MircoRNA-33a inhibits epithelial-to-mesenchymal transition and metastasis and could be a prognostic marker in non-small cell lung cancer.

abstract：:On-chip integration of optical detection units into the microfluidic systems for online monitoring is highly desirable for many applications and is also well in line with the spirit of optofluidics technology-fusion of optics and microfluidics for advanced functionalities. This paper reports the construction of a UV-V...

journal_title：Scientific reports

authors： Wang N,Tan F,Zhao Y,Tsoi CC,Fan X,Yu W,Zhang X

更新日期：2016-06-29 00:00:00

abstract：:Ocean warming increasingly endangers the fitness of marine invertebrates. Transgenerational effects (TE) potentially mitigate the impacts of environmental stress on the embryos of marine invertebrates. The molecular mechanisms, however, remain largely unknown. Using high-throughput RNA sequencing technology, we invest...

journal_title：Scientific reports

authors： Shi D,Zhao C,Chen Y,Ding J,Zhang L,Chang Y

更新日期：2020-05-13 00:00:00

abstract：:For a high-performance cocatalyst-modified photocatalyst, an effective interfacial separation of photogenerated electron from its corresponding holes and its following reduction reaction at the active sites are highly required. However, it is difficult for a single-component cocatalyst to simultaneously realize the cr...

journal_title：Scientific reports

authors： Yu H,Tian J,Chen F,Wang P,Wang X

更新日期：2015-08-14 00:00:00

abstract：:There is a growing desire to integrate the food requirements of predators living in marine ecosystems impacted by humans into sustainable fisheries management. We used non-invasive video-recording, photography and focal observations to build time-energy budget models and to directly estimate the fish mass delivered to...

journal_title：Scientific reports

authors： Gaglio D,Sherley RB,Ryan PG,Cook TR

更新日期：2018-05-29 00:00:00

abstract：:Bacterial blight and bacterial leaf streak are serious, economically damaging, diseases of rice caused by the bacteria Xanthomonas oryzae pv. oryzae and X. oryzae pv. oryzicola. Bacillus amyloliquefaciens FZB42 was shown to possess biocontrol activity against these Xanthomonas strains by producing the antibiotic compo...

journal_title：Scientific reports

authors： Wu L,Wu H,Chen L,Yu X,Borriss R,Gao X

更新日期：2015-08-13 00:00:00

abstract：:Jasmonates (JAs) play important roles in plant growth, development and defense. Comprehensive metabolomics profiling of plants under JA treatment provides insights into the interaction and regulation network of plant hormones. Here we applied high resolution mass spectrometry based metabolomics approach on Arabidopsis...

journal_title：Scientific reports

authors： Cao J,Li M,Chen J,Liu P,Li Z

更新日期：2016-11-24 00:00:00

abstract：:Altered neural mechanisms are well-acknowledged in irritable bowel syndrome (IBS), a disorder of brain-gut-communication highly comorbid with anxiety and depression. As a key hub in corticolimbic inhibition, medial prefrontal cortex (mPFC) may be involved in disturbed emotion regulation in IBS. However, aberrant mPFC ...

journal_title：Scientific reports

authors： Icenhour A,Tapper S,Bednarska O,Witt ST,Tisell A,Lundberg P,Elsenbruch S,Walter S

更新日期：2019-09-19 00:00:00

abstract：:The accumulation of repetitive DNA sequences on the sex-limited W or Y chromosomes is a well-known process that is likely triggered by the suppression of recombination between the sex chromosomes, which leads to major differences in their sizes and genetic content. Here, we report an analysis conducted on the satellit...

journal_title：Scientific reports

authors： Utsunomia R,Silva DMZA,Ruiz-Ruano FJ,Goes CAG,Melo S,Ramos LP,Oliveira C,Porto-Foresti F,Foresti F,Hashimoto DT

更新日期：2019-04-10 00:00:00

abstract：:Small heat shock proteins are ubiquitous molecular chaperones that form the first line of defence against the detrimental effects of cellular stress. Under conditions of stress they undergo drastic conformational rearrangements in order to bind to misfolded substrate proteins and prevent cellular protein aggregation. ...

journal_title：Scientific reports

authors： Mani N,Bhandari S,Moreno R,Hu L,Prasad BVV,Suguna K

更新日期：2016-04-07 00:00:00

abstract：:Bone is the most common site of metastasis in metastatic castration-resistant prostate cancer (mCRPC), which is associated with pain and skeletal events. Radium-223 dichloride (Xofigo) is an alpha-emitting radioactive isotope that can specifically target bone lesions. Herein, we report the results of a retrospective a...

journal_title：Scientific reports

authors： Rizzini EL,Dionisi V,Ghedini P,Morganti AG,Fanti S,Monari F

更新日期：2020-04-21 00:00:00

abstract：:The life-like fidelity of organisms captured in amber is unique among all kinds of fossilization and represents an invaluable source for different fields of palaeontological and biological research. One of the most challenging aspects in amber research is the study of traits related to behaviour. Here, indirect eviden...

journal_title：Scientific reports

authors： Stebner F,Szadziewski R,Rühr PT,Singh H,Hammel JU,Kvifte GM,Rust J

更新日期：2016-10-04 00:00:00

abstract：:Previous analyses of the Atlantic cod genome showed unique combinations of lacking and expanded number of genes for the immune system. The present study examined lysozyme activity, lysozyme gene distribution and expression in cod. Enzymatic assays employing specific bacterial lysozyme inhibitors provided evidence for ...

journal_title：Scientific reports

authors： Seppola M,Bakkemo KR,Mikkelsen H,Myrnes B,Helland R,Irwin DM,Nilsen IW

更新日期：2016-06-21 00:00:00

abstract：:The aim of this study was to investigate left ventricular (LV) global myocardial strain and LV involvement characteristics in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) and to evaluate their predictive value of adverse cardiac events. Sixty consecutive ARVD/C patients with a defin...

journal_title：Scientific reports

authors： Shen MT,Yang ZG,Diao KY,Jiang L,Zhang Y,Liu X,Gao Y,Hu BY,Huang S,Guo YK

更新日期：2019-10-02 00:00:00

abstract：:Strong pinning depends on the pinning force strength and number density of effective defects. Using the hydrostatic pressure method, we demonstrate here that hydrostatic pressure of 1.2 GPa can significantly enhance flux pinning or the critical current density (Jc) of optimally doped Ba0.6K0.4Fe2As2 crystals by a fact...

journal_title：Scientific reports

authors： Shabbir B,Wang X,Ma Y,Dou SX,Yan SS,Mei LM

更新日期：2016-03-17 00:00:00

abstract：:Glutamate (Glu), the key excitatory neurotransmitter in the central nervous system, is considered essential for brain functioning and has a vital role in learning and memory formation. Earlier it was considered as a harmful agent but later found to be useful for many body functions. However, studies regarding the effe...

journal_title：Scientific reports

authors： Tabassum S,Ahmad S,Madiha S,Shahzad S,Batool Z,Sadir S,Haider S

更新日期：2020-07-08 00:00:00

abstract：:Cancer is widely recognized as a genetic disease in which somatic mutations are sequentially accumulated to drive tumor progression. Although genomic landscape studies are informative for individual cancer types, a comprehensive comparative study of tumorigenic mutations across cancer types based on integrative data s...

journal_title：Scientific reports

authors： Tan H,Bao J,Zhou X

更新日期：2015-07-27 00:00:00

abstract：:In unpredictable environments in which reliable cues for predicting environmental variation are lacking, a diversifying bet-hedging strategy for diapause exit is expected to evolve, whereby only a portion of diapausing forms will resume development at the first occurrence of suitable conditions. This study focused on ...

journal_title：Scientific reports

authors： Tarazona E,Lucas-Lledó JI,Carmona MJ,García-Roger EM

更新日期：2020-12-07 00:00:00

abstract：:Recent reports have suggested a reproducible association between the rs11121615 SNP, located within an intron of the castor zinc finger 1 (CASZ1) gene, and varicose veins. This study aimed to determine if this variant is also differentially associated with the various clinical classifications of chronic venous disease...

journal_title：Scientific reports

authors： Jones GT,Marsman J,Pardo LM,Nijsten T,De Maeseneer M,Phillips V,Lynch-Sutherland C,Horsfield J,Krysa J,van Rij AM

更新日期：2019-09-30 00:00:00

abstract：:IgLONs are members of the immunoglobulin superfamily of cell adhesion proteins implicated in the process of neuronal outgrowth, cell adhesion and subdomain target recognition. IgLONs form homophilic and heterophilic complexes on the cell surface that repress or promote growth depending on the neuronal population, the ...

journal_title：Scientific reports

authors： Sanz RL,Ferraro GB,Girouard MP,Fournier AE

更新日期：2017-08-11 00:00:00

abstract：:Despite strengthened antimicrobial therapy, biofilm infections of Acinetobacter baumannii are associated with poor prognosis and limited therapeutic options. Assessing antibiotics on planktonic bacteria can result in failure against biofilm infections. Currently, antibiotics to treat biofilm infections are administere...

journal_title：Scientific reports

authors： Wannigama DL,Hurst C,Pearson L,Saethang T,Singkham-In U,Luk-In S,Storer RJ,Chatsuwan T

更新日期：2019-04-19 00:00:00

abstract：:Skeletal muscle represents the largest pool of body zinc, however, little is known about muscle zinc homeostasis or muscle-specific zinc functions. Zip14 (Slc39a14) was the most highly expressed zinc transporter in skeletal muscle of mice in response to LPS-induced inflammation. We compared metabolic parameters of ske...

journal_title：Scientific reports

authors： Kim J,Aydemir TB,Jimenez-Rondan FR,Ruggiero CH,Kim MH,Cousins RJ

更新日期：2020-03-04 00:00:00

abstract：:Magnetic skyrmions are promising candidates for the next generation of spintronic devices due to their small size and topologically protected structure. One challenge for using these magnetic states in applications lies on controlling the nucleation process and stabilization that usually requires an external force. He...

journal_title：Scientific reports

authors： Brandão J,Dugato DA,Seeger RL,Denardin JC,Mori TJA,Cezar JC

更新日期：2019-03-11 00:00:00

abstract：:p53 and aldehyde dehydrogenase (ALDH) have been implicated in key tumorigenesis processes including cancer initiating cell (CIC) maintenance; however, the relationship between these two mediators remains poorly defined. In this study, ALDH isoform expression diversity was revealed in CICs with disparate p53 functional...

journal_title：Scientific reports

authors： Gui S,Xie X,O'Neill WQ,Chatfield-Reed K,Yu JG,Teknos TN,Pan Q

更新日期：2020-01-23 00:00:00

abstract：:Accumulating evidence suggests that the gut microbiota dysbiosis and their host metabolic phenotype alteration is an important factor in human disease development. A traditional Chinese herbal formula, Chaihu-Shu-Gan-San (CSGS), has been effectively used in the treatment of various gastrointestinal (GI) disorders. The...

journal_title：Scientific reports

authors： Yu M,Jia HM,Zhou C,Yang Y,Sun LL,Zou ZM

更新日期：2017-04-20 00:00:00

abstract：:Biological networks play a key role in determining biological function and therefore, an understanding of their structure and dynamics is of central interest in systems biology. In Boolean models of such networks, the status of each molecule is either "on" or "off" and along with the molecules interact with each other...

journal_title：Scientific reports

authors： Chen H,Wang G,Simha R,Du C,Zeng C

更新日期：2016-01-29 00:00:00

abstract：:The rainbow trout, a carnivorous fish, displays a 'glucose-intolerant' phenotype revealed by persistent hyperglycaemia when fed a high carbohydrate diet (HighCHO). Epigenetics refers to heritable changes in gene activity and is closely related to environmental changes and thus to metabolism adjustments governed by nut...

journal_title：Scientific reports

authors： Marandel L,Lepais O,Arbenoits E,Véron V,Dias K,Zion M,Panserat S

更新日期：2016-08-26 00:00:00

abstract：:The newly discovered Candidatus 'Methanoperedens nitroreducens' (M. nitroreducens), mediating nitrate-dependent anaerobic oxidation of methane, is an important microorganism in linking carbon and nitrogen cycles. In order to explore the diversity of M. nitroreducens-like archaea in various environmental niches with ad...

journal_title：Scientific reports

authors： Xu S,Cai C,Guo J,Lu W,Yuan Z,Hu S

更新日期：2018-05-16 00:00:00

abstract：:Rickettsiales are important zoonotic pathogens, causing severe disease in humans globally. Although mosquitoes are an important vector for diverse pathogens, with the exception of members of the genus Wolbachia little is known about their role in the transmission of Rickettsiales. Herein, Rickettsiales were identified...

journal_title：Scientific reports

authors： Guo WP,Tian JH,Lin XD,Ni XB,Chen XP,Liao Y,Yang SY,Dumler JS,Holmes EC,Zhang YZ

更新日期：2016-12-09 00:00:00

abstract：:Cholestasis impairs liver regeneration following partial liver resection (PHx). Bile acid receptor farnesoid X-receptor (FXR) is a key mediator of liver regeneration. The effects of FXR agonist obeticholic acid (OCA) on liver (re)growth were therefore studied in cholestatic rats. Animals underwent sham surgery or reve...

journal_title：Scientific reports

authors： van Golen RF,Olthof PB,Lionarons DA,Reiniers MJ,Alles LK,Uz Z,de Haan L,Ergin B,de Waart DR,Maas A,Verheij J,Jansen PL,Damink SWO,Schaap FG,van Gulik TM,Heger M

更新日期：2018-11-08 00:00:00

abstract：:H. pylori-induced chronic inflammation is considered the most important cause of gastric cancer. The actual process how chronic inflammation triggers gastric carcinogenesis is still not clear. In this study, neutrophils and relative markers in gastric cancer development were examined with immunohistochemistry and fluo...

journal_title：Scientific reports

authors： Fu H,Ma Y,Yang M,Zhang C,Huang H,Xia Y,Lu L,Jin W,Cui D

更新日期：2016-07-14 00:00:00