Multiple oligomeric structures of a bacterial small heat shock protein.

Abstract:

:Small heat shock proteins are ubiquitous molecular chaperones that form the first line of defence against the detrimental effects of cellular stress. Under conditions of stress they undergo drastic conformational rearrangements in order to bind to misfolded substrate proteins and prevent cellular protein aggregation. Owing to the dynamic nature of small heat shock protein oligomers, elucidating the structural basis of chaperone action and oligomerization still remains a challenge. In order to understand the organization of sHSP oligomers, we have determined crystal structures of a small heat shock protein from Salmonella typhimurium in a dimeric form and two higher oligomeric forms: an 18-mer and a 24-mer. Though the core dimer structure is conserved in all the forms, structural heterogeneity arises due to variation in the terminal regions.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Mani N,Bhandari S,Moreno R,Hu L,Prasad BVV,Suguna K

doi

10.1038/srep24019

subject

Has Abstract

pub_date

2016-04-07 00:00:00

pages

24019

issn

2045-2322

pii

srep24019

journal_volume

6

pub_type

杂志文章
  • Nanocarrier-mediated delivery of α-mangostin for non-surgical castration of male animals.

    abstract::The overpopulation of abandoned and stray companion animals has become a global crisis. The main purpose of this study was to develop a novel nanomedicine-based antifertility compound for non-surgical castration of male animals. Mangosteen (Garcinia mangostana L) pericarp extract has been shown to exhibit anti-fertili...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-16563-3

    authors: Yostawonkul J,Surassmo S,Namdee K,Khongkow M,Boonthum C,Pagseesing S,Saengkrit N,Ruktanonchai UR,Chatdarong K,Ponglowhapan S,Yata T

    更新日期:2017-11-24 00:00:00

  • Strong-correlated behavior of 4f electrons and 4f5d hybridization in PrO2.

    abstract::Bringing oxygen atoms from infinite, passing equilibrium until short enough distances, we aim to reveal the 4f5d electron bonding property and its relevance to the peculiar physical properties within PrO2 based on both accounting for electron Coulomb repulsion and spin-orbit coupling effects in combination with Wannie...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-34336-4

    authors: Zhang L,Meng J,Yao F,Liu X,Meng J,Zhang H

    更新日期:2018-10-30 00:00:00

  • New endoscopic procedure for bladder wall closure: results from the porcine model.

    abstract::Upper urinary tract urothelial carcinomas are usually managed by radical nephroureterectomy (RNU), often followed by intravesical chemotherapy to minimize recurrence. Open surgery is the gold standard procedure for RNU, but it associates with high morbidity, and it has been increasingly replaced by minimally invasive ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-54304-w

    authors: Oliveira C,Barros AA,Reis RL,Correia-Pinto J,Lima E

    更新日期:2019-12-10 00:00:00

  • New Insight into Mixing Fluoride and Chloride in Bioactive Silicate Glasses.

    abstract::Adding fluoride into bioactive glasses leads to fluorapatite formation and a decrease in glass transition temperature. Recently, chloride has been introduced into glasses as an alternative to fluoride. The presence of the large chloride ion lowers glass crystallisation tendency and increases glass molar volume, which ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-19544-2

    authors: Chen X,Chen X,Pedone A,Apperley D,Hill RG,Karpukhina N

    更新日期:2018-01-22 00:00:00

  • Domestic cats (Felis catus) discriminate their names from other words.

    abstract::Two of the most common nonhuman animals that interact with humans are domestic dogs (Canis familiaris) and cats (Felis catus). In contrast to dogs, the ability of domestic cats to communicate with humans has not been explored thoroughly. We used a habituation-dishabituation method to investigate whether domestic cats ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40616-4

    authors: Saito A,Shinozuka K,Ito Y,Hasegawa T

    更新日期:2019-04-04 00:00:00

  • Photodynamic effect of Zirconium phosphate biocompatible nano-bilayers containing methylene blue on cancer and normal cells.

    abstract::Pharmaceutical applications of methylene blue, especially as photosensitizer, have been limited due to its rapid enzymatic reduction in the biological systems. In this study nano-platelet zirconium phosphate was synthesized and its biocompatibility was evaluated. The synthesized material was considered as drug deliver...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51359-7

    authors: Hosseinzadeh R,Khorsandi K

    更新日期:2019-10-17 00:00:00

  • Hemidesmus indicus induces apoptosis via proteasome inhibition and generation of reactive oxygen species.

    abstract::Proteasome inhibition represents an important anticancer strategy. Here, we studied the mechanisms at the basis of the pro-apoptotic activity of the standardized decoction of Hemidesmus indicus, a plant evoking a complex anticancer activity, and explored its inhibition of proteasome activity in human leukemia cells. A...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43609-5

    authors: Turrini E,Catanzaro E,Ferruzzi L,Guerrini A,Tacchini M,Sacchetti G,Paganetto G,Maffei F,Pellicioni V,Poli F,Hrelia P,Mandrone M,Sestili P,Brigotti M,Fimognari C

    更新日期:2019-05-10 00:00:00

  • Author Correction: Summertime Primary and Secondary Contributions to Southern Ocean Cloud Condensation Nuclei.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-019-46788-3

    authors: Fossum KN,Ovadnevaite J,Ceburnis D,Dall'Osto M,Marullo S,Bellacicco M,Simó R,Liu D,Flynn M,Zuend A,O'Dowd C

    更新日期:2019-07-18 00:00:00

  • Nanocomposite Metamaterials Based on Self-assembled Titanium Dioxide Rolls with Embedded Gold Nanoparticles.

    abstract::An experimental method for fabrication of a nanocomposite metamaterial based on a self-assembly of titanium dioxide microtubes with encapsulated gold nanoparticles (NPs) is proposed. The formation of microtubes is induced by laser irradiation in the presence of an external magnetic field. It is shown that the variatio...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43588-7

    authors: Kutrovskaya S,Kucherik A,Osipov A,Samyshkin V,Istratov A,Kavokin AV

    更新日期:2019-05-07 00:00:00

  • Fast spectrally encoded Mueller optical scanning microscopy.

    abstract::Mueller microscopes enable imaging of the optical anisotropic properties of biological or non-biological samples, in phase and amplitude, at sub-micrometre scale. However, the development of Mueller microscopes poses an instrumental challenge: the production of polarimetric parameters must be sufficiently quick to ens...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40467-z

    authors: Rivet S,Dubreuil M,Bradu A,Le Grand Y

    更新日期:2019-03-08 00:00:00

  • Focusing on Plates: Controlling Guided Waves using Negative Refraction.

    abstract::Elastic waves are guided along finite structures such as cylinders, plates, or rods through reflection, refraction, and mode conversion at the interfaces. Such wave propagation is ubiquitous in the world around us, and studies of elastic waveguides first emerged in the later part of the 19(th) century. Early work on e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep11112

    authors: Philippe FD,Murray TW,Prada C

    更新日期:2015-06-08 00:00:00

  • Comparing Sanger sequencing and high-throughput metabarcoding for inferring photobiont diversity in lichens.

    abstract::The implementation of HTS (high-throughput sequencing) approaches is rapidly changing our understanding of the lichen symbiosis, by uncovering high bacterial and fungal diversity, which is often host-specific. Recently, HTS methods revealed the presence of multiple photobionts inside a single thallus in several lichen...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-26947-8

    authors: Paul F,Otte J,Schmitt I,Dal Grande F

    更新日期:2018-06-05 00:00:00

  • Evaluation of Immunodiagnostic Tests for Leprosy in Brazil, China and Ethiopia.

    abstract::Leprosy remains persistently endemic in several low- or middle income countries. Transmission is still ongoing as indicated by the unabated rate of leprosy new case detection, illustrating the insufficiency of current prevention methods. Therefore, low-complexity tools suitable for large scale screening efforts to spe...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-36323-1

    authors: van Hooij A,Tjon Kon Fat EM,Batista da Silva M,Carvalho Bouth R,Cunha Messias AC,Gobbo AR,Lema T,Bobosha K,Li J,Weng X,Salgado CG,Spencer JS,Corstjens PLAM,Geluk A

    更新日期:2018-12-18 00:00:00

  • Heterogeneous grain-scale response in ferroic polycrystals under electric field.

    abstract::Understanding coupling of ferroic properties over grain boundaries and within clusters of grains in polycrystalline materials is hindered due to a lack of direct experimental methods to probe the behaviour of individual grains in the bulk of a material. Here, a variant of three-dimensional X-ray diffraction (3D-XRD) i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep22820

    authors: Daniels JE,Majkut M,Cao Q,Schmidt S,Wright J,Jo W,Oddershede J

    更新日期:2016-03-09 00:00:00

  • Plasma extracellular vesicle proteins are associated with stress-induced myocardial ischemia in women presenting with chest pain.

    abstract::Diagnosing stable ischemic heart disease (IHD) is challenging, especially in females. Currently, no blood test is available. Plasma extracellular vesicles (EV) are emerging as potential biomarker source. We therefore aimed to identify stress induced ischemia due to stable IHD with plasma extracellular vesicle protein ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69297-0

    authors: Dekker M,Waissi F,van Bennekom J,Silvis MJM,Timmerman N,Bank IEM,Walter JE,Mueller C,Schoneveld AH,Schiffelers RM,Pasterkamp G,Grobbee DE,de Winter RJ,Mosterd A,de Kleijn DPV,Timmers L

    更新日期:2020-07-23 00:00:00

  • Forward genetic screen for auxin-deficient mutants by cytokinin.

    abstract::Identification of mutants with impairments in auxin biosynthesis and dynamics by forward genetic screening is hindered by the complexity, redundancy and necessity of the pathways involved. Furthermore, although a few auxin-deficient mutants have been recently identified by screening for altered responses to shade, eth...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep11923

    authors: Wu L,Luo P,Di DW,Wang L,Wang M,Lu CK,Wei SD,Zhang L,Zhang TZ,Amakorová P,Strnad M,Novák O,Guo GQ

    更新日期:2015-07-06 00:00:00

  • CD4+CD28null T Lymphocytes are Associated with the Development of Atrial Fibrillation after Elective Cardiac Surgery.

    abstract::Post-operative atrial fibrillation (POAF) is postulated as a complex interaction of different pathogenic factors, suggesting inflammatory processes as a main trigger of this particular type of atrial fibrillation. Therefore, the study sought to assess the impact of cellular immunity on the development of POAF. Compari...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章

    doi:10.1038/s41598-018-28046-0

    authors: Sulzgruber P,Thaler B,Koller L,Baumgartner J,Pilz A,Steininger M,Schnaubelt S,Fleck T,Laufer G,Steinlechner B,Winter MP,Goliasch G,Wojta J,Niessner A

    更新日期:2018-06-25 00:00:00

  • Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery.

    abstract::Two-dimensional (2D) cell cultures growing on plastic do not recapitulate the three dimensional (3D) architecture and complexity of human tumors. More representative models are required for drug discovery and validation. Here, 2D culture and 3D mono- and stromal co-culture models of increasing complexity have been est...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28951

    authors: Stock K,Estrada MF,Vidic S,Gjerde K,Rudisch A,Santo VE,Barbier M,Blom S,Arundkar SC,Selvam I,Osswald A,Stein Y,Gruenewald S,Brito C,van Weerden W,Rotter V,Boghaert E,Oren M,Sommergruber W,Chong Y,de Hoogt R,Grae

    更新日期:2016-07-01 00:00:00

  • Author Correction: Correction-free force calibration for magnetic tweezers experiments.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-018-36219-0

    authors: Ostrofet E,Papini FS,Dulin D

    更新日期:2018-12-10 00:00:00

  • Clinical efficacy of Stereotactic Body Radiation Therapy (SBRT) for adrenal gland metastases: A multi-center retrospective study from China.

    abstract::To evaluate the efficacy and safety of CyberKnife Stereotactic Body Radiation Therapy (SBRT) in the treatment of adrenal gland metastases (AGM), we designed a large-scale multicenter retrospective study to report the safety and efficacy of SBRT for inoperable AGM. In this study, 75 (61 males, 14 females) patients with...

    journal_title:Scientific reports

    pub_type: 杂志文章,多中心研究

    doi:10.1038/s41598-020-64770-2

    authors: Zhao X,Zhu X,Zhuang H,Guo X,Song Y,Ju X,Wang P,Yuan Z,Zhang H

    更新日期:2020-05-12 00:00:00

  • liputils: a Python module to manage individual fatty acid moieties from complex lipids.

    abstract::Lipidomic analyses address the problem of characterizing the lipid components of given cells, tissues and organisms by means of chromatographic separations coupled to high-resolution, tandem mass spectrometry analyses. A number of software tools have been developed to help in the daunting task of mass spectrometry sig...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70259-9

    authors: Manzini S,Busnelli M,Colombo A,Kiamehr M,Chiesa G

    更新日期:2020-08-07 00:00:00

  • Pathologist-level classification of histologic patterns on resected lung adenocarcinoma slides with deep neural networks.

    abstract::Classification of histologic patterns in lung adenocarcinoma is critical for determining tumor grade and treatment for patients. However, this task is often challenging due to the heterogeneous nature of lung adenocarcinoma and the subjective criteria for evaluation. In this study, we propose a deep learning model tha...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40041-7

    authors: Wei JW,Tafe LJ,Linnik YA,Vaickus LJ,Tomita N,Hassanpour S

    更新日期:2019-03-04 00:00:00

  • Conditions for escape of a rotor in a rotary nanobearing from short triple-wall nanotubes.

    abstract::In a short nanobearing system made from carbon nanotubes, the rotor with high rotational frequency may escape from the stator, which may cause a stability problem to the system of a nanodevice with such a nanobearing. In the present work, nanobearings with tri-walled nanotubes are investigated to reveal the conditions...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-07184-x

    authors: Shi J,Liu LN,Cai K,Qin QH

    更新日期:2017-07-28 00:00:00

  • Transcriptomic and life history responses of the mayfly Neocloeon triangulifer to chronic diel thermal challenge.

    abstract::To better understand the effects of transient thermal stress in an aquatic insect, we first identified static temperatures associated with fitness deficits, and then reared larvae from egg hatch to adulthood under diurnally variable regimens including daily forays into deleterious temperatures. We sampled mature larva...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-75064-y

    authors: Chou H,Jima DD,Funk DH,Jackson JK,Sweeney BW,Buchwalter DB

    更新日期:2020-11-05 00:00:00

  • Transcriptomic analysis of micropapillary high grade T1 urothelial bladder cancer.

    abstract::No consensus currently exist on the optimal treatment of patients with high-risk nonmuscle invasive (HGT1) micropapillary variant of bladder cancer (MPBC). Transcripsome analysis may allow stratification of MPBC-HGT1 enabling prediction of recurrence and guide therapeutic management for individual patients. Whole tran...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76904-7

    authors: Bowden M,Nadal R,Zhou CW,Werner L,Barletta J,Juanpere N,Lloreta J,Hernandez-Llodrà S,Morote J,de Torres I,Orsola A,Cejas P,Long H,Bellmunt J

    更新日期:2020-11-18 00:00:00

  • Effects of plant species richness on 13C assimilate partitioning in artificial grasslands of different established ages.

    abstract::Artificial grasslands play a role in carbon storage on the Qinghai-Tibetan Plateau. The artificial grasslands exhibit decreased proportions of graminate and increased species richness with age. However, the effect of the graminate proportions and species richness on ecosystem C stocks in artificial grasslands have not...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40307

    authors: Xu L,Yao B,Wang W,Wang F,Zhou H,Shi J,Zhao X

    更新日期:2017-01-09 00:00:00

  • Estimation of High-Speed Liquid-Jet Velocity Using a Pyro Jet Injector.

    abstract::The high-speed liquid-jet velocity achieved using an injector strongly depends on the piston motion, physical property of the liquid, and container shape of the injector. Herein, we investigate the liquid ejection mechanism and a technique for estimating the ejection velocity of a high-speed liquid jet using a pyro je...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-56511-x

    authors: Takagaki N,Kitaguchi T,Iwayama M,Shinoda A,Kumamaru H,Honda I

    更新日期:2019-12-27 00:00:00

  • RhoA phosphorylation mediated by Rho/RhoA-associated kinase pathway improves the anti-freezing potentiality of murine hatched and diapaused blastocysts.

    abstract::Embryonic cryopreservation has a relatively low survival rate because of cytoskeletal damage. However, molecular anti-freezing mechanisms have been largely unexplored. This study investigated the significance of RhoA, involved in embryonic development, and the Rho/RhoA-associated kinase (ROCK) signalling pathway in cr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-07066-2

    authors: Gu M,Ni H,Sheng X,Pauciullo A,Liu Y,Guo Y

    更新日期:2017-07-27 00:00:00

  • Four-dimensional in vivo X-ray microscopy with projection-guided gating.

    abstract::Visualizing fast micrometer scale internal movements of small animals is a key challenge for functional anatomy, physiology and biomechanics. We combine phase contrast tomographic microscopy (down to 3.3 μm voxel size) with retrospective, projection-based gating (in the order of hundreds of microseconds) to improve th...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep08727

    authors: Mokso R,Schwyn DA,Walker SM,Doube M,Wicklein M,Müller T,Stampanoni M,Taylor GK,Krapp HG

    更新日期:2015-03-12 00:00:00

  • A special three-layer step-index fiber for building compact STED systems.

    abstract::Up to now, most of stimulated-emission-depletion (STED) systems were lens-based bulky systems. Exchanging some spatial light paths with optical fiber components will make the systems more flexible and will benefit various fields. A big problem to achieve this goal is that the STED beam generated by the traditional met...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-44905-w

    authors: Luo H,Wang G,Yuan L

    更新日期:2019-06-11 00:00:00