Abstract：
:Calcitriol, a metabolite of vitamin D, is often used in osteoporosis clinics. However, the material has other bioactivities; for example, it accelerates angiogenesis, has anti-inflammatory properties, and inhibits oxidative stress. We investigated the effects of calcitriol in a random skin flap rat model. "McFarlane flap" models were established in 84 male Sprague Dawley rats, divided into two groups. One group received intraperitoneal injections of calcitriol (2 μg/kg/day) whereas control rats received intraperitoneal injections of saline. The percentage flap survival area and tissue water content were measured 7 days later, which showed that calcitriol improved flap survival area and reduced tissue edema. It also increased the mean vessel density and upregulated levels of VEGF mRNA/protein, both of which promote flap angiogenesis. Moreover, it decreased leukocyte and macrophage infiltration, reduced the inflammatory proteins IL1β and IL6, increased SOD activity, decreased MDA content, and upregulated the level of autophagy. Overall, our results suggest that calcitriol promotes skin flap survival by accelerating angiogenesis, having anti-inflammatory effects, reducing oxidative stress, and promoting autophagy.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhou KL,Zhang YH,Lin DS,Tao XY,Xu HZdoi
10.1038/srep18945subject
Has Abstractpub_date
2016-01-06 00:00:00pages
18945issn
2045-2322pii
srep18945journal_volume
6pub_type
杂志文章abstract：:TLR4 location, and bacterial species-derived lipopolysaccharides, play a significant role in the downstream activation of transcription factors, accessory molecules, and products. Here, this is demonstrated through the use of classically-activated and alternatively-activated macrophages. We show that, when polarized, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79145-w
更新日期：2021-01-14 00:00:00
abstract：:Understanding and manipulating the dynamic properties of the magnetic vortices stabilized in patterned ferromagnetic structures are of great interest owing to the superior resonant features with the high thermal stability and their flexible tunability. So far, numerous methods for investigating the dynamic properties ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17922
更新日期：2015-12-09 00:00:00
abstract：:Invariant natural killer T (iNKT) cells are a specialized subset of T cells contributing to both, the innate and adaptive immune responses. In contrast to conventional T lymphocytes they recognize lipid antigens. The aim of the project is to establish a novel model system, to study iNKT-TCR - ligand interaction. An iN...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43529-4
更新日期：2019-05-15 00:00:00
abstract：:At 50 kg in estimated weight, the extinct Siamogale melilutra is larger than all living otters, and ranks among the largest fossil otters. The biomechanical capability of S. melilutra jaws as related to their large size is unknown but crucial to reconstructing the species' potentially unique ecological niche. Here we ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15391-9
更新日期：2017-11-09 00:00:00
abstract：:Finding strategies to preserve quantum resources in open systems is nowadays a main requirement for reliable quantum-enhanced technologies. We address this issue by considering structured cavities embedding qubits driven by a control technique known as frequency modulation. We first study a single qubit in a lossy cav...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32661-2
更新日期：2018-09-24 00:00:00
abstract：:Determining the success of eradication of an invasive species requires a way to decide when its risk of reoccurrence has become acceptably low. In Japan, the area populated by the Argentine ant, Linepithema humile (Mayr), is expanding, and eradication via chemical treatment is ongoing at various locations. One such pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03516-z
更新日期：2017-06-13 00:00:00
abstract：:The loss of retinal pericytes (RPCs) is a hallmark of early stage diabetic retinopathy (DR), but the mechanism underlying RPC death is unclear. Although it was postulated in previous studies using bovine RPCs that autoantibodies against RPCs might develop and induce RPC death, it is unknown whether autoantibodies agai...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20341
更新日期：2016-02-03 00:00:00
abstract：:Estrogen-related receptor alpha (ESRRa) regulates a number of cellular processes including development of bone and muscles. However, direct evidence regarding its involvement in cartilage development remains elusive. In this report, we establish an in vivo role of Esrra in cartilage development during embryogenesis in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18011
更新日期：2015-12-10 00:00:00
abstract：:Period circadian clock (Per) genes Per1 and Per2 have essential roles in circadian oscillation. In this study, we identified a new role of Per1-Per2 cooperation, and its mechanism, using our new experimental methods. Under constant light conditions, the period length of Per1 and Per2 knockout mice depended on the copy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32769
更新日期：2016-09-09 00:00:00
abstract：:Enamel proteins form a scaffold for growing hydroxyapatite crystals during enamel formation. They are then almost completely degraded during enamel maturation, resulting in a protein content of only 1% (w/v) in mature enamel. Nevertheless, this small amount of remaining proteins has important effects on the mechanical...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15194
更新日期：2015-10-15 00:00:00
abstract：:We aimed to evaluate the etiologies of constipation in patients with anorectal malformations having a good prognosis for bowel control but a high risk of constipation. We included twenty-five patients from the Odense university hospital in Denmark. Patients were subjected to colon transit time examination and high res...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76841-5
更新日期：2020-11-12 00:00:00
abstract：:We present a model on the simulation of the measurement-device independent quantum key distribution (MDI-QKD) with phase randomized general sources. It can be used to predict experimental observations of a MDI-QKD with linear channel loss, simulating corresponding values for the gains, the error rates in different bas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04612
更新日期：2014-04-14 00:00:00
abstract：:Although prolactin (PRL) and its receptor (PRLR) have been detected in glioblastoma multiforme (GBM), their role in its pathogenesis remains unclear. Our aim was to explore their contribution in GBM pathogenesis. We detected PRL and PRLR in all GBM cell lines tested. PRLR activation or overexpression using plasmid tra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55860-x
更新日期：2019-12-20 00:00:00
abstract：:Little work has been done on the prediction of malignancy risk in patients with subcentimeter thyroid nodule (TN) categorized as atypia/follicular lesion of undetermined significance (AUS/FLUS). We performed a retrospective analysis on the medical records of subcentimeter TNs whose initial fine-needle aspiration (FNA)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50597-z
更新日期：2019-10-18 00:00:00
abstract：:Bacterial infections are a major threat to the health of patients in healthcare facilities including hospitals. One of the major causes of patient morbidity is infection with Staphylococcus aureus. One of the the most dominant nosocomial bacteria, Methicillin Resistant Staphylococcus aureus (MRSA) have been reported t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24770
更新日期：2016-04-21 00:00:00
abstract：:Baeyer-Villiger monooxygenases (BVMOs) can be used for the biosynthesis of lactones and esters from ketones. However, the BVMO-based biocatalysts are not so stable under process conditions. Thereby, this study focused on enhancing stability of the BVMO-based biocatalysts. The biotransformation of ricinoleic acid into ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28575-8
更新日期：2018-07-06 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-58755-4
更新日期：2020-01-30 00:00:00
abstract：:The parasitic salmon louse, and its resistance to chemical delousing agents, represents one of the largest challenges to the salmon aquaculture industry. We genotyped lice sampled from wild salmon and sea trout throughout Norway with the recently identified Phe362Tyr mutation that conveys resistance to organophosphate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14681-6
更新日期：2017-10-27 00:00:00
abstract：:Porcine circovirus 2 (PCV-2) is a virus characterized by a high evolutionary rate, promoting the potential emergence of different genotypes and strains. Despite the likely relevance in the emergence of new PCV-2 variants, the subtle evolutionary patterns of PCV-2 at the individual-host level or over short transmission...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33849-2
更新日期：2018-10-19 00:00:00
abstract：:The influence of catechol-o-methyltransferase (COMT) Val(158)Met on brain activation and functional connectivity has been widely reported. However, voxel-wise effects of this genotype on resting-state brain networks remain unclear. Here, we used resting-state fMRI and eigenvector centrality to examine the effects of C...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10105
更新日期：2015-06-09 00:00:00
abstract：:The realization of reliable quantum channels, able to transfer a quantum state with high fidelity, is a fundamental step in the construction of scalable quantum devices. In this paper we describe a transmission scheme based on the genuinely quantum effect known as Bloch oscillations. The proposed protocol makes it pos...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26054
更新日期：2016-05-18 00:00:00
abstract：:The patient-derived tumor xenograft (PDTX) model has become the most realistic model for preclinical studies. PDTX models of gastric cancer using surgical tissues are reported occasionally; however, the PDTX models using gastroscopic biopsies, which are best for evaluating new drugs, are unreported. In our study, a to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08542
更新日期：2015-02-25 00:00:00
abstract：:Clobetasol propionate (CLO) is a potent glucocorticoid used to treat inflammation-based skin, scalp, and hair disorders. In such conditions, hair follicles (HF) are not only the target site but can also act as drug reservoirs when certain formulations are topically applied. Recently, we have demonstrated nanostructure...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56760-w
更新日期：2020-01-13 00:00:00
abstract：:In the present study, the synergistic effect on the corrosion protection properties of Mg alloys subjected to plasma electrolytic oxidation and chemically treated with thiourea as an inhibitor is investigated by surface microstructure analysis, evaluation of the electrochemical performance, and chemical quantum calcul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29299-5
更新日期：2018-07-19 00:00:00
abstract：:The centrosome is the microtubule organizing center of human cells and facilitates a myriad of cellular functions including organization of the mitotic spindle to ensure faithful chromosome segregation during mitosis, cell polarization and migration, and primary cilia formation. A numerical increase in centrosomes, or...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68629-4
更新日期：2020-07-17 00:00:00
abstract：:Feynman once asked physicists to build better electron microscopes to be able to watch biology at work. While electron microscopes can now provide atomic resolution, electron beam induced specimen damage precludes high resolution imaging of sensitive materials, such as single proteins or polymers. Here, we use simulat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01841-x
更新日期：2017-05-10 00:00:00
abstract：:Here we present an ultraviolet responsive inorganic-organic hybrid solar cell based on titania/poly(3-hexylthiophene) (TiO(2)/P3HT) heterojuction. In this solar cell, TiO(2) is an ultraviolet light absorber and electronic conductor, P3HT is a hole conductor, the light-to-electrical conversion is realized by the cooper...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01283
更新日期：2013-01-01 00:00:00
abstract：:Dislocations in crystals are linear crystallographic defects, which move in lattice when crystals are plastically deformed. Motion of a partial dislocation may remove or create stacking fault characterized with a partial of a lattice translation vector. Here we report that motion of partial dislocations inside an inte...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01039
更新日期：2013-01-01 00:00:00
abstract：:Inhibition of immune checkpoint proteins like programmed death 1 (PD-1) is a promising therapeutic approach for several cancers, including non-small cell lung cancer (NSCLC). Although PD-1 ligand (PD-L1) expression is used to predict anti-PD-1 therapy responses in NSCLC, its accuracy is relatively less. Therefore, we ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65666-x
更新日期：2020-06-03 00:00:00
abstract：:In the northeastern United States, chronic wasting disease has recently been detected in white-tailed deer (Odocoileus virginianus) populations, and understanding the relationship between landscape configuration and home range may improve disease surveillance and containment efforts. The objectives of our study were t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32937-7
更新日期：2018-10-02 00:00:00
