Abstract：
:Proteasome inhibition represents an important anticancer strategy. Here, we studied the mechanisms at the basis of the pro-apoptotic activity of the standardized decoction of Hemidesmus indicus, a plant evoking a complex anticancer activity, and explored its inhibition of proteasome activity in human leukemia cells. Additionally, we preliminary tested the cytotoxicity of some H. indicus's phytochemicals on leukemia cells and their intestinal absorption on a human intestinal epithelium model consisting of a monolayer of differentiated Caco2 cells. We observed a potent antileukemic effect for H. indicus, imputable to the modulation of different critical targets at protein and mRNA levels and the reduction of the 26S proteasome expression. We found that some phytomarkers of H. indicus decoction passed through the enterocyte monolayer. Overall, our study supports the pharmacological potential of H. indicus, which can represent an interesting botanical drug in the oncological area.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Turrini E,Catanzaro E,Ferruzzi L,Guerrini A,Tacchini M,Sacchetti G,Paganetto G,Maffei F,Pellicioni V,Poli F,Hrelia P,Mandrone M,Sestili P,Brigotti M,Fimognari Cdoi
10.1038/s41598-019-43609-5subject
Has Abstractpub_date
2019-05-10 00:00:00pages
7199issue
1issn
2045-2322pii
10.1038/s41598-019-43609-5journal_volume
9pub_type
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