Abstract:
:Little work has been done on the prediction of malignancy risk in patients with subcentimeter thyroid nodule (TN) categorized as atypia/follicular lesion of undetermined significance (AUS/FLUS). We performed a retrospective analysis on the medical records of subcentimeter TNs whose initial fine-needle aspiration (FNA) diagnosis was AUS/FLUS at our center between November 2013 and August 2018. Univariate analysis and multivariate logistic regression analysis were used to select independent factors associated with malignancy. Of the 324 patients who were classified as AUS/FLUS on initial FNA, 153 patients underwent surgical procedures and showed an associated malignancy rate of 45.10% (69/153). The malignancy rates in AUS/FLUS settings with and without repeat FNA were 38.30% (18/47), and 48.11% (51/106), respectively, p = 0.260. Multivariate logistic regression analysis revealed that age < 55 (OR 3.015, 95% CI 1.196-7.596), microcalcification (OR 9.162, 95% CI 3.332-25.916) and taller than wide shape (OR 10.785, 95% CI 4.108-28.319) were three independent predictors for malignancy. The malignancy rates in the patients with one or none of predictor and patients with two or three above predictors were 20.5% (17/83) and 74.3% (52/70), respectively, p < 0.001 (OR 11.216, 95% CI 5.266-23.885). In conclusion, our study showed that for subcentimeter TNs with AUS/FLUS category, patient's age, taller than wide shape and microcalcification were three independent predictive factors for malignancy, which was helpful for decision-making of surgery or observation in such patient population.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ding J,Jiang L,Fang J,Jiang Y,Zhu Y,Hua T,Yuan Y,Wu Wdoi
10.1038/s41598-019-50597-zsubject
Has Abstractpub_date
2019-10-18 00:00:00pages
14973issue
1issn
2045-2322pii
10.1038/s41598-019-50597-zjournal_volume
9pub_type
杂志文章abstract::Many tissues exhibit subatmospheric interstitial pressures under normal physiologic conditions. The mechanisms by which the lymphatic system extracts fluid from these tissues against the overall pressure gradient are unknown. We address this important physiologic issue by combining experimental measurements of contrac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11599-x
更新日期:2017-09-21 00:00:00
abstract::Cyanobacteria harbor unique photoreceptors, designated as cyanobacteriochromes (CBCRs). In this study, we attempted to engineer the chromatic acclimation sensor CcaS, a CBCR derived from the cyanobacterium Synechocystis sp. PCC 6803. The wild-type CcaS induces gene expression under green light illumination and repress...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37595
更新日期:2016-11-24 00:00:00
abstract::The parasitic salmon louse, and its resistance to chemical delousing agents, represents one of the largest challenges to the salmon aquaculture industry. We genotyped lice sampled from wild salmon and sea trout throughout Norway with the recently identified Phe362Tyr mutation that conveys resistance to organophosphate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14681-6
更新日期:2017-10-27 00:00:00
abstract::While H2N2 viruses have been sporadically isolated from wild and domestic birds, H2N2 viruses have not been detected among human populations since 1968. Should H2N2 viruses adapt to domestic poultry they may pose a risk of infection to people, as most anyone born after 1968 would likely be susceptible to their infecti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07588
更新日期:2014-12-23 00:00:00
abstract::Aggregates of corundum crystals with skeletal to hopper morphology occur in pyroclastic rocks erupted from Cretaceous basaltic volcanoes on Mt Carmel, N. Israel. The rapid growth of the crystals trapped volumes of the parental Al2O3-supersaturated melt; phenocrysts of tistarite (Ti2O3) in the trapped melts indicate cr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79739-4
更新日期:2021-01-28 00:00:00
abstract::Angiotensin-converting enzyme (ACE) is an evolutionarily conserved peptidyl dipeptidase. Mammalian ACE converts angiotensin I to the active vasoconstrictor angiotensin II, thus playing a critical role for homeostasis of the renin-angiotensin system. In Drosophila, the ACE homolog Ance is expressed in specific regions ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13487-w
更新日期:2017-10-13 00:00:00
abstract::Mutations in the TGFβR2 gene have been associated with a life threatening risk of aortic dissection but no arrhythmic death has been previously reported. Two young females carrying a TGFβR2 mutation, initially diagnosed as Marfan syndrome or Loeys Dietz syndrome, presented sudden death with autopsy ruling out dissecti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31298-5
更新日期:2018-08-29 00:00:00
abstract::One of the challenges that plasma research encounters is how to generate a large-scale plasma plume at atmospheric pressure. Through utilizing a third electrode biased by a direct-current voltage, a longer plasma plume is generated by a plasma jet in dielectric barrier discharge configurations. Results indicate that t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35653
更新日期:2016-10-19 00:00:00
abstract::Urban climate is determined by a variety of factors, whose knowledge can help to attenuate heat stress in the context of ongoing urbanization and climate change. We study the influence of city size and urban form on the Urban Heat Island (UHI) phenomenon in Europe and find a complex interplay between UHI intensity and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04242-2
更新日期:2017-07-06 00:00:00
abstract::Angiogenesis is a key restorative process following stroke but has also been linked to increased vascular permeability and blood brain barrier (BBB) disruption. Previous pre-clinical approaches primarily focused on the administration of vascular endothelial growth factor (VEGF) to promote vascular repair after stroke....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56634-1
更新日期:2019-12-27 00:00:00
abstract::Silicon nanowires (SiNWs) attached to a wafer substrate are converted to inversely tapered silicon nanocones (SiNCs). After excitation with visible light, individual SiNCs show a 200-fold enhanced integral band-to-band luminescence as compared to a straight SiNW reference. Furthermore, the reverse taper is responsible...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17089
更新日期:2015-11-26 00:00:00
abstract::Spontaneous ultra-weak photon emission from living organisms, designated as biophoton emission, is a generally observed phenomenon irrespective of the organism species. Biophoton emission is attributed to the production of excited molecules in a metabolic biochemical reaction, especially in processes involving reactiv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45007-3
更新日期:2019-06-12 00:00:00
abstract::The cytoskeletal filament vimentin is inherent to the endothelial phenotype and is critical for the proper function of endothelial cells in adult mice. It is unclear, however, if the presence of vimentin is necessary during differentiation to the endothelial phenotype. Here we evaluated gene and protein expression of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30814
更新日期:2016-08-02 00:00:00
abstract::Screening programs for lung cancer aim to allow diagnosis at the early stage, and therefore the decline in mortality rates. Thus, the aim of this retrospective cohort study was to the comparison of screened and non-screened lung cancer in terms of lung cancer characteristics, overdiagnosis and survival rate. A retrosp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56025-6
更新日期:2019-12-18 00:00:00
abstract::Misuse of antibiotics in the clinical and agricultural sectors has caused the emergence of multidrug-resistant (MDR) Klebsiella pneumoniae which contributes a threat to human health. In this study, we assessed the feasibility of lavender essential oil (LVO) as an antimicrobial agent in combinatory therapy with meropen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55601-0
更新日期:2020-01-21 00:00:00
abstract::This study aims to evaluate the necessity of urgent neuroimaging for emergency admissions exhibiting symptomatology of profound hyponatremia. We retrospectively analyzed the medical records of all patients admitted to the emergency room of the University Hospital Münster from 2010 to 2014 with a serum sodium value < 1...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02030-6
更新日期:2017-05-16 00:00:00
abstract::Exploiting new, low-cost and efficient electrocatalysts for hydrogen evolution reaction (HER) is important to resolve the energy crisis and environment pollution. In this work, graphene decorated with Ni nanoparticles (NPs) were synthesized via one-pot reduction using graphene oxide (GO, the obtained composite was den...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10589
更新日期:2015-06-12 00:00:00
abstract::Extreme weather events (e.g., cyclones, floods, droughts) are capable of changing ecosystems and altering how animals obtain resources. Understanding the behavioural responses of animals being impacted by these natural events can help initiate and ameliorate conservation or management programs. This study investigated...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50523-3
更新日期:2019-10-03 00:00:00
abstract::The toxicity associated with concentrated synthetic surfactants and the poor stability at gastrointestinal condition are two major constraints for practical applications of solid lipid nanoparticles (SLN) as oral delivery vehicles. In this study, a synthetic surfactant-free and cross-linker-free method was developed t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02867-x
更新日期:2017-06-05 00:00:00
abstract::Micro/nanophotonic structures that are capable of optical wave-front shaping are implemented in optical waveguides and passive optical devices to alter the phase of the light propagating through them. The beam division directions and beam power distribution depend on the design of the micro/nanostructures. The ultimat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44333
更新日期:2017-03-09 00:00:00
abstract::A novel three dimensional blood brain barrier (BBB) platform was developed by independently supplying different types of media to separate cell types within a single device. One channel (vascular channel, VC) is connected to the inner lumen of the vascular network while the other supplies media to the neural cells (ne...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07416-0
更新日期:2017-08-14 00:00:00
abstract::Polymersome nanoparticles (PMs) are attractive candidates for spatio-temporal controlled delivery of therapeutic agents. Although many studies have addressed cellular uptake of solid nanoparticles, there is very little data available on intracellular release of molecules encapsulated in membranous carriers, such as po...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29460
更新日期:2016-07-11 00:00:00
abstract::In our previous study, a liver-targeting peptide CSP I-plus modified recombinant human Endostatin (rEndostatin, endostar) (rES-CSP) was constructed and showed potent antiangiogenic capability and could specifically bind to human hepatocellular carcinoma cells to make a direct inhibition in vitro. In this study, the bi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14320-0
更新日期:2017-10-26 00:00:00
abstract::The expression of aminoglycoside-modifying enzymes represents a survival strategy of antibiotic-resistant bacteria. Aminoglycoside 2'-N-acetyltransferase [AAC(2')] neutralizes aminoglycoside drugs by acetylation of their 2' amino groups in an acetyl coenzyme A (CoA)-dependent manner. To understand the structural featu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78699-z
更新日期:2020-12-09 00:00:00
abstract::Inappropriate sleep duration and poor sleep quality are associated with risk of stroke, but their interactive effect on stroke is unknown. We explored the interactive effect of sleep quality and duration on stroke risk. A prospective cohort study was conducted with 41,786 adults. Sleep quality was assessed using the P...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65611-y
更新日期:2020-05-26 00:00:00
abstract::Silver has long been employed as an electrically conductive component, and morphology-dependent properties have been actively investigated. Here we present a novel scalable synthesis method of flower-shaped silver nanoparticles (silver nanoflowers, Ag NFs). The preferential affinity of citrate molecules on (111) surfa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34894
更新日期:2016-10-07 00:00:00
abstract::Here we present an experimental as well as theoretical study of third-harmonic generation in tightly focused femtosecond filaments in air at the wavelength of [Formula: see text]. At low intensities, longitudinal phase matching is dominating in the formation of 3rd harmonics, whereas at higher intensities locked X-wav...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74263-x
更新日期:2020-10-15 00:00:00
abstract::Numerical aberration of the centrosome results in chromosome missegregation, eventually leading to chromosomal instability, a hallmark of human tumor malignancy. Large tumor suppressors 1 and 2 (Lats1 and Lats2) are central kinases in the Hippo pathway and regulate development and tumorigenesis by coordinating the bal...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16173
更新日期:2015-11-04 00:00:00
abstract::Learning to successfully navigate social environments is a critical developmental goal, predictive of long-term wellbeing. However, little is known about how people learn to adjust to different social environments, and how this behaviour emerges across development. Here, we use a series of economic games to assess how...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78546-1
更新日期:2020-12-10 00:00:00
abstract::Walnuts (Juglans spp.) are economically important nut and timber species with a worldwide distribution. Using the published Persian walnut genome as a reference for the assembly of short reads from six Juglans species and several interspecific hybrids, we identified simple sequence repeats in 12 Juglans nuclear and or...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39793-z
更新日期:2019-03-06 00:00:00