Abstract:
:Alpha melanocyte stimulating hormone (α-MSH) and Forkhead box C2 protein (Foxc2) enhance lipolysis in multiple tissues. However, their relationship in adipose fatty acid oxidation (FAO) remains unclear. Here, we demonstrated that α-MSH and Foxc2 increased palmitate oxidation to CO2 in white (WAT) and brown adipose tissue (BAT). C/EBPβ expression was reduced by α-MSH and Foxc2. FFA level was elevated by α-MSH and pc-Foxc2 treatment along with increased FAO in white and brown adipocytes. The expression of FAO key enzymes, medium-chain acyl-CoA dehydrogenase (MCAD) and long-chain acyl-CoA dehydrogenase (LCAD) were increased in α-MSH and pc-Foxc2 group. Combination of α-MSH and Foxc2 treatment synergistically promoted FAO through increasing the activity of CPT-1 and phosphorylation of ACC. We found C/EBPβ bind to MC5R and Foxc2 promoter regions and inhibited FAO. cAMP level was increased by α-MSH and Foxc2 individually treated or combined treatment. Furthermore, cAMP/PKA pathway-specific inhibitor (H89) blocked the FAO, despite in α-MSH and Foxc2 both added group. While forskolin, the cAMP agonist, promoted FAO and enhanced the effect of α-MSH and Foxc2. Collectively, α-MSH and Foxc2 mutual promote FAO in WAT and BAT via cAMP/PKA signal pathway. And C/EBPβ as a transcription suppressor inhibits α-MSH and Foxc2 expression and FAO.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Gan L,Liu Z,Chen Y,Dan Luo,Feng F,Liu G,Sun Cdoi
10.1038/srep36661subject
Has Abstractpub_date
2016-11-07 00:00:00pages
36661issn
2045-2322pii
srep36661journal_volume
6pub_type
杂志文章abstract::Large classes of electronic, photonic, and acoustic crystals and quasi-crystals have been predicted to support topological wave-modes. Some of these modes are stabilized by certain symmetries but others occur as pure wave phenomena, hence they can be observed in many other media that support wave propagation. Surface ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21462-2
更新日期:2018-02-20 00:00:00
abstract::Hepatitis C virus (HCV) has long been observed to take advantage of the host mitochondria to support viral replication and assembly. The HCV core protein has been implicated to fragment host mitochondria. In this report, we have discovered that the non-structural protein 5A (NS5A) plays an instructive role in attachin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23464
更新日期:2016-03-24 00:00:00
abstract::It has been shown that bamboo leaf flavone (BLF) displays biological and pharmacological activities in mammals. However, the effects of BLF on broiler gut microbiota and related immune function have not been investigated. The aim of this study was to test our hypothesis that BLF can improve the health status of broile...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69010-1
更新日期:2020-07-23 00:00:00
abstract::Air-core magnetometers are amongst the most commonly used magnetic field detectors in biomedical instruments. They offer excellent sensitivity, low fabrication complexity and a robust, cost-effective solution. However, air-core magnetometers must be tailored to the specific application to achieve high sensitivity, whi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02099-z
更新日期:2017-05-23 00:00:00
abstract::Predictive coding theory suggests that predictable responses are "explained away" (i.e., reduced) by feedback. Experimental evidence for feedback inhibition, however, is inconsistent: most neuroimaging studies show reduced activity by predictive feedback, while neurophysiology indicates that most inter-areal cortical ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22944
更新日期:2016-03-14 00:00:00
abstract::This paper studies the social acceptability and feasibility of a focused protection strategy against coronavirus disease 2019 (COVID-19). We propose a control scheme to develop herd immunity while satisfying the following two basic requirements for a viable policy option. The first requirement is social acceptability:...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81630-9
更新日期:2021-01-21 00:00:00
abstract::The use of metabolomic and lipidomic strategies for selecting potential biomarkers for obstructive sleep apnoea (OSA) has been little explored. We examined adult male patients with OSA (defined by an apnoea-hypopnoea index ≥15 events/hour), as well as age-, gender-, and fat-composition-matched volunteers without OSA. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29727-6
更新日期:2018-07-26 00:00:00
abstract::We investigate whether the collapse of the quantum state of a single photon split between two space-like separated places takes a nonvanishing time. We realize this by using a source of heralded single photons, then splitting the resulting single photon state and letting it propagate over distances much larger than th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48387-8
更新日期:2019-08-15 00:00:00
abstract::Complex regulatory networks control epithelial-to-mesenchymal transition (EMT) but the underlying epigenetic control is poorly understood. Lysine-specific demethylase 1 (LSD1) is a key histone demethylase that alters the epigenetic landscape. Here we explored the role of LSD1 in global epigenetic regulation of EMT, ca...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17913-x
更新日期:2018-01-08 00:00:00
abstract::The bacterial second messenger cyclic di-3',5'-guanosine monophosphate (c-di-GMP) is a key regulator of bacterial motility and virulence. As high levels of c-di-GMP are associated with the biofilm lifestyle, c-di-GMP hydrolysing phosphodiesterases (PDEs) have been identified as key targets to aid development of novel ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42166
更新日期:2017-02-10 00:00:00
abstract::The efficacy of different modalities of treating breast cancer is inhibited by several limitations such as off-targeted drug distribution, rapid drug clearance, and drug resistance. To overcome these limitations, we developed Lf-Doxo-PMNSs for combined chemo-MF-PTT. The PMNSs were synthesized by hydrothermal method an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62429-6
更新日期:2020-04-03 00:00:00
abstract::We formerly developed an automatic colony count system based on the time-lapse shadow image analysis (TSIA). Here this system has been upgraded and applied to practical rapid decision. A microbial sample was spread on/in an agar plate with 90 mm in diameter as homogeneously as possible. We could obtain the results wit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10061
更新日期:2015-05-15 00:00:00
abstract::Most Group I Clostridium botulinum strains harbor botulinum neurotoxin (bont) genes on their chromosome, while some carry these genes (including bont/a, bont/b, and bont/f) on large plasmids. Prior work in our laboratory demonstrated that Group I BoNT plasmids were mobilized to C. botulinum recipient strains containin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21342-9
更新日期:2018-02-15 00:00:00
abstract::Methamphetamine (Meth) is one of the most frequently abused drugs worldwide. Recent studies have indicated that antibodies with high affinity for Meth reduce its pharmacological effects. The purpose of this study was to develop a technique for virus-based passive immunization against Meth effects. We generated a recom...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46301
更新日期:2017-04-07 00:00:00
abstract::Parasites exhibiting a high degree of host specificity are expected to be intimately associated with their hosts. Therefore, the evolution of host-specific parasites is at least partially shaped by the evolutionary history and distribution of such hosts. Gill ectoparasites of Dactylogyrus (Monogenea) are specific to c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31382-w
更新日期:2018-08-29 00:00:00
abstract::We found a novel spontaneous mouse mutant with depigmentation in the ventral body, which we called White Spotting (WS) mouse. Genetic investigation revealed deletion of a > 1.2-Mb genomic region containing nine genes (Kit, Kdr, Srd5a3, Tmeme165, Clock, Pdcl2, Nmu, Exoc1, and Cep135). We designated this mutant allele K...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13632
更新日期:2015-09-08 00:00:00
abstract::Nanoscale wavelength-converted optical components are promising components for communication and optical information processing in integrated photonic system. In this work, we report a facile strategy for realizing continuously tunable wavelength-converted wave-guiding in dye-doped nanofibers. The nanofibers with diam...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01674
更新日期:2013-01-01 00:00:00
abstract::In the fifty years since the postulation of Moore's Law, the increasing energy consumption in silicon electronics has motivated research into emerging devices. An attractive research direction is processing information via the phase of spin waves within magnonic-logic circuits, which function without charge transport ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08114-7
更新日期:2017-08-11 00:00:00
abstract::The predictions for a warmer and drier climate and for increased likelihood of climate extremes raise high concerns about the possible collapse of dryland ecosystems, and about the formation of new drylands where native species are less tolerant to water stress. Using a dryland-vegetation model for plant species that ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56080-z
更新日期:2019-12-20 00:00:00
abstract::Cathelicidins are short cationic host defense peptides and play a central role in host innate immune system. Here we identified two novel cathelicidins, Cl-CATH2 and 3, from Columba livia. Evolutionary analysis of avian cathelicidins via phylogenetic tree and Ka/Ks calculations supported the positive selection that pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11082
更新日期:2015-07-21 00:00:00
abstract::Super-Planckian near-field radiative heat transfer allows effective heat transfer between a hot and a cold body to increase beyond the limits long known for black bodies. Until present, experimental techniques to measure the radiative heat flow relied on steady-state systems. Here, we present a dynamic measurement app...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14242-x
更新日期:2017-10-24 00:00:00
abstract::Colorectal cancer (CRC) is one of the most prevalent cancers worldwide and Alpha B-crystallin (CRYAB) protein has been identified as a prognostic biomarker for CRC. We evaluated CRYAB C-802G (rs14133)polymorphism in association with CRC risk and survival in Chinese population. We genotyped for CRYAB C-802G (rs14133), ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29589-y
更新日期:2018-08-06 00:00:00
abstract::FcRn mediates recycling and transcytosis of IgG and albumin in various cell types. The MHC-class-I-like protein of the FcRn heterodimer is encoded by FCGRT. Few determinants of variable FCGRT expression in humans have been identified so far. In this study, we investigated the presence of DNA methylation in regulatory ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45203-1
更新日期:2019-06-17 00:00:00
abstract::Society's increasing interactions with technology are creating extensive "digital traces" of our collective human behavior. These new data sources are fuelling the rapid development of the new field of computational social science. To investigate user attention to the Hurricane Sandy disaster in 2012, we analyze data ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03141
更新日期:2013-11-05 00:00:00
abstract::Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studies (GWAS) have not stratified by sex. Potential sex-specific gen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24580-z
更新日期:2018-05-09 00:00:00
abstract::The next-generation logic and memory devices using magnetic skyrmions as spintronic information carriers are frequently studied, thanks to their remarkable magnetic stability, extremely compact size and very-low-cost driving forces within nanotracks. In order to realize skyrmion-based spintronic devices, understanding...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40220-6
更新日期:2019-03-05 00:00:00
abstract::In the last years, great advances have been made in therapies based in cold atmospheric plasmas (CAP). CAP generate reactive oxygen and nitrogen species (RONS) which can be transferred to liquids. These CAP activated liquids display the same biological efficacy (i.e. on killing cancer cells) as CAP themselves, opening...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52673-w
更新日期:2019-11-06 00:00:00
abstract::Accumulating evidence indicates the absence of paternally derived miRNAs, piwiRNAs, and proteins may be one important factor contributing to developmental failure in somatic cell cloned embryos. In the present study, we found microRNA-449b (miR-449b) was highly expressed in sperm. Target gene predictions and experimen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13899-8
更新日期:2017-10-17 00:00:00
abstract::Salts containing radical cations of 1,2,4,5-tetrakis(isopropylthio)benzene (TPB) and 1,2,4,5-tetrakis(ethylthio) benzene (TEB) have been successfully synthesized with . These newly synthesized salts have been characterized by UV-Vis absorption, EPR spectroscopy, conductivity measurement, single crystal X-ray diffracti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29314
更新日期:2016-07-11 00:00:00
abstract::The group-IV tin has been hypothesized to possess intriguing electronic properties in an atom-thick hexagonal form. An attractive pathway of producing sizable 2D crystallites of tin is based on deintercalation of bulk compounds with suitable tin frameworks. Here, we have identified a new synthesizable metal distannide...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28369
更新日期:2016-07-08 00:00:00