Abstract：
:Photoswitchable fluorescent proteins with controllable light-dark states and spectral shifts in emission in response to light have led to breakthroughs in the study of cell biology. Nevertheless, conventional photoswitching is not applicable for weakly fluorescent proteins and requires UV light with low depth penetration in bio-tissue. Here we introduce a novel concept of photoswitchable hybrid probes consisting of thermochromic dye and absorbing nanoparticles, in which temperature-sensitive light-dark states and spectral shifts in absorption can be switched through controllable photothermal heating of doped nanoparticles. The proof-of-concept is demonstrated through the use of two different types of temperature-sensitive dyes doped with magnetic nanoparticles and reversibly photoswitched by a near-infrared laser. Photoacoustic imaging revealed the high contrast of these probes, which is sufficient for their visualization in cells and deep tissue. Our results suggest that these new photoswitchable multicolour probes can be used for multimodal cellular diagnostics and potentially for magnetic and photothermal therapy.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Harrington WN,Haji MR,Galanzha EI,Nedosekin DA,Nima ZA,Watanabe F,Ghosh A,Biris AS,Zharov VPdoi
10.1038/srep36417subject
Has Abstractpub_date
2016-11-08 00:00:00pages
36417issn
2045-2322pii
srep36417journal_volume
6pub_type
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