Identification of novel factors enhancing recombinant protein production in multi-copy Komagataella phaffii based on transcriptomic analysis of overexpression effects.

abstract：:Glaucoma is a major cause of visual impairment, and secondary glaucoma manifested as neovascular glaucoma has long been known to occur following high-dose fractionated radiation therapy. In contrast, little is known as to whether ionizing radiation exposure causes primary glaucoma, except that a single study in Japane...

journal_title：Scientific reports

authors： Bragin EV,Azizova TV,Bannikova MV,Grigoryeva ES,Hamada N

更新日期：2019-08-28 00:00:00

abstract：:This study presents atomic scale characterization of grain boundary defect structure in a functional oxide with implications for a wide range of electrochemical and electronic behavior. Indeed, grain boundary engineering can alter transport and kinetic properties by several orders of magnitude. Here we report experime...

journal_title：Scientific reports

authors： An J,Park JS,Koh AL,Lee HB,Jung HJ,Schoonman J,Sinclair R,Gür TM,Prinz FB

更新日期：2013-01-01 00:00:00

abstract：:We propose a virtual sound barrier system that blocks sound transmission through openings without affecting access, light and air circulation. The proposed system applies active control technique to cancel sound transmission with a double layered loudspeaker array at the edge of the opening. Unlike traditional transpa...

journal_title：Scientific reports

authors： Wang S,Tao J,Qiu X

更新日期：2017-10-17 00:00:00

abstract：:The temporal correspondence between two arbitrarily chosen pairs of alternating features can generally be reported for rates up to 3-4 Hz. This limit is however surpassed for specialised visual mechanisms that encode conjunctions of features. Here we show that this 3-4 Hz limit is exceeded for eye gaze and eyebrow pai...

journal_title：Scientific reports

authors： Harrison C,Binetti N,Mareschal I,Johnston A

更新日期：2018-06-13 00:00:00

abstract：:Cervical sagittal alignment is considered to have a special role in the pathogenesis and evaluation of cervical diseases. Previous studies have demonstrated that cervical sagittal alignment is correlated with thoracolumbar and pelvic alignments. As the direct anatomical structures connect to the cervical region, howev...

journal_title：Scientific reports

authors： Zhu W,Sha S,Liu Z,Li Y,Xu L,Zhang W,Qiu Y,Zhu Z

更新日期：2018-10-18 00:00:00

abstract：:In our previous study, a liver-targeting peptide CSP I-plus modified recombinant human Endostatin (rEndostatin, endostar) (rES-CSP) was constructed and showed potent antiangiogenic capability and could specifically bind to human hepatocellular carcinoma cells to make a direct inhibition in vitro. In this study, the bi...

journal_title：Scientific reports

authors： Yan M,Dongmei B,Jingjing Z,Xiaobao J,Jie W,Yan W,Jiayong Z

更新日期：2017-10-26 00:00:00

abstract：:There has been a rapid increase in Danish pig herds testing positive for livestock-associated Methicillin-resistant Staphylococcus aureus (LA-MRSA) since the first screening in 2008. Despite a national action plan to control LA-MRSA in the Danish pig population, 88% of pig herds tested positive in a 2016 cross-section...

journal_title：Scientific reports

authors： Schulz J,Boklund A,Toft N,Halasa T

更新日期：2019-01-24 00:00:00

abstract：:Synesthesia, an anomalous blending of senses in which stimulation of one sensory modality produces sensation in a different modality, provides a unique opportunity to study how multimodal information is represented in the human brain. We investigated how pitch classes (do, re, mi, etc.) are associated with the three d...

journal_title：Scientific reports

authors： Itoh K,Sakata H,Kwee IL,Nakada T

更新日期：2017-12-19 00:00:00

abstract：:Quantum walks often provide telling insights about the structure of the system on which they are performed. In [Formula: see text]-symmetric and lossy dimer lattices, the topological properties of the band structure manifest themselves in the quantization of the mean displacement of such a walker. We investigate the f...

journal_title：Scientific reports

authors： Harter AK,Saxena A,Joglekar YN

更新日期：2018-08-13 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death worldwide. The use of alpha fetoprotein (AFP) alone was not an accurate biomarker for HCC despite its high specificity. Therefore, we assessed the possible role of serum biomarkers that have been mentioned briefly in previous studie...

journal_title：Scientific reports

authors： N Zekri AR,El Kassas M,Salam ESE,Hassan RM,Mohanad M,Gabr RM,M Lotfy M,Abdel-Zaher RAT,Bahnassy AA,Ahmed OS

更新日期：2020-03-20 00:00:00

abstract：:We aimed to develop and validate a multiparametric MR radiomics model using conventional, diffusion-, and perfusion-weighted MR imaging for better prognostication in patients with newly diagnosed glioblastoma. A total of 216 patients with newly diagnosed glioblastoma were enrolled from two tertiary medical centers and...

journal_title：Scientific reports

authors： Park JE,Kim HS,Jo Y,Yoo RE,Choi SH,Nam SJ,Kim JH

更新日期：2020-03-06 00:00:00

abstract：:Irisin is conventionally regarded as a myokine involved in the browning of white adipose tissue, energy expenditure and glucose tolerance. Its potential link to fat accumulation and metabolic dysfunction is debated. We sought to explore the relationship between circulating irisin and components of body composition in ...

journal_title：Scientific reports

authors： Mai S,Grugni G,Mele C,Vietti R,Vigna L,Sartorio A,Aimaretti G,Scacchi M,Marzullo P

更新日期：2020-01-23 00:00:00

abstract：:Recent discoveries have highlighted the novel metabolic functions of adipose tissue in enhancing hypermetabolism after trauma. As the exact function and expression profiles of serum lipids and free fatty acids (FFA) are essentially unknown, we determined the lipidomic expression profile after burn in correlation to cl...

journal_title：Scientific reports

authors： Qi P,Abdullahi A,Stanojcic M,Patsouris D,Jeschke MG

更新日期：2016-12-16 00:00:00

abstract：:Emergence and time evolution of micro-structured new-phase domains play a crucial role in determining the macroscopic physical and mechanical behaviors of iron under shock compression. Here, we investigate, through molecular dynamics simulations and theoretical modelings, shock-induced phase transition process of iron...

journal_title：Scientific reports

authors： Pang WW,Zhang P,Zhang GC,Xu AG,Zhao XG

更新日期：2014-01-10 00:00:00

abstract：:Microorganisms in vertebrate guts have been recognized as important symbionts influencing host life. However, it remains unclear about the gut microbiota in long-distance migratory Anseriformes herbivores, which could be functionally important for these wetland-dependent animals. We collected faeces of the greater whi...

journal_title：Scientific reports

authors： Yang Y,Deng Y,Cao L

更新日期：2016-09-07 00:00:00

abstract：:A microwave domain characterization approach is proposed to determine the properties of high quality factor optical resonators. This approach features a very high precision in frequency and aims to acquire a full knowledge of the complex transfer function (amplitude and phase) characterizing an optical resonator using...

journal_title：Scientific reports

authors： Abdallah Z,Boucher YG,Fernandez A,Balac S,Llopis O

更新日期：2016-06-02 00:00:00

abstract：:Accurate and precise structural ensembles of proteins and macromolecular complexes can be obtained with metainference, a recently proposed Bayesian inference method that integrates experimental information with prior knowledge and deals with all sources of errors in the data as well as with sample heterogeneity. The s...

journal_title：Scientific reports

authors： Bonomi M,Camilloni C,Vendruscolo M

更新日期：2016-08-26 00:00:00

abstract：:We study the entanglement structure and the topological edge states of the ground state of the spin-1/2 XXZ model with bond alternation. We employ parity-density matrix renormalization group with periodic boundary conditions. The finite-size scaling of Rényi entropies S2 and S∞ are used to construct the phase diagram ...

journal_title：Scientific reports

authors： Tzeng YC,Dai L,Chung MC,Amico L,Kwek LC

更新日期：2016-05-24 00:00:00

abstract：:Spin torque oscillator (STO) has been attracting a great deal of attention as a candidate for the next generation microwave signal sources for various modern electronics systems since its advent. However, the phase noise of STOs under free running oscillation is still too large to be used in practical microwave applic...

journal_title：Scientific reports

authors： Tamaru S,Kubota H,Yakushiji K,Yuasa S,Fukushima A

更新日期：2015-12-11 00:00:00

abstract：:Species in the genus Suaeda have few diagnostic characters and substantial morphological plasticity. Hence, regional floras do not provide clear taxonomic information for Suaeda spp. in East Asia. In order to assess the taxonomy of four species in the genus Suaeda (S. australis, S. maritima, S. japonica, and S. hetero...

journal_title：Scientific reports

authors： Park JS,Jin DP,Choi BH

更新日期：2020-12-01 00:00:00

abstract：:SHH Medulloblastoma (SHH-MB) is a pediatric brain tumor characterized by an inappropriate activation of the developmental Hedgehog (Hh) signaling. SHH-MB patients treated with the FDA-approved vismodegib, an Hh inhibitor that targets the transmembrane activator Smoothened (Smo), have shown the rapid development of dru...

journal_title：Scientific reports

authors： Coni S,Mancuso AB,Di Magno L,Sdruscia G,Manni S,Serrao SM,Rotili D,Spiombi E,Bufalieri F,Petroni M,Kusio-Kobialka M,De Smaele E,Ferretti E,Capalbo C,Mai A,Niewiadomski P,Screpanti I,Di Marcotullio L,Canettieri G

更新日期：2017-03-09 00:00:00

abstract：:We consider escape from a metastable state of a nonlinear oscillator driven close to triple its eigenfrequency. The oscillator can have three stable states of period-3 vibrations and a zero-amplitude state. Because of the symmetry of period-tripling, the zero-amplitude state remains stable as the driving increases. Ho...

journal_title：Scientific reports

authors： Tadokoro Y,Tanaka H,Dykman MI

更新日期：2020-06-26 00:00:00

abstract：:Diseases and toxins may lead to death of active liver tissue, resulting in a loss of total clearance capacity at the whole-body level. However, it remains difficult to study, whether the loss of metabolizing tissue is sufficient to explain loss of metabolic capacity of the liver or whether the surviving tissue undergo...

journal_title：Scientific reports

authors： Schenk A,Ghallab A,Hofmann U,Hassan R,Schwarz M,Schuppert A,Schwen LO,Braeuning A,Teutonico D,Hengstler JG,Kuepfer L

更新日期：2017-07-24 00:00:00

abstract：:This corrects the article DOI: 10.1038/srep20029. ...

journal_title：Scientific reports

authors： Yu C,Gao K,Zhu L,Wang W,Wang L,Zhang F,Liu C,Li M,Wormald MR,Rudd PM,Wang J

更新日期：2017-06-30 00:00:00

abstract：:Early diagnosis of dementia including Alzheimer's disease (AD) is an urgent medical and welfare issue. However, to date, no simple biometrics have been available. We reported that blood DNA methylation levels of the COASY gene, which encodes coenzyme A synthase, were increased in individuals with AD and amnestic mild ...

journal_title：Scientific reports

authors： Kobayashi N,Shinagawa S,Niimura H,Kida H,Nagata T,Tagai K,Shimada K,Oka N,Shikimoto R,Noda Y,Nakajima S,Mimura M,Shigeta M,Kondo K

更新日期：2020-07-22 00:00:00

abstract：:Previous studies demonstrated independent contributions of plasma free amino acids (PFAAs) and high uric acid (UA) concentrations to increased risks of lifestyle-related diseases (LSRDs), but the important associations between these factors and LSRDs remain unknown. We quantified PFAAs and UA amongst Japanese subjects...

journal_title：Scientific reports

authors： Mahbub MH,Yamaguchi N,Takahashi H,Hase R,Ishimaru Y,Sunagawa H,Amano H,Kobayashi-Miura M,Kanda H,Fujita Y,Yamamoto H,Yamamoto M,Kikuchi S,Ikeda A,Kageyama N,Nakamura M,Tanabe T

更新日期：2017-12-15 00:00:00

abstract：:We propose a novel class of mixed fluctuations with different orientations and fractal scaling features as a model for anisotropic two-dimensional (2D) trajectories hypothesized to appear in complex systems. Furthermore, we develop the oriented fractal scaling component analysis (OFSCA) to decompose such mixed fluctua...

journal_title：Scientific reports

authors： Seleznov I,Popov A,Kikuchi K,Kolosova E,Kolomiiets B,Nakata A,Kaneko M,Kiyono K

更新日期：2020-12-14 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Lebreton L,Egger M,Slat B

更新日期：2020-01-30 00:00:00

abstract：:The Vavilov Institute of Plant Genetic Resources (VIR), in St. Petersburg, Russia, houses a unique genebank, with historical collections of landraces. When they were collected, the geographical distribution and genetic diversity of most crops closely reflected their historical patterns of cultivation established over ...

journal_title：Scientific reports

authors： Plekhanova E,Vishnyakova MA,Bulyntsev S,Chang PL,Carrasquilla-Garcia N,Negash K,Wettberg EV,Noujdina N,Cook DR,Samsonova MG,Nuzhdin SV

更新日期：2017-07-06 00:00:00

abstract：:Zika virus is a teratogenic mosquito-transmitted flavivirus that is associated with birth defects in newborns and Guillain-Barré syndrome in adults. The virus can also be sexually transmitted, but currently, very little is known about the cell types supporting virus replication and persistence in human testes. Using p...

journal_title：Scientific reports

authors： Kumar A,Jovel J,Lopez-Orozco J,Limonta D,Airo AM,Hou S,Stryapunina I,Fibke C,Moore RB,Hobman TC

更新日期：2018-04-03 00:00:00