Abstract:
:Cathelicidins are short cationic host defense peptides and play a central role in host innate immune system. Here we identified two novel cathelicidins, Cl-CATH2 and 3, from Columba livia. Evolutionary analysis of avian cathelicidins via phylogenetic tree and Ka/Ks calculations supported the positive selection that prompted evolution of CATH2 to CATH1 and 3, which originate from common ancestor and could belong to one superfamily. Cl-CATH2 and 3 both adopt amphipathic α-helical comformations identified by circular dichroism and the 3D structures built by Rosetta. Cl-CATH2 of CATH2 family with the most expression abundance in bird, exhibited relatively weak antimicrobial activity, but acted instead on the innate immune response without showing undesirable toxicities. In macrophages primed by LPS, Cl-CATH2 significantly down-regulated the gene and protein expressions of inducible nitric oxide synthase and pro-inflammatory cytokines while enhancing the anti-inflammatory cytokine, acting through MAPK and NF-κB signaling pathways. Molecular docking shows for the first time that cathelicidin binds to the opening region of LPS-binding pocket on myeloid differentiation factor 2 (MD-2) of toll-like receptor (TLR)4-MD-2 complex, which in turn inhibits the TLR4 pathway. Our results, therefore, provide new insight into the mechanism underlying the blockade of TLR4 signaling by cathelicidins.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Yu H,Lu Y,Qiao X,Wei L,Fu T,Cai S,Wang C,Liu X,Zhong S,Wang Ydoi
10.1038/srep11082subject
Has Abstractpub_date
2015-07-21 00:00:00pages
11082issn
2045-2322pii
srep11082journal_volume
5pub_type
杂志文章abstract::Genomic selection (GS) by selecting lines prior to field phenotyping using genotyping data has the potential to enhance the rate of genetic gains. Genotype × environment (G × E) interaction inclusion in GS models can improve prediction accuracy hence aid in selection of lines across target environments. Phenotypic dat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30027-2
更新日期:2018-08-03 00:00:00
abstract::Most glioblastoma patients have a dismal prognosis, although some survive several years. However, only few biomarkers are available to predict the disease course. EGR1 and EGR3 have been linked to glioblastoma stemness and tumour progression, and this study aimed to investigate their spatial expression and prognostic ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66236-x
更新日期:2020-06-09 00:00:00
abstract::Measuring handgrip strength is the initial step to diagnose sarcopenia. To investigate whether the serum creatinine (Cr)/cystatin C (CysC) ratio could serve as a case-finding tool for low handgrip strength, we conducted a diagnostic accuracy study. Adults (aged ≥ 40 years) with normal renal function were recruited. Tr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71028-4
更新日期:2020-08-20 00:00:00
abstract::Gliomas are the most common brain tumors affecting the central nervous system and are associated with a high mortality rate. DCF1 is a membrane protein that was previously found to play a role in neural stem cell differentiation. In the present study, we found that overexpression of dcf1 significantly inhibited cell p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03702
更新日期:2014-01-15 00:00:00
abstract::Anaerobic ammonium oxidation (anammox) bacteria significantly improve the efficiency and reduce cost of nitrogen removal in wastewater treatment plants. However, their slow growth and vulnerable activity limit the application of anammox technology. In this paper, the enhancement of biotin on the nitrogen removal activ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81738-y
更新日期:2021-01-21 00:00:00
abstract::Major overturn within a magma chamber can bring together felsic and mafic magmas, prompting de-volatilisation and acting as the driver for Plinian eruptions. Until now identification of mixing has been limited to analysis of lavas or individual crystals ejected during eruptions. We have recovered partially developed c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00731
更新日期:2012-01-01 00:00:00
abstract::Mycoplasma mobile, a fish pathogen, exhibits its own specialized gliding motility on host cells based on ATP hydrolysis. The special protein machinery enabling this motility is composed of surface and internal protein complexes. Four proteins, MMOBs 1630, 1660, 1670, and 4860 constitute the internal complex, including...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60535-z
更新日期:2020-03-02 00:00:00
abstract::The TCP transcription factors usually act as integrators of multiple growth regulatory and environmental stimuli. However, little is known about this gene family in the important tropical crop cassava (Manihot esculenta). In this study, 36 TCP genes were identified and renamed based on cassava whole-genome sequence an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09398-5
更新日期:2017-08-30 00:00:00
abstract::An ultra-fast physical random number generator is demonstrated utilizing a photonic integrated device based broadband chaotic source with a simple post data processing method. The compact chaotic source is implemented by using a monolithic integrated dual-mode amplified feedback laser (AFL) with self-injection, where ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45900
更新日期:2017-04-04 00:00:00
abstract::Animals have evolved limb proportions adapted to different environments, but it is not yet clear to what extent these proportions are directly influenced by the environment during prenatal development. The developing skeleton experiences mechanical loading resulting from embryo movement. We tested the hypothesis that ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41926
更新日期:2017-02-06 00:00:00
abstract::Recombinant Mycobacterium strains such as recombinant BCG (rBCG) have received considerable attention for the HIV-1 vaccine development. Recently, we described a temperature-sensitive Mycobacterium paragordonae (Mpg) strain as a novel live tuberculosis vaccine that is safer and showed an enhanced protective effect aga...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51875-6
更新日期:2019-10-29 00:00:00
abstract::A paper-based upconversion fluorescence resonance energy transfer assay device is proposed for sensitive detection of CEA. The device is fabricated on a normal filter paper with simple nano-printing method. Upconversion nanoparticles tagged with specific antibodies are printed to the test zones on the test paper, foll...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23406
更新日期:2016-03-22 00:00:00
abstract::Stem and progenitor cells are the critical units for tissue maintenance, regeneration, and repair. The activation of regenerative events in response to tissue injury has been correlated with mobilization of tissue-resident progenitor cells, which is functional to the wound healing process. However, until now there has...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16574
更新日期:2015-11-12 00:00:00
abstract::Climate change is expected to have profound, partly unforeseeable effects on the composition of functional traits of complex ecosystems, such as coral reefs, and some ecosystem properties are at risk of disappearing. This study applies a novel spatially explicit, individual-based model to explore three critical life h...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38962-4
更新日期:2019-03-06 00:00:00
abstract::Recently, there has been a debate whether implicit Theory of Mind can be reliably measured using anticipatory looking tasks. Previous anticipatory looking paradigms used video stimuli to measure implicit Theory of Mind; however, numerous replications of these paradigms were unsuccessful. This lack of replications may ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80614-5
更新日期:2021-01-13 00:00:00
abstract::The ability of radial glial progenitors (RGPs) to generate cortical neurons is determined by local extracellular factors and signaling pathways intrinsic to RGPs. Here we find that GPR157, an orphan G protein-coupled receptor, localizes to RGPs' primary cilia exposed to the cerebrospinal fluid (CSF). GPR157 couples wi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25180
更新日期:2016-05-04 00:00:00
abstract::The interaction of a mechanical oscillator with the operation actions and environment fields will give rise to the splitting of normal modes. In this study, we investigate the normal mode splitting behaviour of a moving-particles-pumped single-span clamped-hinged elastic homogeneous beam based on the proposed multi-oc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27989-8
更新日期:2018-06-28 00:00:00
abstract::Programmed cell death 5 (PDCD5) is believed to play a crucial role in p53 activation; however, the underlying mechanism of how PDCD5 function is regulated during apoptosis remains obscure. Here, we report that the serine/threonine phosphatase PPEF-1 interacts with and dephosphorylates PDCD5 at Ser-119, which leads to ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39222
更新日期:2017-01-04 00:00:00
abstract::Herbicides are the most commonly used means of controlling weeds. Recently, there has been growing concern over the potential impacts of global climate change, specifically, increasing temperatures and elevated carbon dioxide (CO2) concentrations, on the sensitivity of weeds to herbicides. Here, glyphosate response of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38729-x
更新日期:2019-02-18 00:00:00
abstract::In this work, TiN film deposited by plasma enhanced atomic layer deposition (PEALD) is adopted to modify the commercial anatase TiO2 powders. A series of analyses indicate that the surface modification of 20, 50 and 100 cycles of TiN by PEALD does not change the morphology, crystal size, lattice parameters, and surfac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30726-w
更新日期:2018-08-14 00:00:00
abstract::Recent studies showed that anomalous dry conditions and limited moisture supply roughly between 1998 and 2008, especially in the Southern Hemisphere, led to reduced vegetation productivity and ceased growth in land evapotranspiration (ET). However, natural variability of Earth's climate system can degrade capabilities...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15956
更新日期:2015-10-30 00:00:00
abstract::Hair loss is a common medical problem. In this study, we investigated the proliferation, migration, and growth factor expression of human dermal papilla (DP) cells in the presence or absence of treatment with mesenchymal stem cell extracellular vesicles (MSC-EVs). In addition, we tested the efficacy of MSC-EV treatmen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15505-3
更新日期:2017-11-14 00:00:00
abstract::Endothelial mesenchymal transition (EndMT) plays a critical role in the pathogenesis and progression of interstitial and perivascular fibrosis after acute myocardial infarction (AMI). Pigment epithelium-derived factor (PEDF) is shown to be a new therapeutic target owing to its protective role in cardiovascular disease...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41932
更新日期:2017-02-07 00:00:00
abstract::Glucosinolates (GSLs) and their hydrolysis products present in Brassicales play important roles in plants against herbivores and pathogens as well as in the protection of human health. To elucidate the molecular mechanisms underlying the formation of species-specific GSLs and their hydrolysed products in Raphanus sati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16306-4
更新日期:2017-11-22 00:00:00
abstract::Jute fibre is the second most important fibre next to cotton. It is obtained from the bark of plant through microbial retting process. Here we report optimized microbial retting protocol that can lower retting period and produce high fibre quality. A total of 451 bacterial colonies have been isolated from five jute re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61898-z
更新日期:2020-03-20 00:00:00
abstract::Food and beverage consumption has a great impact on the environment, although there is a lack of information concerning the whole diet. The environmental impact of 153 Italian adults (51 omnivores, 51 ovo-lacto-vegetarians, 51 vegans) and the inter-individual variability within dietary groups were assessed in a real-l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06466-8
更新日期:2017-07-21 00:00:00
abstract::Here we present an ultraviolet responsive inorganic-organic hybrid solar cell based on titania/poly(3-hexylthiophene) (TiO(2)/P3HT) heterojuction. In this solar cell, TiO(2) is an ultraviolet light absorber and electronic conductor, P3HT is a hole conductor, the light-to-electrical conversion is realized by the cooper...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01283
更新日期:2013-01-01 00:00:00
abstract::Myeloid-derived suppressor cells (MDSCs) expand during inflammation and exhibit immunomodulatory functions on innate and adaptive immunity. However, their impact on trauma-induced immune responses, characterized by an early pro-inflammatory phase and dysregulated adaptive immunity involving lymphocyte apoptosis, exhau...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44419-5
更新日期:2019-05-29 00:00:00
abstract::Systemic antioxidative status has been implicated in glaucoma pathogenesis. Additionally, corneal hysteresis (CH) may contribute to glaucoma progression. Here, we evaluated the relationship between biological antioxidant potential (BAP) and CH. This study included 103 patients with open-angle glaucoma (OAG). We used a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57520-x
更新日期:2020-01-17 00:00:00
abstract::Coupled networks are extremely fragile because a node failure of a network would trigger a cascade of failures on the entire system. Existing studies mainly focused on the cascading failures and the robustness of coupled networks when the networks suffer from attacks. In reality, it is necessary to recover the damaged...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08439
更新日期:2015-02-13 00:00:00