Abstract：
:Cancer is widely recognized as a genetic disease in which somatic mutations are sequentially accumulated to drive tumor progression. Although genomic landscape studies are informative for individual cancer types, a comprehensive comparative study of tumorigenic mutations across cancer types based on integrative data sources is still a pressing need. We systematically analyzed ~10(6) non-synonymous mutations extracted from COSMIC, involving ~8000 genome-wide screened samples across 23 major human cancers at both the amino acid and gene levels. Our analysis identified cancer-specific heterogeneity that traditional nucleotide variation analysis alone usually overlooked. Particularly, the amino acid arginine (R) turns out to be the most favorable target of amino acid alteration in most cancer types studied (P < 10(-9), binomial test), reflecting its important role in cellular physiology. The tumor suppressor gene TP53 is mutated exclusively with the HYDIN, KRAS, and PTEN genes in large intestine, lung, and endometrial cancers respectively, indicating that TP53 takes part in different signaling pathways in different cancers. While some of our analyses corroborated previous observations, others indicated relevant candidates with high priority for further experimental validation. Our findings have many ramifications in understanding the etiology of cancer and the underlying molecular mechanisms in particular cancers.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Tan H,Bao J,Zhou Xdoi
10.1038/srep12566subject
Has Abstractpub_date
2015-07-27 00:00:00pages
12566issn
2045-2322pii
srep12566journal_volume
5pub_type
杂志文章abstract：:We present a new class of TiBw/Ti6Al4V composites with a network reinforcement architecture that exhibits a significant creep resistance compared to monolithic Ti6Al4V alloys. Creep tests performed at temperatures between 773 K and 923 K and stress range of 100 MPa-300 MPa indicate both a significant improvement of th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40823
更新日期：2017-01-17 00:00:00
abstract：:Two types of periodic and transient motions of large woodpeckers are considered. A drumming woodpecker may be modeled as a harmonic oscillator with a periodic forcing function. The transient behavior that occurs after the forcing is turned off suggests that the double knocks of Campephilus woodpeckers may be modeled i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13035-6
更新日期：2017-10-02 00:00:00
abstract：:Coral reefs are vital for the marine ecosystem and their potential disappearance can have unequivocal consequences on our environment. Aside from pollution-related threats (changes in water temperature, plastics, and acidity), corals can be injured by diseases, predators, humans and other invasive species. Diseases pl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57980-1
更新日期：2020-01-22 00:00:00
abstract：:Src kinase is known to regulate fibroblast migration. However, the contribution of integrin and Src kinase interaction to lung fibrosis has not been mechanistically investigated. Our data demonstrate that integrin alpha v (αV) recruited Src kinase and that leads to subsequent Src activation in fibroblasts plated on fi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46357
更新日期：2017-04-11 00:00:00
abstract：:Polypoidal choroidal vasculopathy (PCV) is a distinctive type of neovascular age-related macular degeneration prevalent in many Asian countries. However, there is still some controversy in how the subtypes of PCV are classified. This post-hoc study redefined the branching vascular network (BVN) and PCV subtypes throug...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80731-1
更新日期：2021-01-11 00:00:00
abstract：:Protein corona significantly affects in vivo fate of nanoparticles including biodistribution and half-life. Without manipulating the physicochemical properties of nanoparticles with considering their biointerference, attaining effective treatment protocols is impossible. For this reason, protein corona evolution and b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66572-y
更新日期：2020-06-15 00:00:00
abstract：:Receptivity is a limited time in which uterine endometrium can establish a successful dialogue with blastocyst. This study was to investigate the effect of asynchronous embryo transfer on uterine receptivity in mice. Embryos under different stages were transferred into two oviduct sides of a recipient mouse on day 1 o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15897
更新日期：2015-11-04 00:00:00
abstract：:Cortical neural activities lead to changes in the cerebral blood flow (CBF), which involves astrocytic control of cerebrovascular tone. However, the manner in which astrocytic activity specifically leads to vasodilation or vasoconstriction is difficult to determine. Here, cortical astrocytes genetically expressing a l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11455
更新日期：2015-06-16 00:00:00
abstract：:Activation-induced cytidine deaminase (AID) triggers antibody diversification in B cells by catalysing deamination and subsequently mutating immunoglobulin (Ig) genes. Association of AID with RNA Pol II and occurrence of epigenetic changes during Ig gene diversification suggest participation of AID in epigenetic regul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07380-9
更新日期：2017-08-08 00:00:00
abstract：:Viral upper respiratory tract infection (URTI) predisposes to bacterial pneumonia possibly by facilitating growth of bacteria such as Streptococcus pneumoniae colonising the nasopharynx. We investigated whether viral URTI is temporally associated with an increase in nasopharyngeal pneumococcal concentration. Episodes ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29119-w
更新日期：2018-07-23 00:00:00
abstract：:Congenital cataract is the most frequent inherited ocular disorder and the most leading cause of lifelong visual loss. The screening of pathogenic mutations can be very challenging in some cases, for congenital cataracts are clinically and genetically heterogeneous diseases. The aim of this study is to investigate the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01182-9
更新日期：2017-04-27 00:00:00
abstract：:The individual response of patients to propofol results from the influence of genetic factors. However, the state of knowledge in this matter still remains insufficient. The aim of our study was to determine genetic predictors of variable pharmacokinetics and pharmacodynamics of propofol within selected 9 genes coding...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-017-15657-2
更新日期：2017-11-13 00:00:00
abstract：:Divalent metal-ion transporter 1 (DMT1) has been found to play an important role in the iron metabolism and hemogenesis. However, little is known about the potential role of DMT1 in the pathogenesis of anemia from patients with inflammatory bowel disease (IBD). Herein, we investigated expression of DMT1 in the intesti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16344
更新日期：2015-11-17 00:00:00
abstract：:Ecuadorian pottery is renowned for its beauty and the particularly rich colour of its pigments. However, a major challenge for art historians is the proper assessment of the provenance of individual pieces due to their lack of archaeological context. Of particular interest is the Jama-Coaque culture, which produced fa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38293-w
更新日期：2019-02-25 00:00:00
abstract：:A loss of function mutation in the TRESK K2P potassium channel (KCNK18), has recently been linked with typical familial migraine with aura. We now report the functional characterisation of additional TRESK channel missense variants identified in unrelated patients. Several variants either had no apparent functional ef...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00237
更新日期：2012-01-01 00:00:00
abstract：:To investigate the prognostic role of the estrogen receptor (ER) in gastric cancer (GC) patients, tumor tissues from 932 patients with advanced GC were assessed for ER expression using immunohistochemistry, and their clinicopathologic features were evaluated. Forty patients (4.3%) had ER expression and they were more ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/srep07592
更新日期：2014-12-23 00:00:00
abstract：:Prostate cancer (PCa) is the second most common cancer among men worldwide. Its etiology remains largely unknown compared to other common cancers. We have developed a risk stratification model combining environmental factors with family history and genetic susceptibility. 818 PCa cases and 1,006 healthy controls were ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09386-9
更新日期：2017-08-21 00:00:00
abstract：:Based on the pro-drug principle, aspirin and eugenol were used to synthesize aspirin eugenol ester (AEE) by esterification reaction. In present study, the anti-atherosclerosis effects of AEE were investigated in hamsters with the utilization of metabonomic approach based on UPLC-Q-TOF/MS. Biochemical parameters and hi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11422-7
更新日期：2017-09-05 00:00:00
abstract：:In the last forty years therapy outcomes for depression have remained the same with approximately 50% of patients responding to treatments. Advances are urgently required. We hypothesised that a recent treatment, metacognitive therapy (MCT), might be more effective, by targeting mental control processes that directly ...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-020-64577-1
更新日期：2020-05-12 00:00:00
abstract：:Practical applications of bacteriophages in medicine and biotechnology induce a great need for technologies of phage purification. None of the popular methods offer solutions for separation of a phage from another similar phage. We used affinity chromatography combined with competitive phage display (i) to purify T4 b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03220
更新日期：2013-11-14 00:00:00
abstract：:Sensing infrared radiation is done inexpensively with pyroelectric detectors that generate a temporary voltage when they are heated by the incident infrared radiation. Unfortunately the performance of these detectors deteriorates for longer wavelengths, leaving the detection of, for instance, millimetre-wave radiation...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21079
更新日期：2016-02-16 00:00:00
abstract：:Natural infection with measles virus (MV) establishes lifelong immunity. Persistent infection with MV is likely involved in this phenomenon, as non-replicating protein antigens never induce such long-term immunity. Although MV establishes stable persistent infection in vitro and possibly in vivo, the mechanism by whic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37163
更新日期：2016-11-24 00:00:00
abstract：:Nociceptive neurons play an essential role in pain sensation by transmitting painful stimuli to the central nervous system. However, investigations of nociceptive neuron biology have been hampered by the lack of accessibility of human nociceptive neurons. Here, we describe a system for efficiently guiding human embryo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16821
更新日期：2015-11-19 00:00:00
abstract：:A hybrid optoplasmonic amplifier, injection-seeded by an internally-generated Raman signal and operating in the visible (563-675 nm), is proposed and evidence for amplification is presented. Comprising a gain medium tethered to a whispering gallery mode (WGM) resonator with a protein, and a plasmonic surface, the opti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06168
更新日期：2014-08-26 00:00:00
abstract：:Drug addiction remains a prevalent and fatal disease worldwide that carries significant social and economic impacts. Recent reports suggest illicit pregabalin (Lyrica) use may be increasing among youth, however the addictive potential of pregabalin has not been well established. Drug seeking behavior and chronic drug ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51556-4
更新日期：2019-10-22 00:00:00
abstract：:Skeletal muscle thickness is a valuable indicator of several aspects of a muscle's functional capabilities. We used computational analysis of ultrasound images, recorded from 10 humans walking and running at a range of speeds (0.7-5.0 m s-1), to quantify interactions in thickness change between three ankle plantar fle...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-019-51510-4
更新日期：2019-10-21 00:00:00
abstract：:HIV subtypes or clades differentially induce HIV-associated neurocognitive disorders (HAND) and substance abuse is known to accelerate HIV disease progression. The HIV-1 envelope protein gp120 plays a major role in binding and budding in the central nervous system (CNS) and impacts dopaminergic functions. However, the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11130
更新日期：2015-06-09 00:00:00
abstract：:It is well known the thermal properties of three-dimensional (3-D) hybrid graphene (GR)-carbon nanotube (CNT) structures are not superior to that of the individual GR and CNT, however, the 3-D hybrid GR-CNT structures can effectively improve the thermal properties of polymer matrix. Therefore, understanding the therma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14710-4
更新日期：2017-10-31 00:00:00
abstract：:KIBRA has been suggested as a key regulator of the hippo pathway, regulating organ size, cell contact inhibition as well as tissue regeneration and tumorigenesis. Recently, alterations of KIBRA expression caused by promotor methylation have been reported for several types of cancer. Our current study aimed to design a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22600-6
更新日期：2018-03-09 00:00:00
abstract：:We report the new insight into the dielectric barrier discharge (DBD) induced inactivation of Microcystis aeruginosa, the dominant algae which caused harmful cyanobacterial blooms in many developing countries. In contrast with the previous work, we employed flow cytometry to examine the algal cells, so that we could a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13683
更新日期：2015-09-08 00:00:00
