Abstract：
:Studies investigating association of depression with overall survival (OS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) yielded conflicting results. A nationwide cohort study, which included all adult patients [n = 7,170; depression group, 13.3% (N = 956); non-depression group, 86.7% (N = 6,214)] who received allo-HSCT from 2002 to 2018 in South Korea, analyzed risk of pre-transplant depression in OS of allo-HSCT. Subjects were followed from the day they received allo-HSCT, to occurrence of death, or last follow-up day (December 31, 2018). Median age at allo-HSCT for depression and non-depression groups were 50 and 45 (p < 0.0001), respectively. Two groups also differed in rate of females (depression group, 55.8%; non-depression group, 43.8%; p < 0.0001) and leukemia (depression group, 61.4%; non-depression group, 49.7%; p < 0.0001). After a median follow-up of 29.1 months, 5-year OS rate was 63.1%. Cox proportional-hazard regression evaluated an adjusted risk of post-transplant mortality related to depression: OS decreased sequentially from no depression (adjusted hazard ratio [aHR] = 1) to pre-transplant depression only (aHR = 1.167, CI: 1.007-1.352, p = 0.04), and to having both depression and anxiety disorder (aHR = 1.202, CI: 1.038-1.393, p = 0.014) groups. Pre-transplant anxiety (anxiety only) did not have significant influence in OS. Additional medical and psychiatric care might be necessary in patients who experienced depression, especially with anxiety, before allo-HSCT.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wang SM,Park SS,Park SH,Kim NY,Kang DW,Na HR,Lee JW,Han S,Lim HKdoi
10.1038/s41598-020-71208-2subject
Has Abstractpub_date
2020-09-17 00:00:00pages
15265issue
1issn
2045-2322pii
10.1038/s41598-020-71208-2journal_volume
10pub_type
杂志文章abstract：:Forest conservation includes stemming deforestation as well as preserving its vegetation condition. Traditional Protected Area (PA) effectiveness evaluations have assessed changes in forest extent but have mostly ignored vegetation condition. Tiger Reserves (TRs) are India's PAs with highest protection and management ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51118-8
更新日期：2019-10-18 00:00:00
abstract：:Two-dimensional (2D) porous carbon AC-SPN-3 possessing of amazing high micropore volume ratio of 83% and large surface area of about 1069 m(2) g(-1) is high-yield obtained by pyrolysis of natural waste Pistachio nutshells with KOH activation. The AC-SPN-3 has a curved 2D lamellar morphology with the thickness of each ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05545
更新日期：2014-07-02 00:00:00
abstract：:Soil erosion due to underground leakage is a major factor causing land degradation in karst regions. Rhizosphere effects (REs) on soil anti-erodibility (SAE) can alleviate this type of soil erosion by improving soil physical processes such as aggregate stability. However, the magnitudes and causes of interspecific var...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58784-z
更新日期：2020-02-12 00:00:00
abstract：:Thaumatin is an intensely sweet-tasting protein that elicits sweet taste at a concentration of 50 nM, a value 100,000 times larger than that of sucrose on a molar basis. Here we attempted to produce a protein with enhanced sweetness by removing negative charges on the interacting side of thaumatin with the taste recep...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20255
更新日期：2016-02-03 00:00:00
abstract：:Recent studies of Asian glaciers have shown that glaciers in eastern Karakoram and West Kunlun have been slightly gaining mass while those in nearby Jammu Kashmir and Himalayas are losing mass, at rates of more than 0.5 m w.e.yr-1 and about 0.3 m w.e.yr-1, respectively. Two possible explanations have been proposed for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14256-5
更新日期：2017-10-20 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-60584-4
更新日期：2020-02-27 00:00:00
abstract：:The platinum-based chemotherapeutic agent, oxaliplatin, is used to treat advanced colorectal cancer (CRC). Unfortunately, nearly all patients acquire resistance to oxaliplatin after long-term use, limiting its therapeutic efficacy. Since COX-2 and PGE2 signaling can impact colon cancer cell proliferation and survival,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40848-4
更新日期：2019-03-20 00:00:00
abstract：:The Holocene drying trend in the northern Altai Mountains and the wetting trend in the southern Altai Mountains inferred from the paleoclimatic studies indicated it is needed to understand the modern climatic characters in this region. However, a detailed analysis of modern climate variations in the northern and south...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21637-x
更新日期：2018-02-19 00:00:00
abstract：:The mechanisms of controlling airway smooth muscle (ASM) tone are of utmost clinical importance as inappropriate constriction is a hallmark in asthma and chronic obstructive pulmonary disease. Receptors for acetylcholine and serotonin, two relevant mediators in this context, appear to be incorporated in specialized, c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25445-1
更新日期：2018-05-14 00:00:00
abstract：:Since its first implementation in otolaryngological surgery nearly a century ago, the surgical microscope has improved the accuracy and the safety of microsurgeries. However, the microscope shows only a magnified surface view of the surgical region. To overcome this limitation, either optical coherence tomography (OCT...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35176
更新日期：2016-10-12 00:00:00
abstract：:Parasites exhibiting a high degree of host specificity are expected to be intimately associated with their hosts. Therefore, the evolution of host-specific parasites is at least partially shaped by the evolutionary history and distribution of such hosts. Gill ectoparasites of Dactylogyrus (Monogenea) are specific to c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31382-w
更新日期：2018-08-29 00:00:00
abstract：:The transport properties of films assembled from metal nanoclusters can be significantly different from the metals in their bulk or thin film forms due to quantum confinement effects and several competing energy and length scales. For a film composed of metal nanoclusters as its building blocks, the cluster size and t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07685
更新日期：2015-01-08 00:00:00
abstract：:The microbiota colonized on human body is renowned as "a forgotten organ" due to its big impacts on human health and disease. Recently, microbiome studies have identified a large number of microbes differentially regulated in a variety of conditions, such as disease and diet. However, methods for discovering biologica...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40200
更新日期：2017-01-10 00:00:00
abstract：:A classic example of solid-state topochemical reactions is the ultraviolet-light induced photodimerization of α-trans-cinnamic acid (CA). Here, we report the first observation of an X-ray-induced dimerization of CA and monitor it in situ using nonresonant inelastic X-ray scattering spectroscopy (NRIXS). The time-evolu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15851
更新日期：2015-11-16 00:00:00
abstract：:Recent studies suggest a functional involvement of Epithelial-Mesenchymal Transition (EMT) in tumor chemoresistance. Specifically, EMT is associated with chemoresistance and poor prognosis in triple-negative breast cancer. However, no effective therapy targeting EMT has been developed. Here, we report that periostin, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22340-7
更新日期：2018-03-05 00:00:00
abstract：:Previously, we cloned a new gene termed 'tongue cancer resistance-associated protein 1' (TCRP1), which modulates tumorigenesis, enhances cisplatin (cDDP) resistance in cancers, and may be a potential target for reversing drug resistance. However, the mechanisms for regulating TCRP1 expression remain unclear. Herein, w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03763-0
更新日期：2017-06-16 00:00:00
abstract：:Self-heating induced failure of graphene devices synthesized from both chemical vapor deposition (CVD) and epitaxial means is compared using a combination of infrared thermography and Raman imaging. Despite a larger thermal resistance, CVD devices dissipate >3x the amount of power before failure than their epitaxial c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26457
更新日期：2016-06-09 00:00:00
abstract：:Peroxisome proliferator-activated receptor-γ (PPARγ) is a ligand-activated nuclear receptor which controls lipid and glucose metabolism. It is also the master regulator of adipogenesis. In adipocytes, ligand-dependent PPARγ activation is associated with proteasomal degradation; therefore, regulation of PPARγ degradati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38550
更新日期：2016-12-05 00:00:00
abstract：:Beta amyloid peptides (Aβ) are known risk factors involved in cognitive impairment, neuroinflammatory and apoptotic processes in Alzheimer's disease (AD). Phosphodiesterase 2 (PDE2) inhibitors increase the intracellular cAMP and/or cGMP activities, which may ameliorate cognitive deficits associated with AD. However, i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08070-2
更新日期：2017-09-21 00:00:00
abstract：:A method is proposed to drive an ultrafast non-adiabatic dynamics of an ultracold gas trapped in a time-dependent box potential. The resulting state is free from spurious excitations associated with the breakdown of adiabaticity, and preserves the quantum correlations of the initial state up to a scaling factor. The p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00648
更新日期：2012-01-01 00:00:00
abstract：:The human β-defensin-1 (HBD1) is an antimicrobial peptide constitutively expressed by epithelial cells at mucosal surfaces. In addition to its microbicidal properties, the loss of HBD1 expression in several cancers suggests that it may also have an anti-tumor activity. Here, we investigated the link between HBD1 expre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36387-z
更新日期：2018-12-21 00:00:00
abstract：:Addiction to cocaine and other psychostimulants represents a major public health crisis. The development and persistence of addictive behaviors comes from a complex interaction of genes and environment - the precise mechanisms of which remain elusive. In recent years a surge of evidence has suggested that the gut micr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35455
更新日期：2016-10-18 00:00:00
abstract：:Multiple Sclerosis (MS) require medications controlling severity of the pathology and depression, affecting more than half of the patients. In this study, the effect of antidepressant drug fluvoxamine, a selective serotonin reuptake inhibitor, was investigated in vitro and in vivo. Nanomolar concentrations of fluvoxam...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04968-z
更新日期：2017-07-07 00:00:00
abstract：:Grain yield is a complicated trait, which is highly associated with biomass productivity. The cell wall is a central element of biomass, and its biogenesis contributes to plant architecture and development. However, the genetic link between cell-wall property and grain yield is largely unclear. Here, we report on iden...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12903-5
更新日期：2017-10-02 00:00:00
abstract：:A method for defect characterization is presented that allows to measure the activation energy, capture cross-section, and defect density in dielectric materials. This is exemplarily performed on aluminum oxide thin films deposited on hydrogen-terminated diamond. During the measurement, samples were illuminated using ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69240-3
更新日期：2020-07-27 00:00:00
abstract：:The Dirac materials, such as graphene and three-dimensional topological insulators, have attracted much attention because they exhibit novel quantum phenomena with their low energy electrons governed by the relativistic Dirac equations. One particular interest is to generate Dirac cone anisotropy so that the electrons...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05385
更新日期：2014-06-20 00:00:00
abstract：:Bisoprolol (B) exerts potential cardioprotective effects against myocardial ischemia/reperfusion (I/R) injury. Unfolded protein response (UPR) attenuates I/R injury induced apoptosis by reducing oxidative damage and inflammation response. The current study investigated whether the protective effects of bisoprolol resu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12366-8
更新日期：2017-09-19 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep41699. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/srep46942
更新日期：2018-02-12 00:00:00
abstract：:A novel eco-friendly procedure was developed to produce safer, stable and highly pure zinc oxide nanoparticles (ZnO NPs) using microalgae Chlorella extract. The ZnO NPs were synthesized simply using zinc nitrate and microalgae Chlorella extract which conducted at ambient conditions. In this recipe, microalgae Chlorell...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43368-3
更新日期：2019-05-03 00:00:00
abstract：:Aconiti Lateralis Radix Praeparata (Fuzi) and Fritillariae Thunbergii bulbus (Beimu) have been widely used clinically to treat cardiopulmonary related diseases in China. However, according to the classic rules of traditional Chinese medicine, Fuzi and Beimu should be prohibited to use as a combination for their incomp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34903
更新日期：2016-10-14 00:00:00
