Abstract:
:The calcifying shell is an excellent model for studying biomineralization and evolution. However, the molecular mechanisms of shell formation are only beginning to be elucidated in Mollusca. It is known that shell matrix proteins (SMPs) play important roles in shell formation. With increasing data of shell matrix proteomes from various species, we carried out a BLASTp bioinformatics analysis using the shell matrix proteome from Crassostrea gigas against 443 SMPs from nine other species. The highly conserved tyrosinase and chitin related proteins were identified in bivalve. In addition, the relatively conserved proteins containing domains of carbonic anhydrase, Sushi, Von Willebrand factor type A, and chitin binding, were identified from all the ten species. Moreover, 25 genes encoding SMPs were annotated and characterized that are involved in CaCO3 crystallization and represent chitin related or ECM related proteins. Together, data from these analyses provide new knowledge underlying the molecular mechanism of shell formation in C.gigas, supporting a refined shell formation model including chitin and ECM-related proteins.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Feng D,Li Q,Yu H,Kong L,Du Sdoi
10.1038/srep45754subject
Has Abstractpub_date
2017-04-04 00:00:00pages
45754issn
2045-2322pii
srep45754journal_volume
7pub_type
杂志文章abstract::Eucalyptus globulus is an aromatic medicinal plant which known for its 1,8-cineole main pharmacological constituent exhibits as natural analgesic agent. Eucalyptus globulus-loaded micellar nanoparticle was developed via spontaneous emulsification technique and further evaluation for its analgesic efficacy study, in vi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50134-y
更新日期:2019-09-23 00:00:00
abstract::Foliar fungi of silver birch (Betula pendula) in an experimental Finnish forest were investigated across a gradient of tree species richness using molecular high-throughput sequencing and visual macroscopic assessment. We hypothesized that the molecular approach detects more fungal taxa than visual assessment, and tha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41801
更新日期:2017-02-02 00:00:00
abstract::Because Africa's climate hampers DNA preservation, knowledge of its genetic variability is mainly restricted to modern samples, even though population genetics dynamics and back-migrations from Eurasia may have modified haplotype frequencies, masking ancient genetic scenarios. Thanks to improved methodologies, ancient...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39802-1
更新日期:2019-03-05 00:00:00
abstract::Bif-1 is a membrane-curvature inducing protein that is implicated in the regulation of autophagy and tumorigenesis. Here, we report that Bif-1 plays a critical role in regulating lipid catabolism to control the size of lipid droplets and prevent the development of obesity and insulin resistance upon aging or dietary c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20453
更新日期:2016-02-09 00:00:00
abstract::Recombinant protein and virus-like particle (VLP) production based on the baculovirus expression vector system is fast, flexible, and offers high yields. Independent from the product, a multitude of parameters are screened during process development/optimisation. Early development acceleration is a key requirement for...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57761-w
更新日期:2020-01-23 00:00:00
abstract::The cancer stem cell (CSC) hypothesis proposes a hierarchical organization of tumors, in which stem-like cells sustain tumors and drive metastasis. The molecular mechanisms underlying the acquisition of CSCs and metastatic traits are not well understood. SOX9 is a transcription factor linked to stem cell maintenance a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32350
更新日期:2016-08-30 00:00:00
abstract::The physiological roles of the protease inhibitor SERPINB3 (SB3) are still largely unknown. The study was addressed to assess the biological effects of this serpin in vivo using a SB3 transgenic mouse model. Two colonies of mice (123 transgenic for SB3 and 148 C57BL/6J controls) have been studied. Transgenic (TG) mice...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03056
更新日期:2013-10-28 00:00:00
abstract::The values of physiological indices and the enzymes activities involved in the overwintering stage were studied in D. armandi larvae in each month from October 2014 to March 2015. The sorbitol, trehalose and glycerol values initially tended to increase as the ambient temperature decreased, before declining until the e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34698
更新日期:2016-10-05 00:00:00
abstract::When faced with adverse environmental conditions, the marsupial Dromiciops gliroides uses either daily or seasonal torpor to support survival and is the only known hibernating mammal in South America. As the sole living representative of the ancient Order Microbiotheria, this species can provide crucial information ab...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24627
更新日期:2016-04-19 00:00:00
abstract::Greater levels of solar energy storage provide an effective solution to the inherent nature of intermittency, and can substantially improve reliability, availability, and quality of the renewable energy source. Here we demonstrated an all-vanadium (all-V) continuous-flow photoelectrochemical storage cell (PESC) to ach...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00585-y
更新日期:2017-04-04 00:00:00
abstract::The interaction between two different materials can present novel phenomena that are quite different from the physical properties observed when each material stands alone. Strong electronic correlations, such as magnetism and superconductivity, can be produced as the result of enhanced Coulomb interactions between ele...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21460
更新日期:2016-02-18 00:00:00
abstract::Black phosphorus (BP) has recently been rediscovered as a new and interesting two-dimensional material due to its unique electronic and optical properties. Here, we study the linear and nonlinear optical properties of BP flakes. We observe that both the linear and nonlinear optical properties are anisotropic and can b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15899
更新日期:2015-10-30 00:00:00
abstract::Glycans are biologically important structures synthesised by glycosyltransferase (GT) enzymes. Disruptive genetic null variants in GT genes can lead to serious illness but benign phenotypes are also seen, including antigenic differences on the red blood cell (RBC) surface, giving rise to blood groups. To characterise ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24445-5
更新日期:2018-04-16 00:00:00
abstract::The Vavilov Institute of Plant Genetic Resources (VIR), in St. Petersburg, Russia, houses a unique genebank, with historical collections of landraces. When they were collected, the geographical distribution and genetic diversity of most crops closely reflected their historical patterns of cultivation established over ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05087-5
更新日期:2017-07-06 00:00:00
abstract::Mid-infrared quantum cascade lasers operating under external optical feedback and external periodic bias forcing are shown to exhibit a deterministic chaotic pattern composed of frequencies which are linked to the one of the forcing. Results also show that both the amplitude and the frequency of the forcing play a key...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40861-7
更新日期:2019-03-14 00:00:00
abstract::Aquaporins (AQPs) are a ubiquitous family of transmembrane water channel proteins. A subgroup of AQP water channels also facilitates transmembrane diffusion of small, polar solutes. A constriction within the pore, the aromatic/arginine (ar/R) selectivity filter, is thought to control solute permeability: previous stud...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56814-z
更新日期:2019-12-30 00:00:00
abstract::Micro-algae, Schizochytrium sp., is rich source of docosahexaenoic acid, DHA (66%-lipid with 27%-DHA). Eight nutritionally balanced-diets were formulated: diet 1 (control) consisted of only fish oil (FO); diets 2 and 3 had increasing amounts of algae-meal and soybean oil (SBO) at the expense of FO; diet 4 consisted of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41020-8
更新日期:2019-04-16 00:00:00
abstract::Bioartificial livers (BAL) may offer acute liver failure (ALF) patients an opportunity for cure without liver transplantation. We evaluated the efficacy of a spheroid-based BAL system, containing aggregates of porcine hepatocytes, in a porcine model of ALF. ALF pigs were divided into three groups. The control group co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03424-2
更新日期:2017-06-19 00:00:00
abstract::There has been much interest in understanding collective dynamics in networks of brain regions due to their role in behavior and cognitive function. Here we show that a simple, homogeneous system of densely connected oscillators, representing the aggregate activity of local brain regions, can exhibit a rich variety of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22074
更新日期:2016-02-26 00:00:00
abstract::Toxin-antitoxin (TA) systems were initially discovered as plasmid addiction systems on low-copy-number plasmids. Thousands of TA loci have since been identified on chromosomes, plasmids and mobile elements in bacteria and archaea with diverse roles in bacterial physiology and in maintenance of genetic elements. Here, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46318-1
更新日期:2019-07-08 00:00:00
abstract::Prognostic biomarkers for the pancreatic neuroendocrine tumors are needed. Proteomic study on insulinoma has been rarely reported. We identified the differential expression of proteins between insulinoma and their paired tissues by proteomic analysis, and evaluated the prognostic significance of specific proteins in p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02051-1
更新日期:2017-05-19 00:00:00
abstract::Concerns related to pulmonary toxicity and non-specificity of nanoparticles have limited their clinical applications for aerosol delivery of chemotherapeutics in lung cancer. We hypothesized that pulmonary surfactant mimetic nanoparticles that offer pH responsive release specifically in tumor may be a possible solutio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07085
更新日期:2014-11-18 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-32881-6
更新日期:2018-10-12 00:00:00
abstract::Underutilization due to performance limitations imposed by species and charge transports is one of the key issues that persist with various lithium-ion batteries. To elucidate the relevant mechanisms, two groups of characteristic parameters were proposed. The first group contains three characteristic time parameters, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32639
更新日期:2016-09-07 00:00:00
abstract::Potato (Solanum tuberosum L.) is the fourth most important crop worldwide. Potato virus A (PVA) is one of the most harmful viruses infecting potatoes. However, the molecular mechanisms governing the responses to PVA infection in potato at the transcriptional and post-transcriptional levels are not well understood. In ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17059-w
更新日期:2017-12-05 00:00:00
abstract::Hypoxia-inducible factor (HIF)-1α and HIF-2α play an important role in liver fibrosis. von Hippel-Lindau protein (VHL), a key mediator of HIF-α, regulates fibrosis in an organ- and cell-specific way. In this study, human liver samples were collected from hepatitis C-, alcoholic-, and cholestatic-associated fibrotic an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41038
更新日期:2017-01-23 00:00:00
abstract::Non-human animals sometimes show marked intraspecific variation in their cognitive abilities that may reflect variation in external inputs and experience during the developmental period. We examined variation in exploration and cognitive performance on a problem-solving task in a large sample of captive orang-utans (P...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40052
更新日期:2017-01-09 00:00:00
abstract::Endocannabinoids are amphiphilic molecules that play crucial neurophysiological functions acting as lipid messengers. Antagonists and knockdown of the classical CB1 and CB2 cannabinoid receptors do not completely abolish many endocannabinoid activities, supporting the idea of a mechanism independent of receptors whose...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41362
更新日期:2017-01-27 00:00:00
abstract::Limbal stem cell deficiency can be treated with transplantation of cultured human limbal epithelial cells (LEC). It can be advantageous to produce LEC in centralized labs and thereafter ship them to eye clinics. The present study used transport simulations of LEC to determine if vigorous shaking during transport alter...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28553-0
更新日期:2018-07-12 00:00:00
abstract::At the post-synaptic density (PSD), large protein complexes dynamically form and dissociate in response to synaptic activity, comprising the biophysical basis for learning and memory. The use of detergents to isolate the PSD and release its membrane-associated proteins complicates studies of these activity-dependent p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46690-y
更新日期:2019-07-26 00:00:00