Abstract：
:In this study we used the Illumina Infinium Methylation array to investigate in a cohort of matched archival human tissue samples (n = 32) from 14 individuals with soft tissue sarcomas if genome-wide methylation changes occur during metastatic and recurrent (Met/Rec) disease. A range of sarcoma types were selected for this study: leiomyosarcoma (LMS), myxofibrosarcoma (MFS), rhabdomyosarcoma (RMS) and synovial sarcoma (SS). We identified differential methylation in all Met/Rec matched samples, demonstrating that epigenomic differences develop during the clonal evolution of sarcomas. Differentially methylated regions and genes were detected, not been previously implicated in sarcoma progression, including at PTPRN2 and DAXX in LMS, WT1-AS and TNXB in SS, VENTX and NTRK3 in pleomorphic RMS and MEST and the C14MC / miR-379/miR-656 in MFS. Our overall findings indicate the presence of objective epigenetic differences across primary and Met/Rec human tissue samples not previously reported.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Vargas AC,Gray LA,White CL,Maclean FM,Grimison P,Ardakani NM,Bonar F,Algar EM,Cheah AL,Russell P,Mahar A,Gill AJdoi
10.1038/s41598-020-79648-6subject
Has Abstractpub_date
2021-01-12 00:00:00pages
667issue
1issn
2045-2322pii
10.1038/s41598-020-79648-6journal_volume
11pub_type
杂志文章abstract：:Uncertainties over future climatic conditions pose significant challenges when selecting appropriate conservation strategies for heritage sites. Choosing effective strategies is especially important for earthen heritage sites located in dryland regions, as many are experiencing rapid environmentally-driven deteriorati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73456-8
更新日期：2020-10-02 00:00:00
abstract：:We study localized photonic excitations in a quasi-two-dimensional non-ideal binary microcavity lattice with use of the virtual crystal approximation. The effect of point defects (vacancies) on the excitation spectrum is investigated by numerical modelling. We obtain the dispersion and the energy gap of the electromag...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2014-11-06 00:00:00
abstract：:In recent years, the monolithic material has been developed increasingly in the high performance liquid phase field, and it could also be applied in the field of catalyst, as a monolithic catalyst carrier, since it has a large specific surface area, and could be customized based on the mould. The monolithic catalyst i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35021-2
更新日期：2018-11-09 00:00:00
abstract：:The S385Y/D469T/R520Q variant of E. coli transketolase was evolved previously with three successive smart libraries, each guided by different structural, bioinformatical or computational methods. Substrate-walking progressively shifted the target acceptor substrate from phosphorylated aldehydes, towards a non-phosphor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35716
更新日期：2016-10-21 00:00:00
abstract：:Support from human genetics increases the probability of success in drug development. However, few examples exist of successful genomically-driven drug repositioning. Given that a Mendelian form of severe enterocolitis is due to up-regulation of the interleukin-18 (IL18) signaling pathway, and pharmacologic inhibition...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45747-2
更新日期：2019-06-28 00:00:00
abstract：:Carcinoembryonic antigen (CEA) is the only blood based protein biomarker at present, used for preoperative screening of advanced colorectal cancer (CRC) patients to determine the appropriate curative treatments and post-surveillance screening for tumour recurrence. Current diagnostics for CRC detection have several li...
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journal_title：Scientific reports
pub_type： 杂志文章,评审
doi：10.1038/srep05801
更新日期：2014-07-23 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
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更新日期：2020-11-02 00:00:00
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journal_title：Scientific reports
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journal_title：Scientific reports
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更新日期：2017-08-15 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-12-30 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-08-17 00:00:00
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