018-11-07 00:00:00
abstract::A possible association between depression and either the severity of constipation or dysosmia in Parkinson's disease (PD) patients was investigated in this cross-sectional study. One-hundred six patients who had the history of PD for less than 5 years were recruited. Depression was measured using the Beck Depression I...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72381-0
更新日期:2020-09-23 00:00:00
abstract::Insects' exoskeleton, gut, hemocoel, and cells are colonized by various microorganisms that often play important roles in their host life. Moreover, insects are frequently infected by vertically transmitted symbionts that can manipulate their reproduction. The aims of this study were the characterization of bacterial ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32747-x
更新日期:2018-09-26 00:00:00
abstract::Soil moisture is an important variable for land-climate and hydrological interactions. To investigate emergent large-scale, long-term interactions between soil moisture and other key hydro-climatic variables (precipitation, actual evapotranspiration, runoff, temperature), we analyze monthly values and anomalies of the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61621-y
更新日期:2020-03-16 00:00:00
abstract::In this study we present an image analysis methodology capable of quantifying morphological changes in tissue collagen fibril organization caused by pathological conditions. Texture analysis based on first-order statistics (FOS) and second-order statistics such as gray level co-occurrence matrix (GLCM) was explored to...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02190
更新日期:2013-01-01 00:00:00
abstract::Polarization sensitive and insensitive color filters have important applications in the area of nano-spectroscopy and CCD imaging applications. Metallic nanostructures provide an efficient way to design and engineer ultrathin color filters. These nanostructures have capability to split the white light into fundamental...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07986-z
更新日期:2017-08-14 00:00:00
abstract::Site conditions and forest management affect dendrometric parameters of chestnut (Castanea sativa Mill.) coppices, but there is modest knowledge on the effect of stand dendrometric characters on physical and mechanical wood characteristics. The aim of this study was to verify these relationships in chestnut coppices t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80558-w
更新日期:2021-01-15 00:00:00
abstract::Undulator based synchrotron light sources and Free Electron Lasers (FELs) are valuable modern probes of matter with high temporal and spatial resolution. Laser Plasma Accelerators (LPAs), delivering GeV electron beams in few centimeters, are good candidates for future compact light sources. However the barriers set by...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55209-4
更新日期:2019-12-13 00:00:00
abstract::Reef sharks are vulnerable predators experiencing severe population declines mainly due to overexploitation. However, beyond direct exploitation, human activities can produce indirect or sub-lethal effects such as behavioral alterations. Such alterations are well known for terrestrial fauna but poorly documented for m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37145-x
更新日期:2019-02-27 00:00:00
abstract::The objective of this meta-analysis is to compare hybrid surgery (HS) and cervical discectomy and fusion (ACDF) for multilevel cervical degenerative disc diseases (DDD). Systematic searches of all published studies through March 2015 were identified from Cochrane Library, Medline, PubMed, Embase, ScienceDirect, CNKI, ...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析,评审
doi:10.1038/srep13454
更新日期:2015-08-26 00:00:00
abstract::The promyelocytic leukemia (PML) protein is an essential component of PML nuclear bodies (PML NBs) frequently lost in cancer. PML NBs coordinate chromosomal regions via modification of nuclear proteins that in turn may regulate genes in the vicinity of these bodies. However, few PML NB-associated genes have been ident...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45038
更新日期:2017-03-23 00:00:00
abstract::Strongly coupled quantum dot-cavity systems provide a non-linear configuration of hybridized light-matter states with promising quantum-optical applications. Here, we investigate the coherent interaction between strong laser pulses and quantum dot-cavity polaritons. Resonant excitation of polaritonic states and their ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25172
更新日期:2016-04-26 00:00:00
abstract::Predation plays a central role in the lives of most organisms. Predators must find and subdue prey to survive and reproduce, whereas prey must avoid predators to do the same. The resultant antagonistic coevolution often leads to extreme adaptations in both parties. Few examples capture the imagination like a rapid str...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40412
更新日期:2017-01-13 00:00:00
abstract::Choosing an option increases a person's preference for that option. This phenomenon, called choice-based learning (CBL), has been investigated separately in the contexts of internally guided decision-making (IDM, e.g., preference judgment), for which no objectively correct answer exists, and externally guided decision...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32477
更新日期:2016-08-31 00:00:00
abstract::Acute kidney disease (AKD) is a state between acute kidney injury (AKI) and chronic kidney disease (CKD), but the prognosis of AKD is unclear and there are no risk-prediction tools to identify high-risk patients. 2,556 AKI patients were selected from 277,898 inpatients of three affiliated hospitals of Central South Un...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72651-x
更新日期:2020-09-24 00:00:00
abstract::Diagnostic criteria for pathological gambling and alcohol dependence (AD) include repeated addictive behavior despite severe negative consequences. However, the concept of loss aversion (LA) as a facet of value-based decision making has not yet been used to directly compare these disorders. We hypothesized reduced LA ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16433-y
更新日期:2017-11-24 00:00:00
abstract::CRISPR/Cas9-based gene knockout in animal cells, particularly in teleosts, has proven to be very efficient with regards to mutation rates, but the precise insertion of exogenous DNA or gene knock-in via the homology-directed repair (HDR) pathway has seldom been achieved outside of the model organisms. Here, we succeed...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79409-5
更新日期:2020-12-17 00:00:00
abstract::Heterogeneity is inherent to biology, thus it is imperative to realize methods capable of obtaining spatially-resolved genomic and transcriptomic profiles of heterogeneous biological samples. Here, we present a new method for local lysis of live adherent cells for nucleic acid analyses. This method addresses bottlenec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29579
更新日期:2016-07-14 00:00:00
abstract::Inositol Requiring Enzyme-1 (IRE1) is the most conserved transducer of the Unfolded Protein Response (UPR), a surveillance mechanism that ensures homeostasis of the endoplasmic reticulum (ER) in eukaryotes. IRE1 activation orchestrates adaptive responses, including lipid anabolism, metabolic reprogramming, increases i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16662-1
更新日期:2017-11-28 00:00:00
abstract::Long-term supply of synthetic nitrogen (N) has the potential to affect the soil N processes. This study aimed to (i) establish N response curves to find the best balance between inputs and outputs of N over four ratoons; (ii) use 15N-labeled fertilizer to estimate the N recovery efficiency of fertilizer applied in the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75971-0
更新日期:2020-11-02 00:00:00