当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > The N-terminal region of Jaw1 has a role to inhibit the formation of organized smooth endoplasmic reticulum as an intrinsically disordered region.

The N-terminal region of Jaw1 has a role to inhibit the formation of organized smooth endoplasmic reticulum as an intrinsically disordered region.

Abstract：

:Jaw1/LRMP is a type II integral membrane protein that is localized at the endoplasmic reticulum (ER) and outer nuclear membrane. We previously reported that a function of Jaw1 is to maintain the nuclear shape as a KASH protein via its carboxyl terminal region, a component of linker of nucleoskeleton and cytoskeleton complex in the oligomeric state. Although the oligomerization of some KASH proteins via the cytosolic regions serves to stabilize protein-protein interactions, the issue of how the oligomerization of Jaw1 is regulated is not completely understood. Therefore, we focused on three distinct regions on the cytosolic face of Jaw1: the N-terminal region, the coiled-coil domain and the stem region, in terms of oligomerization. A co-immunoprecipitation assay showed that its coiled-coil domain is a candidate for the oligomerization site. Furthermore, our data indicated that the N-terminal region prevents the aberrant oligomerization of Jaw1 as an intrinsically disordered region (IDR). Importantly, the ectopic expression of an N-terminal region deleted mutant caused the formation of organized smooth ER (OSER), structures such as nuclear karmellae and whorls, in B16F10 cells. Furthermore, this OSER interfered with the localization of the oligomer and interactors such as the type III inositol 1,4,5-triphosphate receptor (IP3R3) and SUN2. In summary, the N-terminal region of Jaw1 inhibits the formation of OSER as an IDR to maintain the homeostatic localization of interactors on the ER membrane.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Kozono T,Sato H,Okumura W,Jogano C,Tamura-Nakano M,Kawamura YI,Rohrer J,Tonozuka T,Nishikawa A

doi

10.1038/s41598-020-80258-5

subject

Has Abstract

pub_date

2021-01-12 00:00:00

pages

753

issue

1

issn

2045-2322

pii

10.1038/s41598-020-80258-5

journal_volume

11

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Rapid Nipah virus entry into the central nervous system of hamsters via the olfactory route.

    abstract：:Encephalitis is a hallmark of Nipah virus (NiV) infection in humans. The exact route of entry of NiV into the central nervous system (CNS) is unknown. Here, we performed a spatio-temporal analysis of NiV entry into the CNS of hamsters. NiV initially predominantly targeted the olfactory epithelium in the nasal turbinat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00736

    authors： Munster VJ,Prescott JB,Bushmaker T,Long D,Rosenke R,Thomas T,Scott D,Fischer ER,Feldmann H,de Wit E

    更新日期：2012-01-01 00:00:00

  • High-velocity deformation of Al0.3CoCrFeNi high-entropy alloy: Remarkable resistance to shear failure.

    abstract：:The mechanical behavior of a single phase (fcc) Al0.3CoCrFeNi high-entropy alloy (HEA) was studied in the low and high strain-rate regimes. The combination of multiple strengthening mechanisms such as solid solution hardening, forest dislocation hardening, as well as mechanical twinning leads to a high work hardening ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42742

    authors： Li Z,Zhao S,Diao H,Liaw PK,Meyers MA

    更新日期：2017-02-17 00:00:00

  • Grammatical category and the neural processing of phrases.

    abstract：:The interlocking roles of lexical, syntactic and semantic processing in language comprehension has been the subject of longstanding debate. Recently, the cortical response to a frequency-tagged linguistic stimulus has been shown to track the rate of phrase and sentence, as well as syllable, presentation. This could be...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-81901-5

    authors： Burroughs A,Kazanina N,Houghton C

    更新日期：2021-01-28 00:00:00

  • Unique subgingival microbiota associated with periodontitis in cirrhosis patients.

    abstract：:Liver cirrhosis is a severe disease with major impact on the overall health of the patient including poor oral health. Lately, there has been increasing focus on oral diseases as cirrhosis-related complications due to the potential impact on systemic health and ultimately mortality. Periodontitis is one of the most co...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-28905-w

    authors： Jensen A,Ladegaard Grønkjær L,Holmstrup P,Vilstrup H,Kilian M

    更新日期：2018-07-16 00:00:00

  • Hierarchical Porous Chitosan Sponges as Robust and Recyclable Adsorbents for Anionic Dye Adsorption.

    abstract：:Biomass waste treatment and detrimental dye adsorption are two of the crucial environmental issues nowadays. In this study, we investigate to simultaneously resolve the aforementioned issues by synthesizing chitosan sponges as adsorbents toward rose bengal (RB) dye adsorption. Through a temperature-controlled freeze-c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-18302-0

    authors： Wang M,Ma Y,Sun Y,Hong SY,Lee SK,Yoon B,Chen L,Ci L,Nam JD,Chen X,Suhr J

    更新日期：2017-12-22 00:00:00

  • River Metabolism along a Latitudinal Gradient across Japan and in a global scale.

    abstract：:Since temperature is a key factor affecting photosynthetic and respiration rates, the rates of gross primary production (GPP) and ecosystem respiration (ER) are expected to be lower for rivers at higher latitudes, while the net ecosystem production (NEP) rate likely decrease in rivers at lower latitude due to higher s...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-41427-3

    authors： Gurung A,Iwata T,Nakano D,Urabe J

    更新日期：2019-03-20 00:00:00

  • Surface and Bulk Carbide Transformations in High-Speed Steel.

    abstract：:We have studied the transformation of carbides in AISI M42 high-speed steels in the temperature window used for forging. The annealing was found to result in the partial transformation of the large, metastable M2C carbides into small, more stable grains of M6C, with an associated change in the crystal orientation. In ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16202

    authors： Godec M,Večko Pirtovšek T,Šetina Batič B,McGuiness P,Burja J,Podgornik B

    更新日期：2015-11-05 00:00:00

  • Colloidal crystal grain boundary formation and motion.

    abstract：:The ability to assemble nano- and micro- sized colloidal components into highly ordered configurations is often cited as the basis for developing advanced materials. However, the dynamics of stochastic grain boundary formation and motion have not been quantified, which limits the ability to control and anneal polycrys...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep06132

    authors： Edwards TD,Yang Y,Beltran-Villegas DJ,Bevan MA

    更新日期：2014-08-20 00:00:00

  • Ideal memcapacitors and meminductors are overunity devices.

    abstract：:It is rigorously proved that ideal memcapacitors and meminductors are not passive or cyclo-passive devices. Equivalently, this implies that there exist excitation profiles that allow to extract more energy from the device than it is supplied with; so that their energy conversion efficiency exceeds 100%. This means tha...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73833-3

    authors： Jeltsema D,van der Schaft A

    更新日期：2020-10-07 00:00:00

  • Fabrication-Method-Dependent Excited State Dynamics in CH3NH3PbI3 Perovskite Films.

    abstract：:Understanding the excited-state dynamics in perovskite photovoltaics is necessary for progress in these materials, but changes in dynamics depending on the fabrication processes used for perovskite photoactive layers remain poorly characterised. Here we report a comparative study on femtosecond transient absorption (T...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-16654-1

    authors： Kim IS,Jo C,Kang R,Kim DY,Son SJ,Hwang IW,Ko DK

    更新日期：2017-11-28 00:00:00

  • On the understanding and feasibility of "Breakthrough" Osmosis.

    abstract：:Osmosis is the movement of solvent across a permselective membrane induced by a solute-concentration gradient. Now in 'Forward Osmosis' it is empirically observed that the diffusion of the solute is counter to that of the solvent i.e. there is so-called "reverse salt diffusion". However it has been recently suggested,...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-53417-6

    authors： Wu JJ,Field RW

    更新日期：2019-11-11 00:00:00

  • Improved drought stress tolerance in Arabidopsis by CRISPR/dCas9 fusion with a Histone AcetylTransferase.

    abstract：:Drought episodes decrease plant growth and productivity, which in turn cause high economic losses. Plants naturally sense and respond to water stress by activating specific signalling pathways leading to physiological and developmental adaptations. Genetically engineering genes that belong to these pathways might impr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44571-y

    authors： Roca Paixão JF,Gillet FX,Ribeiro TP,Bournaud C,Lourenço-Tessutti IT,Noriega DD,Melo BP,de Almeida-Engler J,Grossi-de-Sa MF

    更新日期：2019-05-30 00:00:00

  • Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle.

    abstract：:The mechanistic target of rapamycin (mTOR) is a central mediator of protein synthesis in skeletal muscle. We utilized immunofluorescence approaches to study mTOR cellular distribution and protein-protein co-localisation in human skeletal muscle in the basal state as well as immediately, 1 and 3 h after an acute bout o...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-05483-x

    authors： Song Z,Moore DR,Hodson N,Ward C,Dent JR,O'Leary MF,Shaw AM,Hamilton DL,Sarkar S,Gangloff YG,Hornberger TA,Spriet LL,Heigenhauser GJ,Philp A

    更新日期：2017-07-10 00:00:00

  • Characterising the interspecific variations and convergence of gut microbiota in Anseriformes herbivores at wintering areas.

    abstract：:Microorganisms in vertebrate guts have been recognized as important symbionts influencing host life. However, it remains unclear about the gut microbiota in long-distance migratory Anseriformes herbivores, which could be functionally important for these wetland-dependent animals. We collected faeces of the greater whi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep32655

    authors： Yang Y,Deng Y,Cao L

    更新日期：2016-09-07 00:00:00

  • Protein arginine methyltransferase 1 (PRMT1) represses MHC II transcription in macrophages by methylating CIITA.

    abstract：:Efficient presentation of alien antigens triggers activation of T lymphocytes and robust host defense against invading pathogens. This pathophysiological process relies on the expression of major histocompatibility complex (MHC) molecules in antigen presenting cells such as macrophages. Aberrant MHC II transactivation...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40531

    authors： Fan Z,Li J,Li P,Ye Q,Xu H,Wu X,Xu Y

    更新日期：2017-01-17 00:00:00

  • Empathy skill-dependent modulation of working memory by painful scene.

    abstract：:As an important online information retaining and processing function, working memory plays critical roles in many other cognitive functions. Several long-term factors, such as age, addiction and diseases, have been affirmed to impair working memory, but whether or how the short-term factors, like painful stimuli or em...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04702-9

    authors： Chen M,Wang YZ,Ma CC,Li QZ,Zhou H,Fu J,Yang QQ,Zhang YM,Liu Y,Cao JL

    更新日期：2017-07-03 00:00:00

  • Bulks of Al-B-C obtained by reactively spark plasma sintering and impact properties by Split Hopkinson Pressure Bar.

    abstract：:Mixtures of B4C, α-AlB12 and B powders were reactively spark plasma sintered at 1800 °C. Crystalline and amorphous boron powders were used. Samples were tested for their impact behavior by the Split Hopkinson Pressure Bar method. When the ratio R = B4C/α-AlB12 ≥ 1.3 for a constant B-amount, the major phase in the samp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-55888-z

    authors： Vasylkiv O,Borodianska H,Demirskyi D,Li P,Suzuki TS,Grigoroscuta MA,Pasuk I,Kuncser A,Badica P

    更新日期：2019-12-20 00:00:00

  • Coherent beam control with an all-dielectric transformation optics based lens.

    abstract：:Transformation optics (TO) concept well known for its huge possibility in patterning the path of electromagnetic waves is exploited to design a beam steering lens. The broadband directive in-phase emission in a desired off-normal direction from an array of equally fed radiators is numerically and experimentally report...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep18819

    authors： Yi J,Burokur SN,Piau GP,de Lustrac A

    更新日期：2016-01-05 00:00:00

  • Bufonid herpesvirus 1 (BfHV1) associated dermatitis and mortality in free ranging common toads (Bufo bufo) in Switzerland.

    abstract：:Here we report the discovery and partial characterization of a novel herpesvirus tentatively named Bufonid herpesvirus 1 (BfHV1) from severe dermatitis in free ranging common toads (Bufo bufo) in Switzerland. The disease has been observed in toads every year since 2014, in spring, during the mating season, at differen...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-32841-0

    authors： Origgi FC,Schmidt BR,Lohmann P,Otten P,Meier RK,Pisano SRR,Moore-Jones G,Tecilla M,Sattler U,Wahli T,Gaschen V,Stoffel MH

    更新日期：2018-10-03 00:00:00

  • The possible involvement of oxidative stress in the oocyte ageing process in goldfish Carassius auratus (Linnaeus, 1758).

    abstract：:Decreasing egg quality following oocyte ageing is a major restricting factor for the breeding programs. The mechanisms behind this process has not yet been clarified. To examine the possible involvement of oxidative stress in the oocyte ageing process, the relative mRNA abundance of specific transcripts were determine...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-46895-1

    authors： Samarin AM,Samarin AM,Østbye TK,Ruyter B,Sampels S,Burkina V,Blecha M,Policar T

    更新日期：2019-07-18 00:00:00

  • Human rhinovirus internal ribosome entry site element enhances transgene expression in transfected CHO-S cells.

    abstract：:Chinese hamster ovary (CHO) cells are mainly used for recombinant protein production. However, the unstable transgene expression and lower transgene copy numbers are the major issues need to be resolved. Here, eleven internal ribosome entry site (IRES) elements from viral and cellular IRES were evaluated for foreign g...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-25049-9

    authors： Chai YR,Ge MM,Wei TT,Jia YL,Guo X,Wang TY

    更新日期：2018-04-27 00:00:00

  • Nyctinastic thallus movement in the liverwort Marchantia polymorpha is regulated by a circadian clock.

    abstract：:The circadian clock coordinates an organism's growth, development and physiology with environmental factors. One illuminating example is the rhythmic growth of hypocotyls and cotyledons in Arabidopsis thaliana. Such daily oscillations in leaf position are often referred to as sleep movements or nyctinasty. Here, we re...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-65372-8

    authors： Lagercrantz U,Billhardt A,Rousku SN,Ljung K,Eklund DM

    更新日期：2020-05-26 00:00:00

  • Linear response of a superfluid Fermi gas inside its pair-breaking continuum.

    abstract：:We study the signatures of the collective modes of a superfluid Fermi gas in its linear response functions for the order-parameter and density fluctuations in the Random Phase Approximation (RPA). We show that a resonance associated to the Popov-Andrianov (or sometimes "Higgs") mode is visible inside the pair-breaking...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-65371-9

    authors： Kurkjian H,Tempere J,Klimin SN

    更新日期：2020-07-14 00:00:00

  • A doping-less junction-formation mechanism between n-silicon and an atomically thin boron layer.

    abstract：:The interest in nanostructures of silicon and its dopants has significantly increased. We report the creation of an ultimately-shallow junction at the surface of n-type silicon with excellent electrical and optical characteristics made by depositing an atomically thin boron layer at a relatively low temperature where ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-13100-0

    authors： Mohammadi V,Nihtianov S,Fang C

    更新日期：2017-10-16 00:00:00

  • Comparison and Interpretation of Taxonomical Structure of Bacterial Communities in Two Types of Lakes on Yun-Gui plateau of China.

    abstract：:Bacterial communities from freshwater lakes are shaped by various factors such as nutrients, pH value, temperature, etc. Their compositions and relative abundances would undergo changes to adapt the changing environments, and in turn could affect the environments of freshwater lakes. Analyses of the freshwater lake's ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep30616

    authors： Han M,Gong Y,Zhou C,Zhang J,Wang Z,Ning K

    更新日期：2016-07-27 00:00:00

  • Percutaneous Irreversible Electroporation: Long-term survival analysis of 71 patients with inoperable malignant hepatic tumors.

    abstract：:Aim of this retrospective analysis was to evaluate the survival times after percutaneous irreversible electroporation (IRE) in inoperable liver tumors not amenable to thermal ablation. 71 patients (14 females, 57 males, median age 63.5 ± 10.8 years) with 103 liver tumors were treated in 83 interventions using IRE (Nan...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep43687

    authors： Niessen C,Thumann S,Beyer L,Pregler B,Kramer J,Lang S,Teufel A,Jung EM,Stroszczynski C,Wiggermann P

    更新日期：2017-03-07 00:00:00

  • High therapeutic efficacy of Cathelicidin-WA against postweaning diarrhea via inhibiting inflammation and enhancing epithelial barrier in the intestine.

    abstract：:Diarrhea is a leading cause of death among young mammals, especially during weaning. Here, we investigated the effects of Cathelicidin-WA (CWA) on diarrhea, intestinal morphology, inflammatory responses, epithelial barrier and microbiota in the intestine of young mammals during weaning. Piglets with clinical diarrhea ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep25679

    authors： Yi H,Zhang L,Gan Z,Xiong H,Yu C,Du H,Wang Y

    更新日期：2016-05-16 00:00:00

  • The face inversion effect in non-human primates revisited - an investigation in chimpanzees (Pan troglodytes).

    abstract：:Faces presented upside-down are harder to recognize than presented right-side up, an effect known as the face inversion effect. With inversion the perceptual processing of the spatial relationship among facial parts is disrupted. Previous literature indicates a face inversion effect in chimpanzees toward familiar and ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep02504

    authors： Dahl CD,Rasch MJ,Tomonaga M,Adachi I

    更新日期：2013-01-01 00:00:00

  • Particulate matter (PM2.5) as a potential SARS-CoV-2 carrier.

    abstract：:The rapid spread of the SARS-CoV-2 in the COVID-19 pandemic had raised questions on the route of transmission of this disease. Initial understanding was that transmission originated from respiratory droplets from an infected host to a susceptible host. However, indirect contact transmission of viable virus by fomites ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-81935-9

    authors： Nor NSM,Yip CW,Ibrahim N,Jaafar MH,Rashid ZZ,Mustafa N,Hamid HHA,Chandru K,Latif MT,Saw PE,Lin CY,Alhasa KM,Hashim JH,Nadzir MSM

    更新日期：2021-01-28 00:00:00

  • Observation of strongly enhanced photoluminescence from inverted cone-shaped silicon nanostructures. [corrected].

    abstract：:Silicon nanowires (SiNWs) attached to a wafer substrate are converted to inversely tapered silicon nanocones (SiNCs). After excitation with visible light, individual SiNCs show a 200-fold enhanced integral band-to-band luminescence as compared to a straight SiNW reference. Furthermore, the reverse taper is responsible...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep17089

    authors： Schmitt SW,Sarau G,Christiansen S

    更新日期：2015-11-26 00:00:00