Abstract:
:Nucleoplasmin (NP) is a pentameric histone chaperone that regulates the condensation state of chromatin in different cellular processes. We focus here on the interaction of NP with the histone octamer, showing that NP could bind sequentially the histone components to assemble an octamer-like particle, and crosslinked octamers with high affinity. The three-dimensional reconstruction of the NP/octamer complex generated by single-particle cryoelectron microscopy, revealed that several intrinsically disordered tail domains of two NP pentamers, facing each other through their distal face, encage the histone octamer in a nucleosome-like conformation and prevent its dissociation. Formation of this complex depended on post-translational modification and exposure of the acidic tract at the tail domain of NP. Finally, NP was capable of transferring the histone octamers to DNA in vitro, assembling nucleosomes. This activity may have biological relevance for processes in which the histone octamer must be rapidly removed from or deposited onto the DNA.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Franco A,Arranz R,Fernández-Rivero N,Velázquez-Campoy A,Martín-Benito J,Segura J,Prado A,Valpuesta JM,Muga Adoi
10.1038/s41598-019-45726-7subject
Has Abstractpub_date
2019-07-01 00:00:00pages
9487issue
1issn
2045-2322pii
10.1038/s41598-019-45726-7journal_volume
9pub_type
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