Abstract：
:Tumor aggressiveness is usually associated with metastasis. MDA-MB 231, a triple-negative breast cancer (TNBC), is an aggressive type of breast cancer and associated with early metastasis. The Rho/ROCK pathway is a key regulator of cell motility involving cytoskeleton regulation through stabilization of actin filaments and stress fiber formation. In this study we show that Fasudil, a ROCK inhibitor, inhibited the migration of MDA-MB 231 and A549 cells, without altering the viability of these cells at the concentration of 10 μM, modified tumor cell morphology, with disorganization of stress fibers and promotes activation of the canonical-Wnt/beta-catenin pathway. Therefore, Fasudil present a promising approach to the prevention of breast cancer metastasis through a different mechanism of action from the well-known one.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Guerra FS,Oliveira RG,Fraga CAM,Mermelstein CDS,Fernandes PDdoi
10.1038/s41598-017-14216-zsubject
Has Abstractpub_date
2017-10-20 00:00:00pages
13723issue
1issn
2045-2322pii
10.1038/s41598-017-14216-zjournal_volume
7pub_type
杂志文章abstract：:High frequency repetitive transcranial magnetic stimulation (HF-rTMS) over the left dorsolateral prefrontal cortex (L-DLPFC) is a widely applied treatment protocol for chronic smoking and major depressive disorder. However, no previous study has measured the effects of rTMS on both nicotine consumption and anxiety/dep...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80927-5
更新日期：2021-01-15 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-23132-9
更新日期：2018-03-19 00:00:00
abstract：:Auditory neuropathy (AN) is a hearing disorder characterized by normal cochlear amplification to sound but poor temporal processing and auditory perception in noisy backgrounds. These deficits likely result from impairments in auditory neural synchrony; such dyssynchrony of the neural responses has been linked to demy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06600-6
更新日期：2017-07-25 00:00:00
abstract：:The Farnesoid X receptor (FXR) regulates bile salt, glucose and cholesterol homeostasis by binding to DNA response elements, thereby activating gene expression (direct transactivation). FXR also inhibits the immune response via tethering to NF-κB (tethering transrepression). FXR activation therefore has therapeutic po...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14086
更新日期：2015-09-15 00:00:00
abstract：:One of the challenges of implementing free-space quantum key distribution (QKD) systems working in daylight is to remove unwanted background noise photons from sunlight. Elaborate elimination of background photons in the spectral, temporal, and spatial domains is an indispensable requirement to decrease the quantum bi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33699-y
更新日期：2018-10-17 00:00:00
abstract：:Estrogen deprivation aggravates cardiac injury after myocardial ischemia and reperfusion (I/R) injury. Although either estrogen or the dipeptidyl peptidase-4 (DPP-4) inhibitor, vildagliptin, reduces myocardial damage following cardiac I/R, their effects on the heart in obese-insulin resistant and estrogen deprived con...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44306
更新日期：2017-03-10 00:00:00
abstract：:Huntington's disease (HD) is a devastating hereditary movement disorder, characterized by degeneration of neurons in the striatum and cortex. Studies in human patients and mouse HD models suggest that disturbances of neuronal function in the neocortex play an important role in disease onset and progression. However, t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43024-w
更新日期：2019-04-29 00:00:00
abstract：:Multifactorial lifestyle intervention is known to be more effective for ameliorating cognitive decline than single factor intervention; however, the effects of combining exercise with long-chain polyunsaturated fatty acids (LCPUFA) on the elderlies' cognitive function remain unclear. We conducted a randomised, single-...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-020-69560-4
更新日期：2020-07-31 00:00:00
abstract：:We report the use of 2H-NbS2 film as a novel counter electrode in perovskite solar cells fabricated with a cold isostatic pressing method. The 2H-NbS2 film, which was prepared through an exfoliation method followed by restacking from LixNbS2 powder, shows high electrical conductivity of 8.7 × 103 S cm-1 and work funct...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25449-x
更新日期：2018-05-04 00:00:00
abstract：:Induction chemotherapy treatment for nasopharyngeal carcinoma (NPC) is controversial. The aim of this study was to evaluate the treatment outcomes and toxicities between two induction chemotherapy regimens, with both followed by concurrent chemoradiotherapy. The first strategy used docetaxel, cisplatin and fluorouraci...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33614-5
更新日期：2018-10-22 00:00:00
abstract：:Unlike their wolf ancestors, dogs have unique social skills for communicating and cooperating with humans. Previously, significant heritabilities for human-directed social behaviors have been found in laboratory beagles. Here, a Genome-Wide Association Study identified two genomic regions associated with dog's human-d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33439
更新日期：2016-09-29 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep25577. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/srep46944
更新日期：2018-02-16 00:00:00
abstract：:Graphene-based materials have been studied in many applications, owing to the excellent electrical, mechanical, and thermal properties of graphene. In the current study, an environmentally friendly approach to the preparation of a reduced graphene oxide-gold nanoparticle (rGO-AuNP) nanocomposite was developed by using...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15210-1
更新日期：2017-11-03 00:00:00
abstract：:The development and maturation of cortical circuits relies on the coordinated actions of long and short range axonal guidance cues. In this regard, the class 3 semaphorins and their receptors have been seen to be involved in the development and maturation of the hippocampal connections. However, although the role of m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19794-0
更新日期：2018-01-22 00:00:00
abstract：:We report the development of on-chip fluorescence switching system based on DNA strand displacement and DNA hybridization for the construction of a rewritable and randomly accessible data storage device. In this study, the feasibility and potential effectiveness of our proposed system was evaluated with a series of we...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16535-7
更新日期：2018-01-10 00:00:00
abstract：:Weight regain is one of the most common problems in the long-term after bariatric surgery. It is unknown if high-intensity exercise programs applied in late phases of post-surgical follow-up could counteract this trend. After a 3-year follow-up, 21 patients underwent sleeve gastrectomy were randomized into an exercise...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-020-60044-z
更新日期：2020-02-20 00:00:00
abstract：:A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-22153-8
更新日期：2018-03-06 00:00:00
abstract：:The formation of OD (order-disorder) phases of the LPSO (long-period stacking ordered)-type in Mg-Al-RE (RE (rare earth) = Y, La, Ce, Nd, Sm, Dy, Ho, Er and Yb) ternary systems has been investigated for both as-solidified and annealed conditions. The OD phase is found to form in those systems with RE = Y, Nd, Sm, Dy, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12506-0
更新日期：2017-09-25 00:00:00
abstract：:Arctic river watersheds are important components of the global climate system and show an amplified response to climate change. Here, we characterize origins and transformations of dissolved organic matter (DOM) in five major Arctic rivers (Kolyma, Lena, Yenisei, Ob, Mackenzie) over 3 years with seasonal sampling peri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12729-1
更新日期：2017-10-19 00:00:00
abstract：:Biomodels made of poly(vinyl alcohol) (PVA) are demanded because they can represent the geometries and mechanical properties of human tissues realistically. Injecting and molding, commonly used in three-dimensional (3D) modeling, help to represent the blood vessels accurately. However, these techniques sometimes requi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34986-4
更新日期：2018-11-08 00:00:00
abstract：:We present a new transcriptome assembly of the Pacific whiteleg shrimp (Litopenaeus vannamei), the species most farmed for human consumption. Its functional annotation, a substantial improvement over previous ones, is provided freely. RNA-Seq with Illumina HiSeq technology was used to analyze samples extracted from sh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07081
更新日期：2014-11-25 00:00:00
abstract：:Toward the increasing demands of portable energy storage and electric vehicle applications, the widely used graphite anodes with significant drawbacks become more and more unsuitable. Herein, we report a novel scaffold of hierarchical silicon nanowires-carbon textiles anodes fabricated via a facile method. Further, co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01622
更新日期：2013-01-01 00:00:00
abstract：:Carotenoids are anti-oxidative agents. Human skin and eyes contain specific carotenoid species known to prevent various pathologies caused by oxidative stress. We quantified skin and eye carotenoid levels and investigated their potential correlation in a population including 985 Japanese patients and staff members of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45751-6
更新日期：2019-06-27 00:00:00
abstract：:Vascular leakage is a life-threatening complication of dengue virus (DENV) infection. Previously, association between "paracellular" endothelial hyperpermeability and plasma leakage had been extensively investigated. However, whether "transcellular" endothelial leakage is involved in dengue hemorrhagic fever (DHF) and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31855
更新日期：2016-08-22 00:00:00
abstract：:We describe a spin wave modulator - spintronic device aimed to control spin wave propagation by an electric field. The modulator consists of a ferromagnetic film serving as a spin wave bus combined with a synthetic multiferroic comprising piezoelectric and magnetostrictive materials. Its operation is based on the stre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28878-w
更新日期：2018-07-18 00:00:00
abstract：:Selective amygdalohippocampectomy is an effective treatment for patients with therapy-refractory temporal lobe epilepsy but may cause visual field defect (VFD). Here, we aimed to describe tissue-specific pre- and postoperative imaging correlates of the VFD severity using whole-brain analyses from voxel- to network-lev...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80751-x
更新日期：2021-01-14 00:00:00
abstract：:Advances in single-photon sources (SPSs) and single-photon detectors (SPDs) promise unique applications in the field of quantum information technology. In this paper, we report long-distance quantum key distribution (QKD) by using state-of-the-art devices: a quantum-dot SPS (QD SPS) emitting a photon in the telecom ba...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14383
更新日期：2015-09-25 00:00:00
abstract：:Acoustic manipulation by an ultrasonic phased array provides an entirely new approach to processes such as coalescence, mixing, separation, and evaporation occurring in the generation of new materials, physical property measurement, the biomedical industry, etc. However, to date, ultrasonic phased arrays have not been...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28451-5
更新日期：2018-07-05 00:00:00
abstract：:Broadband acoustic absorbers with thin thickness are highly desired in practical situations such as architectural acoustics, yet it is still challenging to achieve high absorption by using structure with limited thickness. Here we report the theoretical optimal design, numerical simulation and experimental demonstrati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67688-x
更新日期：2020-07-01 00:00:00
abstract：:Type 2 Diabetes (T2D) is increasing but the effectiveness of large-scale diabetes screening programmes is debated. We assessed associations between coverage of a national cardiovascular and diabetes risk assessment programme in England (NHS Health Check) and detection and management of incident cases of non-diabetic h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58033-3
更新日期：2020-01-27 00:00:00
