Structural Analysis of an Evolved Transketolase Reveals Divergent Binding Modes.

abstract：:The adaptation of herbivorous insects to various host plants facilitates the spread and outbreak of many important invasive pests, however, the molecular mechanisms that underneath this process are poorly understood. In the past three decades, two species of the whitefly Bemisia tabaci complex, Middle East-Asia Minor ...

journal_title：Scientific reports

authors： Xia WQ,Wang XR,Liang Y,Liu SS,Wang XW

更新日期：2017-09-21 00:00:00

abstract：:Saponins from defatted root-extract of Securidaca longipedunculata were systematically entrapped in emulsion monolayer-barrier and finally recovered in pure form through demulsification. First, their molecules were dispersed in water to engineer a monomolecular film architecture, via self-assembly. Emulsifying with et...

journal_title：Scientific reports

authors： Obasi TC,Moldovan R,Toiu A,Braicu C,Bodoki E,Berindan-Neagoe I,Oniga I,Sandulescu R,Oprean R

更新日期：2017-11-06 00:00:00

abstract：:Adapters bind motor proteins to cargoes and therefore play essential roles in Kinesin-1 mediated intracellular transport. The regulatory mechanisms governing adapter functions and the spectrum of cargoes recognized by individual adapters remain poorly defined. Here, we show that cargoes transported by the Kinesin-1 ad...

journal_title：Scientific reports

authors： Butkevich E,Härtig W,Nikolov M,Erck C,Grosche J,Urlaub H,Schmidt CF,Klopfenstein DR,Chua JJ

更新日期：2016-06-01 00:00:00

abstract：:The dorsal striatum is a brain region involved in action control, with dorsomedial striatum (DMS) mediating goal-directed actions and dorsolateral striatum (DLS) mediating habitual actions. Presynaptic long-term synaptic depression (LTD) plasticity at glutamatergic inputs to dorsal striatum mediates many dorsal striat...

journal_title：Scientific reports

authors： Muñoz B,Haggerty DL,Atwood BK

更新日期：2020-04-29 00:00:00

abstract：:We set out to determine the usability of serum neurofilament light chain (sNfL), serum glial fibrillary acidic protein (sGFAP), and retinal parameters by using optical coherence tomography (OCT) as reliable biomarkers of the progression of oxaliplatin-induced peripheral neuropathy (OIPN). Forty-three patients schedule...

journal_title：Scientific reports

authors： Kim SH,Choi MK,Park NY,Hyun JW,Lee MY,Kim HJ,Jung SK,Cha Y

更新日期：2020-05-14 00:00:00

abstract：:The control of Salmonella from farm to fork is challenging due to the emergence of antimicrobial-resistant isolates and the limited effects of current control methods. Advanced chemical technologies have made accessible a wide range of uncharacterized small molecules (SMs) with encouraging chemical properties for anti...

journal_title：Scientific reports

authors： Deblais L,Helmy YA,Kathayat D,Huang HC,Miller SA,Rajashekara G

更新日期：2018-09-06 00:00:00

abstract：:Spontaneous clearance of hepatitis C virus (HCV) occurs in 10-40% of the infections. Specific human leukocyte antigen (HLA) alleles have been identified in associating with HCV clearance. However, data on the association of HLA with the spontaneous clearance of HCV are scarce in the Chinese population. In the current ...

journal_title：Scientific reports

authors： Huang J,Huang K,Xu R,Wang M,Liao Q,Xiong H,Li C,Tang X,Shan Z,Zhang M,Rong X,Nelson K,Fu Y

更新日期：2016-08-11 00:00:00

abstract：:Burley tobacco (Nicotiana Tabacum) is a chlorophyll-deficiency mutant. Nitrate is one precursor of tobacco-specific nitrosamines (TSNAs) and is largely accumulated in burley tobacco. To decrease nitrate accumulation in burley tobacco, glycerol, a polyhydric alcohol compound and physiological regulating material, was s...

journal_title：Scientific reports

authors： Li Y,Chang D,Yang H,Wang J,Shi H

更新日期：2018-09-05 00:00:00

abstract：:AS1411 is a G-rich DNA oligonucleotide that functions as an aptamer of the protein nucleolin, found at high levels on the surface of cancer cells but not on the surface of normal cells. Herein, we have studied AS1411 as a supramolecular carrier for the delivery of an acridine-based G-quadruplex ligand, C8, to HeLa can...

journal_title：Scientific reports

authors： Carvalho J,Paiva A,Cabral Campello MP,Paulo A,Mergny JL,Salgado GF,Queiroz JA,Cruz C

更新日期：2019-05-28 00:00:00

abstract：:Measurement of intracranial aneurysm wall motion may refine the current rupture risk estimation. A golden standard for measuring aneurysm pulsation is lacking. The aim is to evaluate magnitudes of aneurysm pulsation as published in current literature. Embase and PubMed were searched for publications containing quantit...

journal_title：Scientific reports

authors： Stam LB,Aquarius R,de Jong GA,Slump CH,Meijer FJA,Boogaarts HD

更新日期：2021-01-26 00:00:00

abstract：:Mucus is responsible for controlling transport and barrier function in biological systems, and its properties can be significantly affected by compositional and environmental changes. In this study, the impacts of pH and CaCl2 were examined on the solution-to-gel transition of mucin, the primary structural component o...

journal_title：Scientific reports

authors： Curnutt A,Smith K,Darrow E,Walters KB

更新日期：2020-05-29 00:00:00

abstract：:Osteogenesis is categorized into two groups based on developmental histology, intramembranous and endochondral ossification. The role of blood vessels during endochondral ossification is well known, while their role in intramembranous ossification, especially the intertissue pathway, is poorly understood. Here, we dem...

journal_title：Scientific reports

authors： Uemura M,Nagasawa A,Terai K

更新日期：2016-06-07 00:00:00

abstract：:In order to screen out an effective bone loss protectant from natural plant polyphenol and to elucidate the mechanism of the plant polyphenols that alleviate bone loss under simulated microgravity, the proliferation activities of 9 total polyphenol extracts from natural product (TPENP) on osteoblasts were measured. Po...

journal_title：Scientific reports

authors： Diao Y,Chen B,Wei L,Wang Z

更新日期：2018-08-24 00:00:00

abstract：:The aim of the current manuscript was to test the applicability of a nanocomposite system of penetration enhancer vesicles (PEVs) within polymeric in situ forming gel network composed of poloxamer and hyaluronic acid for the intranasal delivery of the antiemetic dimenhydrinate (DMH). PEVs were prepared using phospholi...

journal_title：Scientific reports

authors： Barakat SS,Nasr M,Ahmed RF,Badawy SS,Mansour S

更新日期：2017-08-30 00:00:00

abstract：:The peptidyl nucleoside blasticidin S (BS) isolated from Streptomyces griseochromogenes was the first non-mercurial fungicide used on a large scale to prevent rice blast. In the biosynthesis of BS, leucylblasticidin S (LBS) was suggested as the penultimate metabolite with 20-fold less inhibitory activity than the fina...

journal_title：Scientific reports

authors： Yu G,Li L,Liu X,Liu G,Deng Z,Zabriskie MT,Jiang M,He X

更新日期：2015-12-01 00:00:00

abstract：:Bone metastasis of breast cancer cells is a major concern, as it causes increased morbidity and mortality in patients. Bone tissue-derived CXCL12 preferentially recruits breast cancer cells expressing CXCR4 to bone metastatic sites. Thus, understanding how CXCR4 expression is regulated in breast cancer cells could sug...

journal_title：Scientific reports

authors： Masuda T,Endo M,Yamamoto Y,Odagiri H,Kadomatsu T,Nakamura T,Tanoue H,Ito H,Yugami M,Miyata K,Morinaga J,Horiguchi H,Motokawa I,Terada K,Morioka MS,Manabe I,Iwase H,Mizuta H,Oike Y

更新日期：2015-03-16 00:00:00

abstract：:Drug-based treatments are the most widely used interventions for cancer management. Personalized drug response profiling remains inherently challenging with low cell count harvested from tumour sample. We present a 96well-formatted microfluidic plate with built-in micro-gap that preserves up to 99.2% of cells during m...

journal_title：Scientific reports

authors： Ma WY,Hsiung LC,Wang CH,Chiang CL,Lin CH,Huang CS,Wo AM

更新日期：2015-04-13 00:00:00

abstract：:Prolonged tomato consumption can mitigate ultraviolet (UV) light induced sunburn via unknown mechanisms. Dietary carotenoids distributed to skin are hypothesized to protect skin against UV-induced damage, although other phytochemicals may play a role. We hypothesize that tomato consumption would protect against skin c...

journal_title：Scientific reports

authors： Cooperstone JL,Tober KL,Riedl KM,Teegarden MD,Cichon MJ,Francis DM,Schwartz SJ,Oberyszyn TM

更新日期：2017-07-11 00:00:00

abstract：:To date there are thirteen species validly assigned to the genus Anaerococcus. Most of the species in this genus are anaerobic and of human origin. Anaerococcus urinimassiliensis sp. nov., strain Marseille-P2143T is member of family Peptoniphilaceae, which was isolated from the urine of a 17-year-old boy affected by a...

journal_title：Scientific reports

authors： Morand A,Tall ML,Kuete Yimagou E,Ngom II,Lo CI,Cornu F,Tsimaratos M,Lagier JC,Levasseur A,Raoult D,Fournier PE

更新日期：2021-01-29 00:00:00

abstract：:Gastric diseases are common in China, and gastroduodenoscopy could provide accurate diagnoses. Our previous study verified that linked colour imaging (LCI) can improve endoscopic diagnostic accuracy. This study aimed for the first time to establish an LCI-based endoscopic model called colour-microstructure-vessel (CMV...

journal_title：Scientific reports

authors： Sun X,Bi Y,Dong T,Min M,Shen W,Xu Y,Liu Y

更新日期：2017-07-17 00:00:00

abstract：:Photoacoustic (optoacoustic) imaging can visualize vasculature deep in tissue using the high contrast of hemoglobin to light, with the high-resolution possible with ultrasound detection. Since angiogenesis, one of the hallmarks of cancer, leads to increased vascularity, photoacoustics holds promise in imaging breast c...

journal_title：Scientific reports

authors： Heijblom M,Piras D,Brinkhuis M,van Hespen JC,van den Engh FM,van der Schaaf M,Klaase JM,van Leeuwen TG,Steenbergen W,Manohar S

更新日期：2015-07-10 00:00:00

abstract：:The behavior of diatomic molecular solids under pressure have attracted great interest and been extensively studied. Under ambient pressure, the structure of bromine is known to be a molecular phase (phase I). With increasing pressure, it transforms into an incommensurate phase (phase V) before eventually to a monoato...

journal_title：Scientific reports

authors： Wu M,Tse JS,Pan Y

更新日期：2016-05-09 00:00:00

abstract：:Whipple's disease is a systemic infectious disease associated with the bacterium Tropheryma whipplei. Numerous reports have presented puzzling discrepancies between diagnosis methods. We addressed this confusion using fluorescent in situ hybridization and immunofluorescence assays to evaluate 34 duodenal biopsies and ...

journal_title：Scientific reports

authors： Audoly G,Fenollar F,Lagier JC,Lepidi H,Raoult D

更新日期：2016-03-30 00:00:00

abstract：:Molecular taxonomy often uncovers cryptic species, reminding us that taxonomic incompleteness is even more severe than previous thought. The importance of cryptic species for conservation is poorly understood. Although some cryptic species may be seriously threatened or otherwise important, they are rarely included in...

journal_title：Scientific reports

authors： Delić T,Trontelj P,Rendoš M,Fišer C

更新日期：2017-06-13 00:00:00

abstract：:The human genome is persistently exposed to damage caused by xenobiotics, therefore the assessment of genotoxicity of substances having a direct contact with humans is of importance. Phthalates are commonly used in industrial applications. Widespread exposure to phthalates has been evidenced by their presence in human...

journal_title：Scientific reports

authors： Sicińska P,Mokra K,Wozniak K,Michałowicz J,Bukowska B

更新日期：2021-01-18 00:00:00

abstract：:The analysis of questionnaires often involves representing the high-dimensional responses in a low-dimensional space (e.g., PCA, MCA, or t-SNE). However questionnaire data often contains categorical variables and common statistical model assumptions rarely hold. Here we present a non-parametric approach based on Fishe...

journal_title：Scientific reports

authors： Har-Shemesh O,Quax R,Lansing JS,Sloot PMA

更新日期：2020-05-25 00:00:00

abstract：:Early diagnosis of Parkinson's disease (PD) remains a challenge to date. New evidence highlights the potential clinical value of circulating trace amines (TAs) in early-stage PD and their involvement in disease progression. A new ultra performance chromatography mass spectrometry (UPLC-MS/MS) method was developed to q...

journal_title：Scientific reports

authors： D'Andrea G,Pizzolato G,Gucciardi A,Stocchero M,Giordano G,Baraldi E,Leon A

更新日期：2019-04-16 00:00:00

abstract：:The increasing demand for healthy baked goods boosted studies on sourdough microbiota with beneficial metabolic traits, to be used as potential functional starters. Here, 139 yeasts isolated from cereal-based fermented foods were in vitro characterized for their phytase and antioxidant activities. The molecular charac...

journal_title：Scientific reports

authors： Palla M,Blandino M,Grassi A,Giordano D,Sgherri C,Quartacci MF,Reyneri A,Agnolucci M,Giovannetti M

更新日期：2020-07-30 00:00:00

abstract：:We report the experimental observation of extreme instabilities in a self-pulsing fiber laser under the influence of stimulated Brillouin scattering (SBS). Specifically, we observe temporally localized structures with high intensities that can be referred to as rogue events through their statistical behaviour with hig...

journal_title：Scientific reports

authors： Hanzard PH,Talbi M,Mallek D,Kellou A,Leblond H,Sanchez F,Godin T,Hideur A

更新日期：2017-04-04 00:00:00

abstract：:Changes in N-glycosylation of plasma proteins are observed in many types of cancer, nevertheless, few studies suggest the exact mechanism involved in aberrant protein glycosylation. Here we studied the impact of DNA methylation on the N-glycome in the secretome of the HepG2 cell line derived from hepatocellular carcin...

journal_title：Scientific reports

authors： Klasić M,Krištić J,Korać P,Horvat T,Markulin D,Vojta A,Reiding KR,Wuhrer M,Lauc G,Zoldoš V

更新日期：2016-04-13 00:00:00