Iodine accumulation of the liver in patients treated with amiodarone can be unmasked using material decomposition from multiphase spectral-detector CT.

Abstract:

:Amiodarone accumulates in the liver, where it increases x-ray attenuation due to its iodine content. We evaluated liver attenuation in patients treated and not treated with amiodarone using true-non-contrast (TNC) and virtual-non-contrast (VNC) images acquired with spectral-detector-CT (SDCT). 142 patients, of which 21 have been treated with amiodarone, receiving SDCT-examinations (unenhanced-chest CT [TNC], CT-angiography of chest and abdomen [CTA-Chest, CTA-Abdomen]) were included. TNC, CTA-Chest, CTA-Abdomen, and corresponding VNC-images (VNC-Chest, VNC-Abdomen) were reconstructed. Liver-attenuation-index (LAI) was calculated as difference between liver- and spleen-attenuation. Liver-attenuation and LAI derived from TNC-images of patients receiving amiodarone were higher. Contrary to TNC, liver-attenuation and LAI were not higher in amiodarone patients in VNC-Chest and in VNC-Abdomen. To verify these initial results, a phantom scan was performed and an additional patient cohort included, both confirming that VNC is viable of accurately subtracting iodine of hepatic amiodarone-deposits. This might help to monitor liver-attenuation more accurately and thereby detect liver steatosis as a sign of liver damage earlier as well as to verify amiodarone accumulation in the liver.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Laukamp KR,Lennartz S,Hashmi A,Obmann M,Ho V,Große Hokamp N,Graner FP,Gilkeson R,Persigehl T,Gupta A,Ramaiya N

doi

10.1038/s41598-020-64002-7

subject

Has Abstract

pub_date

2020-04-24 00:00:00

pages

6994

issue

1

issn

2045-2322

pii

10.1038/s41598-020-64002-7

journal_volume

10

pub_type

杂志文章
  • Genesis and mechanisms controlling tornillo seismo-volcanic events in volcanic areas.

    abstract::Volcanic activity is often preceded or accompanied by different types of seismo-volcanic signals. Among these signals, the so-called tornillo (Spanish for "screw") events are considered to belong to a unique class of volcano-seismicity characterised by a long-duration coda, amplitude modulation and high-quality factor...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43842-y

    authors: Fazio M,Alparone S,Benson PM,Cannata A,Vinciguerra S

    更新日期:2019-05-14 00:00:00

  • 3'-Sialyllactose prebiotics prevents skin inflammation via regulatory T cell differentiation in atopic dermatitis mouse models.

    abstract::3'-Sialyllactose (3'-SL), a natural prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. Although regulatory T cells (Tregs) prevent excessive inflammation and maintain immune tolerance, the effect of 3'-SL on Treg regulation is unclear. This study aimed to investigate the e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62527-5

    authors: Kang LJ,Oh E,Cho C,Kwon H,Lee CG,Jeon J,Lee H,Choi S,Han SJ,Nam J,Song CU,Jung H,Kim HY,Park EJ,Choi EJ,Kim J,Eyun SI,Yang S

    更新日期:2020-03-27 00:00:00

  • Dramatically Enhanced Spin Dynamo with Plasmonic Diabolo Cavity.

    abstract::The applications of spin dynamos, which could potentially power complex nanoscopic devices, have so far been limited owing to their extremely low energy conversion efficiencies. Here, we present a unique plasmonic diabolo cavity (PDC) that dramatically improves the spin rectification signal (enhancement of more than t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-05634-0

    authors: Gou P,Qian J,Xi F,Zou Y,Cao J,Yu H,Zhao Z,Yang L,Xu J,Wang H,Zhang L,An Z

    更新日期:2017-07-13 00:00:00

  • Tuning coercive force by adjusting electric potential in solution processed Co/Pt(111) and the mechanism involved.

    abstract::A combination of a solution process and the control of the electric potential for magnetism represents a new approach to operating spintronic devices with a highly controlled efficiency and lower power consumption with reduced production cost. As a paradigmatic example, we investigated Co/Pt(111) in the Bloch-wall reg...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep43700

    authors: Chang CH,Kuo WH,Chang YC,Tsay JS,Yau SL

    更新日期:2017-03-03 00:00:00

  • Effect of surface and porosity of biochar on water holding capacity aiming indirectly at preservation of the Amazon biome.

    abstract::As part of efforts to reduce pressure on the Amazon and other biomes, one approach considered by Brazilian authorities and scientists is more intensive use of the soils of the interior of the northeast of the country, which are generally sandy, with low contents of organic matter and low water holding capacity and are...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-28794-z

    authors: Batista EMCC,Shultz J,Matos TTS,Fornari MR,Ferreira TM,Szpoganicz B,de Freitas RA,Mangrich AS

    更新日期:2018-07-16 00:00:00

  • Additive manufacturing of laminar flow cells for single-molecule experiments.

    abstract::A microfluidic laminar flow cell (LFC) forms an indispensable component in single-molecule experiments, enabling different substances to be delivered directly to the point under observation and thereby tightly controlling the biochemical environment immediately surrounding single molecules. Despite substantial progres...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-53151-z

    authors: Ahmadi A,Till K,Hafting Y,Schüttpelz M,Bjørås M,Glette K,Tørresen J,Rowe AD,Dalhus B

    更新日期:2019-11-14 00:00:00

  • Nearly perfect near-infrared luminescence efficiency of Si nanocrystals: A comprehensive quantum yield study employing the Purcell effect.

    abstract::Thin layers of silicon nanocrystals (SiNC) in oxide matrix with optimized parameters are fabricated by the plasma-enhanced chemical vapor deposition. These materials with SiNC sizes of about 4.5 nm and the SiO2 barrier thickness of 3 nm reveal external quantum yield (QY) close to 50% which is near to the best chemical...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47825-x

    authors: Valenta J,Greben M,Dyakov SA,Gippius NA,Hiller D,Gutsch S,Zacharias M

    更新日期:2019-08-02 00:00:00

  • Potential for high yield with increased seedling density and decreased N fertilizer application under seedling-throwing rice cultivation.

    abstract::Fertilizer application for rice production has increased significantly in southern China to raise yields, but has led to problems with lodging, quality decline and environmental pollution. Therefore, research on fertilizer-saving cultivation technologies for high-yielding rice is necessary. A two-factor experiment was...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-36978-w

    authors: Liu Y,Li C,Fang B,Fang Y,Chen K,Zhang Y,Zhang H

    更新日期:2019-01-24 00:00:00

  • TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis.

    abstract::Structural cardiac remodeling, accompanying cytoskeletal reorganization of cardiac cells, is a major clinical outcome of diastolic heart failure. A highly local Ca2+ influx across the plasma membrane has been suggested to code signals to induce Rho GTPase-mediated fibrosis, but it is obscure how the heart specifically...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep39383

    authors: Numaga-Tomita T,Kitajima N,Kuroda T,Nishimura A,Miyano K,Yasuda S,Kuwahara K,Sato Y,Ide T,Birnbaumer L,Sumimoto H,Mori Y,Nishida M

    更新日期:2016-12-19 00:00:00

  • High power laser-driven ceramic phosphor plate for outstanding efficient white light conversion in application of automotive lighting.

    abstract::We report on Y3Al5O12: Ce(3+) ceramic phosphor plate (CPP) using nano phosphor for high power laser diode (LD) application for white light in automotive lighting. The prepared CPP shows improved luminous properties as a function of Ce(3+) concentration. The luminous properties of the Y3Al5O12: Ce(3+) CPP nano phosphor...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep31206

    authors: Song YH,Ji EK,Jeong BW,Jung MK,Kim EY,Yoon DH

    更新日期:2016-08-09 00:00:00

  • Comparative Transcriptome Analysis of Raccoon Dog Skin to Determine Melanin Content in Hair and Melanin Distribution in Skin.

    abstract::The raccoon dog (Nyctereutes procyonoides) is an important canid fur-bearing animal species worldwide. Chinese raccoon dogs that present a white mutation, especially those with a white coat. Exploring melanin biosynthesis in the hair and skin of raccoon dogs is important for understanding the survival and evolutionary...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40903

    authors: Du Z,Huang K,Zhao J,Song X,Xing X,Wu Q,Zhang L,Xu C

    更新日期:2017-01-18 00:00:00

  • Effects of calcitriol on random skin flap survival in rats.

    abstract::Calcitriol, a metabolite of vitamin D, is often used in osteoporosis clinics. However, the material has other bioactivities; for example, it accelerates angiogenesis, has anti-inflammatory properties, and inhibits oxidative stress. We investigated the effects of calcitriol in a random skin flap rat model. "McFarlane f...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep18945

    authors: Zhou KL,Zhang YH,Lin DS,Tao XY,Xu HZ

    更新日期:2016-01-06 00:00:00

  • Early postoperative weight gain is associated with increased risk of graft failure in living donor liver transplant recipients.

    abstract::Fluid overload (FO) has been shown to adversely affect multiple organs and survival in critically ill patients. Liver transplantation (LT) carries the risk of massive transfusion, which frequently results in FO. We investigated the association of postoperative weight gain with graft failure, early allograft dysfunctio...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-56543-3

    authors: Jeong HW,Jung KW,Kim SO,Kwon HM,Moon YJ,Jun IG,Song JG,Hwang GS

    更新日期:2019-12-27 00:00:00

  • BCR-associated factors driving chronic lymphocytic leukemia cells proliferation ex vivo.

    abstract::A chronic antigenic stimulation is believed to sustain the leukemogenic development of chronic lymphocytic leukemia (CLL) and most of lymphoproliferative malignancies developed from mature B cells. Reproducing a proliferative stimulation ex vivo is critical to decipher the mechanisms of leukemogenesis in these maligna...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-36853-8

    authors: Schleiss C,Ilias W,Tahar O,Güler Y,Miguet L,Mayeur-Rousse C,Mauvieux L,Fornecker LM,Toussaint E,Herbrecht R,Bertrand F,Maumy-Bertrand M,Martin T,Fournel S,Georgel P,Bahram S,Vallat L

    更新日期:2019-01-24 00:00:00

  • Efficient Generation of Transgenic Buffalos (Bubalus bubalis) by Nuclear Transfer of Fetal Fibroblasts Expressing Enhanced Green Fluorescent Protein.

    abstract::The possibility of producing transgenic cloned buffalos by nuclear transfer of fetal fibroblasts expressing enhanced green fluorescent protein (EGFP) was explored in this study. When buffalo fetal fibroblasts (BFFs) isolated from a male buffalo fetus were transfected with pEGFP-N1 (EGFP is driven by CMV and Neo is dri...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-25120-5

    authors: Lu F,Luo C,Li N,Liu Q,Wei Y,Deng H,Wang X,Li X,Jiang J,Deng Y,Shi D

    更新日期:2018-05-03 00:00:00

  • M. tuberculosis infection and antigen specific cytokine response in healthcare workers frequently exposed to tuberculosis.

    abstract::Tuberculosis (TB) is the leading cause of death due to an infectious agent, but only a small fraction of those infected develop the disease. Cytokines are involved in the mediation and regulation of immunity, and their secretion patterns may reflect the infection status. To increase our understanding of immune respons...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-44294-0

    authors: Essone PN,Leboueny M,Maloupazoa Siawaya AC,Alame-Emane AK,Aboumegone Biyogo OC,Dapnet Tadatsin PH,Mveang Nzoghe A,Essamazokou DU,Mvoundza Ndjindji O,Padzys GS,Agnandji ST,Takiff H,Gicquel B,Djoba Siawaya JF

    更新日期:2019-06-03 00:00:00

  • Suit-type Wearable Robot Powered by Shape-memory-alloy-based Fabric Muscle.

    abstract::A suit-type wearable robot (STWR) is a new type of soft wearable robot (SWR) that can be worn easily anywhere and anytime to assist the muscular strength of wearers because it can be worn like normal clothes and is comfortable to wear even with no power supply. This paper proposes an STWR, in which a shape-memory-allo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45722-x

    authors: Park SJ,Park CH

    更新日期:2019-06-24 00:00:00

  • Controlling the Polarity of the Molecular Beam Epitaxy Grown In-Bi Atomic Film on the Si(111) Surface.

    abstract::Synchrotron radiation core-level photoemission spectroscopy, scanning tunneling microscopy (STM), and first-principles calculations have been utilized to explore the growth processes and the atomic structure of the resulting films during the two-step molecular beam epitaxy (MBE) of In and Bi on the Si(111) surface. De...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37051-2

    authors: Lin CY,Hsu CH,Huang YZ,Hsieh SC,Chen HD,Huang L,Huang ZQ,Chuang FC,Lin DS

    更新日期:2019-01-24 00:00:00

  • Ameliorative effect of Silybin on bisphenol A induced oxidative stress, cell proliferation and steroid hormones oxidation in HepG2 cell cultures.

    abstract::Bisphenol A (BPA) and silybin are considered xenoestrogens and could interfere with the action of endogenous hormones. It was demonstrated a higher level of BPA in plasma of nonalcoholic steatohepatitis (NASH) patients, compared to those with steatosis (NAFL). We investigated the effect of BPA and silybin, alone or in...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40105-8

    authors: Lama S,Vanacore D,Diano N,Nicolucci C,Errico S,Dallio M,Federico A,Loguercio C,Stiuso P

    更新日期:2019-03-01 00:00:00

  • Recombinant Thrombomodulin Exerts Anti-autophagic Action in Endothelial Cells and Provides Anti-atherosclerosis Effect in Apolipoprotein E Deficient Mice.

    abstract::Stress-induced alteration in endothelial cells (ECs) integrity precedes the development of atherosclerosis. Previous studies showed that the soluble recombinant thrombomodulin (rTM) not only increases ECs proliferation but also exerts anti-apoptotic activity in ECs. However, the functional significance of soluble rTM ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-03443-z

    authors: Chen PS,Wang KC,Chao TH,Chung HC,Tseng SY,Luo CY,Shi GY,Wu HL,Li YH

    更新日期:2017-06-12 00:00:00

  • Delivery of subunit influenza vaccine to skin with microneedles improves immunogenicity and long-lived protection.

    abstract::Influenza infection represents a major socio-economic burden worldwide. Novel delivery methods can render influenza vaccination easier and more acceptable by the public, and importantly confer protection equal or superior to that induced by conventional systemic administration. An attractive target for vaccine deliver...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep00357

    authors: Koutsonanos DG,Vassilieva EV,Stavropoulou A,Zarnitsyn VG,Esser ES,Taherbhai MT,Prausnitz MR,Compans RW,Skountzou I

    更新日期:2012-01-01 00:00:00

  • Quasisolitons in self-diffusive excitable systems, or Why asymmetric diffusivity obeys the Second Law.

    abstract::Solitons, defined as nonlinear waves which can reflect from boundaries or transmit through each other, are found in conservative, fully integrable systems. Similar phenomena, dubbed quasi-solitons, have been observed also in dissipative, "excitable" systems, either at finely tuned parameters (near a bifurcation) or in...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30879

    authors: Biktashev VN,Tsyganov MA

    更新日期:2016-08-05 00:00:00

  • Cleavage of poly(A)-binding protein by duck hepatitis A virus 3C protease.

    abstract::During viral infections, some viruses subvert the host proteins to promote the translation or RNA replication with their protease-mediated cleavage. Poly (A)-binding protein (PABP) is a target for several RNA viruses; however, the impact of duck hepatitis A virus (DHAV) on PABP remains unknown. In this study, we demon...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-16484-1

    authors: Sun D,Wang M,Wen X,Cheng A,Jia R,Sun K,Yang Q,Wu Y,Zhu D,Chen S,Liu M,Zhao X,Chen X

    更新日期:2017-11-24 00:00:00

  • Can you see what I am talking about? Human speech triggers referential expectation in four-month-old infants.

    abstract::Infants' sensitivity to selectively attend to human speech and to process it in a unique way has been widely reported in the past. However, in order to successfully acquire language, one should also understand that speech is a referential, and that words can stand for other entities in the world. While there has been ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep13594

    authors: Marno H,Farroni T,Vidal Dos Santos Y,Ekramnia M,Nespor M,Mehler J

    更新日期:2015-09-01 00:00:00

  • The N-terminal region of Jaw1 has a role to inhibit the formation of organized smooth endoplasmic reticulum as an intrinsically disordered region.

    abstract::Jaw1/LRMP is a type II integral membrane protein that is localized at the endoplasmic reticulum (ER) and outer nuclear membrane. We previously reported that a function of Jaw1 is to maintain the nuclear shape as a KASH protein via its carboxyl terminal region, a component of linker of nucleoskeleton and cytoskeleton c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-80258-5

    authors: Kozono T,Sato H,Okumura W,Jogano C,Tamura-Nakano M,Kawamura YI,Rohrer J,Tonozuka T,Nishikawa A

    更新日期:2021-01-12 00:00:00

  • Direct evidence for significant spin-polarization of EuS in Co/EuS multilayers at room temperature.

    abstract::The new era of spintronics promises the development of nanodevices, where the electron spin will be used to store information and charge currents will be replaced by spin currents. For this, ferromagnetic semiconductors at room temperature are needed. We report on significant room-temperature spin polarization of EuS ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep01333

    authors: Pappas SD,Poulopoulos P,Lewitz B,Straub A,Goschew A,Kapaklis V,Wilhelm F,Rogalev A,Fumagalli P

    更新日期:2013-01-01 00:00:00

  • Peripheral T cell cytotoxicity predicts T cell function in the tumor microenvironment.

    abstract::Cancer immunotherapy, including immune checkpoint inhibitors, exerts beneficial effects in cancer patients. However, immune checkpoint inhibitors are only advantageous for a limited population of cancer patients. Therefore, companion diagnostics are needed in order to identify patients for whom these therapies are eff...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39345-5

    authors: Iwahori K,Shintani Y,Funaki S,Yamamoto Y,Matsumoto M,Yoshida T,Morimoto-Okazawa A,Kawashima A,Sato E,Gottschalk S,Okumura M,Kumanogoh A,Wada H

    更新日期:2019-02-22 00:00:00

  • A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK.

    abstract::Mycobacterium tuberculosis, the etiological agent of the infectious disease tuberculosis, kills approximately 1.5 million people annually, while the spread of multidrug-resistant strains is of great global concern. Thus, continuous efforts to identify new antitubercular drugs as well as novel targets are crucial. Rece...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-21614-4

    authors: Chiarelli LR,Mori G,Orena BS,Esposito M,Lane T,de Jesus Lopes Ribeiro AL,Degiacomi G,Zemanová J,Szádocka S,Huszár S,Palčeková Z,Manfredi M,Gosetti F,Lelièvre J,Ballell L,Kazakova E,Makarov V,Marengo E,Mikusova K,Col

    更新日期:2018-02-16 00:00:00

  • Steering Bell-diagonal states.

    abstract::We investigate the steerability of two-qubit Bell-diagonal states under projective measurements by the steering party. In the simplest nontrivial scenario of two projective measurements, we solve this problem completely by virtue of the connection between the steering problem and the joint-measurement problem. A neces...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep22025

    authors: Quan Q,Zhu H,Liu SY,Fei SM,Fan H,Yang WL

    更新日期:2016-02-25 00:00:00

  • Lasing with Topological Weyl Semimetal.

    abstract::Lasing behavior of optically active planar topological Weyl semimetal (TWS) is investigated in view of the Kerr and Faraday rotations. Robust topological character of TWS is revealed by the presence of Weyl nodes and relevant surface conductivities. We focus our attention on the surfaces where no Fermi arcs are formed...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-59423-3

    authors: Oktay G,Sarısaman M,Tas M

    更新日期:2020-02-20 00:00:00