Controlling evolution of protein corona: a prosperous approach to improve chitosan-based nanoparticle biodistribution and half-life.

abstract：:Deriving cell populations from human embryonic stem cells (hESCs) for cell-based therapy is considered a promising strategy to achieve functional cells, yet its translation to clinical practice depends on achieving fully defined differentiated cells. In this work, we generated a miRNA-responsive lethal mRNA construct ...

journal_title：Scientific reports

authors： Elovic E,Etzion S,Cohen S

更新日期：2019-10-10 00:00:00

abstract：:CD47 is overexpressed in many human cancers, its level positively correlates with tumor invasion and metastasis. However, it is largely unknown whether CD47 overexpression drives metastasis and how CD47 lead to tumor metastasis in non-small cell lung cancer (NSCLC). In this study, we analyzed NSCLC specimens and cell ...

journal_title：Scientific reports

authors： Zhao H,Wang J,Kong X,Li E,Liu Y,Du X,Kang Z,Tang Y,Kuang Y,Yang Z,Zhou Y,Wang Q

更新日期：2016-07-14 00:00:00

abstract：:The relative and combined effects of sleep apnea with diabetes mellitus (DM) on cardiovascular outcomes in patients undergoing coronary artery bypass grafting (CABG) remain unknown. In this secondary analysis of data from the SABOT study, 1007 patients were reclassified into four groups based on their sleep apnea and ...

journal_title：Scientific reports

authors： Aung AT,Koo CY,Tam WW,Chen Z,Kristanto W,Sim HW,Kojodjojo P,Kofidis T,Lee CH

更新日期：2020-12-10 00:00:00

abstract：:Determination of the absolute configrations for natural products is one of the most important and challenging tasks, especially when the molecules display high conformational flexibility. In this paper, eight new prenylxanthones, aspergixanthones A-H (1-8), and one known analogue (9), were isolated from the marine-der...

journal_title：Scientific reports

authors： Zhu A,Yang MY,Zhang YH,Shao CL,Wang CY,Hu LD,Cao F,Zhu HJ

更新日期：2018-07-13 00:00:00

abstract：:The high-speed liquid-jet velocity achieved using an injector strongly depends on the piston motion, physical property of the liquid, and container shape of the injector. Herein, we investigate the liquid ejection mechanism and a technique for estimating the ejection velocity of a high-speed liquid jet using a pyro je...

journal_title：Scientific reports

authors： Takagaki N,Kitaguchi T,Iwayama M,Shinoda A,Kumamaru H,Honda I

更新日期：2019-12-27 00:00:00

abstract：:Clinical trials have recently demonstrated the effectiveness of Pre-Exposure Prophylaxis (PrEP) in preventing HIV infection. Consequently, PrEP may soon be used for epidemic control. We model the dynamic interactions that will occur between treatment programs and potential PrEP interventions in resource-constrained co...

journal_title：Scientific reports

authors： Supervie V,Barrett M,Kahn JS,Musuka G,Moeti TL,Busang L,Blower S

更新日期：2011-01-01 00:00:00

abstract：:Organic matter production and decomposition primarily modulate the atmospheric O2 and CO2 levels. The long term marine primary productivity is controlled by the terrestrial input of phosphorus (P), while the marine P cycle would also affect organic matter production. In the past 540 million years, the evolution of ter...

journal_title：Scientific reports

authors： Wang R,Lang X,Ding W,Liu Y,Huang T,Tang W,Shen B

更新日期：2020-04-02 00:00:00

abstract：:The preferential degeneration of Substantia nigra dopamine midbrain neurons (SN DA) causes the motor-symptoms of Parkinson's disease (PD). Voltage-gated L-type calcium channels (LTCCs), especially the Cav1.3-subtype, generate an activity-related oscillatory Ca(2+) burden in SN DA neurons, contributing to their degener...

journal_title：Scientific reports

authors： Poetschke C,Dragicevic E,Duda J,Benkert J,Dougalis A,DeZio R,Snutch TP,Striessnig J,Liss B

更新日期：2015-09-18 00:00:00

abstract：:We have previously shown that MicroRNA (miR) -144 is a key modulator of the acute cardioprotection associated with remote ischemic preconditioning and post myocardial infarction (MI) remodeling. In this study we examine the biology of the remodeling response after permanent ligation of the left anterior descending cor...

journal_title：Scientific reports

authors： He Q,Wang F,Honda T,James J,Li J,Redington A

更新日期：2018-11-15 00:00:00

abstract：:The widely used mood stabilizer valproate (VPA) causes perturbation of energy metabolism, which is implicated in both the therapeutic mechanism of action of the drug as well as drug toxicity. To gain insight into these mechanisms, we determined the effects of VPA on energy metabolism in yeast. VPA treatment increased ...

journal_title：Scientific reports

authors： Salsaa M,Pereira B,Liu J,Yu W,Jadhav S,Hüttemann M,Greenberg ML

更新日期：2020-07-16 00:00:00

abstract：:The diversity of DNA sequencing methods and algorithms for genome assemblies presents scientists with a bewildering array of choices. Here, we construct and compare eight candidate assemblies combining overlapping shotgun read data, mate-pair and Chicago libraries and four different genome assemblers to produce a high...

journal_title：Scientific reports

authors： Fernandez-Silva I,Henderson JB,Rocha LA,Simison WB

更新日期：2018-01-24 00:00:00

abstract：:In this study we describe a new methodology to physically probe individual complexes formed between proteins and DNA. By combining nanoscale, high speed physical force measurement with sensitive fluorescence imaging we investigate the complex formed between the prokaryotic DNA repair protein UvrA2 and DNA. This approa...

journal_title：Scientific reports

authors： Simons M,Pollard MR,Hughes CD,Ward AD,Van Houten B,Towrie M,Botchway SW,Parker AW,Kad NM

更新日期：2015-12-22 00:00:00

abstract：:Tumors are characterized by a rigid, highly cross-linked extracellular matrix (ECM), which impedes homogeneous drug distribution and potentially protects malignant cells from exposure to therapeutics. Lysyl oxidases are major contributors to tissue stiffness and the elevated expression of these enzymes observed in mos...

journal_title：Scientific reports

authors： Schütze F,Röhrig F,Vorlová S,Gätzner S,Kuhn A,Ergün S,Henke E

更新日期：2015-12-01 00:00:00

abstract：:Juvenile hormone (JH) plays crucial roles in many aspects of the insect life. All the JH actions are initiated by transport of JH in the hemolymph as a complex with JH-binding protein (JHBP) to target tissues. Here, we report structural mechanism of JH delivery by JHBP based upon the crystal and solution structures of...

journal_title：Scientific reports

authors： Suzuki R,Fujimoto Z,Shiotsuki T,Tsuchiya W,Momma M,Tase A,Miyazawa M,Yamazaki T

更新日期：2011-01-01 00:00:00

abstract：:Dibutyl phthalate (DBP) is recognized as an environmental endocrine disruptor that has been detected in fetal and postnatal samples. Recent evidence found that in utero DBP exposure was associated with an increase of adipose tissue weight and serum lipids in offspring, but the precise mechanism is unknown. Here we aim...

journal_title：Scientific reports

authors： Li H,Li J,Qu Z,Qian H,Zhang J,Wang H,Xu X,Liu S

更新日期：2020-10-01 00:00:00

abstract：:Key calcifying reef taxa are currently threatened by thermal stress associated with elevated sea surface temperatures (SST) and reduced calcification linked to ocean acidification (OA). Here we undertook an 8 week experimental exposure to near-future climate change conditions and explored the microbiome response of th...

journal_title：Scientific reports

authors： Webster NS,Negri AP,Botté ES,Laffy PW,Flores F,Noonan S,Schmidt C,Uthicke S

更新日期：2016-01-13 00:00:00

abstract：:α-Dystroglycanopathy (α-DGP) is a group of muscular dystrophy characterized by abnormal glycosylation of α-dystroglycan (α-DG), including Fukuyama congenital muscular dystrophy (FCMD), muscle-eye-brain disease, Walker-Warburg syndrome, and congenital muscular dystrophy type 1D (MDC1D), etc. LARGE, the causative gene f...

journal_title：Scientific reports

authors： Ohtsuka Y,Kanagawa M,Yu CC,Ito C,Chiyo T,Kobayashi K,Okada T,Takeda S,Toda T

更新日期：2015-02-09 00:00:00

abstract：:Circulating compounds such as drugs and nutritional components might adhere to the oxygenator fibers and tubing during ECMO support. This study evaluated the amount of nutritional supplements adsorbed to the ECMO circuit under controlled ex vivo conditions. Six identical ECMO circuits were primed with fresh human whol...

journal_title：Scientific reports

authors： Lindberg BR,Videm V,Dahl T,Sørensen G,Fiane AE,Thiara AS

更新日期：2020-11-06 00:00:00

abstract：:Circulating tumor DNA (ctDNA) has become an attractive biomarker in human oncology, and its use may be informative in canine cancer. Thus, we used droplet digital PCR or PCR for antigen receptor rearrangement, to explore tumor-specific point mutations, copy number alterations, and chromosomal rearrangements in the pla...

journal_title：Scientific reports

authors： Prouteau A,Denis JA,De Fornel P,Cadieu E,Derrien T,Kergal C,Botherel N,Ulvé R,Rault M,Bouzidi A,François R,Dorso L,Lespagnol A,Devauchelle P,Abadie J,André C,Hédan B

更新日期：2021-01-13 00:00:00

abstract：:Ascertaining the existence of hidden objects in a complex system, objects that cannot be observed from the external world, not only is curiosity-driven but also has significant practical applications. Generally, uncovering a hidden node in a complex network requires successful identification of its neighboring nodes, ...

journal_title：Scientific reports

authors： Su RQ,Lai YC,Wang X,Do Y

更新日期：2014-02-03 00:00:00

abstract：:The controllability of a network is a theoretical problem of relevance in a variety of contexts ranging from financial markets to the brain. Until now, network controllability has been characterized only on isolated networks, while the vast majority of complex systems are formed by multilayer networks. Here we build a...

journal_title：Scientific reports

authors： Menichetti G,Dall'Asta L,Bianconi G

更新日期：2016-02-12 00:00:00

abstract：:Tropical forests are known for their high diversity. Yet, forest patches do occur in the tropics where a single tree species is dominant. Such "monodominant" forests are known from all of the main tropical regions. For Amazonia, we sampled the occurrence of monodominance in a massive, basin-wide database of forest-inv...

journal_title：Scientific reports

authors： Ter Steege H,Henkel TW,Helal N,Marimon BS,Marimon-Junior BH,Huth A,Groeneveld J,Sabatier D,Coelho LS,Filho DAL,Salomão RP,Amaral IL,Matos FDA,Castilho CV,Phillips OL,Guevara JE,Carim MJV,Cárdenas López D,Magnusson WE

更新日期：2019-09-25 00:00:00

abstract：:SNPs may restrict cell detoxification activity and be a potential risk factor for cancer chemosensitivity. We evaluated the predictive value of these polymorphisms on the sensitivity of bladder cancer patients to epirubicin and mitomycin chemotherapy instillation as well as their toxicities. SNPs were analyzed by TaqM...

journal_title：Scientific reports

authors： Deng X,Yang X,Cheng Y,Liu X,Li X,Zhao R,Qin C,Lu Q,Yin C

更新日期：2015-09-10 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Kamath PL,Manlove K,Cassirer EF,Cross PC,Besser TE

更新日期：2020-04-22 00:00:00

abstract：:Increasing evidence demonstrates that berberine (BBR) is beneficial for obesity-associated non-alcoholic fatty liver disease (NAFLD). However, it remains to be elucidated how BBR improves aspects of NAFLD. Here we revealed an AMP-activated protein kinase (AMPK)-independent mechanism for BBR to suppress obesity-associa...

journal_title：Scientific reports

authors： Guo T,Woo SL,Guo X,Li H,Zheng J,Botchlett R,Liu M,Pei Y,Xu H,Cai Y,Zeng T,Chen L,Li X,Li Q,Xiao X,Huo Y,Wu C

更新日期：2016-03-03 00:00:00

abstract：:Nucleoplasmin (NP) is a pentameric histone chaperone that regulates the condensation state of chromatin in different cellular processes. We focus here on the interaction of NP with the histone octamer, showing that NP could bind sequentially the histone components to assemble an octamer-like particle, and crosslinked ...

journal_title：Scientific reports

authors： Franco A,Arranz R,Fernández-Rivero N,Velázquez-Campoy A,Martín-Benito J,Segura J,Prado A,Valpuesta JM,Muga A

更新日期：2019-07-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder, and the exact causal mechanism is unknown. Dysregulated allele-specific expression (ASE) has been identified in persons with ASD; however, a comprehensive analysis of ASE has not been conducted in a family quartet with ASD. To fill this ...

journal_title：Scientific reports

authors： Lin CY,Chang KW,Lin CY,Wu JY,Coon H,Huang PH,Ho HN,Akbarian S,Gau SS,Huang HS

更新日期：2018-03-09 00:00:00

abstract：:Tuned gene expression is crucial to the proper growth and response to the environmental changes of an organism. To enable tunable gene expression as designed is desirable in both scientific research and industrial application. Here, we introduce a novel promoter switching method based on the DDI2 promoter (PDDI2) that...

journal_title：Scientific reports

authors： Wang Y,Zhang K,Li H,Xu X,Xue H,Wang P,Fu YV

更新日期：2019-08-29 00:00:00

abstract：:In order to limit the smoking tobacco sector crisis, a new non-GMO Nicotiana tabacum L. cv. Solaris was proposed as oil seed crop. Residues of oil extraction were successfully used in swine nutrition. The aim of this study was to explore the full potential of this innovative tobacco cultivar as multitasking feedstock ...

journal_title：Scientific reports

authors： Fatica A,Di Lucia F,Marino S,Alvino A,Zuin M,De Feijter H,Brandt B,Tommasini S,Fantuz F,Salimei E

更新日期：2019-11-14 00:00:00

abstract：:Precise mitotic spindle orientation is essential for both cell fate and tissue organization while defects in this process are associated with tumorigenesis and other diseases. In most animal cell types, the dynein motor complex is anchored at the cell cortex and exerts pulling forces on astral microtubules to position...

journal_title：Scientific reports

authors： Vodicska B,Cerikan B,Schiebel E,Hoffmann I

更新日期：2018-04-20 00:00:00