Abstract：
:Feynman once asked physicists to build better electron microscopes to be able to watch biology at work. While electron microscopes can now provide atomic resolution, electron beam induced specimen damage precludes high resolution imaging of sensitive materials, such as single proteins or polymers. Here, we use simulations to show that an electron microscope based on a multi-pass measurement protocol enables imaging of single proteins, without averaging structures over multiple images. While we demonstrate the method for particular imaging targets, the approach is broadly applicable and is expected to improve resolution and sensitivity for a range of electron microscopy imaging modalities, including, for example, scanning and spectroscopic techniques. The approach implements a quantum mechanically optimal strategy which under idealized conditions can be considered interaction-free.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Juffmann T,Koppell SA,Klopfer BB,Ophus C,Glaeser RM,Kasevich MAdoi
10.1038/s41598-017-01841-xsubject
Has Abstractpub_date
2017-05-10 00:00:00pages
1699issue
1issn
2045-2322pii
10.1038/s41598-017-01841-xjournal_volume
7pub_type
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