TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis.

abstract：:Lactobacilli are thought to be beneficial for human health, with lactobacilli-associated infections being confined to immune-compromised individuals. However, Lactobacillus fermentum AGR1487 negatively affects barrier integrity in vitro so we hypothesized that it caused a pro-inflammatory response in the host. We comp...

journal_title：Scientific reports

authors： Anderson RC,Ulluwishewa D,Young W,Ryan LJ,Henderson G,Meijerink M,Maier E,Wells JM,Roy NC

更新日期：2016-02-04 00:00:00

abstract：:In this study we used the Illumina Infinium Methylation array to investigate in a cohort of matched archival human tissue samples (n = 32) from 14 individuals with soft tissue sarcomas if genome-wide methylation changes occur during metastatic and recurrent (Met/Rec) disease. A range of sarcoma types were selected for...

journal_title：Scientific reports

authors： Vargas AC,Gray LA,White CL,Maclean FM,Grimison P,Ardakani NM,Bonar F,Algar EM,Cheah AL,Russell P,Mahar A,Gill AJ

更新日期：2021-01-12 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Williams C,Suderman M,Guggenheim JA,Ellis G,Gregory S,Iles-Caven Y,Northstone K,Golding J,Pembrey M

更新日期：2019-12-16 00:00:00

abstract：:Stemborers (Busseola fusca, Sesamia calamistis and Chilo partellus), the fall armyworm (Spodoptera frugiperda) and associated parasitoids constitute an interacting system in maize fields in Kenya. This work aims at developing and evaluating models that represent the evolution of those interactions by applying system t...

journal_title：Scientific reports

authors： Sokame BM,Tonnang HEZ,Subramanian S,Bruce AY,Dubois T,Ekesi S,Calatayud PA

更新日期：2021-01-14 00:00:00

abstract：:Giant magnetoresistive (GMR) biosensors consisting of many rectangular stripes are being developed for high sensitivity medical diagnostics of diseases at early stages, but many aspects of the sensing mechanism remain to be clarified. Using e-beam patterned masks on the sensors, we showed that the magnetic nanoparticl...

journal_title：Scientific reports

authors： Lee JR,Sato N,Bechstein DJ,Osterfeld SJ,Wang J,Gani AW,Hall DA,Wang SX

更新日期：2016-01-05 00:00:00

abstract：:As an emerging sterilization technology, cold atmospheric plasma offers a dry, non-thermal, rapid process that is minimally damaging to a majority of substrates. However, the mechanisms by which plasma interacts with living cells are poorly understood and the plasma generation apparatuses are complex and resource-inte...

journal_title：Scientific reports

authors： Pai K,Timmons C,Roehm KD,Ngo A,Narayanan SS,Ramachandran A,Jacob JD,Ma LM,Madihally SV

更新日期：2018-11-12 00:00:00

abstract：:Granule cells at the input layer of the cerebellum comprise over half the neurons in the human brain and are thought to be critical for learning. However, little is known about granule neuron signaling at the population scale during behavior. We used calcium imaging in awake zebrafish during optokinetic behavior to re...

journal_title：Scientific reports

authors： Sylvester SJG,Lee MM,Ramirez AD,Lim S,Goldman MS,Aksay ERF

更新日期：2017-11-24 00:00:00

abstract：:Tropical Pacific stalagmites are commonly affected by dating uncertainties because of their low U concentration and/or elevated initial 230Th content. This poses problems in establishing reliable trends and periodicities for droughts and pluvial episodes in a region vulnerable to climate change. Here we constrain the ...

journal_title：Scientific reports

authors： Faraji M,Borsato A,Frisia S,Hellstrom JC,Lorrey A,Hartland A,Greig A,Mattey DP

更新日期：2021-01-26 00:00:00

abstract：:Leishmaniasis is a Neglected Tropical Disease caused by the insect-vector borne protozoan parasite, Leishmania species. Infection affects millions of the world's poorest, however vaccines are absent and drug therapy limited. Recently, public-private partnerships have developed to identify new modes of controlling leis...

journal_title：Scientific reports

authors： Norcliffe JL,Mina JG,Alvarez E,Cantizani J,de Dios-Anton F,Colmenarejo G,Valle SG,Marco M,Fiandor JM,Martin JJ,Steel PG,Denny PW

更新日期：2018-03-02 00:00:00

abstract：:Several reviews have analyzed the factors that affect the change in soil organic C (SOC) when forest is converted to agricultural land; however, the effects of forest type and cultivation stage on these changes have generally been overlooked. We collated observations from 453 paired or chronosequential sites where for...

journal_title：Scientific reports

authors： Wei X,Shao M,Gale W,Li L

更新日期：2014-02-11 00:00:00

abstract：:Functional reactivation of p53 pathway, although arduous, can potentially provide a broad-based strategy for cancer therapy owing to frequent p53 inactivation in human cancer. Using a phosphoprotein-screening array, we found that Benzyl Isothiocynate, (BITC) increases p53 phosphorylation in breast cancer cells and rev...

journal_title：Scientific reports

authors： Xie B,Nagalingam A,Kuppusamy P,Muniraj N,Langford P,Győrffy B,Saxena NK,Sharma D

更新日期：2017-01-10 00:00:00

abstract：:Phytophthora root and stem rot of soybean [Glycine max (L.) Merr.] caused by Phytophthora sojae is a destructive disease worldwide. Phenylalanine ammonia-lyase (PAL) is one of the most extensively studied enzymes related to plant responses to biotic and abiotic stresses. However, the molecular mechanism of PAL in soyb...

journal_title：Scientific reports

authors： Zhang C,Wang X,Zhang F,Dong L,Wu J,Cheng Q,Qi D,Yan X,Jiang L,Fan S,Li N,Li D,Xu P,Zhang S

更新日期：2017-08-03 00:00:00

abstract：:Inverse Compton scattering between ultra-relativistic electrons and an intense laser field has been proposed as a major route to generate compact high-brightness and high-energy γ-rays. Attributed to the inherent synchronization mechanism, an all-optical Compton scattering γ-ray source, using one laser to both acceler...

journal_title：Scientific reports

authors： Yu C,Qi R,Wang W,Liu J,Li W,Wang C,Zhang Z,Liu J,Qin Z,Fang M,Feng K,Wu Y,Tian Y,Xu Y,Wu F,Leng Y,Weng X,Wang J,Wei F,Yi Y,Song Z,Li R,Xu Z

更新日期：2016-07-13 00:00:00

abstract：:Plasmonics is a rapidly emerging platform for quantum state engineering with the potential for building ultra-compact and hybrid optoelectronic devices. Recent experiments have shown that despite the presence of decoherence and loss, photon statistics and entanglement can be preserved in single plasmonic systems. This...

journal_title：Scientific reports

authors： Asano M,Bechu M,Tame M,Kaya Özdemir Ş,Ikuta R,Güney DÖ,Yamamoto T,Yang L,Wegener M,Imoto N

更新日期：2015-12-16 00:00:00

abstract：:Many host specific mutations have been detected in influenza A viruses (IAVs). However, their effects on hydrogen bond (H-bond) variations have rarely been investigated. In this study, 60 host specific sites were identified in the internal proteins of avian and human IAVs, 27 of which contained mutations with effects ...

journal_title：Scientific reports

authors： Luo J,Deng L,Ding X,Quan L,Wu A,Jiang T

更新日期：2017-10-30 00:00:00

abstract：:Capacitation is the final maturation step spermatozoa undergo prior to fertilisation. The efflux of cholesterol from the sperm membrane to the extracellular environment is a crucial step during capacitation but current methods to quantify this process are suboptimal. In this study, we validate the use of a BODIPY-chol...

journal_title：Scientific reports

authors： Bernecic NC,Zhang M,Gadella BM,Brouwers JFHM,Jansen JWA,Arkesteijn GJA,de Graaf SP,Leahy T

更新日期：2019-07-08 00:00:00

abstract：:Y14 (RBM8A) is an RNA recognition motif-containing protein that forms heterodimers with MAGOH and serves as a core factor of the RNA surveillance machinery for the exon junction complex (EJC). The role of the Y14 C-terminal serine/arginine (RS) repeat-containing region, which has been reported to undergo modifications...

journal_title：Scientific reports

authors： Tatsuno T,Ishigaki Y

更新日期：2018-01-12 00:00:00

abstract：:Different marine habitats are characterised by different soundscapes. How or which differences may be representative of the habitat characteristics and/or community structure remains however to be explored. A growing project in passive acoustics is to find a way to use soundscapes to have information on the habitat an...

journal_title：Scientific reports

authors： Bertucci F,Parmentier E,Lecellier G,Hawkins AD,Lecchini D

更新日期：2016-09-15 00:00:00

abstract：:The aim of this study was to investigate the value of multiple parameters retrieved from the FDG PET/CT studies, including SUVmax, SUVmean, SUVpeak, MTV, TLG, tumour size in differentiating retroperitoneal paragangliomas from UCD. 28 patients with solitary retroperitoneal masses who had undergone preoperative 18F-FDG ...

journal_title：Scientific reports

authors： Jiang Y,Hou G,Zhu Z,Huo L,Li F,Cheng W

更新日期：2020-07-30 00:00:00

abstract：:Recent advances in next-generation sequencing technologies have paved the path for a considerable amount of sequencing data at a relatively low cost. This has revolutionized the genomics and transcriptomics studies. However, different challenges are now created in handling such data with available bioinformatics platf...

journal_title：Scientific reports

authors： Naranpanawa DNU,Chandrasekara CHWMRB,Bandaranayake PCG,Bandaranayake AU

更新日期：2020-10-26 00:00:00

abstract：:Epidemiological studies using saliva have revealed relationships between the oral microbiome and many oral and systemic diseases. However, when collecting from a large number of participants such as a large-scale cohort study, the time it takes to collect saliva can be a problem. Mouth-rinsed water, which is water tha...

journal_title：Scientific reports

authors： Jo R,Nishimoto Y,Umezawa K,Yama K,Aita Y,Ichiba Y,Murakami S,Kakizawa Y,Kumagai T,Yamada T,Fukuda S

更新日期：2019-11-06 00:00:00

abstract：:The last decade has seen an exponential expansion of interest in conjugating multiple enzymes of cascades in close proximity to each other, with the overarching goal being to accelerate the overall reaction rate. However, some evidence has emerged that there is no effect of proximity channeling on the reaction velocit...

journal_title：Scientific reports

authors： Kuzmak A,Carmali S,von Lieres E,Russell AJ,Kondrat S

更新日期：2019-01-24 00:00:00

abstract：:The nutrient ecological stoichiometry of plants and soil is important for the growth and dynamics of species, but the stoichiometric relationships among leaf, litter, and soil remain poorly understood. We analyzed the carbon (C), nitrogen (N), and phosphorus (P) stoichiometry of the leaves, litter, and soil for 31 spe...

journal_title：Scientific reports

authors： Zhang G,Zhang P,Peng S,Chen Y,Cao Y

更新日期：2017-09-18 00:00:00

abstract：:Bioavailability of α-tocopherol varies with source, dose and duration of supplementation. The effect of source and dose of α-tocopherol on response of α-tocopherol stereoisomers in plasma and tissues of mink kits during the weaning period was studied. Twelve mink kits were euthanised in CO2 at the beginning of the exp...

journal_title：Scientific reports

authors： Lashkari S,Clausen TN,Foldager L,Jensen SK

更新日期：2021-01-29 00:00:00

abstract：:The methylotrophic yeast Komagataella phaffii (Pichia pastoris) has been developed into a highly successful system for heterologous protein expression in both academia and industry. However, overexpression of recombinant protein often leads to severe burden on the physiology of K. phaffii and triggers cellular stress....

journal_title：Scientific reports

authors： Yu XW,Sun WH,Wang YZ,Xu Y

更新日期：2017-11-24 00:00:00

abstract：:Miscarriage affects ~20% of pregnancies and maternal infections account for ~15% of early miscarriages. Chlamydia trachomatis (Ct) has been associated with miscarriage but the underlying mechanisms are unknown. Successful implantation requires endometrial stromal cell (ESC) decidualisation. Maintenance of pregnancy re...

journal_title：Scientific reports

authors： Giakoumelou S,Wheelhouse N,Brown J,Wade J,Simitsidellis I,Gibson D,Saunders PTK,Horner P,Entrican G,Howie SEM,Horne AW

更新日期：2017-05-17 00:00:00

abstract：:The functions of purinergic P2 receptors (P2Rs) for extracellular adenosine triphosphate (ATP) are poorly understood. Here, for the first time, we show that activation of P2Rs in an important arousal region, the basal forebrain (BF), promotes wakefulness, whereas inhibition of P2Rs promotes sleep. Infusion of a non-hy...

journal_title：Scientific reports

authors： Yang C,Larin A,McKenna JT,Jacobson KA,Winston S,Strecker RE,Kalinchuk A,Basheer R,Brown RE

更新日期：2018-07-16 00:00:00

abstract：:Bone marrow and adipose tissue represent the two most commonly exploited sources of adult mesenchymal stem cells for musculoskeletal applications. Unfortunately the sampling of bone marrow and fat tissue is invasive and does not always lead to a sufficient number of cells. The present study describes a novel sampling ...

journal_title：Scientific reports

authors： Ceusters J,Lejeune JP,Sandersen C,Niesten A,Lagneaux L,Serteyn D

更新日期：2017-04-06 00:00:00

abstract：:Extracellular vesicles (EVs) have important roles in physiology, pathology, and more recently have been identified as efficient carriers of therapeutic cargoes. For efficient study of EVs, a single-step, rapid and scalable isolation strategy is necessary. Chromatography techniques are widely used for isolation of biol...

journal_title：Scientific reports

authors： Heath N,Grant L,De Oliveira TM,Rowlinson R,Osteikoetxea X,Dekker N,Overman R

更新日期：2018-04-10 00:00:00

abstract：:The purpose of this study was to permit bone marrow mesenchymal stem cells (BMSCs) to reach their full potential in the treatment of chronic wounds. A biocompatible multifunctional crosslinker based temperature sensitive hydrogel was developed to deliver BMSCs, which improve the chronic inflammation microenvironments ...

journal_title：Scientific reports

authors： Chen S,Shi J,Zhang M,Chen Y,Wang X,Zhang L,Tian Z,Yan Y,Li Q,Zhong W,Xing M,Zhang L,Zhang L

更新日期：2015-12-08 00:00:00