Abstract：
:Estrogen-related receptor alpha (ESRRa) regulates a number of cellular processes including development of bone and muscles. However, direct evidence regarding its involvement in cartilage development remains elusive. In this report, we establish an in vivo role of Esrra in cartilage development during embryogenesis in zebrafish. Gene expression analysis indicates that esrra is expressed in developing pharyngeal arches where genes necessary for cartilage development are also expressed. Loss of function analysis shows that knockdown of esrra impairs expression of genes including sox9, col2a1, sox5, sox6, runx2 and col10a1 thus induces abnormally formed cartilage in pharyngeal arches. Importantly, we identify putative ESRRa binding elements in upstream regions of sox9 to which ESRRa can directly bind, indicating that Esrra may directly regulate sox9 expression. Accordingly, ectopic expression of sox9 rescues defective formation of cartilage induced by the knockdown of esrra. Taken together, our results indicate for the first time that ESRRa is essential for cartilage development by regulating sox9 expression during vertebrate development.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kim YI,No Lee J,Bhandari S,Nam IK,Yoo KW,Kim SJ,Oh GS,Kim HJ,So HS,Choe SK,Park Rdoi
10.1038/srep18011subject
Has Abstractpub_date
2015-12-10 00:00:00pages
18011issn
2045-2322pii
srep18011journal_volume
5pub_type
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