Abstract:
:TLR4 location, and bacterial species-derived lipopolysaccharides, play a significant role in the downstream activation of transcription factors, accessory molecules, and products. Here, this is demonstrated through the use of classically-activated and alternatively-activated macrophages. We show that, when polarized, human macrophages differentially express and localize TLR4, resulting in biased recognition and subsequent signalling of LPS derived from Pseudomonas aeruginosa, Escherichia coli, and Salmonella enterica. Analysis of activation demonstrated that in classically activated macrophages, P. aeruginosa signals from the plasma membrane via TLR4 to p65 dependent on TAK1 and TBK1 signalling. E. coli signals dependent or independent of the endosome, utilizing both TAK1- and TBK1-signalling to induce P65 and IRF3 inducible genes and cytokines. S. enterica however, only induces P65 and IRF3 phosphorylation through signalling via the endosome. This finding outlines clear signalling mechanisms by which innate immune cells, such as macrophages, can distinguish between bacterial species and initiate specialized responses through TLR4.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Stephens M,Liao S,von der Weid PYdoi
10.1038/s41598-020-79145-wsubject
Has Abstractpub_date
2021-01-14 00:00:00pages
1335issue
1issn
2045-2322pii
10.1038/s41598-020-79145-wjournal_volume
11pub_type
杂志文章abstract::One of the greatest challenges in the field of biofabrication remains the discovery of suitable bioinks that satisfy physicochemical and biological requirements. Despite recent advances in tissue engineering and biofabrication, progress has been limited to the development of technologies using polymer-based materials....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59632-w
更新日期:2020-02-18 00:00:00
abstract::Reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) is an accurate and fast method to measure gene expression. Reproducibility of the analyses is the main limitation of RT-qPCR experiments. Galaxy is an open, web-based, genomic workbench for a reproducible, transparent, and accessible scie...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53155-9
更新日期:2019-11-26 00:00:00
abstract::Gene targeting in embryonic stem cells (ESCs) has become the principal technology for generating knockout models. Although numerous studies have predicted that the disruption of p53 leads to increased developmental anomalies and malignancies, most p53 knockout mice develop normally. Therefore, the role of p53 in anima...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00945
更新日期:2012-01-01 00:00:00
abstract::Envelope (E) and temporal fine structure (TFS) are important features of acoustic signals and their corresponding perceptual function has been investigated with various listening tasks. To further understand the underlying neural processing of TFS, experiments in humans and animals were conducted to demonstrate the ef...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12975-3
更新日期:2017-10-17 00:00:00
abstract::Recently, platelet-rich plasma (PRP) has received attention as a treatment for patients with osteoarthritis of the knee (OAK), a chronic degenerative disease, to bridge the gap between conservative and surgical treatments. Here, we investigated the differences in the humoral factors present in two types of PRP purifie...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67099-y
更新日期:2020-06-29 00:00:00
abstract::Quartz is a common phase in high-silica igneous rocks and is resistant to post-eruptive alteration, thus offering a reliable record of magmatic processes in silicic magma systems. Here we employ the 75 ka Toba super-eruption as a case study to show that quartz can resolve late-stage temporal changes in magmatic δ18O v...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40624
更新日期:2017-01-25 00:00:00
abstract::LL37 exerts a dual pathogenic role in psoriasis. Bound to self-DNA/RNA, LL37 licenses autoreactivity by stimulating plasmacytoid dendritic cells-(pDCs)-Type I interferon (IFN-I) and acts as autoantigen for pathogenic Th17-cells. In systemic lupus erythematosus (SLE), LL37 also triggers IFN-I in pDCs and is target of p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62480-3
更新日期:2020-04-03 00:00:00
abstract::Filamentous fungi grow exclusively at their tips, where many growth-related fungal processes, such as enzyme secretion and invasion into host cells, take place. Hyphal tips are also a site of active metabolism. Understanding metabolic dynamics within the tip region is therefore important for biotechnology and medicine...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80270-9
更新日期:2021-01-14 00:00:00
abstract::Helicobacter pullorum is an avian bacterium that causes gastroenteritis, intestinal bowel and hepatobiliary diseases in humans. Although H. pullorum has been shown to activate the mammalian innate immunity with release of nitric oxide (NO), the proteins that afford protection against NO and reactive nitrogen species (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10375-1
更新日期:2017-08-30 00:00:00
abstract::Acute heart failure (AHF) emerges either de novo or from worsening of chronic heart failure (CHF). The aim of the present study was to evaluate the association between worsening of CHF and mortality in AHF patients. Out of 152 included AHF patients, 47 (30.9%) were de novo AHF patients and 105 (69%) were AHF patients ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28027-3
更新日期:2018-06-25 00:00:00
abstract::Mineral dust aerosols are responsible for some of the largest sources of uncertainties in our current understanding of climate change. Here we show that a severe drought is having a significant impact in one of largest sources of mineral dust aerosols of the U.S., the Owens Lake area in California's southwest. Measure...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01829-7
更新日期:2017-05-11 00:00:00
abstract::Relocation of earthquakes recorded by the agency for meteorology, climatology and geophysics (BMKG) in Indonesia and inversions of global positioning system (GPS) data reveal clear seismic gaps to the south of the island of Java. These gaps may be related to potential sources of future megathrust earthquakes in the re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72142-z
更新日期:2020-09-17 00:00:00
abstract::Discovery of novel biomarkers is critical for early diagnosis of acute coronary syndrome (ACS). Serum metabolite profiling of ST-elevation myocardial infarction (STEMI), unstable angina (UA) and healthy controls was performed using gas chromatography mass spectrometry (GC/MS), solid-phase microextraction coupled to ga...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36359
更新日期:2016-11-08 00:00:00
abstract::This corrects the article DOI: 10.1038/srep40641. ...
journal_title:Scientific reports
pub_type: 杂志文章,已发布勘误
doi:10.1038/srep46890
更新日期:2017-08-29 00:00:00
abstract::Polycyclic aromatic hydrocarbons (PAHs) pollutions often occur in marine and other saline environment, largely due to anthropogenic activities. However, study of the PAHs-degradation genotypes in halophiles is limited, compared with the mesophilic terrestrial PAHs degraders. In this study, a bacterial consortium (CY-1...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12979-z
更新日期:2017-10-02 00:00:00
abstract::The morphology of hexagonal phase NaYF4:Er(3+) nanorods synthesized by hydrothermal method changed greatly after a continuing calcination, along with a phase transformation to cubic phase. Photoluminescence (PL) spectra indicated that mid-infrared (MIR) emission was obtained in both hexagonal and cubic phase NaYF4:Er(...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29871
更新日期:2016-07-25 00:00:00
abstract::We performed continuous recordings (May 2015 - January 2017) of hydraulic pressure and electrical conductivity of groundwater in the 190 m-long horizontal S13 borehole drilled next to the deep underground laboratories of Gran Sasso (LNGS-INFN), located in the core of the Gran Sasso carbonate aquifer (central Italy) at...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34444-1
更新日期:2018-10-29 00:00:00
abstract::The aims of this study were as follows: to estimate the mortality and years of life lost, assessed by disability-adjusted life years (DALYs), due to breast cancer attributable to physical inactivity in Brazilian women; to compare the estimates attributable to physical inactivity and to other modifiable risk factors; a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29467-7
更新日期:2018-07-24 00:00:00
abstract::The development of 2D nanomaterial coatings across metal surfaces is a challenge due to the mismatch between the metal microstructure and the nanoscale materials. The naturally occurring thin oxidative layer present across all metal surfaces, may lead to low adherence and connectivity. In this paper, graphene/titania/...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26447-9
更新日期:2018-05-25 00:00:00
abstract::Acoustic telemetry is one of the primary technologies for studying the behavior and survival of fishes throughout the world. The size and performance of the transmitter are key limiting factors. The newly developed injectable transmitter is the first acoustic transmitter that can be implanted via injection instead of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42999
更新日期:2017-02-21 00:00:00
abstract::We study a three-mode (i.e., a clockwise mode, a counterclockwise mode, and a mechanical mode) coherent coupling regime of the optical whispering-gallery-mode (WGM) microresonator optomechanical system by considering a pair of counterpropagating modes in a general case. The WGM microresonator is coherently driven by a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39781
更新日期:2017-01-03 00:00:00
abstract::Metabolic syndrome, including obesity and insulin resistance, has been reported to lower lung function in elderly subjects with asthma or chronic obstructive lung disease. This study aimed to find the association between lung function and insulin resistance in Korean young adults. This study used data from the Korean ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11337-3
更新日期:2017-09-15 00:00:00
abstract::Zika virus (ZIKV) is an arboviral infection that has been shown to be sexually transmitted. The study outlined herein aims to determine if accessory sex glands and epididymal epithelial cells are sources of viral persistence in subacute and chronic ZIKV infection, and if infection of these organs is important in sexua...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44582-9
更新日期:2019-06-06 00:00:00
abstract::Botulinum-toxin A (BoNT/A) is used for a wide range of conditions. Intramuscular administration of BoNT/A inhibits the release of acetylcholine at the neuromuscular junction from presynaptic motor neurons causing muscle-paralysis. The aim of the present study was to investigate the effect of high dose intramuscular Bo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14997-3
更新日期:2017-11-07 00:00:00
abstract::Leishmaniases are an ensemble of diseases caused by the protozoan parasite of the genus Leishmania. Current antileishmanial treatments are limited and present main issues of toxicity and drug resistance emergence. Therefore, the generation of new inhibitors specifically directed against a leishmanial target is an attr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00848-8
更新日期:2017-04-07 00:00:00
abstract::The influence of meteorological determinants on tuberculosis (TB) incidence remains severely under-discussed, especially through the perspective of time series analysis. In the current study, we used a distributed lag nonlinear model (DLNM) to analyze a 10-year series of consecutive surveillance data. We found that, a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28426-6
更新日期:2018-07-03 00:00:00
abstract::Expression profiling of multiple microRNAs (miRNAs) generally provides valuable information for understanding various biological processes. Thus, it is necessary to develop a sensitive and accurate miRNA assay suitable for multiplexing. Isothermal exponential amplification reaction (EXPAR) has received significant int...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11895-6
更新日期:2017-09-12 00:00:00
abstract::The lateral motion of a magnetic skyrmion, arising because of the skyrmion Hall effect, imposes a number of restrictions on the use of this spin state in the racetrack memory. A skyrmionium is a more promising spin texture for memory applications, since it has zero total topological charge and propagates strictly alon...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34934-2
更新日期:2018-11-16 00:00:00
abstract::Non-infectious anterior uveitis (AU) is a potentially sight threatening inflammatory condition. The current gold standard for treatment is topical steroids, but low ocular bioavailability and compliance issues with the intensive dosing regimen limit the efficacy of this treatment. Liposomes as a drug delivery system m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24545-2
更新日期:2018-04-26 00:00:00
abstract::Individuals with high trait anxiety form a non-clinical group with a predisposition for an anxiety-related bias in emotional and cognitive processing that is considered by some to be a prerequisite for psychiatric disorders. Anxious individuals tend to experience more worry under uncertainty, and processing uncertain ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21298
更新日期:2016-02-19 00:00:00