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Bamboo leaf flavone changed the community of cecum microbiota and improved the immune function in broilers.

Abstract：

:It has been shown that bamboo leaf flavone (BLF) displays biological and pharmacological activities in mammals. However, the effects of BLF on broiler gut microbiota and related immune function have not been investigated. The aim of this study was to test our hypothesis that BLF can improve the health status of broilers by modulating the gut microbiota. A total of 300 one-day-old Arbor Acres (AA) broilers were used to characterize their gut microbiota and immune status after feeding diet supplemented with BLF. The V4 hypervariable region of the 16S rRNA gene from cecal bacteria was sequenced via the Illumina MiSeq platform. The Immune status and related parameters were assessed, including the immune organ index (the spleen, thymus, and bursa), serum concentrations of IL-2 and INF-γ, and spleen IL-2 and INF-γ gene expressions. The results showed the BLF diet had an Immune enhancement effect on broilers. In addition, BFL caused the changes of the gut microbial community structure, resulting in greater proportions of bacterial taxa belonging to Lactobacillus, Clostridiales, Ruminococcus, and Lachnospiraceae. These bacteria have been used as probiotics for producing short chain fatty acids in hosts. These results indicate that BLF supplement improves immune function in chicken via modulation of the gut microbiota.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Shu G,Kong F,Xu D,Yin L,He C,Lin J,Fu H,Wang K,Tian Y,Zhao X

doi

10.1038/s41598-020-69010-1

subject

Has Abstract

pub_date

2020-07-23 00:00:00

pages

12324

issue

1

issn

2045-2322

pii

10.1038/s41598-020-69010-1

journal_volume

10

pub_type

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