Abstract:
:All-trans-retinoic acid (atRA), the active metabolite of vitamin A, is a critical signaling molecule during embryonic and fetal development and is necessary for maternal health. Fetal exposure to endogenous atRA is tightly regulated during gestation in a tissue specific manner and maternal exposure to exogenous retinoids during pregnancy is teratogenic. The clearance of atRA is primarily mediated by the cytochrome P450 (CYP) 26 enzymes, which play an essential role in controlling retinoid gradients during organogenesis. We hypothesized that CYP26 enzymes in the human fetal liver also function as a protective barrier to prevent maternal atRA reaching fetal circulation. Using human fetal liver tissue, we found that the mRNA of CYP26A1 and CYP26B1 enzymes is expressed in the human fetal liver. However, based on inhibition studies, metabolite profiles and correlation of atRA metabolism with testosterone hydroxylation, clearance of atRA in the fetal livers was mediated by CYP3A7. Based on in vitro-to-in vivo scaling, atRA clearance in the fetal liver was quantitatively minimal, thus providing an insufficient maternal-fetal barrier for atRA exposure.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Topletz AR,Zhong G,Isoherranen Ndoi
10.1038/s41598-019-40995-8subject
Has Abstractpub_date
2019-03-15 00:00:00pages
4620issue
1issn
2045-2322pii
10.1038/s41598-019-40995-8journal_volume
9pub_type
杂志文章abstract::On-chip integration of optical detection units into the microfluidic systems for online monitoring is highly desirable for many applications and is also well in line with the spirit of optofluidics technology-fusion of optics and microfluidics for advanced functionalities. This paper reports the construction of a UV-V...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28928
更新日期:2016-06-29 00:00:00
abstract::Mesenchymal stromal cells (MSCs) have been considered as one of the pivotal type of cells composing the tumor microenvironment. Although contact-dependent mechanisms and paracrine factors are thought to collaborate in governing the MSCs-based effects on tumors progression, the underlying mechanisms remain largely unkn...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23651-5
更新日期:2018-04-03 00:00:00
abstract::Building porosity in monolithic materials is highly desired to design 3D electrodes, however ex-situ introduction or in-situ generation of nano-scale sacrificial template is still a great challenge. Here Al-Si eutectic droplet templates are uniformly injected into bulk Si through Al-induced solid-solid convection to c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10381
更新日期:2015-05-19 00:00:00
abstract::Seed setting is an important trait that contributes to seed yield and relies greatly on starch accumulation. In this study, a sulfoquinovosyl transferase-like protein, designated as SQD2.2 involved in seed setting and flavonoid accumulation, was identified and characterized in rice. Rice SQD2.2 is localized to the cyt...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04002-2
更新日期:2017-07-05 00:00:00
abstract::Plasmonics has established itself as a branch of physics which promises to revolutionize data processing, improve photovoltaics, and increase sensitivity of bio-detection. A widespread use of plasmonic devices is notably hindered by high losses and the absence of stable and inexpensive metal films suitable for plasmon...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05517
更新日期:2014-07-01 00:00:00
abstract::The remineralization mechanism in dental caries lesions is not completely understood. This study reports on ultrastructural and chemical changes observed within arrested caries lesions. Carious human teeth were observed using scanning electron microscopy (SEM) and focused-ion-beam (FIB)-SEM. The crystals detected in t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61111-1
更新日期:2020-03-09 00:00:00
abstract::GSK3α has been identified as a new target in the treatment of acute myeloid leukemia (AML). However, most GSK3 inhibitors lack specificity for GSK3α over GSK3β and other kinases. We have previously shown in lung cancer cells that GSK3α and to a lesser extent GSK3β are inhibited by the advanced clinical candidate tivan...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37174-6
更新日期:2019-01-24 00:00:00
abstract::Invasive alien species are regarded a nuisance. This extends into a lack of conservation efforts in their native range. As a consequence, conservation of e.g. range-edge populations is neglected. Gobiidae have many representatives of alien species in European freshwaters, and therefore they have a bad reputation. Obje...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56264-7
更新日期:2019-12-23 00:00:00
abstract::Gastroenteritis is common among children. Campylobacter jejuni is one of the main causative bacterial pathogens, together with Shigella, Salmonella and invasive Escherichia coli. Campylobacteriosis is a zoonotic, usually self-limited disease that does not always require antibiotic treatment. In cases of protracted dia...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62744-y
更新日期:2020-04-02 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with aggregation of TAR DNA-binding protein-43 (TDP-43) in neuronal cells and manifests as motor neuron dysfunction &muscle atrophy. The carboxyl-terminal prion-like domain of TDP-43 can aggregate in vitro into toxic β-sheet rich amylo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39490
更新日期:2016-12-21 00:00:00
abstract::Maritime ecosystems in Vietnam such as mangroves and mud flats are characterized by high biodiversity. However, elements of its biodiversity remain unclear and highly threatened. In this context, the assessment of rare species is a starting point to develop effective strategies for the conservation of entire ecosystem...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75200-8
更新日期:2020-10-30 00:00:00
abstract::Mutations in the TGFβR2 gene have been associated with a life threatening risk of aortic dissection but no arrhythmic death has been previously reported. Two young females carrying a TGFβR2 mutation, initially diagnosed as Marfan syndrome or Loeys Dietz syndrome, presented sudden death with autopsy ruling out dissecti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31298-5
更新日期:2018-08-29 00:00:00
abstract::Constrained by the diffraction limit, a lens can only resolve features larger than half of the incident wavelength owing to the decaying nature of evanescent waves. Several novel devices have been proposed, for example, superlenses and hyperlenses to break this limit. In this work, we present a flat hyperlens composed...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62243-0
更新日期:2020-03-24 00:00:00
abstract::Neurotransmitter release is mediated by the SNARE complex, but the role of its phosphorylation has scarcely been elucidated. Although PKC activators are known to facilitate synaptic transmission, there has been a heated debate on whether PKC mediates facilitation of neurotransmitter release through phosphorylation. On...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08237-x
更新日期:2017-08-11 00:00:00
abstract::The insect vector borne bacterium Xylella fastidiosa was first detected in olive trees in Southern Italy in 2013, and identified as the main culprit behind the 'olive quick decline syndrome'. Since then, the disease has spread rapidly through Italy's main olive oil producing region. The epidemiology of the outbreak is...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00077-z
更新日期:2017-03-06 00:00:00
abstract::The ability to shape the index profile of optical fibers holds the key to fully flexible engineering of their optical properties and future applications. We present a new approach for the development of a graded index fused silica fiber based on core nanostructurization. A graded index core is obtained by means of dis...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30284-1
更新日期:2018-08-17 00:00:00
abstract::The nucleotides guanosine tetraphosphate and pentaphosphate (together known as (p)ppGpp or magic spot) are produced in plant plastids from GDP/GTP and ATP by RelA-SpoT homologue (RSH) enzymes. In the model plant Arabidopsis (p)ppGpp regulates chloroplast transcription and translation to affect growth, and is also impl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54207-w
更新日期:2019-11-27 00:00:00
abstract::Models on how perceptual and cognitive information on others' mental states are treated by the cognitive architecture are often framed as duplex models considering two independent systems. In the context of the neuroscience of empathy analogous systems have been described. Using event-related potentials (i.e., ERPs) t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07424
更新日期:2014-12-11 00:00:00
abstract::Spin thermoelectrics represents a new paradigm of thermoelectricity that has a potential to overcome the fundamental limitation posed by the Wiedmann-Franz law on the efficiency of conventional thermoelectric devices. A typical spin thermoelectric device consists of a bilayer of a magnetic insulator and a high spin-or...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40021-x
更新日期:2019-02-28 00:00:00
abstract::A novel process for improving tar yield through catalytic depolymerization of a typical lignite was put forward. The catalytic depolymerization of the lignite over CoCl2 and ZnCl2 catalyst in different concentrations were investigated by a Gray-King apparatus. The optimal catalyst concentrations of CoCl2 and ZnCl2 cat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14869-w
更新日期:2017-10-31 00:00:00
abstract::The relative and combined effects of sleep apnea with diabetes mellitus (DM) on cardiovascular outcomes in patients undergoing coronary artery bypass grafting (CABG) remain unknown. In this secondary analysis of data from the SABOT study, 1007 patients were reclassified into four groups based on their sleep apnea and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78700-9
更新日期:2020-12-10 00:00:00
abstract::The rectifying properties of α,ω-dithiol terminated oligo(phenylene ethynylene) molecules sandwiched between heterometallic electrodes, including the molecular length and side group effects, are theoretically investigated using the fully self-consistent nonequilibrium Green's function method combined with density func...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06357
更新日期:2014-09-15 00:00:00
abstract::Dissolved organic carbon (DOC) concentrations and water colour are increasing in many inland waters across northern Europe and northeastern North America. This inland-water "browning" has profound physical, chemical and biological repercussions for aquatic ecosystems affecting water quality, biological community struc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52912-0
更新日期:2019-11-13 00:00:00
abstract::Nociceptive neurons play an essential role in pain sensation by transmitting painful stimuli to the central nervous system. However, investigations of nociceptive neuron biology have been hampered by the lack of accessibility of human nociceptive neurons. Here, we describe a system for efficiently guiding human embryo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16821
更新日期:2015-11-19 00:00:00
abstract::Chronic alcohol feeding causes lipid accumulation and apoptosis in the liver. This study investigated the role of bioactive lipid metabolites in alcohol-induced liver damage and tested the potential of targeting arachidonate 15-lipoxygenase (ALOX15) in treating alcoholic liver disease (ALD). Results showed that chroni...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02759-0
更新日期:2017-08-21 00:00:00
abstract::The dorsal striatum is a brain region involved in action control, with dorsomedial striatum (DMS) mediating goal-directed actions and dorsolateral striatum (DLS) mediating habitual actions. Presynaptic long-term synaptic depression (LTD) plasticity at glutamatergic inputs to dorsal striatum mediates many dorsal striat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64203-0
更新日期:2020-04-29 00:00:00
abstract::Bioartificial livers (BAL) may offer acute liver failure (ALF) patients an opportunity for cure without liver transplantation. We evaluated the efficacy of a spheroid-based BAL system, containing aggregates of porcine hepatocytes, in a porcine model of ALF. ALF pigs were divided into three groups. The control group co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03424-2
更新日期:2017-06-19 00:00:00
abstract::Uterosacral ligaments (USLs) provide structural support to the female pelvic floor, and a loss of USL structural integrity or biomechanical function may induce pelvic organ prolapse (POP). Alterations in extracellular matrix composition and organization dictate USL mechanical function. Changes in USL microstructure an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64192-0
更新日期:2020-04-30 00:00:00
abstract::The ligand-induced dimerization of cell surface single-transmembrane receptors is essential for their activation. However, physiological molecules that inhibit their dimerization and activation have not been identified. ErbB3 dimerizes with ErbB2 upon binding of heregulin (HRG) to ErbB3, causing the ErbB2-catalyzed ty...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10107-5
更新日期:2017-09-12 00:00:00
abstract::Hyperspectral imaging technology is playing an increasingly important role in the fields of food analysis, medicine and biotechnology. To improve the speed of operation and increase the light throughput in a compact equipment structure, a Fourier transform hyperspectral imaging system based on a single-pixel technique...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45209
更新日期:2017-03-24 00:00:00