Transcriptomic analysis of micropapillary high grade T1 urothelial bladder cancer.

abstract：:Combining endurance training with resistance training (RT) may attenuate skeletal muscle hypertrophic adaptation versus RT alone; however, the underlying mechanisms are unclear. We investigated changes in markers of ribosome biogenesis, a process linked with skeletal muscle hypertrophy, following concurrent training v...

journal_title：Scientific reports

authors： Fyfe JJ,Bishop DJ,Bartlett JD,Hanson ED,Anderson MJ,Garnham AP,Stepto NK

更新日期：2018-01-12 00:00:00

abstract：:Memory function deficits induced by Alzheimer's disease (AD) are believed to be one of the causes of an increased risk of tripping in patients. Working memory contributes to accurate stepping over obstacles during locomotion, and AD-induced deficits of this memory function may lead to an increased risk of contact with...

journal_title：Scientific reports

authors： Setogawa S,Yamaura H,Arasaki T,Endo S,Yanagihara D

更新日期：2014-11-27 00:00:00

abstract：:Cyanobacteria exhibit a great capacity to adapt to different environmental conditions through changes in gene expression. Although this plasticity has been extensively studied in the model cyanobacterium Synechocystis sp. PCC 6803, a detailed analysis of the coordinated transcriptional adaption across varying conditio...

journal_title：Scientific reports

authors： Hernández-Prieto MA,Semeniuk TA,Giner-Lamia J,Futschik ME

更新日期：2016-02-29 00:00:00

abstract：:The calcifying shell is an excellent model for studying biomineralization and evolution. However, the molecular mechanisms of shell formation are only beginning to be elucidated in Mollusca. It is known that shell matrix proteins (SMPs) play important roles in shell formation. With increasing data of shell matrix prot...

journal_title：Scientific reports

authors： Feng D,Li Q,Yu H,Kong L,Du S

更新日期：2017-04-04 00:00:00

abstract：:N-acetyltransferase 2 (NAT2) acetylator status can be classified into three groups depending on the number of rapid alleles (e.g., NAT2*4): rapid, intermediate, and slow acetylators. Such acetylator status may influence the occurrence of adverse drug reactions (ADRs) during sulfasalazine treatment. This systematic rev...

journal_title：Scientific reports

authors： Yee J,Kim SM,Han JM,Lee N,Yoon HY,Gwak HS

更新日期：2020-02-27 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Lee HC,Childs J,Chung HJ,Park J,Hong J,Cho SB

更新日期：2019-12-02 00:00:00

abstract：:Heterostructures of oxides have been widely investigated in optical, catalytic and electrochemical applications, because the heterostructured interfaces exhibit pronouncedly different transport, charge, and reactivity characteristics compared to the bulk of the oxides. Here we fabricated a three-dimensional (3D) heter...

journal_title：Scientific reports

authors： Zhou W,Liang F,Shao Z,Chen J,Zhu Z

更新日期：2011-01-01 00:00:00

abstract：:The gut microbiota (GM) is related to obesity and other metabolic diseases. To detect GM markers for obesity in patients with different metabolic abnormalities and investigate their relationships with clinical indicators, 1,914 Chinese adults were enrolled for 16S rRNA gene sequencing in this retrospective study. Base...

journal_title：Scientific reports

authors： Zeng Q,Li D,He Y,Li Y,Yang Z,Zhao X,Liu Y,Wang Y,Sun J,Feng X,Wang F,Chen J,Zheng Y,Yang Y,Sun X,Xu X,Wang D,Kenney T,Jiang Y,Gu H,Li Y,Zhou K,Li S,Dai W

更新日期：2019-09-17 00:00:00

abstract：:Several MRI contrast agent clinical formulations are now known to leave deposits of the heavy metal gadolinium in the brain, bones, and other organs of patients. This persistent biological accumulation of gadolinium has been recently recognized as a deleterious outcome in patients administered Gd-based contrast agents...

journal_title：Scientific reports

authors： Rees JA,Deblonde GJ,An DD,Ansoborlo C,Gauny SS,Abergel RJ

更新日期：2018-03-13 00:00:00

abstract：:The aim of this study is to develop an internal-external correlation model for internal motion estimation for lung cancer radiotherapy. Deformation vector fields that characterize the internal-external motion are obtained by respectively registering the internal organ meshes and external surface meshes from the 4DCT i...

journal_title：Scientific reports

authors： Chen H,Zhong Z,Yang Y,Chen J,Zhou L,Zhen X,Gu X

更新日期：2018-02-27 00:00:00

abstract：:Coral reefs all over the Indo-Pacific suffer from substantial damage caused by the crown-of-thorns seastar Acanthaster planci, a voracious predator that moves on and between reefs to seek out its coral prey. Chemoreception is thought to guide A. planci. As vision was recently introduced as another sense involved in se...

journal_title：Scientific reports

authors： Sigl R,Steibl S,Laforsch C

更新日期：2016-08-01 00:00:00

abstract：:Type 2 diabetes mellitus is a major health concern worldwide; however, the molecular mechanism underlying its development is poorly understood. The hormone amylin is postulated to be involved, as human amylin forms amyloid in the pancreases of diabetic patients, and oligomers have been shown to be cytotoxic to β-cells...

journal_title：Scientific reports

authors： Nie T,Zhang S,Vazhoor Amarsingh G,Liu H,McCann MJ,Cooper GJS

更新日期：2019-10-10 00:00:00

abstract：:The uncertainty relation is a fundamental limit in quantum mechanics and is of great importance to quantum information processing as it relates to quantum precision measurement. Due to interactions with the surrounding environment, a quantum system will unavoidably suffer from decoherence. Here, we investigate the dyn...

journal_title：Scientific reports

authors： Wang D,Huang AJ,Hoehn RD,Ming F,Sun WY,Shi JD,Ye L,Kais S

更新日期：2017-04-21 00:00:00

abstract：:Genetic factors affect host susceptibility to pathogens. In this population-based case control study, we explored the genetic polymorphisms of IL-17, TLR4 and miR-146a in association with pulmonary tuberculosis in a Chinese Han population. We recruited 1601 pulmonary tuberculosis patients matched with 1526 healthy con...

journal_title：Scientific reports

authors： Wang M,Xu G,Lü L,Xu K,Chen Y,Pan H,Burstrom B,Burstrom K,Wang J

更新日期：2016-06-24 00:00:00

abstract：:Spliced leader dependent trans-splicing (SLTS) has been described as an important RNA regulatory process that occurs in different organisms, including the trematode Schistosoma mansoni. We identified more than seven thousand putative SLTS sites in the parasite, comprising genes with a wide spectrum of functional class...

journal_title：Scientific reports

authors： Boroni M,Sammeth M,Gava SG,Jorge NAN,Macedo AM,Machado CR,Mourão MM,Franco GR

更新日期：2018-03-01 00:00:00

abstract：:Superresolution microscopy offers the advantage of imaging biological structures within cells at the nano-scale. Here we apply two superresolution microscopy techniques, specifically 3D structured illumination microscopy (3D-SIM) and direct stochastic optical reconstruction microscopy (dSTORM), a type of single molecu...

journal_title：Scientific reports

authors： Sudhaharan T,Hariharan S,Lim JSY,Liu JZ,Koon YL,Wright GD,Chiam KH,Ahmed S

更新日期：2019-02-21 00:00:00

abstract：:Invasive motor Cortex Stimulation (iMCS) was introduced in the 1990's for the treatment of chronic neuropathic orofacial pain (CNOP), although its effectiveness remains doubtful. However, CNOP is known to be a heterogeneous group of orofacial pain disorders, which can lead to different responses to iMCS. Therefore, th...

journal_title：Scientific reports

authors： Henssen D,Kurt E,van Walsum AVC,Kozicz T,van Dongen R,Bartels R

更新日期：2020-04-28 00:00:00

abstract：:This study investigated a rabbit model of autologous simple oral mucosal epithelium transplantation (SOMET) for limbal stem cell deficiency (LSCD). LSCD was created in the SOMET group and the Control group. In the SOMET group, oral mucosa harvested from the buccal region was treated with dispase, cut into small pieces...

journal_title：Scientific reports

authors： Inamochi A,Tomioka A,Kitamoto K,Miyai T,Usui T,Aihara M,Yamagami S

更新日期：2019-12-02 00:00:00

abstract：:Multi-drug resistant Pseudomonas aeruginosa has increased progressively and impedes further regression in mortality in burn patients. Such wound infections serve as bacterial reservoir for nosocomial infections and are associated with significant morbidity and costs. Anti-microbial polycationic dendrimers G3KL and G3R...

journal_title：Scientific reports

authors： Abdel-Sayed P,Kaeppeli A,Siriwardena T,Darbre T,Perron K,Jafari P,Reymond JL,Pioletti DP,Applegate LA

更新日期：2016-02-25 00:00:00

abstract：:Individuals in the state of psychological suboptimal health keep increasing, only scales and questionnaires were used to diagnose in clinic under current conditions, and symptoms of high reliability and accuracy are destitute. Therefore, the noninvasive and precise laboratory diagnostic methods are needed. This study ...

journal_title：Scientific reports

authors： Tian JS,Xia XT,Wu YF,Zhao L,Xiang H,Du GH,Zhang X,Qin XM

更新日期：2016-09-21 00:00:00

abstract：:Abdominal aortic aneurysm (AAA) is a leading cause of sudden death in aged people. Activation of ubiquitin proteasome system (UPS) plays a critical role in the protein quality control and various diseases. However, the functional role of UPS in AAA formation remains unclear. In this study, we found that the proteasome...

journal_title：Scientific reports

authors： Ren H,Li F,Tian C,Nie H,Wang L,Li HH,Zheng Y

更新日期：2015-10-28 00:00:00

abstract：:Substance P (SP) has been implicated in major depressive disorder (MDD), with SP antagonists being studied as potential antidepressants. Although impaired neural plasticity is considered a key mechanism in MDD pathophysiology, the association between SP and brain structural changes in depression has not been investiga...

journal_title：Scientific reports

authors： Won E,Kang J,Choi S,Kim A,Han KM,Yoon HK,Cho SH,Tae WS,Lee MS,Joe SH,Kim YK,Ham BJ

更新日期：2017-08-29 00:00:00

abstract：:Loss of seed shattering has been regarded as a key step during crop domestication. Mutagenesis contributes to the development of novel crop cultivars with a desired seed-shattering habit in a relatively short period of time, but also to uncovering the genetic architecture of seed shattering. 'Minamiyutaka', a non-shat...

journal_title：Scientific reports

authors： Li F,Komatsu A,Ohtake M,Eun H,Shimizu A,Kato H

更新日期：2020-09-10 00:00:00

abstract：:Evidence suggest that overexpression of hypoxia-inducible factor-1α (HIF-1α) is linked to multidrug resistance of epilepsy. Here we explored whether aberrant expression of HIF-1α is regulated by miRNAs. Genome-wide microRNA expression profiling was performed on temporal cortex resected from mesial temporal lobe epilep...

journal_title：Scientific reports

authors： Li Y,Huang C,Feng P,Jiang Y,Wang W,Zhou D,Chen L

更新日期：2016-08-24 00:00:00

abstract：:Practical applications of bacteriophages in medicine and biotechnology induce a great need for technologies of phage purification. None of the popular methods offer solutions for separation of a phage from another similar phage. We used affinity chromatography combined with competitive phage display (i) to purify T4 b...

journal_title：Scientific reports

authors： Ceglarek I,Piotrowicz A,Lecion D,Miernikiewicz P,Owczarek B,Hodyra K,Harhala M,Górski A,Dąbrowska K

更新日期：2013-11-14 00:00:00

abstract：:Network alignment (NA) compares networks with the goal of finding a node mapping that uncovers highly similar (conserved) network regions. Existing NA methods are homogeneous, i.e., they can deal only with networks containing nodes and edges of one type. Due to increasing amounts of heterogeneous network data with nod...

journal_title：Scientific reports

authors： Gu S,Johnson J,Faisal FE,Milenković T

更新日期：2018-08-21 00:00:00

abstract：:The coal fires, a global catastrophe for hundreds of years, have been proved extremely difficult to control, and hit almost every coal-bearing area globally. Meanwhile, underground coal fires contain tremendous reservoir of geothermal energy. Approximately one billion tons of coal burns underground annually in the wor...

journal_title：Scientific reports

authors： Shi B,Su H,Li J,Qi H,Zhou F,Torero JL,Chen Z

更新日期：2017-07-13 00:00:00

abstract：:p53 is a representative transcription factor that activates multiple target genes. To realize stimulus-dependent specificities, p53 has to recognize targets with structural variety, of which molecular mechanisms are largely unknown. Here, we conducted a series of long-time scale (totally more than 100-ms) coarse-grain...

journal_title：Scientific reports

authors： Terakawa T,Takada S

更新日期：2015-11-24 00:00:00

abstract：:Stimulation with lipopolysaccharide (LPS; endotoxin) not only causes rapid production of proinflammatory cytokines, but also induces a state of LPS hypo-responsiveness to a second LPS stimulation (endotoxin tolerance (ET)). Murine bone marrow-derived MCs (BMMCs) and peritoneal MCs (PMCs) developed ET as shown by an ab...

journal_title：Scientific reports

authors： Poplutz M,Levikova M,Lüscher-Firzlaff J,Lesina M,Algül H,Lüscher B,Huber M

更新日期：2017-07-03 00:00:00

abstract：:Emerging evidence suggests substantial health benefits from using meditation. While there are some indications that the popularity of meditation is increasing, little is known about the prevalence, patterns, and predictors of meditation use in the general population. In this secondary analysis of data from the 2012 US...

journal_title：Scientific reports

authors： Cramer H,Hall H,Leach M,Frawley J,Zhang Y,Leung B,Adams J,Lauche R

更新日期：2016-11-10 00:00:00